Appearance of breast cysts in planar geometry photoacoustic mammography using 1064-nm excitation.

abstract：:Microscopic visualization of islets of Langerhans under normal and diabetic conditions is essential for understanding the pathophysiology of the disease. The intrinsic opacity of pancreata, however, limits optical accessibility for high-resolution light microscopy of islets in situ. Because the standard microtome-base...

journal_title：Journal of biomedical optics

authors： Fu YY,Lu CH,Lin CW,Juang JH,Enikolopov G,Sibley E,Chiang AS,Tang SC

更新日期：2010-07-01 00:00:00

abstract：:Diffuse optical spectroscopy (DOS) provides a powerful tool for fast and noninvasive disease diagnosis. The ability to leverage DOS to accurately quantify tissue optical parameters hinges on the model used to estimate light-tissue interaction. We describe the accuracy of a lookup table (LUT)-based inverse model for me...

journal_title：Journal of biomedical optics

authors： Nichols BS,Rajaram N,Tunnell JW

更新日期：2012-05-01 00:00:00

abstract：:We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal-oxide-semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in...

journal_title：Journal of biomedical optics

authors： Liu Y,Njuguna R,Matthews T,Akers WJ,Sudlow GP,Mondal S,Tang R,Gruev V,Achilefu S

更新日期：2013-10-01 00:00:00

abstract：:Selective laser targeting of the retinal pigment epithelium (RPE) is an attractive method for treating RPE-associated disorders. We are developing a method for optically detecting intracellular microcavitation that can potentially serve as an immediate feedback of the treatment outcome. Thermal denaturation or intrace...

journal_title：Journal of biomedical optics

authors： Lee H,Alt C,Pitsillides CM,Lin CP

更新日期：2007-11-01 00:00:00

abstract：:We present a simple wide-field imaging technique, called HiLo microscopy, that is capable of producing optically sectioned images in real time, comparable in quality to confocal laser scanning microscopy. The technique is based on the fusion of two raw images, one acquired with speckle illumination and another with st...

journal_title：Journal of biomedical optics

authors： Lim D,Ford TN,Chu KK,Mertz J

更新日期：2011-01-01 00:00:00

abstract：:A simple empirical method is presented to determine the scattering coefficient mu' s from backscattered polarized images of turbid media. It uses the ratio, pixel by pixel, of two images that are the second and the first backscattered Stokes parameter images Q and I, respectively. Taking this image ratio, then integra...

journal_title：Journal of biomedical optics

authors： Jaillon F,Saint-Jalmes H

更新日期：2005-05-01 00:00:00

abstract：:Keratoconus is an eye disease in which the cornea progressively deforms due to loss of cornea mechanical rigidity, and thus causes deterioration of visual acuity. Techniques to characterize the mechanical characteristics of the cornea are important to better monitor changes and response to treatments. To investigate t...

journal_title：Journal of biomedical optics

authors： Ortega-Martinez A,Touchette G,Zhu H,Kochevar IE,Franco W

更新日期：2017-09-01 00:00:00

abstract：:Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mo...

journal_title：Journal of biomedical optics

authors： Jia Y,Alkayed N,Wang RK

更新日期：2009-07-01 00:00:00

abstract：:A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF), resulting in further injury. Since current noninvasive methods used in the clinic can only assess blood flow indirectly, the goal of this research is to develop an optical techniqu...

journal_title：Journal of biomedical optics

authors： Diop M,Tichauer KM,Elliott JT,Migueis M,Lee TY,St Lawrence K

更新日期：2010-09-01 00:00:00

abstract：:We theoretically investigate the effect of noise on frequency-domain heterodyne and/or homodyne measurements of intensity-modulated beams propagating through diffusive media, such as a photon density wave. We assumed that the attenuated amplitude and delayed phase are estimated by taking the Fourier transform of the n...

journal_title：Journal of biomedical optics

authors： Kang D,Kupinski MA

更新日期：2012-01-01 00:00:00

abstract：:We present a new detection instrument for sensor measurements based on excited-state fluorescence lifetimes. This system consists of a primary optoelectronic loop containing a resonance-type rf amplifier, a modulatable fluorescence-excitation light source, a fiber optic feedback loop (with a gap for a fluorescent sens...

