Abstract:
:In the present applications of optical coherence tomography (OCT), parameters besides pure morphology are evaluated in skin tissue under in vivo conditions. Spatially mapped refractive indices and scattering coefficients may support tissue characterization for research and diagnostic purposes in cosmetics/pharmacy and medicine, respectively. The sample arm of our OCT setup has been arranged to permit refractive index evaluation with little mechanical adjustment of a lens within the objective. A simple algorithm has been derived. Known from atmospheric work, the Klett algorithm [J. D. Klett, "Stable analytical inversion solution for processing LIDAR returns," Appl. Opt. 20(2), 211-220 (1981)] has been applied to the same data set for retrieval of scattering coefficients. Both parameters have been measured in layered structures in skin like stratum corneum, epidermis and dermis. Significant water content in a localized sweat gland duct has been observed by refractive index evaluation. Time studies over 1.5 h permitted a first understanding about physiological changes in skin which are not obtainable by intrusive methods.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Knüttel A,Boehlau-Godau Mdoi
10.1117/1.429972subject
Has Abstractpub_date
2000-01-01 00:00:00pages
83-92issue
1eissn
1083-3668issn
1560-2281pii
S1083-3668(00)00801-7journal_volume
5pub_type
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