Abstract:
:Focusing light inside highly scattering media is a challenging task in biomedical optical imaging, manipulation, and therapy. A recent invention has overcome this challenge by time reversing ultrasonically encoded diffuse light to an ultrasound-modulated volume inside a turbid medium. In this technique, a photorefractive (PR) crystal or polymer can be used as the phase conjugate mirror for optical time reversal. Accordingly, a relatively long ultrasound burst, whose duration matches the PR response time of the PR material, is usually used to encode the diffuse light. This long burst results in poor focusing resolution along the acoustic axis. In this work, we propose to use two intersecting ultrasound beams, emitted from two ultrasonic transducers at different frequencies, to modulate the diffuse light at the beat frequency within the intersection volume. We show that the time reversal of the light encoded at the beat frequency can converge back to the intersection volume. Experimentally, an acoustic axial resolution of ~1.1 mm was demonstrated inside turbid media, agreeing with theoretical estimation.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Yang Q,Xu X,Lai P,Xu D,Wang LVdoi
10.1117/1.JBO.18.11.110502subject
Has Abstractpub_date
2013-11-01 00:00:00pages
110502issue
11eissn
1083-3668issn
1560-2281pii
1767221journal_volume
18pub_type
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