Characterization of the Cerenkov scatter function: a convolution kernel for Cerenkov light dosimetry.

abstract：:Hyperspectral reflectance imaging technique has been used for in vivo detection of cervical intraepithelial neoplasia. However, the clinical outcome of this technique is suboptimal owing to multiple limitations such as nonuniform illumination, high-cost and bulky setup, and time-consuming data acquisition and processi...

journal_title：Journal of biomedical optics

authors： Zheng W,Wang C,Chang S,Zhang S,Xu RX

更新日期：2015-12-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:Imaging large areas of tissue rapidly and with high resolution may enable rapid pathology at the bedside. The limited field of view of high-resolution microscopes requires the merging of multiple images that are taken sequentially to cover a large area. This merging or mosaicing of images requires long acquisition and...

journal_title：Journal of biomedical optics

authors： Abeytunge S,Li Y,Larson B,Toledo-Crow R,Rajadhyaksha M

更新日期：2011-05-01 00:00:00

abstract：:Knowledge of neuronal wiring and morphogenesis in Drosophila is essential to understand brain function and dysfunction. The immunoenzyme method based on horseradish peroxidase/diaminobenzidine (HRP/DAB) provides high-contrast images to resolve details underlying neuronal architecture. However, the poor staining penetr...

journal_title：Journal of biomedical optics

authors： Tian Q,Yuan J,Li Y,Jiang T,Gong H,Zhou W

更新日期：2014-09-01 00:00:00

abstract：:Skin cancer diagnosis depends not only on histopathological examination but also on visual inspection before and after the excision of suspected lesion. Neoplasm is accompanied with changes in birefringence of collagen, pleomorphicity, and hyperchromatic state of epithelial nuclei. These phenomena can be measured by s...

journal_title：Journal of biomedical optics

authors： Aharon O,Abdulhalim I,Arnon O,Rosenberg L,Dyomin V,Silberstein E

更新日期：2011-08-01 00:00:00

abstract：:We describe the use of a Teflon-AF liquid core optical fiber (LCOF) geometry to enhance the collection of Raman scattering from the biochemical creatinine, dissolved in water and in urine. At short integration times, where shot noise is most troublesome, the enhanced signal leads to greater accuracy in estimating the ...

journal_title：Journal of biomedical optics

authors： Qi D,Berger AJ

更新日期：2005-05-01 00:00:00

abstract：:We investigate a technology to create a high temperature heat source on the tip surface of the glass fiber proposed for medical surgery applications. Using 4 to 6 W power level semiconductor lasers at a wavelength of 980 nm, a laser coupled fiber tip was preprocessed to contain a certain amount of titanium oxide powde...

journal_title：Journal of biomedical optics

authors： Fujimoto T,Imai Y,Tei K,Ito S,Kanazawa H,Yamaguchi S

更新日期：2014-01-01 00:00:00

abstract：:High resolution is important for sensitive detection of subtle distortions of retinal morphology at an early stage of eye diseases. We demonstrate virtually structured detection (VSD) as a feasible method to achieve in vivo super-resolution ophthalmoscopy. A line-scanning strategy was employed to achieve a super-resol...

journal_title：Journal of biomedical optics

authors： Liu C,Zhi Y,Wang B,Thapa D,Chen Y,Alam M,Lu Y,Yao X

更新日期：2016-12-01 00:00:00

abstract：:We employ Fourier-transform Raman spectroscopy to study normal and tumoral human breast tissues, including several subtypes of cancers. We analyzed 194 Raman spectra from breast tissues that were separated into 9 groups according to their corresponding histopathological diagnosis. The assignment of the relevant Raman ...

journal_title：Journal of biomedical optics

authors： Bitar RA,Martinho Hda S,Tierra-Criollo CJ,Zambelli Ramalho LN,Netto MM,Martin AA

更新日期：2006-09-01 00:00:00

abstract：:Colorectal cancer is one of the most aggressive cancers usually occurring in people above the age of 50 years. In the United States, colorectal cancer is the third most diagnosed cancer. The American Cancer Society has estimated 96,830 new cases of colon cancer and 40,000 new cases of rectal cancer in 2014 in the Unit...

journal_title：Journal of biomedical optics

authors： Salman A,Sebbag G,Argov S,Mordechai S,Sahu RK

更新日期：2015-07-01 00:00:00

abstract：:Metal nanoparticles can be functionalized with biomolecules to selectively localize in precancerous tissues and can act as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo (MC) simulations to analyze photon propagation through nanoparticle-labeled tissues and...

