Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets.

abstract：:The efficacy of existing therapies and the discovery of innovative treatments for central nervous system (CNS) diseases have been limited by the lack of appropriate methods to investigate complex molecular processes at the synaptic level. To improve our capability to investigate complex mechanisms of synaptic signalin...

journal_title：Journal of biomedical optics

authors： Labrecque S,Sylvestre JP,Marcet S,Mangiarini F,Bourgoin B,Verhaegen M,Blais-Ouellette S,De Koninck P

更新日期：2016-04-30 00:00:00

abstract：:Nonviral, site-specific gene delivery to deep tissue is required for gene therapy of a spinal cord injury. However, an efficient method satisfying these requirements has not been established. This study demonstrates efficient and targeted gene transfer into the spinal cord by using photomechanical waves (PMWs), which ...

journal_title：Journal of biomedical optics

authors： Ando T,Sato S,Toyooka T,Uozumi Y,Nawashiro H,Ashida H,Obara M

更新日期：2011-10-01 00:00:00

abstract：:We present an imaging-based method for noncontact spirometry. The method tracks the subtle respiratory-induced shoulder movement of a subject, builds a calibration curve, and determines the flow-volume spirometry curve and vital respiratory parameters, including forced expiratory volume in the first second, forced vit...

journal_title：Journal of biomedical optics

authors： Liu C,Yang Y,Tsow F,Shao D,Tao N

更新日期：2017-05-01 00:00:00

abstract：SIGNIFICANCE:The blood-brain barrier (BBB) is a major obstacle to detecting and treating brain tumors. Overcoming this challenge will facilitate the early and accurate detection of brain lesions and guide surgical resection of tumors. AIM:We generated an orthotopic brain tumor model that simulates the pathophysiology ...

journal_title：Journal of biomedical optics

authors： Habimana-Griffin L,Ye D,Carpenter J,Prior J,Sudlow G,Marsala L,Mixdorf M,Rubin J,Chen H,Achilefu S

更新日期：2020-02-01 00:00:00

abstract：:Photobiological research in the last 30 yr has shown the existence of ultraweak photon emission in biological tissue, which can be detected with sophisticated photomultiplier systems. Although the emission of this ultraweak radiation, often termed biophotons, is extremely low in mammalian cells, it can be efficiently ...

journal_title：Journal of biomedical optics

authors： Niggli HJ,Tudisco S,Privitera G,Applegate LA,Scordino A,Musumeci F

更新日期：2005-03-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:A new, simple, high-speed, and hardware-only integration-based fluorescence-lifetime-sensing algorithm using a center-of-mass method (CMM) is proposed to implement lifetime calculations, and its signal-to-noise-ratio based on statistics theory is also deduced. Compared to the commonly used iterative least-squares meth...

journal_title：Journal of biomedical optics

authors： Li DU,Rae B,Andrews R,Arlt J,Henderson R

更新日期：2010-01-01 00:00:00

abstract：:This study demonstrates the use of optical spectroscopy for monitoring tumor oxygenation and metabolism in response to hyperoxic gas breathing. Hemoglobin saturation and redox ratio were quantified for a set of 14 and 9 mice, respectively, measured at baseline and during carbogen breathing (95% O(2), 5% CO(2)). In par...

journal_title：Journal of biomedical optics

authors： Palmer GM,Viola RJ,Schroeder T,Yarmolenko PS,Dewhirst MW,Ramanujam N

更新日期：2009-03-01 00:00:00

abstract：:The specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. Here, we used functional photoacoustic microscopy (fPAM) to investigate single cerebral blood vessels of rats after left forepaw stimulation. In this s...

journal_title：Journal of biomedical optics

authors： Liao LD,Lin CT,Shih YY,Lai HY,Zhao WT,Duong TQ,Chang JY,Chen YY,Li ML

更新日期：2012-06-01 00:00:00

abstract：:Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the corne...

journal_title：Journal of biomedical optics

authors： Shin S,Bae JK,Ahn Y,Kim H,Choi G,Yoo YS,Joo CK,Moon S,Jung W

更新日期：2017-12-01 00:00:00

abstract：:Intraoperative fluorescence molecular imaging based on targeted fluorescence agents is an emerging approach to improve surgical and endoscopic imaging and guidance. Short exposure times per frame and implementation at video rates are necessary to provide continuous feedback to the physician and avoid motion artifacts....

