Implantable photonic devices for improved medical treatments.

abstract：:Pelvic organ prolapse (POP) occurs when changes to the pelvic organ support structures cause descent or herniation of the pelvic organs into the vagina. Clinical evaluation of POP is a series of manual measurements known as the pelvic organ prolapse quantification (POP-Q) score. However, it fails to identify the mecha...

journal_title：Journal of biomedical optics

authors： Parkinson LA,Gargett CE,Young N,Rosamilia A,Vashi AV,Werkmeister JA,Papageorgiou AW,Arkwright JW

更新日期：2016-12-01 00:00:00

abstract：:The spatiotemporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of alpha-chloralose-urethane anesthetized rats (n=10) with optical imaging at 570 nm through a thinned skull. Activation of the cortex was carried out by elect...

journal_title：Journal of biomedical optics

authors： Li P,Luo Q,Luo W,Chen S,Cheng H,Zeng S

更新日期：2003-10-01 00:00:00

abstract：:Since hyperglycaemia changes the erythrocyte cell membrane fluidity and impairs cell deformity, our goal was to characterize hemoglobin and red blood cell (RBC) light refractive property changes in diabetic patients. Microscopic investigation was carried out on intact and fixed RBCs. To determine the refractive index ...

journal_title：Journal of biomedical optics

authors： Mazarevica G,Freivalds T,Jurka A

更新日期：2002-04-01 00:00:00

abstract：:Obstruction in the upper airway can often cause reductions in breathing or gas exchange efficiency and lead to rest disorders such as sleep apnea. Imaging diagnosis of the obstruction region has been accomplished using computed tomography (CT) and magnetic resonance imaging (MRI). However CT requires the use of ionizi...

journal_title：Journal of biomedical optics

authors： Jing J,Zhang J,Loy AC,Wong BJ,Chen Z

更新日期：2012-11-01 00:00:00

abstract：:Fourier domain (FD) techniques have increasingly gained attention in optical coherence tomography (OCT). This is primarily due to their demonstrated sensitivity of two to three orders of magnitude over conventional time-domain techniques. FDOCT images are subject to two primary sources of artifacts. First, a complex c...

journal_title：Journal of biomedical optics

authors： Davis AM,Choma MA,Izatt JA

更新日期：2005-11-01 00:00:00

abstract：:The properties of polarized light emerging from turbid media in the exact backscattering direction are studied by modulating the incident light polarization state and isolating the synchronous signal with lock-in amplifier detection. The results are reported for polystyrene microsphere suspensions in distilled water, ...

journal_title：Journal of biomedical optics

authors： Studinski RC,Vitkin IA

更新日期：2000-07-01 00:00:00

abstract：:Dynamic analyses of vibrational motion in cell membranes provide a lot of information on the complex dynamic motilities of a red blood cell (RBC). Here, we present the correlation properties of membrane fluctuation in discocyte and spherocyte RBCs by using quantitative phase microscopy (QPM). Since QPM can provide nan...

journal_title：Journal of biomedical optics

authors： Lee S,Lee JY,Park CS,Kim DY

更新日期：2011-07-01 00:00:00

abstract：:We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional in vivo imaging of human breast tumor based on large optical data sets. Images of oxy-, deoxy-, and total hemoglobin concentration as well as blood oxygen saturation and tissue scattering were reconstructed. Tumor ma...

journal_title：Journal of biomedical optics

authors： Choe R,Konecky SD,Corlu A,Lee K,Durduran T,Busch DR,Pathak S,Czerniecki BJ,Tchou J,Fraker DL,Demichele A,Chance B,Arridge SR,Schweiger M,Culver JP,Schnall MD,Putt ME,Rosen MA,Yodh AG

更新日期：2009-03-01 00:00:00

abstract：:Parametric and nonparametric data processing schemes for analyzing translating laser speckle data used to investigate the mechanical behavior of biological tissues are examined. Cross-correlation, minimum mean square estimator, maximum likelihood, and maximum entropy approaches are discussed and compared on speckle da...

journal_title：Journal of biomedical optics

authors： Duncan DD,Kirkpatrick SJ

更新日期：2001-10-01 00:00:00

abstract：:Limited cutaneous systemic sclerosis (lcSSc) was formerly known as CREST syndrome in reference to the associated clinical features: calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasias. The transforming growth factor beta has been identified as a major player in the pathogenic p...

