Abstract:
:Chronic non-healing wounds show delayed and incomplete healing processes and in turn expose patients to a high risk of infection. Treatment currently focuses on dressings that prevent microbial infiltration and keep a balanced moisture and gas exchange environment. Antibacterial delivery from dressings has existed for some time, with responsive systems now aiming to trigger release only if infection occurs. Simultaneously, approaches that stimulate cell proliferation in the wound and encourage healing have been developed. Interestingly, few dressings appear capable of simultaneously impairing or treating infection and encouraging cell proliferation/wound healing. Electrospinning is a simple, cost-effective, and reproducible process that can utilize both synthetic and natural polymers to address these specific wound challenges. Electrospun meshes provide high-surface area, micro-porosity, and the ability to load drugs or other biomolecules into the fibers. Electrospun materials have been used as scaffolds for tissue engineering for a number of years, but there is surprisingly little literature on the interactions of fibers with bacteria and co-cultures of cells and bacteria. This Review examines the literature and data available on electrospun wound dressings and the research that is required to develop smart multifunctional wound dressings capable of treating infection and healing chronic wounds.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Abrigo M,McArthur SL,Kingshott Pdoi
10.1002/mabi.201300561subject
Has Abstractpub_date
2014-06-01 00:00:00pages
772-92issue
6eissn
1616-5187issn
1616-5195journal_volume
14pub_type
杂志文章,评审abstract::Enzyme immobilization is of high interest for industrial applications. However, immobilization may compromise enzyme activity or stability due to the harsh conditions which have to be applied. The authors therefore present a new and improved crosslinked layer-by-layer (cLbL) approach. Two different model enzymes (acid...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700015
更新日期:2017-08-01 00:00:00
abstract::In situ self-assemblies of new biodegradable triblock PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA have been investigated in acetonitrile solution. At first, two series of PLLA-b-PBS-b-PLLA and PDLA-b-PBS-b-PDLA, respectively denoted as the P and Q triblock copolyester series, were prepared with fixed PBS block ((overline)...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400227
更新日期:2005-06-24 00:00:00
abstract::Three different microbial wild-type strains are compared with respect to their potential as industrial scale polyhydroxyalkanoate (PHA) producers from the feed stock whey lactose. The halophilic archaeon Haloferax mediterranei as well as two eubacterial strains (Pseudomonas hydrogenovora and Hydrogenophaga pseudoflava...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600211
更新日期:2007-02-12 00:00:00
abstract::The preparation of histidine enriched dendritic peptide amphiphiles and their self-assembly into multicomponent pH-switchable supramolecular polymers is reported. Alternating histidine and phenylalanine peptide synthons allow the assembly/disassembly to be adjusted in a physiologically relevant range of pH 5.3-6.0. Co...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700111
更新日期:2017-10-01 00:00:00
abstract::In this report, we developed a simple and green process of simultaneous formation of doxorubicin-BSA-dextran nanoparticles in aqueous solution and high-effective encapsulation of doxorubicin. In the presence of BSA-dextran conjugates, which were produced by Maillard reaction, a binding of doxorubicin with BSA can supp...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000125
更新日期:2010-10-08 00:00:00
abstract::In-depth understanding of the biophysicochemical interactions at the nano-bio interface is important for basic cell biology and applications in nanomedicine and nanobiosensors. Here, the extracellular surface potential and topography changes of live cell membranes interacting with polymeric nanomaterials using a scann...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800271
更新日期:2019-02-01 00:00:00
abstract::Fluorescent dye labeled unfunctionalized and functionalized poly(n-butylcyanoacrylate) nanoparticles were prepared using a miniemulsion technique. Amino acid and methoxyPEG functionalization could be introduced by using aqueous solutions as an initiator for the anionic polymerization in the heterophase. All the partic...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700046
更新日期:2007-07-09 00:00:00
abstract::A novel PEGylated biodegradable hyperbranched PEG-b-PDMAEMA has been synthesized. The low toxicity, small molecular weight PDMAEMA chains were crosslinked using a biodegradable disulfide-based dimethacrylate (DSDMA) agent to yield higher molecular weight hyperbranched polymers. PEG chains were linked onto the polymer ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900378
更新日期:2010-06-11 00:00:00
abstract::This study describes the development and cell culture application of nanometer thick photocrosslinkable thermoresponsive polymer films prepared by physical adsorption. Two thermoresponsive polymers, poly(N-isopropylacrylamide (NIPAm)-co-acrylamidebenzophenone (AcBzPh)) and poly(NIPAm-co-AcBzPh-co-N-tertbutylacrylamide...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600175
更新日期:2017-02-01 00:00:00
abstract::Polylaminin (polyLM) is a polymerized form of the extracellular matrix protein laminin obtained upon pH acidification. Here microscopy and spectroscopic tools are used to study the cell compatibility and the structural stability of polyLM, aiming at establishing its robustness as a biopolymer for therapeutic use. Poly...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100125
更新日期:2012-01-01 00:00:00
abstract::Living materials are created through the embedding of live, whole cells into a matrix that can house and sustain the viability of the encapsulated cells. Through the immobilization of these cells, their bioactivity can be harnessed for applications such as bioreactors for the production of high-value chemicals. While ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000121
更新日期:2020-08-01 00:00:00
abstract::The material surface must be considered in the design of scaffolds for bone tissue engineering so that it supports bone cells adhesion, proliferation and differentiation. A biomimetic approach has been developed as a 3D surface modification technique to grow partially carbonated hydroxyapatite (the bonelike mineral) i...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200300017
更新日期:2004-02-20 00:00:00