journal_title：Journal of biomedical optics

authors： Koch M,Glatz J,Ermolayev V,de Vries EG,van Dam GM,Englmeier KH,Ntziachristos V

更新日期：2014-04-01 00:00:00

abstract：:Sinus blockages are a common reason for physician visits, affecting one out of seven people in the United States, and often require medical treatment. Diagnosis in the primary care setting is challenging because symptom criteria (via detailed clinical history) plus objective imaging [computed tomography (CT) or endosc...

journal_title：Journal of biomedical optics

authors： Cerussi AE,Mishra N,You J,Bhandarkar N,Wong B

更新日期：2015-03-01 00:00:00

abstract：:The objective is to characterize the impact of different ablation parameters on the thermal load during corneal refractive surgery by means of excimer laser ablation on porcine eyes. One hundred eleven ablations were performed in 105 porcine eyes. Each ablation was recorded using infrared thermography and analyzed mai...

journal_title：Journal of biomedical optics

authors： Arba Mosquera S,Verma S

更新日期：2015-07-01 00:00:00

abstract：:The aim is to study cerebral vascular functional connectivity during motor tasks and resting state using multichannel frequency-domain near-infrared spectrophotometry. Maps of 5.7 × 10.8 cm size displaying changes in cerebral oxyhemoglobin (O(2)Hb), deoxyhemoglobin (HHb), and total hemoglobin (tHb) concentrations were...

journal_title：Journal of biomedical optics

authors： Wolf U,Toronov V,Choi JH,Gupta R,Michalos A,Gratton E,Wolf M

更新日期：2011-08-01 00:00:00

abstract：:Serum Raman spectroscopy (RS) has previously shown potential in oral cancer diagnosis and recurrence prediction. To evaluate the potential of serum RS in oral cancer screening, premalignant and cancer-specific detection was explored in the present study using 328 subjects belonging to healthy controls, premalignant, d...

journal_title：Journal of biomedical optics

authors： Sahu AK,Dhoot S,Singh A,Sawant SS,Nandakumar N,Talathi-Desai S,Garud M,Pagare S,Srivastava S,Nair S,Chaturvedi P,Murali Krishna C

更新日期：2015-11-01 00:00:00

abstract：:We describe the protocol for an inexpensive and nondestructive optical reflectance assay for the measurement of biofilm formation. Reflectance data are obtained using an Ocean Optics (Dunedin, Florida) USB 2000 spectrometer with a polychromatic light source. A fiber optic cable is used both for illumination and collec...

journal_title：Journal of biomedical optics

authors： Broschat SL,Loge FJ,Peppin JD,White D,Call DR,Kuhn E

更新日期：2005-07-01 00:00:00

abstract：:We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze t...

journal_title：Journal of biomedical optics

authors： Tsai MT,Lee HC,Lu CW,Wang YM,Lee CK,Yang CC,Chiang CP

更新日期：2008-07-01 00:00:00

abstract：:We investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in extent and location, depending on the occurrence of laser-induce...

journal_title：Journal of biomedical optics

authors： Roach WP,Cain CP,Narayan DG,Noojin GD,Boppart SA,Birngruber R,Fujimoto JG,Toth CA

更新日期：2004-11-01 00:00:00

abstract：:Fast estimation of optical properties from reflectance measurements at two spatial frequencies could pave way for real-time, wide-field and quantitative mapping of vital signs of tissues. We present a machine learning-based approach for estimating optical properties in the spatial frequency domain, where a random fore...

journal_title：Journal of biomedical optics

authors： Panigrahi S,Gioux S

更新日期：2018-12-01 00:00:00

abstract：:Multiphoton microscopy has evolved into a powerful bioimaging tool in three dimensions. However, the ability to image biological specimens in-depth can be hindered by sample spherical aberration and scattering. These two phenomena can result in the degradation of image resolution and the loss of detected multiphoton s...

