Abstract:
:Novel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF-2. An intermediate degree of sulfation (DS(S) ) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS increases with DS(S) and concentration. Experiments with trypsin as model proteinase show that protection of FGF-2 from proteolytic digestion depends on DS(S) and the concentration of derivatives in the same manner as cell growth. Studies on stability of FGF-2 added to cultures of 3T3 cells show that the FGF-2 concentration remains higher in the presence of derivatives. Results indicate that the mitogenic activity of CHS and CS is due to protection of FGF-2 from proteolytic cleavage.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Weltrowski A,da Silva Almeida ML,Peschel D,Zhang K,Fischer S,Groth Tdoi
10.1002/mabi.201100518subject
Has Abstractpub_date
2012-06-01 00:00:00pages
740-50issue
6eissn
1616-5187issn
1616-5195journal_volume
12pub_type
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