Abstract:
:A HBSP has been designed as a novel bifunctional enzyme model with SOD and GPx activity by host/guest-directed self-assembly of MnTPyP-M-Ad and 6-Te-diCD. The structure of the host/guest complex was elucidated by (1) H NMR spectra, and the HBSP was characterized by SEM, DLS and measurement of catalytic properties. In the bifunctional enzyme model, the Mn(III) porphyrins act as efficient SOD active sites and the tellurol moieties endow GPx activity. The SOD-like activity (IC(50) ) of this new supramolecular catalyst was found to be 1.05 × 10(-7) M, which corresponds to 2.82% of the activity of the native SOD enzyme. Besides this, the hyperbranched supramolecular polymer also shows a higher GPx activity (ν(0 ) = 21.7 × 10(-6) M · min(-1) ) than other supramolecular enzyme models.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Yu S,Zhang W,Zhu J,Yin Y,Jin H,Zhou L,Luo Q,Xu J,Liu Jdoi
10.1002/mabi.201000478subject
Has Abstractpub_date
2011-06-14 00:00:00pages
821-7issue
6eissn
1616-5187issn
1616-5195journal_volume
11pub_type
杂志文章abstract::Different strategies of chemotherapeutics-based combination cancer therapy have presented enhanced antitumor efficiency and are widely used in clinical cancer treatments. However, several drawbacks of the systems for systemic administration, including low drug accumulation at tumor sites and significant systemic side ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201800240
更新日期:2018-12-01 00:00:00
abstract::The enzymatic transformation into an oligomer was carried out with the objective of developing the chemical recycling of bacterial polyesters. Poly(R-3-hydroxyalkanoate)s (PHAs), such as poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyhexanoate)] and poly[(R-3-hydroxybutyrate)-co-12%(R-3-hydroxyvalerate)], were degraded ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500030
更新日期:2005-07-14 00:00:00
abstract::Thermosensitive polymers enable externally controllable biomolecular interactions but hysteresis effects hamper the reversibility and repeated use of these materials. To quantify the temperature-dependent interactions and hysteresis effects, an optical adhesion assay based on poly(ethylene glycol) microgels (soft coll...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000186
更新日期:2020-10-01 00:00:00
abstract::Photo-crosslinking and self-healing have received considerable attention for the design of intelligent materials. A novel photostimulated, self-healing, and cytocompatible hydrogel system is reported. A coumarin methacrylate crosslinker is synthesized to modify the polyacrylamide-based hydrogels. With the [2+2] cyclo-...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500457
更新日期:2016-09-01 00:00:00
abstract::We recently discovered that poly(aspartate) (PAA) hydrolase-1 from Pedobacter sp. KP-2 has a unique property of specifically cleaving the amide bond between β-aspartate units in thermally synthesized PAA (tPAA). In the present study, the enzymatic synthesis of poly(α-ethyl β-aspartate) (β-PAA) was performed by taking ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000199
更新日期:2011-02-11 00:00:00
abstract::Well-defined amphiphilic polymers of the ABA and ABC type are synthesized, where A is poly(L-lysine hydrochloride) (PLL), B is poly(γ-benzyl-(d7) L-glutamate) (PBLG(-d7)), and C is poly(ethylene oxide) (PEO). The two polymers exhibit similar PBLG(-d7) composition, while in the ABC, the volume fraction of PEO block is ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400137
更新日期:2014-09-01 00:00:00
abstract::Intrinsic antimicrobial thermoplastic A(BC)n copolymers (n = 1, 2, 4), where A was poly(ethylene glycol) (PEG), BC was a random chain of methylmethacrylate (MMA), and alkyl-aminoethyl methacrylate (AAEMA), were synthesized and the antimicrobial activity and hemolyticity were evaluated on plaques obtained by casting as...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400503
更新日期:2015-07-01 00:00:00
abstract::Plant derived flavonoids have not been well explored in tissue engineering applications due to difficulties in efficient formulations with biomaterials for controlled presentation. Here, the authors report that surface coating of epigallocatechin gallate (EGCG) on polymeric substrates including poly (L-lactic acid) (P...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201800392
更新日期:2019-04-01 00:00:00