abstract::This study presents the reactive self-assembly of isocyanate functional and amphiphilic six-arm, star-shaped polyether prepolymers in water into nanogels. Intrinsic molecular amphiphilicity, mainly driven by the isophorone moiety at the distal endings of the star-shaped molecules, allows for the preparation of spheric...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800094
更新日期:2018-10-01 00:00:00
abstract::Herein, a new series of non-ionic dendritic and carbohydrate based amphiphiles is synthesized employing biocompatible starting materials and studied for supramolecular aggregate formation in aqueous solution. The dendritic amphiphiles 12 and 13 possessing poly(glycerol) [G2.0] as hydrophilic unit and C-10 and C-18 hyd...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800019
更新日期:2018-07-01 00:00:00
abstract::In search for effective non-viral gene vectors for the delivery of siRNA, a copolymer was designed and synthesized by grafting hydrophobic poly(gamma-benzyl L-glutamate) segment (PBLG) to hyperbranched polyethylenimine (PEI-PBLG). PEI-PBLG could efficiently deliver siRNA to cells to silence the targeted gene. Markedly...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900249
更新日期:2009-12-08 00:00:00
abstract::Pedobacter sp. KP-2 can degrade and metabolize thermally synthesized alpha,beta-poly(D,L-aspartic acid) (tPAA), which contains 70% of unnatural beta-amide units, with high-molecular-weight. In this study, gene cloning and molecular characterization of PAA hydrolase-1 from KP-2 was carried out. Gene analysis reveals th...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200800106
更新日期:2009-01-09 00:00:00
abstract::Formulation of docetaxel (DOC), a hydrophobic anticancer drug, was successfully achieved in poly(gamma-benzyl L-glutamate)-block-hyaluronan polymersomes using a simple and reproducible nanoprecipitation method. The prepared DOC loaded polymersomes (PolyDOC) was stable either in solution or in a lyophilized form, and s...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900415
更新日期:2010-05-14 00:00:00
abstract::A series of enzymatically recyclable poly(ester-urethane)s consisting of a biodegradable diurethane moiety as a hard segment and an ester moiety as an enzymatically cleavable linkage was chemo-enzymatically prepared by two routes. The poly(ester-urethane) was prepared by a) the ring-opening polymerization of a cyclic ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400176
更新日期:2005-04-19 00:00:00
abstract::Ischemic stroke occurs when a blood clot obstructs or narrows the arteries that supply blood to the brain. Currently, tissue plasminogen activator (tPA), a thrombolytic agent, is the only United States Food and Drug Administration (FDA)-approved pharmacologic treatment for ischemic stroke. Despite its effective usage,...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201700379
更新日期:2018-04-01 00:00:00
abstract::Current approaches to generate core-shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming t...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800213
更新日期:2018-10-01 00:00:00
abstract::High-molecular-weight (co)polymers of trimethylene carbonate and D,L-lactide are efficiently crosslinked using PETA during gamma irradiation. Form-stable networks with gel contents of 86 ± 5 to 96 ± 1 are obtained from non-crystalline (co)polymers. Glass transition temperatures and elastic moduli of the networks can b...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100031
更新日期:2011-07-07 00:00:00
abstract::In this preliminary work we have prepared a fluorinated polymer capable of solubilizing an appreciable amount of O(2) and, at the same time, maintaining a higher water solubility than perfluoroalkanes investigated as injectable O(2) carriers. In particular, we describe the synthesis and characterization of a new macro...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600266
更新日期:2007-06-07 00:00:00
abstract::Open-pore biodegradable foams with controlled porous architectures were prepared by combining gas foaming and microparticulate templating. Microparticulate composites of poly(epsilon-caprolactone) (PCL) and micrometric sodium chloride particles (NaCl), in concentrations ranging from 70/30 to 20/80 wt.-% of PCL/NaCl we...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700278
更新日期:2008-07-07 00:00:00
abstract::Stereoblock poly(lactic acid) consisting of D- and L-lactate stereosequences can be successfully synthesized by solid-state polycondensation of a 1:1 mixture of poly(L-lactic acid) and poly(D-lactic acid). In the first step, melt-polycondensation of L- and D-lactic acids is conducted to synthesize poly(L-lactic acid) ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200400121
更新日期:2005-01-14 00:00:00
abstract::The use of long-lasting polymer coatings on biodevice surfaces has been investigated to improve material-tissue interaction, minimize adverse effects, and enhance their functionality. Natural polymers, especially chitosan, are of particular interest due to their excellent biological properties, such as biocompatibilit...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201900253
更新日期:2020-01-01 00:00:00
abstract::The synthesis of a zwitterionic polymer, poly-sulfobetaine (poly-SPB), which shows remarkable efficiency in the suppression of insulin aggregation is described. Hydrophobic modification of the polymer results in almost complete inhibition at very low polymer concentrations. Further studies reveal that these polymers f...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800016
更新日期:2018-06-01 00:00:00
abstract::Controlled delivery of multiple growth factors (GFs) holds great potential for the clinical treatment of ischemic diseases and might be more therapeutically effective to reestablish vasculature than the provision of a single GF. Vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) are two poten...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300486
更新日期:2014-05-01 00:00:00
abstract::The unicellular cyanobacterium Cyanothece sp. CCY 0110 is a highly efficient producer of extracellular polymeric substances (EPS), releasing up to 75% of the polymer to the culture medium. The carbohydrate polymer released to the medium (RPS) was previously isolated and characterized; it is composed of nine different ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600206
更新日期:2017-02-01 00:00:00
abstract::The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500060
更新日期:2015-08-01 00:00:00
abstract::3D hydrogels better replicate in vivo conditions, and yield different results from 2D substrates. However, imaging interactions between cells and the hydrogel microenvironment is challenging because of light diffraction and poor focal depth. Here, cryosectioning and vibrating microtomy methods and fixation protocols a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600478
更新日期:2017-06-01 00:00:00