Multimodal optical microscope for detecting viability of mouse embryos in vitro.

abstract：:Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components...

journal_title：Journal of biomedical optics

authors： Suzuki Y,Maruo K,Zhang AW,Shimogaki K,Ogawa H,Hirayama F

更新日期：2012-01-01 00:00:00

abstract：:Colorectal cancer is one of the most aggressive cancers usually occurring in people above the age of 50 years. In the United States, colorectal cancer is the third most diagnosed cancer. The American Cancer Society has estimated 96,830 new cases of colon cancer and 40,000 new cases of rectal cancer in 2014 in the Unit...

journal_title：Journal of biomedical optics

authors： Salman A,Sebbag G,Argov S,Mordechai S,Sahu RK

更新日期：2015-07-01 00:00:00

abstract：:Time-resolved measurement of early arriving photons through diffusive media has been shown to effectively reduce the high degree of light scatter in biological tissue. However, the experimentally achievable reduction in photon scatter and the impact of time-gated detection on instrument noise performance is not well u...

journal_title：Journal of biomedical optics

authors： Valim N,Brock J,Niedre M

更新日期：2010-11-01 00:00:00

abstract：:We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional in vivo imaging of human breast tumor based on large optical data sets. Images of oxy-, deoxy-, and total hemoglobin concentration as well as blood oxygen saturation and tissue scattering were reconstructed. Tumor ma...

journal_title：Journal of biomedical optics

authors： Choe R,Konecky SD,Corlu A,Lee K,Durduran T,Busch DR,Pathak S,Czerniecki BJ,Tchou J,Fraker DL,Demichele A,Chance B,Arridge SR,Schweiger M,Culver JP,Schnall MD,Putt ME,Rosen MA,Yodh AG

更新日期：2009-03-01 00:00:00

abstract：:Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative p...

journal_title：Journal of biomedical optics

authors： Byeon H,Ha YR,Lee SJ

更新日期：2015-11-01 00:00:00

abstract：:Ambulatory diffuse optical tomography (aDOT) is based on near-infrared spectroscopy (NIRS) and enables three-dimensional imaging of regional hemodynamics and oxygen consumption during a person’s normal activities. Although NIRS has been previously used for muscle assessment, it has been notably limited in terms of the...

journal_title：Journal of biomedical optics

authors： Hu G,Zhang Q,Ivkovic V,Strangman GE

更新日期：2016-09-01 00:00:00

abstract：:The metabolic rate of oxygen consumption, an important indicator of tissue metabolism, can be expressed as the change of net blood oxygen flux into and out of a tissue region per 100 g of tissue. In this work, we propose a photoacoustic and Doppler ultrasound method for imaging local blood oxygen flux of a single vess...

journal_title：Journal of biomedical optics

authors： Jiang Y,Forbrich A,Harrison T,Zemp RJ

更新日期：2012-03-01 00:00:00

abstract：:An evolving area of biomedical research is related to the creation of implantable units that provide various possibilities for imaging, measurement, and the monitoring of a wide range of diseases and intrabody phototherapy. The units can be autonomic or built-in in some kind of clinically applicable implants. Because ...

journal_title：Journal of biomedical optics

authors： Sheinman V,Rudnitsky A,Toichuev R,Eshiev A,Abdullaeva S,Egemkulov T,Zalevsky Z

更新日期：2014-01-01 00:00:00

abstract：:New diagnostic tools are needed for the characterization of dental caries in the early stages of development. If carious lesions are detected early enough, they can be arrested without the need for surgical intervention. The objective of this study was to demonstrate that polarization sensitive optical coherence tomog...

journal_title：Journal of biomedical optics

authors： Fried D,Xie J,Shafi S,Featherstone JD,Breunig TM,Le C

更新日期：2002-10-01 00:00:00

abstract：:Polarization interferometry (PI) techniques, which are able to improve surface plasmon resonance (SPR) sensing performance and reduce restrictions on allowable parameters of SPR-supporting metal films, have been experimentally realized only in SPR sensors using monochromatic light as a source. Wavelength-interrogation...

journal_title：Journal of biomedical optics

authors： Liu Z,Liu L,Wang X,Shi H,Chong X,Ma S,Ji Y,Guo J,Ma H,He Y

更新日期：2012-03-01 00:00:00

abstract：:Fluorescence spectroscopy is a promising technology for detection of epithelial precancers and cancers. While age and menopausal status influence measurements in the cervix, other variables do not significantly affect the diagnosis. In this study we examine probe pressure as a variable. A fiber optic probe to measure ...