journal_title：Journal of biomedical optics

authors： Cihan C,Arifler D

更新日期：2011-08-01 00:00:00

abstract：:Diffuse near-infrared tomography of tissue reveals scattering changes that originate from the submicroscopic features of the tissue; yet the existing tools to use this information to predict which features contribute to the scattering spectrum are limited by the lack of direct data quantifying the particle sizes. Brea...

journal_title：Journal of biomedical optics

authors： Bartek M,Wang X,Wells W,Paulsen KD,Pogue BW

更新日期：2006-11-01 00:00:00

abstract：:A modified spatial-temporal speckle correlation technique for operational assessment of structural changes in muscle tissues after slaughtering is considered. Coefficient of biological activity as a quantitative indicator of structural changes of biochemical processes in biological tissues is proposed. The experimenta...

journal_title：Journal of biomedical optics

authors： Maksymenko OP,Muravsky LI,Berezyuk MI

更新日期：2015-09-01 00:00:00

abstract：:This paper explains the term low-coherence interferometry, reviews the early development of optical low-coherence reflectometry, and shows some of the paths that led to the field of biomedical optics. This paper demonstrates that early technical developments in the telecommunications industry resulted in a myriad of t...

journal_title：Journal of biomedical optics

authors： Masters BR

更新日期：1999-04-01 00:00:00

abstract：:During emergency medical situations, where the patient has an obstructed airway or necessitates respiratory support, endotracheal intubation (ETI) is the medical technique of placing a tube into the trachea in order to facilitate adequate ventilation of the lungs. Complications during ETI, such as repeated attempts, f...

journal_title：Journal of biomedical optics

authors： Nawn CD,Souhan BE,Carter R 3rd,Kneapler C,Fell N,Ye JY

更新日期：2016-11-01 00:00:00

abstract：:Motion artifacts are the most significant sources of noise in the context of pediatric brain imaging designs and data analyses, especially in applications of functional near-infrared spectroscopy (fNIRS), in which it can completely affect the quality of the data acquired. Different methods have been developed to corre...

journal_title：Journal of biomedical optics

authors： Hu XS,Arredondo MM,Gomba M,Confer N,DaSilva AF,Johnson TD,Shalinsky M,Kovelman I

更新日期：2015-01-01 00:00:00

abstract：:We explore the use of Monte-Carlo-model-based approaches for the analysis of fluorescence and diffuse reflectance spectra measured ex vivo from breast tissues. These models are used to extract the absorption, scattering, and fluorescence properties of malignant and nonmalignant tissues and to diagnose breast cancer ba...

journal_title：Journal of biomedical optics

authors： Zhu C,Palmer GM,Breslin TM,Harter J,Ramanujam N

更新日期：2008-05-01 00:00:00

abstract：:Diffuse optical imaging is an effective technique for noninvasive functional brain imaging. However, the measurements respond to systemic hemodynamic fluctuations caused by the cardiac cycle, respiration, and blood pressure, which may obscure or overwhelm the desired stimulus-evoked response. Previous work on this pro...

journal_title：Journal of biomedical optics

authors： Zhang Y,Brooks DH,Franceschini MA,Boas DA

更新日期：2005-01-01 00:00:00

abstract：:Focusing light inside highly scattering media is a challenging task in biomedical optical imaging, manipulation, and therapy. A recent invention has overcome this challenge by time reversing ultrasonically encoded diffuse light to an ultrasound-modulated volume inside a turbid medium. In this technique, a photorefract...

journal_title：Journal of biomedical optics

authors： Yang Q,Xu X,Lai P,Xu D,Wang LV

更新日期：2013-11-01 00:00:00

abstract：:Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of retinal pathologies with greater penetration into choroidal tissue is compared to conventional...

journal_title：Journal of biomedical optics

authors： Povazay B,Hermann B,Unterhuber A,Hofer B,Sattmann H,Zeiler F,Morgan JE,Falkner-Radler C,Glittenberg C,Blinder S,Drexler W

更新日期：2007-07-01 00:00:00

abstract：:Confocal micro-Raman spectroscopy--a valuable analytical tool in biological and medical field of research-allows probing molecular vibrations of samples without external labels or extensive preparation. We employ confocal micro-Raman spectroscopy to characterize renal tumors and normal tissue. Results show that Raman ...

