Multiwavelength time-resolved detection of fluorescence during the inflow of indocyanine green into the adult's brain.

abstract：:Diffuse near-infrared tomography of tissue reveals scattering changes that originate from the submicroscopic features of the tissue; yet the existing tools to use this information to predict which features contribute to the scattering spectrum are limited by the lack of direct data quantifying the particle sizes. Brea...

journal_title：Journal of biomedical optics

authors： Bartek M,Wang X,Wells W,Paulsen KD,Pogue BW

更新日期：2006-11-01 00:00:00

abstract：:Keratoconus is an eye disease in which the cornea progressively deforms due to loss of cornea mechanical rigidity, and thus causes deterioration of visual acuity. Techniques to characterize the mechanical characteristics of the cornea are important to better monitor changes and response to treatments. To investigate t...

journal_title：Journal of biomedical optics

authors： Ortega-Martinez A,Touchette G,Zhu H,Kochevar IE,Franco W

更新日期：2017-09-01 00:00:00

abstract：:We successfully acquire the in vivo Raman spectrum of melanin from human skin using a rapid near-infrared (NIR) Raman spectrometer. The Raman signals of in vivo cutaneous melanin are similar to those observed from natural and synthetic eumelanins. The melanin Raman spectrum is dominated by two intense and broad peaks ...

journal_title：Journal of biomedical optics

authors： Huang Z,Lui H,Chen XK,Alajlan A,McLean DI,Zeng H

更新日期：2004-11-01 00:00:00

abstract：:A simultaneous multispectral fluorescence imaging system incorporating multiplexed volume holographic grating (VHG) is developed to acquire multispectral images of an object in one shot. With the multiplexed VHG, the imaging system can provide the distribution and spectral characteristics of multiple fluorophores in t...

journal_title：Journal of biomedical optics

authors： Lv Y,Zhang J,Zhang D,Cai W,Chen N,Luo J

更新日期：2016-06-01 00:00:00

abstract：:Lumpectomy coupled with radiation therapy and/or chemotherapy is commonly used to treat breast cancer patients. We are developing an enhanced thermal IR imaging technique that has the potential to provide real-time imaging to guide tissue excision during a lumpectomy by delineating tumor margins. This enhanced thermal...

journal_title：Journal of biomedical optics

authors： Case JR,Young MA,Dréau D,Trammell SR

更新日期：2015-11-01 00:00:00

abstract：:Hemoglobin (Hb), as one of main components of blood, has a unique quaternary structure. Its release of oxygen is controlled by oxygen partial pressure (PO2). We investigate the specific spectroscopic changes in Hb under different PO2 levels to optimize clinical methods of measuring tissue PO2. The transmissivity of Hb...

journal_title：Journal of biomedical optics

authors： Liu P,Zhu Z,Zeng C,Nie G

更新日期：2012-12-01 00:00:00

abstract：:Quantification of nicotinamide adenine dinucleotide (NADH) changes during functional brain activation and pathological conditions provides critical insight into brain metabolism. Of the different imaging modalities, two-photon laser scanning microscopy (TPLSM) is becoming an important tool for cellular-resolution meas...

journal_title：Journal of biomedical optics

authors： Baraghis E,Devor A,Fang Q,Srinivasan VJ,Wu W,Lesage F,Ayata C,Kasischke KA,Boas DA,Sakadzić S

更新日期：2011-10-01 00:00:00

abstract：:We assess the properties of contact pressure applied by manually operated fiber-optic probes as a function of the operator, probe contact area, and sample stiffness. First, the mechanical properties of human skin sites with different skin structures, thicknesses, and underlying tissues were studied by in vivo indentat...

journal_title：Journal of biomedical optics

authors： Bregar M,Cugmas B,Naglic P,Hartmann D,Pernuš F,Likar B,Bürmen M

更新日期：2015-01-01 00:00:00

abstract：:A side-viewing, 2.3-mm diameter, surface magnifying chromoendoscopy-optical coherence tomography (SMC-OCT) endoscope has been designed for simultaneous, nondestructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of the mouse colon. A 30,000 element fib...

journal_title：Journal of biomedical optics

authors： Wall RA,Barton JK

更新日期：2012-08-01 00:00:00

abstract：:Fluorescence microscopy is commonly used to investigate disease progression in biological tissues. Biological tissues, however, are strongly scattering in the visible wavelengths, limiting the application of fluorescence microscopy to superficial (<200µm) regions. Optical clearing, which involves incubation of the tis...