journal_title：Journal of biomedical optics

authors： Nath A,Rivoire K,Chang S,Cox D,Atkinson EN,Follen M,Richards-Kortum R

更新日期：2004-05-01 00:00:00

abstract：:Cerenkov light is created in clinical applications involving high-energy radiation such as in radiation therapy. There is considerable interest in using Cerenkov light as a means to perform in vivo dosimetry during radiation therapy; however, a better understanding of the light-to-dose relationship is needed. One such...

journal_title：Journal of biomedical optics

authors： Brost E,Watanabe Y

更新日期：2018-10-01 00:00:00

abstract：:Biological systems with intrinsic luminescent properties serve as powerful and noninvasive bioreporters for real-time and label-free monitoring of cell physiology. This study employs the bioluminescent marine bacterium Vibrio fischeri to investigate the effects of separated microwave electric (E) and magnetic (H) fiel...

journal_title：Journal of biomedical optics

authors： Williams CF,Geroni GM,Lloyd D,Choi H,Clark N,Pirog A,Lees J,Porch A

更新日期：2019-02-01 00:00:00

abstract：:Optical coherence tomography (OCT) provides more parameters than pure morphology does. In a recent paper [A. Knuettel and M. Boehlau-Godau, J. Biomed. Opt. 5(1) 83-92 (2000)] we have shown that the refractive index (RI) can be evaluated in a localized manner in skin tissue under in vivo conditions. Based on a theory, ...

journal_title：Journal of biomedical optics

authors： Knüttel A,Bonev S,Knaak W

更新日期：2004-03-01 00:00:00

abstract：:Diffusion of two model drugs-benzyl nicotinate and ibuprofen-and the plasma macromolecule albumin across atherosclerotic rabbit aorta was studied ex vivo by attenuated total reflection-Fourier transform infrared (ATR-FTIR) imaging. Solutions of these molecules were applied to the endothelial surface of histological se...

journal_title：Journal of biomedical optics

authors： Palombo F,Danoux CB,Weinberg PD,Kazarian SG

更新日期：2009-07-01 00:00:00

abstract：:It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography...

journal_title：Journal of biomedical optics

authors： Lin Y,Kwong TC,Bolisay L,Gulsen G

更新日期：2012-05-01 00:00:00

abstract：:A method is proposed for determining the glucose concentration on the human fingertip by extracting two optical parameters, namely the optical rotation angle and the depolarization index, using a Mueller optical coherence tomography technique and a genetic algorithm. The feasibility of the proposed method is demonstra...

journal_title：Journal of biomedical optics

authors： Chen TL,Lo YL,Liao CC,Phan QH

更新日期：2018-04-01 00:00:00

abstract：:Amblyopia is a form of visual impairment caused by ocular misalignment (strabismus) or defocus in an otherwise healthy eye. If detected early, the condition can be fully treated, yet over half of all children with amblyopia under age 5 escape detection. We developed a Pediatric Vision Screener (PVS) to detect amblyopi...

journal_title：Journal of biomedical optics

authors： Nassif DS,Piskun NV,Gramatikov BI,Guyton DL,Hunter DG

更新日期：2004-11-01 00:00:00

abstract：:Intercellular heterogeneity is a key factor in a variety of core cellular processes including proliferation, stimulus response, carcinogenesis, and drug resistance. However, cell-to-cell variability studies at the single-cell level have been hampered by the lack of enabling experimental techniques. We present a measur...

journal_title：Journal of biomedical optics

authors： Kelbauskas L,Ashili SP,Houkal J,Smith D,Mohammadreza A,Lee KB,Forrester J,Kumar A,Anis YH,Paulson TG,Youngbull CA,Tian Y,Holl MR,Johnson RH,Meldrum DR

更新日期：2012-03-01 00:00:00

abstract：:Reduction of optical scattering in turbid biological tissues using nonreactive chemical agents has potential applications for light-based diagnostics and therapeutics. Optical clearing effects by exogenous chemical agents, in particular sugars and sugar alcohols, have been found to be temporary with tissue rehydration...

