Abstract:
:The amyloid-β peptide (Aβ) plays a central role in the mechanism of Alzheimer's disease, being the main constituent of the plaque deposits found in AD brains. Aβ amyloid formation and deposition are due to a conformational switching to a β-enriched secondary structure. Our strategy to inhibit Aβ aggregation involves the re-conversion of Aβ conformation by adsorption to nanoparticles. NPs were synthesized by sulfonation and sulfation of polystyrene, leading to microgels and latexes. Both polymeric nanostructures affect the conformation of Aβ inducing an unordered state. Oligomerization was delayed and cytotoxicity reduced. The proper balance between hydrophilic moieties and hydrophobic chains seems to be an essential feature of effective NPs.
journal_name
Macromol Bioscijournal_title
Macromolecular bioscienceauthors
Saraiva AM,Cardoso I,Saraiva MJ,Tauer K,Pereira MC,Coelho MA,Möhwald H,Brezesinski Gdoi
10.1002/mabi.200900448subject
Has Abstractpub_date
2010-10-08 00:00:00pages
1152-63issue
10eissn
1616-5187issn
1616-5195journal_volume
10pub_type
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