Abstract:
:We investigate and assess the utility of a simple scheme for continuous absolute blood flow monitoring based on diffuse correlation spectroscopy (DCS). The scheme calibrates DCS using venous-occlusion diffuse optical spectroscopy (VO-DOS) measurements of arm muscle tissue at a single time-point. A calibration coefficient (γ) for the arm is determined, permitting conversion of DCS blood flow indices to absolute blood flow units, and a study of healthy adults (N=10) is carried out to ascertain the variability of γ. The average DCS calibration coefficient for the right (i.e., dominant) arm was γ=(1.24±0.15)×10(8) (mL·100 mL(−1)·min(−1))/(cm(2)/s). However, variability can be significant and is apparent in our site-to-site and day-to-day repeated measurements. The peak hyperemic blood flow overshoot relative to baseline resting flow was also studied following arm-cuff ischemia; excellent agreement between VO-DOS and DCS was found (R(2)=0.95, slope=0.94±0.07, mean difference=−0.10±0.45). Finally, we show that incorporation of subject-specific absolute optical properties significantly improves blood flow calibration accuracy.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Li Z,Baker WB,Parthasarathy AB,Ko TS,Wang D,Schenkel S,Durduran T,Li G,Yodh AGdoi
10.1117/1.JBO.20.12.125005subject
Has Abstractpub_date
2015-01-01 00:00:00pages
125005issue
12eissn
1083-3668issn
1560-2281pii
2479698journal_volume
20pub_type
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