Real-time microscopic visualization of tissue response to laser thermal therapy.

Abstract:

:We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely registered with high-resolution ( approximately 10 microm) cross sectional images, regions of thermally destroyed tissue can be mapped in relation to pre-existing morphology. Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time.

journal_name

J Biomed Opt

authors

Vakoc BJ,Tearney GJ,Bouma BE

doi

10.1117/1.2714027

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

020501

issue

2

eissn

1083-3668

issn

1560-2281

journal_volume

12

pub_type

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