journal_title：Journal of biomedical optics

authors： Moy AJ,Capulong BV,Saager RB,Wiersma MP,Lo PC,Durkin AJ,Choi B

更新日期：2015-01-01 00:00:00

abstract：:A primary focus of neurointensive care is monitoring the injured brain to detect harmful events that can impair cerebral blood flow (CBF), resulting in further injury. Since current noninvasive methods used in the clinic can only assess blood flow indirectly, the goal of this research is to develop an optical techniqu...

journal_title：Journal of biomedical optics

authors： Diop M,Tichauer KM,Elliott JT,Migueis M,Lee TY,St Lawrence K

更新日期：2010-09-01 00:00:00

abstract：:The application of near-infrared spectroscopy (NIRS) to assess microvascular function has shown promising results. An important limitation when using a single source-detector pair, however, is the lack of depth sensitivity. Diffuse optical tomography (DOT) overcomes this limitation using an array of sources and detect...

journal_title：Journal of biomedical optics

authors： Vidal-Rosas EE,Billings SA,Chico T,Coca D

更新日期：2016-06-01 00:00:00

abstract：:Imaging large areas of tissue rapidly and with high resolution may enable rapid pathology at the bedside. The limited field of view of high-resolution microscopes requires the merging of multiple images that are taken sequentially to cover a large area. This merging or mosaicing of images requires long acquisition and...

journal_title：Journal of biomedical optics

authors： Abeytunge S,Li Y,Larson B,Toledo-Crow R,Rajadhyaksha M

更新日期：2011-05-01 00:00:00

abstract：:Cellularity of the fibrous caps of coronary atheromas, manifested by the infiltration of macrophages (average size, 20 to 30 microm), is thought to weaken the structural integrity of the cap and predispose plaques to rupture. Therefore, an imaging technology capable of identifying macrophages within fibroatheroma caps...

journal_title：Journal of biomedical optics

authors： Tanaka A,Tearney GJ,Bouma BE

更新日期：2010-01-01 00:00:00

abstract：:We propose an algorithm to compensate for the refractive index error in the optical coherence tomography (OCT) images of multilayer tissues, such as skin. The performance of the proposed method has been evaluated on one- and two-layer solid phantoms, as well as the skin of rat paw. ...

journal_title：Journal of biomedical optics

authors： Turani Z,Fatemizadeh E,Xu Q,Daveluy S,Mehregan D,Nasiri Avanaki MR

更新日期：2018-07-01 00:00:00

abstract：:A new imaging approach, structured light scatteroscopy (SLS), is demonstrated, which offers rapid wide-field imaging of microscopic morphological variations in bulk tissue surfaces. Elastic scattering of light offers exquisite sensitivity to ultrastructural changes at multiple size scales ranging from nanometers to mi...

journal_title：Journal of biomedical optics

authors： Krishnaswamy V,Elliott JT,McClatchy DM 3rd,Barth RJ Jr,Wells WA,Pogue BW,Paulsen KD

更新日期：2014-01-01 00:00:00

abstract：:Skin cancer diagnosis depends not only on histopathological examination but also on visual inspection before and after the excision of suspected lesion. Neoplasm is accompanied with changes in birefringence of collagen, pleomorphicity, and hyperchromatic state of epithelial nuclei. These phenomena can be measured by s...

journal_title：Journal of biomedical optics

authors： Aharon O,Abdulhalim I,Arnon O,Rosenberg L,Dyomin V,Silberstein E

更新日期：2011-08-01 00:00:00

abstract：:The essential feature of the confocal laser scanning microscope (cLSM) is the generation of optical sections by the removal of out-of-focus light. About ten years ago, structured illumination microscopy (SIM) was introduced as an alternative method for obtaining optical sections from biological specimens. Here we comp...

journal_title：Journal of biomedical optics

authors： Weigel A,Schild D,Zeug A

更新日期：2009-01-01 00:00:00

abstract：:Higher-order optical errors of the human eye are often responsible for reduced visual acuity in spite of an optimal spherical or cylindrical refraction. These optical aberrations are of natural origin or can result from operations in the eye that involve optical structures. The ocular aberrometer presented is based on...

journal_title：Journal of biomedical optics

authors： Mierdel P,Kaemmerer M,Mrochen M,Krinke HE,Seiler T

更新日期：2001-04-01 00:00:00

abstract：:A new, simple, high-speed, and hardware-only integration-based fluorescence-lifetime-sensing algorithm using a center-of-mass method (CMM) is proposed to implement lifetime calculations, and its signal-to-noise-ratio based on statistics theory is also deduced. Compared to the commonly used iterative least-squares meth...