journal_title：Journal of biomedical optics

authors： Rabinovich E,Sviminoshvilli T,O'Brien MJ,Brueck SR,Lopez GP

更新日期：2004-05-01 00:00:00

abstract：:We have combined a confocal laser scanning head modified for TPE (two-photon excitation) microscopy with some spectroscopic modules to study single molecules and molecular aggregates. The behavior of the TPE microscope unit has been characterized by means of point spread function measurements and of the demonstration ...

journal_title：Journal of biomedical optics

authors： Diaspro A,Chirico G,Federici F,Cannone F,Beretta S,Robello M

更新日期：2001-07-01 00:00:00

abstract：:Two-photon excitation microscopy is one of the key techniques used to observe three-dimensional (3-D) structures in biological samples. We utilized a visible-wavelength laser beam for two-photon excitation in a multifocus confocal scanning system to improve the spatial resolution and image contrast in 3-D live-cell im...

journal_title：Journal of biomedical optics

authors： Oketani R,Suda H,Uegaki K,Kubo T,Matsuda T,Yamanaka M,Arai Y,Smith N,Nagai T,Fujita K

更新日期：2019-11-01 00:00:00

abstract：:The reflection and transmission of coherent light from a biological system can yield information about its condition. In the case of blood exposed to the air, there is a change in the properties of the speckle patterns observed in the coagulation process. This can be studied by means of the rate of temporal variation,...

journal_title：Journal of biomedical optics

authors： Yokoi N,Aizu Y,Uozumi J

更新日期：2018-12-01 00:00:00

abstract：:The refractive index of blood is a key biophysical parameter, which can reflect the physiological state. We measured the refractive index of whole blood and other components, such as serum, plasma, and hemoglobin, based on internal reflection by using a homemade apparatus in the spectral range of 400 to 750 nm. In add...

journal_title：Journal of biomedical optics

authors： Liu S,Deng Z,Li J,Wang J,Huang N,Cui R,Zhang Q,Mei J,Zhou W,Zhang C,Ye Q,Tian J

更新日期：2019-03-01 00:00:00

abstract：:Cancer-related enzyme activity can be detected noninvasively using activatable fluorescent molecular probes. In contrast to "always-on" fluorescent molecular probes, activatable probes are relatively nonfluorescent at the time of administration due to intramolecular fluorescence resonance energy transfer (FRET). Enzym...

journal_title：Journal of biomedical optics

authors： Solomon M,Guo K,Sudlow GP,Berezin MY,Edwards WB,Achilefu S,Akers WJ

更新日期：2011-06-01 00:00:00

abstract：:We report the design of a novel laser line-triangulation laryngoscope for the quantitative visualization of the three-dimensional movements of human vocal folds during phonation. This is the first successful in vivo recording of the three-dimensional movements of human vocal folds in absolute values. Triangulation ima...

journal_title：Journal of biomedical optics

authors： George NA,de Mul FF,Qiu Q,Rakhorst G,Schutte HK

更新日期：2008-11-01 00:00:00

abstract：:Optical spectroscopy has shown potential as a real-time, in vivo, diagnostic tool for identifying neoplasia during endoscopy. We present the development of a diagnostic algorithm to classify elastic-scattering spectroscopy (ESS) spectra as either neoplastic or non-neoplastic. The algorithm is based on pattern recognit...

journal_title：Journal of biomedical optics

authors： Rodriguez-Diaz E,Castanon DA,Singh SK,Bigio IJ

更新日期：2011-06-01 00:00:00

abstract：:Optical technique based on diffuse reflectance measurement combined with indocyanine green (ICG) bolus tracking is extensively tested as a method for clinical assessment of brain perfusion in adults at the bedside. Methodology of multiwavelength and time-resolved detection of fluorescence light excited in the ICG is p...

journal_title：Journal of biomedical optics

authors： Gerega A,Milej D,Weigl W,Botwicz M,Zolek N,Kacprzak M,Wierzejski W,Toczylowska B,Mayzner-Zawadzka E,Maniewski R,Liebert A

更新日期：2012-08-01 00:00:00

abstract：:We have developed a novel nitroimidazole indocyanine dye conjugate for tumor-targeted hypoxia fluorescence tomography. The hypoxia probe has been evaluated in vitro using tumor cell lines and in vivo with tumor targeting in mice. The in vitro cell studies were performed to assess fluorescence labeling differences betw...

journal_title：Journal of biomedical optics

authors： Biswal NC,Pavlik C,Smith MB,Aguirre A,Xu Y,Zanganeh S,Kuhn LT,Claffey KP,Zhu Q

