Biochemical analysis of human breast tissues using Fourier-transform Raman spectroscopy.

abstract：:Intravascular near-infrared fluorescence (NIRF) imaging offers a new approach for characterizing atherosclerotic plaque, but random catheter positioning within the vessel lumen results in variable light attenuation and can yield inaccurate measurements. We hypothesized that NIRF measurements could be corrected for var...

journal_title：Journal of biomedical optics

authors： Dixon AJ,Hossack JA

更新日期：2013-05-01 00:00:00

abstract：:The thulium fiber laser (TFL) is currently being studied as an alternative to the conventional holmium:YAG (Ho:YAG) laser for lithotripsy. The diode-pumped TFL may be electronically modulated to operate with variable parameters (e.g., pulse rate, pulse duration, and duty cycle) for studying the influence of pulse trai...

journal_title：Journal of biomedical optics

authors： Blackmon RL,Irby PB,Fried NM

更新日期：2012-02-01 00:00:00

abstract：:Gap junction-mediated intercellular communication influences a variety of cellular activities. In tendons, gap junctions modulate collagen production, are involved in strain-induced cell death, and are involved in the response to mechanical stimulation. The aim of the present study was to investigate gap junction-medi...

journal_title：Journal of biomedical optics

authors： Kuzma-Kuzniarska M,Yapp C,Pearson-Jones TW,Jones AK,Hulley PA

更新日期：2014-01-01 00:00:00

abstract：:Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast t...

journal_title：Journal of biomedical optics

authors： Michaelsen KE,Krishnaswamy V,Shi L,Vedantham S,Karellas A,Pogue BW,Paulsen KD,Poplack SP

更新日期：2016-09-01 00:00:00

abstract：:Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, curre...

journal_title：Journal of biomedical optics

authors： Petitdidier N,Koenig A,Gerbelot R,Grateau H,Gioux S,Jallon P

更新日期：2018-11-01 00:00:00

abstract：:To evaluate retinal perfusion in the human eye, a dual-wavelength confocal scanning laser ophthalmoscope (cSLO) was developed that provides spectral imaging of the fundus using a combination of red (670 nm) and near-infrared (810 nm) wavelengths. The image of the ocular fundus was analyzed to find out if quantitative ...

journal_title：Journal of biomedical optics

authors： Rasta SH,Manivannan A,Sharp PF

更新日期：2012-11-01 00:00:00

abstract：:Previous works investigated a spectroscopic technique that offered a promising alternative to blood and breath assays for determining in vivo alcohol concentration. Although these prior works measured the dorsal forearm, we report the results of a 26-subject clinical study designed to evaluate the spectroscopic techni...

journal_title：Journal of biomedical optics

authors： Ridder TD,Hull EL,Ver Steeg BJ,Laaksonen BD

更新日期：2011-02-01 00:00:00

abstract：:Abdominal surgeries carry considerable risk of gastrointestinal and intra-abdominal hemorrhage, which could possibly cause patient death. Photoacoustic imaging is one solution to overcome this challenge by providing visualization of major blood vessels during surgery. We investigate the feasibility of in vivo blood ve...

journal_title：Journal of biomedical optics

authors： Kempski KM,Wiacek A,Graham M,González E,Goodson B,Allman D,Palmer J,Hou H,Beck S,He J,Bell MAL

更新日期：2019-08-01 00:00:00

abstract：:Biomedical applications of terahertz (THz) radiation are appealing because THz radiation is nonionizing and has the demonstrated ability to detect intrinsic contrasts between cancerous and normal tissue. A linear polarization-sensitive detection technique for tumor margin delineation has already been demonstrated; how...

journal_title：Journal of biomedical optics

authors： Martin JP,Joseph CS,Giles RH

更新日期：2016-07-01 00:00:00

abstract：:Ambulatory diffuse optical tomography (aDOT) is based on near-infrared spectroscopy (NIRS) and enables three-dimensional imaging of regional hemodynamics and oxygen consumption during a person’s normal activities. Although NIRS has been previously used for muscle assessment, it has been notably limited in terms of the...

journal_title：Journal of biomedical optics

authors： Hu G,Zhang Q,Ivkovic V,Strangman GE

更新日期：2016-09-01 00:00:00

abstract：:In order to monitor dynamic physiological events in near-real time, a variety of photoacoustic computed tomography (PACT) systems have been developed that can rapidly acquire data. Previously reported studies of dynamic PACT have employed conventional static methods to reconstruct a temporally ordered sequence of imag...

