Early diagnosis of teeth erosion using polarized laser speckle imaging.

abstract：:The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient ther...

journal_title：Journal of biomedical optics

authors： Bauer AQ,Nothdurft RE,Erpelding TN,Wang LV,Culver JP

更新日期：2011-09-01 00:00:00

abstract：:We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze t...

journal_title：Journal of biomedical optics

authors： Tsai MT,Lee HC,Lu CW,Wang YM,Lee CK,Yang CC,Chiang CP

更新日期：2008-07-01 00:00:00

abstract：:The development of methods that allow microscale studies of complex biomaterials based on their molecular composition is of great interest to a wide range of research fields. We show that stimulated Raman scattering (SRS) microscopy is an excellent analytical tool to study distributions of different biomolecules in mu...

journal_title：Journal of biomedical optics

authors： Roeffaers MB,Zhang X,Freudiger CW,Saar BG,van Ruijven M,van Dalen G,Xiao C,Xie XS

更新日期：2010-11-01 00:00:00

abstract：:A photoacoustic imaging system that incorporates a commercial ultrasonic camera for real-time imaging of two-dimensional (2-D) projection planes in tissue at video rate (30 Hz) is presented. The system uses a Q-switched frequency-doubled Nd:YAG pulsed laser for photoacoustic generation. The ultrasonic camera consists ...

journal_title：Journal of biomedical optics

authors： Balogun O,Regez B,Zhang HF,Krishnaswamy S

更新日期：2010-03-01 00:00:00

abstract：:In part I of the study, two attachment systems [O-ring; bar-clip (BC)] were used, and the system with three individualized O-rings provided the lowest stress on the implants and the support tissues. Therefore, the aim of this study was to assess the stress distribution, through the photoelastic method, on implant-reta...

journal_title：Journal of biomedical optics

authors： Pesqueira AA,Goiato MC,da Silva EV,Haddad MF,Moreno A,Zahoui A,dos Santos DM

更新日期：2014-06-01 00:00:00

abstract：:The ability to noninvasively image embryonic vascular anatomy in mouse models is an important requirement for characterizing the development of the normal cardiovascular system and malformations in the heart and vascular supply. Photoacoustic imaging, which can provide high resolution non invasive images of the vascul...

journal_title：Journal of biomedical optics

authors： Laufer J,Norris F,Cleary J,Zhang E,Treeby B,Cox B,Johnson P,Scambler P,Lythgoe M,Beard P

更新日期：2012-06-01 00:00:00

abstract：:A fully integrated trimodality fluorescence, diffuse optical, and x-ray computed tomography (FT/DOT/XCT) system for small animal imaging is reported in this work. The main purpose of this system is to obtain quantitatively accurate fluorescence concentration images using a multimodality approach. XCT offers anatomical...

journal_title：Journal of biomedical optics

authors： Lin Y,Barber WC,Iwanczyk JS,Roeck WW,Nalcioglu O,Gulsen G

更新日期：2010-07-01 00:00:00

abstract：:In the present applications of optical coherence tomography (OCT), parameters besides pure morphology are evaluated in skin tissue under in vivo conditions. Spatially mapped refractive indices and scattering coefficients may support tissue characterization for research and diagnostic purposes in cosmetics/pharmacy and...

journal_title：Journal of biomedical optics

authors： Knüttel A,Boehlau-Godau M

更新日期：2000-01-01 00:00:00

abstract：:A model of infrared neural stimulation (INS) has been developed to allow the temporal characteristics of different stimulation parameters and geometries to be better understood. The model uses a finite element approach to solve the heat equation and allow detailed analysis of heat during INS with both microsecond and ...

journal_title：Journal of biomedical optics

authors： Thompson AC,Wade SA,Cadusch PJ,Brown WG,Stoddart PR

更新日期：2013-03-01 00:00:00

abstract：:Cancer is the main cause of canine morbidity and mortality. The existing evaluation of tumors requires an experienced veterinarian and usually includes invasive procedures (e.g., fine-needle aspiration) that can be unpleasant for the dog and the owner. We investigate visible and near-infrared diffuse reflectance spect...

