Abstract:
:Polarization interferometry (PI) techniques, which are able to improve surface plasmon resonance (SPR) sensing performance and reduce restrictions on allowable parameters of SPR-supporting metal films, have been experimentally realized only in SPR sensors using monochromatic light as a source. Wavelength-interrogation SPR sensors modulated by PI techniques have not been reported due to the wavelength-sensitive characterization of PI phase compensators. In this work we develop a specially designed rhombic prism for phase compensating which is totally insensitive to wavelength. For the first time we successfully apply PI technique to a wavelength-interrogation SPR imager. This imager is able to offer two-dimensional imaging of the whole array plane. As a result of PI modulation, resolutions of 1.3×10(-6) refractive index unit (RIU) under the normal condition and 3.9×10(-7) RIU under a more time-consuming condition are acquired. The application of this imager was demonstrated by reading microarrays for identification of bacteria, and SPR results were confirmed by means of fluorescence imaging.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Liu Z,Liu L,Wang X,Shi H,Chong X,Ma S,Ji Y,Guo J,Ma H,He Ydoi
10.1117/1.JBO.17.3.036002subject
Has Abstractpub_date
2012-03-01 00:00:00pages
036002issue
3eissn
1083-3668issn
1560-2281journal_volume
17pub_type
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