journal_title：Journal of biomedical optics

authors： Lo W,Sun Y,Lin SJ,Jee SH,Dong CY

更新日期：2005-05-01 00:00:00

abstract：:Quantitative microscopy has been extensively used in biomedical research and has provided significant insights into structure and dynamics at the cell and tissue level. The entire procedure of quantitative microscopy is comprised of specimen preparation, light absorption/reflection/emission from the specimen, microsco...

journal_title：Journal of biomedical optics

authors： Huang K,Murphy RF

更新日期：2004-09-01 00:00:00

abstract：:Biological systems with intrinsic luminescent properties serve as powerful and noninvasive bioreporters for real-time and label-free monitoring of cell physiology. This study employs the bioluminescent marine bacterium Vibrio fischeri to investigate the effects of separated microwave electric (E) and magnetic (H) fiel...

journal_title：Journal of biomedical optics

authors： Williams CF,Geroni GM,Lloyd D,Choi H,Clark N,Pirog A,Lees J,Porch A

更新日期：2019-02-01 00:00:00

abstract：:We describe a computer eye model that allows for aspheric surfaces and a three-dimensional computer-based ray-tracing technique to simulate optical properties of the human eye and visual perception under various eye defects. Eye surfaces, such as the cornea, eye lens, and retina, are modeled or approximated by a set o...

journal_title：Journal of biomedical optics

authors： Fink W,Micol D

更新日期：2006-09-01 00:00:00

abstract：:Selective laser targeting of the retinal pigment epithelium (RPE) is an attractive method for treating RPE-associated disorders. We are developing a method for optically detecting intracellular microcavitation that can potentially serve as an immediate feedback of the treatment outcome. Thermal denaturation or intrace...

journal_title：Journal of biomedical optics

authors： Lee H,Alt C,Pitsillides CM,Lin CP

更新日期：2007-11-01 00:00:00

abstract：:Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the latter collecting label-free backscattering data with comparable lateral but much higher axia...

journal_title：Journal of biomedical optics

authors： Zhang P,Zam A,Jian Y,Wang X,Li Y,Lam KS,Burns ME,Sarunic MV,Pugh EN Jr,Zawadzki RJ

更新日期：2015-01-01 00:00:00

abstract：:Extension of optical monitoring of intact tissues from the visible and ultraviolet to the near-infrared (NIR) range (700-1300 nm) was first undertaken in 1977 for the purpose of monitoring the redox behavior of Cytochrome c oxidase (cyt c ox) in vivo. Soon it became evident that the much greater NIR translucency of sk...

journal_title：Journal of biomedical optics

authors： Jo Bsis-Vandervliet FF

更新日期：1999-10-01 00:00:00

abstract：:Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved...

journal_title：Journal of biomedical optics

authors： Biris AS,Boldor D,Palmer J,Monroe WT,Mahmood M,Dervishi E,Xu Y,Li Z,Galanzha EI,Zharov VP

更新日期：2009-03-01 00:00:00

abstract：:Cerenkov light is created in clinical applications involving high-energy radiation such as in radiation therapy. There is considerable interest in using Cerenkov light as a means to perform in vivo dosimetry during radiation therapy; however, a better understanding of the light-to-dose relationship is needed. One such...

journal_title：Journal of biomedical optics

authors： Brost E,Watanabe Y

更新日期：2018-10-01 00:00:00

abstract：:Optical quantification of large lesions imaged with diffuse optical tomography in reflection geometry is depth dependence due to the exponential decay of photon density waves. We introduce a depth-correction method that incorporates the target depth information provided by coregistered ultrasound. It is based on balan...

journal_title：Journal of biomedical optics

authors： Tavakoli B,Zhu Q

更新日期：2011-05-01 00:00:00

abstract：:Flow imaging is an important technique in a range of disease areas, but estimating low flow speeds, especially near the walls of blood vessels, remains challenging. Pulsed photoacoustic flow imaging can be an alternative since there is little signal contamination from background tissue with photoacoustic imaging. We p...

journal_title：Journal of biomedical optics

authors： van den Berg PJ,Daoudi K,Steenbergen W

更新日期：2016-02-01 00:00:00