journal_title：Journal of biomedical optics

authors： Cugmas B,Plavec T,Bregar M,Naglič P,Pernuš F,Likar B,Bürmen M

更新日期：2015-03-01 00:00:00

abstract：:Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of retinal pathologies with greater penetration into choroidal tissue is compared to conventional...

journal_title：Journal of biomedical optics

authors： Povazay B,Hermann B,Unterhuber A,Hofer B,Sattmann H,Zeiler F,Morgan JE,Falkner-Radler C,Glittenberg C,Blinder S,Drexler W

更新日期：2007-07-01 00:00:00

abstract：:A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/t...

journal_title：Journal of biomedical optics

authors： Jacques SL,Pogue BW

更新日期：2008-07-01 00:00:00

abstract：:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced ...

journal_title：Journal of biomedical optics

authors： Yeh C,Hu S,Maslov K,Wang LV

更新日期：2012-07-01 00:00:00

abstract：:We have presented an innovative laser-assisted reduction surgery (LARS) based on plasma-induced ablation and photodisruption effects. In addition, we developed a laser operation system. Fetuses of mice from the Institute for Cancer Research that were immersed in physiological saline were irradiated by convergent-pulse...

journal_title：Journal of biomedical optics

authors： Wang Y,Xiong Q,Ye Z,Ge J

更新日期：2013-11-01 00:00:00

abstract：:Discrimination of benign and malignant melanocytic lesions is a major issue in clinical dermatology. Assessment of the thickness of melanoma is critical for prognosis and treatment selection. We aimed to evaluate a novel optical computed tomography (optical-CT) system as a tool for three-dimensional (3-D) imaging of m...

journal_title：Journal of biomedical optics

authors： Kokolakis A,Zacharakis G,Krasagakis K,Lasithiotakis K,Favicchio R,Spiliopoulos G,Giannikaki E,Ripoll J,Tosca A

更新日期：2012-06-01 00:00:00

abstract：:Microvascular network of the retina plays an important role in diagnosis and monitoring of various retinal diseases. We propose a three-dimensional (3-D) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source optical coherence tomography. The automatic 3-D segmentation method is used to...

journal_title：Journal of biomedical optics

authors： Huang S,Piao Z,Zhu J,Lu F,Chen Z

更新日期：2015-07-01 00:00:00

abstract：:The acousto-optic deflector (AOD) is highly preferred in laser scanning microscopy for its fast scanning ability and random-addressing capability. However, its application in two-photon microscopy is frustrated by the dispersion of the AOD, which results in beam distortion and pulse lengthening. We report the analysis...

journal_title：Journal of biomedical optics

authors： Zeng S,Lv X,Bi K,Zhan C,Li D,Chen WR,Xiong W,Jacques SL,Luo Q

更新日期：2007-03-01 00:00:00

abstract：:We experimentally implement label-free phase microscopy using wide-field digital interferometry (WFDI) techniques to retrieve quantitative volumetric data of articular chondrocyte dynamics. Using the scanless interferometric system, we visualize chondrocyte swelling and bursting induced by hypo-osmotic pressure. Recon...

journal_title：Journal of biomedical optics

authors： Shaked NT,Finan JD,Guilak F,Wax A

更新日期：2010-01-01 00:00:00

abstract：:We introduce the application of functional data analysis (fDA) on functional near-infrared spectroscopy (fNIRS) signals for the development of an accurate and clinically practical assessment method of pain perception. We used the cold pressor test to induce different levels of pain in healthy subjects while the fNIRS ...

journal_title：Journal of biomedical optics

authors： Pourshoghi A,Zakeri I,Pourrezaei K

更新日期：2016-10-01 00:00:00

abstract：:We successfully acquire the in vivo Raman spectrum of melanin from human skin using a rapid near-infrared (NIR) Raman spectrometer. The Raman signals of in vivo cutaneous melanin are similar to those observed from natural and synthetic eumelanins. The melanin Raman spectrum is dominated by two intense and broad peaks ...

