Abstract:
:Intraoperative fluorescence molecular imaging based on targeted fluorescence agents is an emerging approach to improve surgical and endoscopic imaging and guidance. Short exposure times per frame and implementation at video rates are necessary to provide continuous feedback to the physician and avoid motion artifacts. However, fast imaging implementations also limit the sensitivity of fluorescence detection. To improve on detection sensitivity in video rate fluorescence imaging, we considered herein an optical flow technique applied to texture-rich color images. This allows the effective accumulation of fluorescence signals over longer, virtual exposure times. The proposed correction scheme is shown to improve signal-to-noise ratios both in phantom experiments and in vivo tissue imaging.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Koch M,Glatz J,Ermolayev V,de Vries EG,van Dam GM,Englmeier KH,Ntziachristos Vdoi
10.1117/1.JBO.19.4.046012subject
Has Abstractpub_date
2014-04-01 00:00:00pages
046012issue
4eissn
1083-3668issn
1560-2281pii
1864741journal_volume
19pub_type
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