Abstract:
:O-carboxymethylchitin (molecular weight = 1.07 x 10(5), degree of carboxymethylation = 80%, degree of N-acetylation = 91%) was chemically attached to superoxide dismutase by the formation of amide linkages through a carbodiimide catalyzed reaction. The glycosidated enzyme contained about 1.8 mole of polysaccharide per mole of protein and retained 57% of the initial catalytic activity. The anti-inflammatory activity of the enzyme was 2.4 times increased after conjugation with the polysaccharide. The modified superoxide dismutase preparation was remarkably more resistant to inactivation with H(2)O(2) and its plasma half-life time was prolonged from 4.8 min to 69 h.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Valdivia A,Perez Y,Dominguez A,Caballero J,Gomez L,Schacht EH,Villalonga Rdoi
10.1002/mabi.200400114subject
Has Abstractpub_date
2005-02-23 00:00:00pages
118-23issue
2eissn
1616-5187issn
1616-5195journal_volume
5pub_type
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