journal_title：Journal of biomedical optics

authors： Yeh AT,Hirshburg J

更新日期：2006-01-01 00:00:00

abstract：:Oblique incidence reflectometry (OIR) is an established technique for the estimation of tissue optical properties. However, a sensing footprint of a few transport mean-free paths is often needed when diffusion-regime-based algorithms are used. Smaller-footprint probes require improved light-propagation models and inve...

journal_title：Journal of biomedical optics

authors： Zemp RJ

更新日期：2013-06-01 00:00:00

abstract：:This study demonstrates the use of optical spectroscopy for monitoring tumor oxygenation and metabolism in response to hyperoxic gas breathing. Hemoglobin saturation and redox ratio were quantified for a set of 14 and 9 mice, respectively, measured at baseline and during carbogen breathing (95% O(2), 5% CO(2)). In par...

journal_title：Journal of biomedical optics

authors： Palmer GM,Viola RJ,Schroeder T,Yarmolenko PS,Dewhirst MW,Ramanujam N

更新日期：2009-03-01 00:00:00

abstract：:An adaptive pulse shaper controlled by multiphoton intrapulse interference phase scanning (MIIPS) was used, together with a prism-pair, to measure and cancel high-order phase distortions introduced by a high-numerical-aperture objective and other dispersive elements of a two-photon laser-scanning microscope. The deliv...

journal_title：Journal of biomedical optics

authors： Xi P,Andegeko Y,Pestov D,Lovozoy VV,Dantus M

更新日期：2009-01-01 00:00:00

abstract：:We investigate and assess the utility of a simple scheme for continuous absolute blood flow monitoring based on diffuse correlation spectroscopy (DCS). The scheme calibrates DCS using venous-occlusion diffuse optical spectroscopy (VO-DOS) measurements of arm muscle tissue at a single time-point. A calibration coeffici...

journal_title：Journal of biomedical optics

authors： Li Z,Baker WB,Parthasarathy AB,Ko TS,Wang D,Schenkel S,Durduran T,Li G,Yodh AG

更新日期：2015-01-01 00:00:00

abstract：:Alcohol testing is an expanding area of interest due to the impacts of alcohol abuse that extend well beyond drunk driving. However, existing approaches such as blood and urine assays are hampered in some testing environments by biohazard risks. A noninvasive, in vivo spectroscopic technique offers a promising alterna...

journal_title：Journal of biomedical optics

authors： Ridder TD,Ver Steeg BJ,Laaksonen BD

更新日期：2009-09-01 00:00:00

abstract：:We report a new two-channel fluorescence microscopy technique for surface-generated fluorescence. The realized fluorescence microscope allows high resolution imaging of aqueous samples. The core element of the instrument is a parabolic mirror objective that is used to collect the fluorescence at large surface angles a...

journal_title：Journal of biomedical optics

authors： Verdes D,Ruckstuhl T,Seeger S

更新日期：2007-05-01 00:00:00

abstract：:The conical shape of the tympanic membrane (TM or eardrum) plays an important role in its function, such that variations in shape alter the acoustically induced motions of the TM. We present a method that precisely determines both shape and acoustically induced transient response of the entire TM using the same optics...

journal_title：Journal of biomedical optics

authors： Razavi P,Tang H,Rosowski JJ,Furlong C,Cheng JT

更新日期：2018-09-01 00:00:00

abstract：:Fluorescence spectroscopy has been widely investigated as a technique for identifying pathological tissue; however, unrelated subject-to-subject variations in spectra complicate data analysis and interpretation. We describe and evaluate a new biosensing technique, differential laser-induced perturbation spectroscopy (...

journal_title：Journal of biomedical optics

authors： Kozikowski RT,Smith SE,Lee JA,Castleman WL,Sorg BS,Hahn DW

更新日期：2012-06-01 00:00:00

abstract：:We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT...

journal_title：Journal of biomedical optics

authors： Wang Y,Bower BA,Izatt JA,Tan O,Huang D

更新日期：2008-11-01 00:00:00

abstract：:Several studies demonstrated that the cyclic adenosine monophosphate (cAMP), an important second messenger, is involved in the mechanism of low-level laser irradiation (LLLI) treatment. However, most of these studies obtained the cAMP level in cell culture extracts or supernatant. In this study, the cAMP level in livi...

journal_title：Journal of biomedical optics

authors： Huang Y,Zheng L,Yang H,Chen J,Wang Y,Li H,Xie S,Zeng H

更新日期：2015-05-01 00:00:00