journal_title：Journal of biomedical optics

authors： Wang K,Xia J,Li C,Wang LV,Anastasio MA

更新日期：2014-05-01 00:00:00

abstract：:The potential of intrinsic optical imaging and resting-state analysis under anesthetized conditions as a tool to study brain networks associated with epileptic seizures is investigated. Using an acute model of epileptiform activity, the 4-aminopyridine model in live mice, we observe the changes in resting-state networ...

journal_title：Journal of biomedical optics

authors： Guevara E,Pouliot P,Nguyen DK,Lesage F

更新日期：2013-07-01 00:00:00

abstract：:Optically sectioned detection of fluorescence immunoassays using a confocal microscope enables the creation of both homo- and heterogeneous planar format assays. We report a set assays requiring optically sectioned detection using a model system and analysis procedures for separating signals of a surface layer from an...

journal_title：Journal of biomedical optics

authors： Ghafari H,Zhou Y,Ali S,Hanley QS

更新日期：2009-11-01 00:00:00

abstract：:Collagen fiber orientation plays an important role in determining the structure and function of the articular cartilage. However, there is currently a lack of nondestructive means to image the fiber orientation from the cartilage surface. The purpose of this study is to investigate whether the newly developed optical ...

journal_title：Journal of biomedical optics

authors： Yao X,Wang Y,Ravanfar M,Pfeiffer FM,Duan D,Yao G

更新日期：2016-11-01 00:00:00

abstract：:Doxorubicin is a commonly used chemotherapeutic employed to treat multiple human cancers, including numerous sarcomas and carcinomas. Furthermore, doxorubicin possesses strong fluorescent properties that make it an ideal reagent for modeling drug delivery by examining its distribution in cells and tissues. However, wh...

journal_title：Journal of biomedical optics

authors： Carlson M,Watson AL,Anderson L,Largaespada DA,Provenzano PP

更新日期：2017-11-01 00:00:00

abstract：:The area of in vivo sensing using optical fibers commonly uses materials such as silica and polymethyl methacrylate, both of which possess much higher modulus than human tissue. The mechanical mismatch between materials and living tissue has been seen to cause higher levels of glial encapsulation, scarring, and inflam...

journal_title：Journal of biomedical optics

authors： McMillan S,Rader C,Jorfi M,Pickrell G,Foster EJ

更新日期：2017-02-01 00:00:00

abstract：:Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, the residual spectrum, the difference between the observed and modeled diffuse reflectance spectra, was attributed to single elastic light scattering from epithelial nucle...

journal_title：Journal of biomedical optics

authors： Lau C,Sćepanović O,Mirkovic J,McGee S,Yu CC,Fulghum S,Wallace M,Tunnell J,Bechtel K,Feld M

更新日期：2009-03-01 00:00:00

abstract：:We fabricate scaffolds with a fine linear grating (periodicity of 1 to 8 microm and height of 1 microm) on a glass substrate for controlling cardiomyocyte orientation. The fabrication is done by the solidification of a liquid photopolymerizable material using two laser beam interference. As the photopolymerizable mate...

journal_title：Journal of biomedical optics

authors： Fujita A,Fujita K,Nakamura O,Matsuda T,Kawata S

更新日期：2006-03-01 00:00:00

abstract：:The ability to quantitatively determine tissue fluorescence is of interest for the purpose of better understanding the details of photodynamic therapy of skin cancer. In particular, we are interested in quantifying protoporphyrin IX (PpIX) in vivo. We present a method of correcting fluorescence for effects of native t...

journal_title：Journal of biomedical optics

authors： Saager RB,Cuccia DJ,Saggese S,Kelly KM,Durkin AJ

更新日期：2011-12-01 00:00:00

abstract：:A method for the prediction of the average photon pathlength in turbid media has been developed. The method is based on spatially resolved diffuse reflectance with discrete source detector distances up to 2 mm. Light reflectance was simulated using a Monte Carlo technique with a one-layer model utilizing a wide range ...

journal_title：Journal of biomedical optics

authors： Nilsson H,Larsson M,Nilsson GE,Strömberg T

更新日期：2002-07-01 00:00:00

abstract：:Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in >25  %   of cases due to positive or closely involved margin...

