Abstract:
:The preparation of histidine enriched dendritic peptide amphiphiles and their self-assembly into multicomponent pH-switchable supramolecular polymers is reported. Alternating histidine and phenylalanine peptide synthons allow the assembly/disassembly to be adjusted in a physiologically relevant range of pH 5.3-6.0. Coassembly of monomers equipped with dendritic tetraethylene glycol chains with monomers bearing peripheral primary amine groups leads to nanorods with a tunable cationic surface charge density. These surface functional supramolecular polycations are able to reversibly bind short interfering RNA (siRNA). The nanorod-like supramolecular polymers, their complexation with siRNA, and the pH-triggered assembly/disassembly of the supramolecular carriers are characterized via circular dichroism spectroscopy, gel electrophoresis, as well as transmission electron microscopy. Multicomponent supramolecular polymers represent a modular and promising strategy for applications as responsive carrier vehicles, codelivery strategies, and gene therapy.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Ahlers P,Frisch H,Holm R,Spitzer D,Barz M,Besenius Pdoi
10.1002/mabi.201700111subject
Has Abstractpub_date
2017-10-01 00:00:00issue
10eissn
1616-5187issn
1616-5195journal_volume
17pub_type
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