Abstract:
:A novel PEGylated biodegradable hyperbranched PEG-b-PDMAEMA has been synthesized. The low toxicity, small molecular weight PDMAEMA chains were crosslinked using a biodegradable disulfide-based dimethacrylate (DSDMA) agent to yield higher molecular weight hyperbranched polymers. PEG chains were linked onto the polymer surface, masking the positive charge (as shown by Zeta potential measurements) and reducing the toxicity of the polymer. The hyperbranched structures were also cleaved under reducing conditions and analyzed, confirming the expected component structures. The hyperbranched polymer was mixed with DNA and efficient binding was shown to occur through electrostatic interactions. The hyperbranched structures could be reduced easily, generating lower toxicity oligomer chains.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Tao L,Chou WC,Tan BH,Davis TPdoi
10.1002/mabi.200900378subject
Has Abstractpub_date
2010-06-11 00:00:00pages
632-7issue
6eissn
1616-5187issn
1616-5195journal_volume
10pub_type
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