journal_title：Journal of biomedical optics

authors： Barolet D

更新日期：2014-01-01 00:00:00

abstract：:The main curative therapy for patients with nonsmall cell lung cancer is surgery. Despite this, the survival rate is only 50%, therefore it is important to more efficiently diagnose and predict prognosis for lung cancer patients. Raman spectroscopy is useful in the diagnosis of malignant and premalignant lesions. The ...

journal_title：Journal of biomedical optics

authors： Magee ND,Beattie JR,Carland C,Davis R,McManus K,Bradbury I,Fennell DA,Hamilton PW,Ennis M,McGarvey JJ,Elborn JS

更新日期：2010-03-01 00:00:00

abstract：:We investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in extent and location, depending on the occurrence of laser-induce...

journal_title：Journal of biomedical optics

authors： Roach WP,Cain CP,Narayan DG,Noojin GD,Boppart SA,Birngruber R,Fujimoto JG,Toth CA

更新日期：2004-11-01 00:00:00

abstract：:When irradiated with nanosecond laser pulses, gold nanoparticles allow for manipulation or destruction of cells and proteins with high spatial and temporal precision. Gold nanorods are especially attractive, because they have an up-to-20-fold stronger absorption than a sphere of equal volume, which is shifted to the o...

journal_title：Journal of biomedical optics

authors： Rudnitzki F,Bever M,Rahmanzadeh R,Brieger K,Endl E,Groll J,Hüttmann G

更新日期：2012-05-01 00:00:00

abstract：:Extension of optical monitoring of intact tissues from the visible and ultraviolet to the near-infrared (NIR) range (700-1300 nm) was first undertaken in 1977 for the purpose of monitoring the redox behavior of Cytochrome c oxidase (cyt c ox) in vivo. Soon it became evident that the much greater NIR translucency of sk...

journal_title：Journal of biomedical optics

authors： Jo Bsis-Vandervliet FF

更新日期：1999-10-01 00:00:00

abstract：SIGNIFICANCE:Despite the importance of the cell membrane in regulation of drug activity, the influence of drug treatments on its physical properties is still poorly understood. The combination of fluorescence lifetime imaging microscopy (FLIM) with specific viscosity-sensitive fluorescent molecular rotors allows the qu...

journal_title：Journal of biomedical optics

authors： Shimolina LE,Gulin AA,Paez-Perez M,López-Duarte I,Druzhkova IN,Lukina MM,Gubina MV,Brooks NJ,Zagaynova EV,Kuimova MK,Shirmanova MV

更新日期：2020-12-01 00:00:00

abstract：:The atrial pacemaker complex is responsible for the initiation and early propagation of cardiac impulses. Optical coherence tomography (OCT), a nondestructive imaging modality with spatial resolutions of ∼1 to 15 μm, can be used to identify unique fiber orientation patterns in this region of the heart. Functionally ch...

journal_title：Journal of biomedical optics

authors： Ambrosi CM,Fedorov VV,Schuessler RB,Rollins AM,Efimov IR

更新日期：2012-07-01 00:00:00

abstract：:We present an imaging-based method for noncontact spirometry. The method tracks the subtle respiratory-induced shoulder movement of a subject, builds a calibration curve, and determines the flow-volume spirometry curve and vital respiratory parameters, including forced expiratory volume in the first second, forced vit...

journal_title：Journal of biomedical optics

authors： Liu C,Yang Y,Tsow F,Shao D,Tao N

更新日期：2017-05-01 00:00:00

abstract：:Diffuse reflectance spectroscopy, which has been demonstrated as a noninvasive diagnostic technique, relies on quantitative models for extracting optical property values from turbid media, such as biological tissues. We review and compare reflectance models that have been published, and we test similar models over a m...

journal_title：Journal of biomedical optics

authors： Calabro KW,Bigio IJ

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:Investigations of foveal aberrations assume circular pupils. However, the pupil becomes increasingly elliptical with increase in visual field eccentricity. We address this and other issues concerning peripheral aberration specification. METHODS:One approach uses an elliptical pupil similar to the actual pupil ...

journal_title：Journal of biomedical optics

authors： Charman WN,Mathur A,Scott DH,Hartwig A,Atchison DA

更新日期：2012-02-01 00:00:00

abstract：:We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely ...