abstract::The aim of this study is to establish the safe and effective ocular delivery system of therapeutic small interfering RNA (siRNA) in corneal neovascularization therapy. The major hurdle present in siRNA-based corneal neovascularization (CNV) therapy is severe cytotoxicity caused by repetitive drug treatment. A reducibl...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600051
更新日期:2016-11-01 00:00:00
abstract::Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章,评审
doi:10.1002/mabi.201300058
更新日期:2013-07-01 00:00:00
abstract::The preclinical development of nanomedicines raises several challenges and requires a comprehensive characterization. Among them is the evaluation of the biodistribution following systemic administration. In previous work, the biocompatibility and in vitro targeting ability of a glycol chitosan (GC) based nanogel have...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500267
更新日期:2016-03-01 00:00:00
abstract::The role viscoelasticity in fibrotic disease progression is an emerging area of interest. Here, a fast-relaxing hydrogel system is exploited to investigate potential crosstalk between calcium signaling and mechanotransduction. Poly(ethylene glycol) (PEG) hydrogels containing boronate and triazole crosslinkers are synt...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000268
更新日期:2020-12-01 00:00:00
abstract::The phase behavior of a water/hydroxypropyl cellulose/maleic acid-styrene copolymer (H2O/HPC/MAc-S) system was investigated in the semi-dilute range by turbidimetry, rheology, and optical microscopy. The two polymers under investigation form interpolymer complexes via hydrogen bonding. In the case of a total polymer c...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200500070
更新日期:2005-10-20 00:00:00
abstract::A gold standard for esophagus reconstruction is not still available. The present work aims to design a polymer patch combining synthetic polylactide-co-polycaprolacton and chitosan biopolymers, tailoring patch properties to esophageal tissue characteristics by a temperature-induced precipitation method, to get multila...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600426
更新日期:2017-06-01 00:00:00
abstract::A ternary complex comprising plasmid DNA, lipopolysaccharide-binding peptide (LBP), and deoxycholic acid-conjugated polyethylenimine (PEI-DA) is prepared for combinational therapy of acute lung injury (ALI). The LBP is designed as an anti-inflammatory peptide based on the lipopolysaccharide (LPS)-binding domain of HMG...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600490
更新日期:2017-08-01 00:00:00
abstract::Living materials are created through the embedding of live, whole cells into a matrix that can house and sustain the viability of the encapsulated cells. Through the immobilization of these cells, their bioactivity can be harnessed for applications such as bioreactors for the production of high-value chemicals. While ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.202000121
更新日期:2020-08-01 00:00:00
abstract::Currently, there is no gadolinium-based contrast agent available for conventional magnetic resonance imaging (MRI) detection of amyloidal beta (Aβ) plaques in Alzheimer's disease (AD). Its timely finding would be vital for patient survival and quality of life. Curcumin (CUR), a common Indian spice effectively binds to...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201500062
更新日期:2015-09-01 00:00:00
abstract::In order to impart antibacterial properties to microfibrous electrospun materials from styrene/maleic anhydride copolymers, quaternized chitosan derivatives (QCh) containing alkyl substituents of different chain lengths are covalently attached to the mats. A complete inhibition of the growth of bacteria, S. aureus (Gr...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201100178
更新日期:2012-01-01 00:00:00
abstract::A simple, robust one pot procedure for the preparation of waterborne multifunctional poly(vinyl amine)s (PVAms) is presented. By post-polymerization modification of PVAm with a bifunctional coupler and functional couplers cationic, reactive azetidinium groups, and alkyl chains are introduced in the side chains of PVAm...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300576
更新日期:2014-08-01 00:00:00