更新日期：2011-06-01 00:00:00

abstract：:To evaluate retinal perfusion in the human eye, a dual-wavelength confocal scanning laser ophthalmoscope (cSLO) was developed that provides spectral imaging of the fundus using a combination of red (670 nm) and near-infrared (810 nm) wavelengths. The image of the ocular fundus was analyzed to find out if quantitative ...

journal_title：Journal of biomedical optics

authors： Rasta SH,Manivannan A,Sharp PF

更新日期：2012-11-01 00:00:00

abstract：:Optical clearing is a well-known phenomenon. It is based on the matching of refractive indices of a bulk material and scattering particles. The same principle is also used in scattering-based optical measurements of different constituents, such as glucose. By registering changes in scattering, it is possible to evalua...

journal_title：Journal of biomedical optics

authors： Kinnunen M,Myllylä R,Vainio S

更新日期：2008-03-01 00:00:00

abstract：:Focusing light inside highly scattering media is a challenging task in biomedical optical imaging, manipulation, and therapy. A recent invention has overcome this challenge by time reversing ultrasonically encoded diffuse light to an ultrasound-modulated volume inside a turbid medium. In this technique, a photorefract...

journal_title：Journal of biomedical optics

authors： Yang Q,Xu X,Lai P,Xu D,Wang LV

更新日期：2013-11-01 00:00:00

abstract：:In the present study, we evaluated the applicability of ex vivo photoacoustic imaging (PAI) on small animal organs. We used photoacoustic tomography (PAT) to visualize infarcted areas within murine hearts and compared these data to other imaging techniques [magnetic resonance imaging (MRI), micro-computed tomography] ...

journal_title：Journal of biomedical optics

authors： Holotta M,Grossauer H,Kremser C,Torbica P,Völkl J,Degenhart G,Esterhammer R,Nuster R,Paltauf G,Jaschke W

更新日期：2011-03-01 00:00:00

abstract：:We propose a useful method to boost the imaging speed for spectral domain optical coherence tomography (SDOCT) by multiplying a number of high-speed spectrometers used in the system with selective precise control of data-recording and data-reading phases for spectral cameras employed in each spectrometer. To demonstra...

journal_title：Journal of biomedical optics

authors： An L,Guan G,Wang RK

更新日期：2011-06-01 00:00:00

abstract：:The capabilities of micro-Raman spectroscopy for differentiating normal and malignant nasopharyngeal tissues were evaluated. Raman scattering signals were acquired from 22 normal and 52 malignant nasopharyngeal tissue samples. Distinctive spectral differences in Raman spectra between normal and malignant nasopharyngea...

journal_title：Journal of biomedical optics

authors： Li Y,Pan J,Chen G,Li C,Lin S,Shao Y,Feng S,Huang Z,Xie S,Zeng H,Chen R

更新日期：2013-02-01 00:00:00

abstract：:We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze t...

journal_title：Journal of biomedical optics

authors： Tsai MT,Lee HC,Lu CW,Wang YM,Lee CK,Yang CC,Chiang CP

更新日期：2008-07-01 00:00:00

abstract：:Water content is an important factor for skin condition. The determination of the hydration state of the skin is necessary to obtain basic knowledge about the penetration and loss of water in the skin stratum corneum. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is used to measure hy...

journal_title：Journal of biomedical optics

authors： Lucassen GW,van Veen GN,Jansen JA

更新日期：1998-07-01 00:00:00

abstract：:Computational modeling of arterial mechanics continues to progress, even to the point of allowing the study of complex regions such as the aortic arch. Nevertheless, most prior studies assign homogeneous and isotropic material properties and constant wall thickness even when implementing patient-specific luminal geome...

journal_title：Journal of biomedical optics

authors： Genovese K,Humphrey JD

更新日期：2015-04-01 00:00:00

abstract：:Dental erosion starts with a chemical attack on dental tissue causing tooth demineralization, altering the tooth structure and making it more sensitive to mechanical erosion. Medical diagnosis of dental erosion is commonly achieved through a visual inspection by the dentist during dental checkups and is therefore high...

journal_title：Journal of biomedical optics

authors： Abou Nader C,Pellen F,Loutfi H,Mansour R,Le Jeune B,Le Brun G,Abboud M

更新日期：2016-07-01 00:00:00