journal_title：Journal of biomedical optics

authors： Huang Z,Lui H,Chen XK,Alajlan A,McLean DI,Zeng H

更新日期：2004-11-01 00:00:00

abstract：:We fabricate scaffolds with a fine linear grating (periodicity of 1 to 8 microm and height of 1 microm) on a glass substrate for controlling cardiomyocyte orientation. The fabrication is done by the solidification of a liquid photopolymerizable material using two laser beam interference. As the photopolymerizable mate...

journal_title：Journal of biomedical optics

authors： Fujita A,Fujita K,Nakamura O,Matsuda T,Kawata S

更新日期：2006-03-01 00:00:00

abstract：:The attenuation of near-infrared (NIR) light intensity as it propagates in a turbid medium like biological tissue is described by modified the Beer–Lambert law (MBLL). The MBLL is generally used to quantify the changes in tissue chromophore concentrations for NIR spectroscopic data analysis. Even though MBLL is effect...

journal_title：Journal of biomedical optics

authors： Bhatt M,Ayyalasomayajula KR,Yalavarthy PK

更新日期：2016-07-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:Alcohol testing is an expanding area of interest due to the impacts of alcohol abuse that extend well beyond drunk driving. However, existing approaches such as blood and urine assays are hampered in some testing environments by biohazard risks. A noninvasive, in vivo spectroscopic technique offers a promising alterna...

journal_title：Journal of biomedical optics

authors： Ridder TD,Ver Steeg BJ,Laaksonen BD

更新日期：2009-09-01 00:00:00

abstract：:The spectroscopy of analyte-specific molecular vibrations in tissue thin sections has opened up a path toward histopathology without the need for tissue staining. However, biomedical vibrational imaging has not yet advanced from academic research to routine histopathology due to long acquisition times for the microsco...

journal_title：Journal of biomedical optics

authors： Kröger N,Egl A,Engel M,Gretz N,Haase K,Herpich I,Kränzlin B,Neudecker S,Pucci A,Schönhals A,Vogt J,Petrich W

更新日期：2014-01-01 00:00:00

abstract：:Cortical spreading depression (CSD) is a pronounced depolarization of neurons and glia that spreads slowly across the cortex followed by a period of depressed electrophysiological activity. The vascular changes associated with CSD are a large transient increase in blood flow followed by a prolonged decrease lasting gr...

journal_title：Journal of biomedical optics

authors： Guiou M,Sheth S,Nemoto M,Walker M,Pouratian N,Ba A,Toga AW

更新日期：2005-01-01 00:00:00

abstract：:Gap junction-mediated intercellular communication influences a variety of cellular activities. In tendons, gap junctions modulate collagen production, are involved in strain-induced cell death, and are involved in the response to mechanical stimulation. The aim of the present study was to investigate gap junction-medi...

journal_title：Journal of biomedical optics

authors： Kuzma-Kuzniarska M,Yapp C,Pearson-Jones TW,Jones AK,Hulley PA

更新日期：2014-01-01 00:00:00

abstract：:We present a hybrid method that combines a multilayered scaling method and a perturbation method to speed up the Monte Carlo simulation of diffuse reflectance from a multilayered tissue model with finite-size tumor-like heterogeneities. The proposed method consists of two steps. In the first step, a set of photon traj...

journal_title：Journal of biomedical optics

authors： Zhu C,Liu Q

更新日期：2012-01-01 00:00:00

abstract：:Invasive brain cancer cells cannot be visualized during surgery and so they are often not removed. These residual cancer cells give rise to recurrences.

journal_title：Journal of biomedical optics

authors： Jermyn M,Desroches J,Mercier J,Tremblay MA,St-Arnaud K,Guiot MC,Petrecca K,Leblond F

更新日期：2016-09-01 00:00:00

abstract：:By applying linear perturbation theory to the radiation transport equation, the inverse problem of optical diffusion tomography can be reduced to a set of linear equations, Wμ=R, where W is the weight function, μ are the cross-section perturbations to be imaged, and R is the detector readings perturbations. We have st...

journal_title：Journal of biomedical optics

authors： Chang J,Graber HL,Barbour RL

更新日期：1998-04-01 00:00:00