Time-reversed ultrasonically encoded optical focusing using two ultrasonic transducers for improved ultrasonic axial resolution.

Abstract:

:Focusing light inside highly scattering media is a challenging task in biomedical optical imaging, manipulation, and therapy. A recent invention has overcome this challenge by time reversing ultrasonically encoded diffuse light to an ultrasound-modulated volume inside a turbid medium. In this technique, a photorefractive (PR) crystal or polymer can be used as the phase conjugate mirror for optical time reversal. Accordingly, a relatively long ultrasound burst, whose duration matches the PR response time of the PR material, is usually used to encode the diffuse light. This long burst results in poor focusing resolution along the acoustic axis. In this work, we propose to use two intersecting ultrasound beams, emitted from two ultrasonic transducers at different frequencies, to modulate the diffuse light at the beat frequency within the intersection volume. We show that the time reversal of the light encoded at the beat frequency can converge back to the intersection volume. Experimentally, an acoustic axial resolution of ~1.1 mm was demonstrated inside turbid media, agreeing with theoretical estimation.

journal_name

J Biomed Opt

authors

Yang Q,Xu X,Lai P,Xu D,Wang LV

doi

10.1117/1.JBO.18.11.110502

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

110502

issue

11

eissn

1083-3668

issn

1560-2281

pii

1767221

journal_volume

18

pub_type

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