journal_title：Journal of biomedical optics

authors： Zhuang Z,Li N,Guo Z,Zhu M,Xiong K,Chen S

更新日期：2013-03-01 00:00:00

abstract：:We quantitatively investigated the measurement sensitivity of spatially resolved spectroscopy (SRS) across six tissue models: cerebral tissue, a small animal brain, the forehead of a fetus, an adult brain, forearm muscle, and thigh muscle. The optical path length in the voxel of the model was analyzed using Monte Carl...

journal_title：Journal of biomedical optics

authors： Niwayama M

更新日期：2018-03-01 00:00:00

abstract：:Raman spectroscopy on single, living epithelial cells captured in a laser trap is shown to have diagnostic power over colorectal cancer. This new single-cell technology comprises three major components: primary culture processing of human tissue samples to produce single-cell suspensions, Raman detection on singly tra...

journal_title：Journal of biomedical optics

authors： Zheng F,Qin Y,Chen K

更新日期：2007-05-01 00:00:00

abstract：:In the last decade, coherent anti-Stokes Raman scattering (CARS) microscopy has emerged as a powerful multiphoton imaging technique offering label-free chemical sensitivity and high three-dimensional resolution. However, its widespread application in the life sciences has been hampered by the use of costly pulsed lase...

journal_title：Journal of biomedical optics

authors： Li B,Borri P,Langbein W

更新日期：2013-06-01 00:00:00

abstract：:The thulium fiber laser (TFL) is currently being studied as an alternative to the conventional holmium:YAG (Ho:YAG) laser for lithotripsy. The diode-pumped TFL may be electronically modulated to operate with variable parameters (e.g., pulse rate, pulse duration, and duty cycle) for studying the influence of pulse trai...

journal_title：Journal of biomedical optics

authors： Blackmon RL,Irby PB,Fried NM

更新日期：2012-02-01 00:00:00

abstract：:The nEUROPt protocol is one of two new protocols developed within the European project nEUROPt to characterize the performances of time-domain systems for optical imaging of the brain. It was applied in joint measurement campaigns to compare the various instruments and to assess the impact of technical improvements. T...

journal_title：Journal of biomedical optics

authors： Wabnitz H,Jelzow A,Mazurenka M,Steinkellner O,Macdonald R,Milej D,Żołek N,Kacprzak M,Sawosz P,Maniewski R,Liebert A,Magazov S,Hebden J,Martelli F,Di Ninni P,Zaccanti G,Torricelli A,Contini D,Re R,Zucchelli L,Spine

更新日期：2014-08-01 00:00:00

abstract：:Utilizing a laser scanning confocal microscope system, the refractive indices of articular cartilage (AC) with mechanical or biochemical degenerations were characterized to investigate whether potential correlations exist between refractive index (RI) and cartilage degeneration. The cartilage samples collected from th...

journal_title：Journal of biomedical optics

authors： Wang K,Wu J,Day R,Kirk TB,Hu X

更新日期：2016-09-01 00:00:00

abstract：:In this work experimental tissue phantoms and numerical models were developed to estimate photon migration through the fetal head in utero. The tissue phantoms incorporate a fetal head within an amniotic fluid sac surrounded by a maternal tissue layer. A continuous wave, dual-wavelength (lambda = 760 and 850 nm) spect...

journal_title：Journal of biomedical optics

authors： Vishnoi G,Hielscher AH,Ramanujam N,Chance B

更新日期：2000-04-01 00:00:00

abstract：:Differential phase optical coherence tomography (DPOCT) is introduced to measure optical path length changes in response to pulsed laser irradiation (585 nm). An analytical equation that includes thermoelastic surface displacement and thermorefractive index change is derived to predict optical path length change in re...

journal_title：Journal of biomedical optics

authors： Kim J,Oh J,Milner TE

更新日期：2006-07-01 00:00:00

abstract：:A Fourier transform spectrometer is used to simultaneously measure distance, dispersion and spectrum. It is shown that short coherence interferometry has the potential to measure the three-dimensional distribution of the spatial structure of a sample with a resolution determined by the coherence length of the light so...

journal_title：Journal of biomedical optics

authors： Hellmuth T,Welle M

更新日期：1998-01-01 00:00:00