journal_title：Journal of biomedical optics

authors： Vakoc BJ,Tearney GJ,Bouma BE

更新日期：2007-03-01 00:00:00

abstract：:We report the use of spectral Doppler optical coherence tomography imaging (SDOCTI) for quantitative evaluation of dynamic blood circulation before and after a localized ischemic stroke in a mouse model. Rose Bengal photodynamic therapy (PDT) is used as a noninvasive means for inducing localized ischemia in cortical m...

journal_title：Journal of biomedical optics

authors： Yu L,Nguyen E,Liu G,Choi B,Chen Z

更新日期：2010-11-01 00:00:00

abstract：:The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

journal_title：Journal of biomedical optics

authors： Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

更新日期：2012-07-01 00:00:00

abstract：:The use of fluorescence video imaging to guide surgery is rapidly expanding, and improvements in camera readout dynamic range have not matched display capabilities. Logarithmic intensity compression is a fast, single-step mapping technique that can map the useable dynamic range of high-bit fluorescence images onto the...

journal_title：Journal of biomedical optics

authors： DSouza AV,Lin H,Gunn J,Pogue BW

更新日期：2015-08-01 00:00:00

abstract：:In near-infrared spectroscopy, concentration changes in oxygenated and deoxygenated hemoglobin are calculated from the changes in the attenuation of the measurement light. This is done by solving a linear equation based on the modified Lambert-Beer law. To solve this equation, we need to know the partial optical pathl...

journal_title：Journal of biomedical optics

authors： Umeyama S,Yamada T

更新日期：2009-05-01 00:00:00

abstract：:Infrared microscopic imaging has been utilized to analyze for the first time the spatial distribution of lipid structure in an ex vivo human organ culture skin wound healing model. Infrared images were collected at zero, two, four, and six days following wounding. Analysis of lipid infrared spectral properties reveale...

journal_title：Journal of biomedical optics

authors： Yu G,Stojadinovic O,Tomic-Canic M,Flach CR,Mendelsohn R

更新日期：2012-09-01 00:00:00

abstract：:Cell morphology is often used as a valuable indicator of the physical condition and general status of living cells. We demonstrate a noninvasive method for morphological characterization of adherent cells. We measure infrared reflectivity spectrum at oblique angle from living cells cultured on thin Au film, and utiliz...

journal_title：Journal of biomedical optics

authors： Yashunsky V,Lirtsman V,Zilbershtein A,Bein A,Schwartz B,Aroeti B,Golosovsky M,Davidov D

更新日期：2012-08-01 00:00:00

abstract：:Quantitative microscopy has been extensively used in biomedical research and has provided significant insights into structure and dynamics at the cell and tissue level. The entire procedure of quantitative microscopy is comprised of specimen preparation, light absorption/reflection/emission from the specimen, microsco...

journal_title：Journal of biomedical optics

authors： Huang K,Murphy RF

更新日期：2004-09-01 00:00:00

abstract：:Imaging large areas of tissue rapidly and with high resolution may enable rapid pathology at the bedside. The limited field of view of high-resolution microscopes requires the merging of multiple images that are taken sequentially to cover a large area. This merging or mosaicing of images requires long acquisition and...

journal_title：Journal of biomedical optics

authors： Abeytunge S,Li Y,Larson B,Toledo-Crow R,Rajadhyaksha M

更新日期：2011-05-01 00:00:00

abstract：:The composition of cartilage is predictive of its in vivo performance. Therefore, the ability to assess its primary macromolecular components, proteoglycan (PG) and collagen, is of great importance. In the current study, we hypothesized that PG content and distribution in tissue engineered cartilage could be determine...

journal_title：Journal of biomedical optics

authors： Kim M,Bi X,Horton WE,Spencer RG,Camacho NP

更新日期：2005-05-01 00:00:00

abstract：:Computer simulation is used to facilitate the design of fiber-probe geometries that enable enhanced detection of optical signals arising from specific tissue depths. Obtaining understanding of the relationship between fiber-probe design and tissue interrogation is critical when developing strategies for optical detect...

journal_title：Journal of biomedical optics

authors： Wang AM,Bender JE,Pfefer J,Utzinger U,Drezek RA

更新日期：2005-07-01 00:00:00