journal_title：Journal of biomedical optics

authors： Schaefer JM,Barth CW,Davis SC,Gibbs SL

更新日期：2019-02-01 00:00:00

abstract：:Polarization interferometry (PI) techniques, which are able to improve surface plasmon resonance (SPR) sensing performance and reduce restrictions on allowable parameters of SPR-supporting metal films, have been experimentally realized only in SPR sensors using monochromatic light as a source. Wavelength-interrogation...

journal_title：Journal of biomedical optics

authors： Liu Z,Liu L,Wang X,Shi H,Chong X,Ma S,Ji Y,Guo J,Ma H,He Y

更新日期：2012-03-01 00:00:00

abstract：:Discrimination of benign and malignant melanocytic lesions is a major issue in clinical dermatology. Assessment of the thickness of melanoma is critical for prognosis and treatment selection. We aimed to evaluate a novel optical computed tomography (optical-CT) system as a tool for three-dimensional (3-D) imaging of m...

journal_title：Journal of biomedical optics

authors： Kokolakis A,Zacharakis G,Krasagakis K,Lasithiotakis K,Favicchio R,Spiliopoulos G,Giannikaki E,Ripoll J,Tosca A

更新日期：2012-06-01 00:00:00

abstract：:Optoacoustic (photoacoustic) diagnostic modality is a technique that combines high optical contrast and ultrasound spatial resolution. We proposed using the optoacoustic technique for a number of applications, including cancer detection, monitoring of thermotherapy (hyperthermia, coagulation, and freezing), monitoring...

journal_title：Journal of biomedical optics

authors： Esenaliev RO

更新日期：2017-09-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) in tumor cells was found to play an important role in maintaining the malignant phenotype. Using laser scanning confocal fluorescence microscopy (LSCFM) in a recent work, we reported a variable fluorescence intensity of ethidium bromide (EB) in mitochondria nucleoids of living carcinoma cells...

journal_title：Journal of biomedical optics

authors： Villa AM,Fusi P,Pastori V,Amicarelli G,Pozzi C,Adlerstein D,Doglia SM

更新日期：2012-04-01 00:00:00

abstract：:The development of accurate and clinically applicable tools to assess cancer risk is essential to define candidates to undergo screening for early-stage cancers at a curable stage or provide a novel method to monitor chemoprevention treatments. With the use of our recently developed optical technology--spatial-domain ...

journal_title：Journal of biomedical optics

authors： Bista RK,Uttam S,Hartman DJ,Qiu W,Yu J,Zhang L,Brand RE,Liu Y

更新日期：2012-06-01 00:00:00

abstract：:We present experiments and analyses of confocal reflectance and two-photon microscopy studies of zebra finch skull samples. The thin and hollow structure of these birds' skulls is quite translucent, which can allow in vivo transcranial two-photon imaging for brain activation monitoring. However, the skull structure is...

journal_title：Journal of biomedical optics

authors： Abi-Haidar D,Olivier T

更新日期：2009-05-01 00:00:00

abstract：:The conical shape of the tympanic membrane (TM or eardrum) plays an important role in its function, such that variations in shape alter the acoustically induced motions of the TM. We present a method that precisely determines both shape and acoustically induced transient response of the entire TM using the same optics...

journal_title：Journal of biomedical optics

authors： Razavi P,Tang H,Rosowski JJ,Furlong C,Cheng JT

更新日期：2018-09-01 00:00:00

abstract：:Frequency domain optical coherence tomography (FD-OCT), based on an all-reflective high-speed InGaAs spectrometer, operating in the 1050 nm wavelength region for retinal diagnostics, enables high-speed, volumetric imaging of retinal pathologies with greater penetration into choroidal tissue is compared to conventional...

journal_title：Journal of biomedical optics

authors： Povazay B,Hermann B,Unterhuber A,Hofer B,Sattmann H,Zeiler F,Morgan JE,Falkner-Radler C,Glittenberg C,Blinder S,Drexler W

更新日期：2007-07-01 00:00:00

abstract：:In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunt...

journal_title：Journal of biomedical optics

authors： McGee S,Mirkovic J,Mardirossian V,Elackattu A,Yu CC,Kabani S,Gallagher G,Pistey R,Galindo L,Badizadegan K,Wang Z,Dasari R,Feld MS,Grillone G

更新日期：2008-11-01 00:00:00