Abstract:
:A simple, robust one pot procedure for the preparation of waterborne multifunctional poly(vinyl amine)s (PVAms) is presented. By post-polymerization modification of PVAm with a bifunctional coupler and functional couplers cationic, reactive azetidinium groups, and alkyl chains are introduced in the side chains of PVAms. The structure-activity relations (effect of hydrophobic and cationic modifications) of these antimicrobial polymers are studied; the minimum inhibitory concentration (MIC) against both (Gram positive and Gram negative bacteria) of the library of multifunctional poly(vinyl amine)s are determined to identify the candidates with the highest efficacy. Furthermore, the hemolytic activity-the effective concentration at which 50 and 10% of red blood cells are killed (HC50 and HC10 )-of selected polymers is determined. The ability of the polymers prepared to differentiate between microorganisms (Gram positive and Gram negative bacteria) and mammalian cells (red blood cells) is understood by comparing MIC and HC values. Finally, as an example, the best polymer is used to prepare an antimicrobial surface.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Chattopadhyay S,Heine ET,Keul H,Möller Mdoi
10.1002/mabi.201300576subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1116-24issue
8eissn
1616-5187issn
1616-5195journal_volume
14pub_type
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