Abstract:
:This study investigates the structural features of porcine gastric mucin (PGM) in aqueous dispersions and its interactions with water-soluble polymers (poly(acrylic acid) (PAA), poly(methacrylic acid) (PMAA), poly(ethylene oxide), and poly(ethylene glycol)) using isothermal titration calorimetry, turbidimetric titration, dynamic light scattering, and transmission electron microscopy. It is established that PAA (450 kDa) and PMAA (100 kDa) exhibit strong specific interactions with PGM causing further aggregation of its particles, while PAA (2 kDa), poly(ethylene oxide) (1 000 kDa), and poly(ethylene glycol) (10 kDa) do not show any detectable effects on mucin. Sonication of mucin dispersions prior to their mixing with PAA (450 kDa) and PMAA (100 kDa) leads to more pronounced intensity of interactions.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Albarkah YA,Green RJ,Khutoryanskiy VVdoi
10.1002/mabi.201500158subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1546-53issue
11eissn
1616-5187issn
1616-5195journal_volume
15pub_type
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