Abstract:
:The control of biofouling, which is the unwanted adsorption of biomolecules and organisms on solid surfaces, is a prerequisite for wider applicability of the functional materials that are currently being used in biomedical industries. One of the frequently used methods for controlling biofouling is the use of surface coatings with antifouling materials. Herein, fucoidan, which is a marine-derived polysaccharide, is reported as a new type of antifouling material that is safe and broadly applicable. Fucoidan is conjugated with catechols, which are known to act as adhesives for grafting functional molecules onto solid substrates. Fucoidan catechol (FD-C) is subsequently utilized for robust fucoidan coatings of solid substrates, and the FD-C-coated surfaces show excellent antifouling capability for fouling organisms, including platelets and bacteria. The FD-C coating is also confirmed to be nonirritating upon skin contact, demonstrating its potential use in public places for inhibiting contagions.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Jeong Y,Thuy LT,Ki SH,Ko S,Kim S,Cho WK,Choi JS,Kang SMdoi
10.1002/mabi.201800137subject
Has Abstractpub_date
2018-10-01 00:00:00pages
e1800137issue
10eissn
1616-5187issn
1616-5195journal_volume
18pub_type
杂志文章abstract::Current approaches to generate core-shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800213
更新日期:2018-10-01 00:00:00
abstract::Several high-resolution imaging techniques such as FESEM, TEM and AFM are compared with respect to their application on alginate hydrogels, a widely used polysaccharide biomaterial. A new AFM method applicable to RGD peptides covalently conjugated to alginate hydrogels is described. High-resolution images of RGD adhes...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700313
更新日期:2008-06-11 00:00:00
abstract::Poly[(R)-3-hydroxybutyrate] (P(3HB)) and its copolymers are accumulated by a wide variety of microorganisms as intracellular carbon and energy material, and are extensively studied as biodegradable and biocompatible thermoplastics. However, these microbial polyesters have not been recognized as practical because of th...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200500066
更新日期:2005-08-12 00:00:00
abstract::Pedobacter sp. KP-2 can degrade and metabolize thermally synthesized alpha,beta-poly(D,L-aspartic acid) (tPAA), which contains 70% of unnatural beta-amide units, with high-molecular-weight. In this study, gene cloning and molecular characterization of PAA hydrolase-1 from KP-2 was carried out. Gene analysis reveals th...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800106
更新日期:2009-01-09 00:00:00
abstract::For use in micro-patterned scaffolds in tissue engineering, novel diacrylated triblock macromers (PLA-b-PCL-b-PLA, PGA-b-PCL-b-PGA and PCL-b-PEO-b-PCL) were synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance spectroscopy (NMR) and gel permeation chromatography (...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200300139
更新日期:2004-07-14 00:00:00
abstract::N-Acetyl-l-cysteine (NAC)-capped poly(methyl methacrylate)-b-polycaprolactone block copolymer (PMMA-b-PCL-NAC) was prepared using the previously described one-pot photoinduced sequential CuAAC/thiol-ene double click procedure. PMMA-b-PCL-NAC had previously shown good applicability as a matrix for cell adhesion of cell...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500099
更新日期:2015-09-01 00:00:00
abstract::The efficient internalization of TGF-beta inhibitor-loaded polyelectrolyte capsules and particles is studied in two HCC cell lines. Two polyelectrolyte pairs (biocompatible but not degradable and biodegradable crosslinked with gluteraldehyde) are employed for coating. The capsules are characterized by SEM. LY is succe...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100457
更新日期:2012-05-01 00:00:00
abstract::Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400121
更新日期:2005-01-14 00:00:00
abstract::Vessel morphogenesis is vital to regenerative medicine strategies. Here, collagen polymers, specified by intermolecular cross-link composition, are used to independently vary microstructure (fibril density, interfibril branching) and physical properties (stiffness) to guide 3D vessel network formation by endothelial c...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300128
更新日期:2013-09-01 00:00:00
abstract::Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and s...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900415
更新日期:2010-05-14 00:00:00
abstract::Two different composite scaffolds, solid-freeform-fabricated PCL/β-TCP supplemented with and without collagen nanofibers are fabricated. These scaffolds are evaluated whether a combination of collagen nanofibers with PCL/β-TCP can promote osteogenesis in a mastoid obliteration. To assess the effects of the cellular ac...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200393
更新日期:2013-05-01 00:00:00
abstract::Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500457
更新日期:2016-09-01 00:00:00
abstract::O-carboxymethylchitin (molecular weight = 1.07 x 10(5), degree of carboxymethylation = 80%, degree of N-acetylation = 91%) was chemically attached to superoxide dismutase by the formation of amide linkages through a carbodiimide catalyzed reaction. The glycosidated enzyme contained about 1.8 mole of polysaccharide per...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400114
更新日期:2005-02-23 00:00:00