abstract::Thermosensitive macroporous scaffolds of poly(N-isopropylacrylamide) (polyNIPA) loaded with chitosan/bemiparin nanoparticles are prepared by the free radical polymerization in cryogenic conditions. Chitosan/bemiparin nanoparticles of 102 ± 6.5 nm diameter are prepared by complex coacervation and loaded into polyNIPA c...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201300184
更新日期:2013-11-01 00:00:00
abstract::In many industrial applications, inadequate cell attachment can be a limitation, especially when serum-free media are used. Nitrogen-rich plasma-polymerised ethylene (PPE:N) exhibits high concentrations of polar groups that can help to promote the attachment of weakly adherent cell types. Tissue plasminogen activator-...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900079
更新日期:2009-10-08 00:00:00
abstract::In search for effective non-viral gene vectors for the delivery of siRNA, a copolymer was designed and synthesized by grafting hydrophobic poly(gamma-benzyl L-glutamate) segment (PBLG) to hyperbranched polyethylenimine (PEI-PBLG). PEI-PBLG could efficiently deliver siRNA to cells to silence the targeted gene. Markedly...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900249
更新日期:2009-12-08 00:00:00
abstract::A facile and easily reproducible technique for assembling biohybrid nanoparticles is a core feature that is highly desired for biomedical applications, considering the nature and limited lifespan of the biopolymers used. Here we show a simple and effective method to enfold single-walled carbon nanotubes (SWNTs) using ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200900349
更新日期:2010-03-10 00:00:00
abstract::BSA adsorption onto negatively and positively charged polystyrene nanoparticles was investigated. The nanoparticles were characterized in terms of particle size, zeta potential, surface group density, and morphology. The adsorption behavior of BSA on the particle surface, as a function of pH and overall charge of the ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000395
更新日期:2011-05-12 00:00:00
abstract::"Three-layered micelles" (3LM) composed of two triblock copolymers, poly(L-lactide)-b-polyethyleneimine-b-poly(L-lactide) (PLLA-PEI-PLLA) and poly(L-lactide)-b-poly(ethylene glycol)-b-poly(L-lactide) (PLLA-PEG-PLLA) are designed to combine electrostatic interaction and solvent-induced condensation of DNA. The low mole...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201400488
更新日期:2015-05-01 00:00:00
abstract::A CMB monomer was polymerized on a glass plate with a surface-confined ATRP initiator containing a 2-bromoisobutyryl group. The glass plate modified with a PCMB brush was highly hydrophilic and showed a strong resistance against non-specific adsorption of proteins and cell adhesion. Upon ion beam irradiation, furtherm...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201000437
更新日期:2011-04-08 00:00:00
abstract::This study aims to develop an effective method to control motile microorganisms and enable their manipulation as functional 'live micro/nano robots'. A novel strategy based on Fe3 O4 nanoparticle-doped alginate hydrogel is developed to fashion an artificial extracellular matrix (ECM) for microbial cells (e.g., Sacchar...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201600143
更新日期:2016-10-01 00:00:00
abstract::The aggregative behaviors of hydroxypropylcellulose (HPC) molecules in aqueous solution and on substrates have been observed by employing laser light scattering (LLS) and, after deposition on a mica surface, atomic force microscopy (AFM). LLS studies showed that the HPC molecules formed large aggregates through self-a...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200600067
更新日期:2006-07-14 00:00:00
abstract::Reaction of a beta-(1 --> 4) linked galactan with TDMS chloride followed by methylation and desilylation yields methyl galactans with unconventional functionalization patterns. The products were characterized via FTIR and NMR of the intact polymer and by CE after controlled depolymerization. A TDMS-derivatized methyl ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.200700120
更新日期:2008-01-09 00:00:00
abstract::Mucoadhesive NP drug carriers have attracted substantial interest as a potential treatment for anterior eye diseases. NPs composed of PLA-Dex surface functionalized with a mucoadhesive ligand, PBA, were developed as drug carriers with particle sizes ranging from 25 to 28 nm. Using CycA as a model drug, we showed that ...
journal_title:Macromolecular bioscience
pub_type: 杂志文章
doi:10.1002/mabi.201200216
更新日期:2012-12-01 00:00:00