journal_title：Journal of biomedical optics

authors： Li DU,Rae B,Andrews R,Arlt J,Henderson R

更新日期：2010-01-01 00:00:00

abstract：:Colorectal cancer is one of the most aggressive cancers usually occurring in people above the age of 50 years. In the United States, colorectal cancer is the third most diagnosed cancer. The American Cancer Society has estimated 96,830 new cases of colon cancer and 40,000 new cases of rectal cancer in 2014 in the Unit...

journal_title：Journal of biomedical optics

authors： Salman A,Sebbag G,Argov S,Mordechai S,Sahu RK

更新日期：2015-07-01 00:00:00

abstract：:UV-induced collagen cross-linking is a promising treatment for keratoconus that stiffens corneal tissue and prevents further degeneration. Since keratoconus is generally localized, the efficacy of collagen cross-linking (CXL) treatments could be improved by stiffening only the weakened parts of the cornea. Here, we de...

journal_title：Journal of biomedical optics

authors： Singh M,Li J,Vantipalli S,Han Z,Larin KV,Twa MD

更新日期：2017-09-01 00:00:00

abstract：:The erratum concerns amendment of Section 2.5 of the published article. ...

journal_title：Journal of biomedical optics

authors： Hu XS,Arredondo MM,Gomba M,Confer N,DaSilva AF,Johnson TD,Shalinsky M,Kovelman I

更新日期：2020-05-01 00:00:00

abstract：:The effect of glucose on fluorescence of synthesized ZnCdS nanoparticles in the presence of glucose oxidase or in a mixture of glucose oxidase and peroxidase has been investigated. Behavior of fluorescence characteristics of ZnCdS nanoparticles with nonstabilized surface and coated with polymer shell is compared. It h...

journal_title：Journal of biomedical optics

authors： Kochubey VI,Volkova EK,Konyukhova JG

更新日期：2014-01-01 00:00:00

abstract：:Fluorescence spectroscopy has been widely investigated as a technique for identifying pathological tissue; however, unrelated subject-to-subject variations in spectra complicate data analysis and interpretation. We describe and evaluate a new biosensing technique, differential laser-induced perturbation spectroscopy (...

journal_title：Journal of biomedical optics

authors： Kozikowski RT,Smith SE,Lee JA,Castleman WL,Sorg BS,Hahn DW

更新日期：2012-06-01 00:00:00

abstract：SIGNIFICANCE:The potential of fluorescence lifetime imaging microscopy (FLIM) is recently being recognized, especially in biological studies. However, FLIM does not directly measure the lifetimes, rather it records the fluorescence decay traces. The lifetimes and/or abundances have to be estimated from these traces dur...

journal_title：Journal of biomedical optics

authors： Guo S,Silge A,Bae H,Tolstik T,Meyer T,Matziolis G,Schmitt M,Popp J,Bocklitz T

更新日期：2021-01-01 00:00:00

abstract：:Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and ...

journal_title：Journal of biomedical optics

authors： Kuck M,Schanzer S,Ulrich M,Garcia Bartels N,Meinke MC,Fluhr J,Krah M,Blume-Peytavi U,Stockfleth E,Lademann J

更新日期：2012-10-01 00:00:00

abstract：:Collagen fiber orientation plays an important role in determining the structure and function of the articular cartilage. However, there is currently a lack of nondestructive means to image the fiber orientation from the cartilage surface. The purpose of this study is to investigate whether the newly developed optical ...

journal_title：Journal of biomedical optics

authors： Yao X,Wang Y,Ravanfar M,Pfeiffer FM,Duan D,Yao G

更新日期：2016-11-01 00:00:00

abstract：:Near-infrared diffuse optical tomography (DOT), one of the most sophisticated optical imaging techniques for observations through biological tissue, allows 3-D quantitative imaging of optical properties, which include functional and anatomical information. With DOT, it is expected to be possible to overcome the limita...

journal_title：Journal of biomedical optics

authors： Hoshi Y,Yamada Y

更新日期：2016-09-01 00:00:00

abstract：:With the advance of computer and photonics technology, imaging photoplethysmography [(PPG), iPPG] can provide comfortable and comprehensive assessment over a wide range of anatomical locations. However, motion artifact is a major drawback in current iPPG systems, particularly in the context of clinical assessment. To ...

journal_title：Journal of biomedical optics

authors： Sun Y,Hu S,Azorin-Peris V,Greenwald S,Chambers J,Zhu Y

更新日期：2011-07-01 00:00:00