abstract::Although chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western world, it remains incurable with conventional chemotherapeutic agents. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an antitumor candidate in cancer therapy. This study examines the proapoptotic effects...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600169
更新日期:2017-05-01 00:00:00
abstract::An increased structural variety expands the number of putative applications for cyanophycin (multi-l-arginyl-poly-[l-aspartic acid], CGP). Therefore, structural modifications of CGP are of major interest; these are commonly obtained by modification and optimization of the bacterial producing strain or by chemical modi...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500433
更新日期:2016-07-01 00:00:00
abstract::A poly(o-methoxyaniline) (POMA)/DNA [weight fraction of DNA (W(DNA)) = 0.45] hybrid was prepared by mixing their solutions in sterilized double distilled water. The solution turned green upon aging for a longer time, and the doping of POMA by DNA was complete after about 15 d of aging. The doping was confirmed from th...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400185
更新日期:2005-05-23 00:00:00
abstract::The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500030
更新日期:2005-07-14 00:00:00
abstract::Functional hydrophilic microspheres (latex particles) have found various applications in life sciences and in medicine - particularly in latex diagnostic tests. This paper presents a comprehensive review of studies on latex particles with a hydrophilic interfacial layer composed of various hydrophilic polymers with re...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200500138
更新日期:2005-12-15 00:00:00
abstract::Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, m...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600165
更新日期:2006-12-08 00:00:00
abstract::HSVEC behavior under physiological shear stress in vitro is investigated on PET surfaces micropatterned with both RGDS and WQPPRARI peptides. This technique allows (i) creating geometries on surface to guide cell orientation under shear stress and (ii) controlling surface chemical composition in order to modulate cell...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200167
更新日期:2012-12-01 00:00:00
abstract::In search for effective non-viral gene vectors for the delivery of siRNA, a copolymer was designed and synthesized by grafting hydrophobic poly(gamma-benzyl L-glutamate) segment (PBLG) to hyperbranched polyethylenimine (PEI-PBLG). PEI-PBLG could efficiently deliver siRNA to cells to silence the targeted gene. Markedly...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900249
更新日期:2009-12-08 00:00:00
abstract::Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and respons...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.200300099
更新日期:2004-05-17 00:00:00
abstract::Treatment of retinal diseases currently demands frequent intravitreal injections due to rapid clearance of the therapeutics. The use of high molecular weight polymers can extend the residence time in the vitreous and prolong the injection intervals. This study reports a water soluble graft copolymer as a potential veh...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700200
更新日期:2018-01-01 00:00:00
abstract::In pluripotent stem cell differentiation, embryoid bodies (EBs) provide a three-dimensional [3D] multicellular precursor in lineage specification. The internal structure of EBs is not well characterized yet is predicted to be an important parameter to differentiation. Here, we use custom SU-8 molds to generate transpa...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500051
更新日期:2015-07-01 00:00:00
abstract::A redox-responsive poly(ethylene glycol) (PEG)-sheddable copolymer of disulfide-linked PEG 5000-lysine-di-tocopherol succinate (P(5k)SSLV) is developed which can self-assemble into nanomicelles in aqueous condition and trigger the rapid release of encapsulated drugs within tumor cells. The reduction-insensitive doxoru...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400149
更新日期:2014-10-01 00:00:00
abstract::Amylose selectively includes poly(L-lactide) (PLLA) among the poly(lactide)s (PLAs) to produce an inclusion complex when the phosphorylase-catalyzed polymerization of α-D-glucose 1-phosphate is performed in the presence of PLLA, poly(D-lactide) (PDLA), or poly(DL-lactide) (PDLLA) (vine-twining polymerization). This re...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100133
更新日期:2011-10-10 00:00:00
abstract::Different strategies of chemotherapeutics-based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201800240
更新日期:2018-12-01 00:00:00
abstract::The unicellular cyanobacterium Cyanothece sp. CCY 0110 is a highly efficient producer of extracellular polymeric substances (EPS), releasing up to 75% of the polymer to the culture medium. The carbohydrate polymer released to the medium (RPS) was previously isolated and characterized; it is composed of nine different ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600206
更新日期:2017-02-01 00:00:00
abstract::The effect of doping graphene oxide (GO) and reduced graphene oxide (rGO) into poly(ε-caprolactone) (PCL) membranes prepared by solvent induced phase separation is evaluated in terms of nanomaterial distribution and compatibility with neural stem cell growth and functional differentiation. Raman spectra analyses demon...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800195
更新日期:2018-11-01 00:00:00
abstract::Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrica...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201800256
更新日期:2019-02-01 00:00:00