Abstract:
:A tissue-engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro-scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create single- and multiple-channeled nanofibrous poly(L-lactic acid) scaffolds. The overall shape, the number and spatial arrangement of channels, the channel wall matrix architecture, the porosity and mechanical properties of the scaffolds are all tunable. The porous NF channel wall matrix provides an excellent microenvironment for protein adsorption and the attachment of PC12 neuronal cells and tendon fibroblast cells, showing potential for neural and tendon tissue regeneration.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Sun C,Jin X,Holzwarth JM,Liu X,Hu J,Gupte MJ,Zhao Y,Ma PXdoi
10.1002/mabi.201200004subject
Has Abstractpub_date
2012-06-01 00:00:00pages
761-9issue
6eissn
1616-5187issn
1616-5195journal_volume
12pub_type
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