Comparison of spectroscopically measured finger and forearm tissue ethanol concentration to blood and breath ethanol measurements.

abstract：:Optical spectroscopy, imaging, and therapy tissue phantoms must have the scattering and absorption properties that are characteristic of human tissues, and over the past few decades, many useful models have been created. In this work, an overview of their composition and properties is outlined, by separating matrix, s...

journal_title：Journal of biomedical optics

authors： Pogue BW,Patterson MS

更新日期：2006-07-01 00:00:00

abstract：:This study aimed to evaluate the concept of using high-resolution optical coherence tomography (OCT) imaging to rapidly assess surgical specimens and determine if cancer positive margins were left behind in the surgical bed. A mouse model of breast cancer was used in this study. Surgical specimens from 30 animals were...

journal_title：Journal of biomedical optics

authors： Savastru D,Chang EW,Miclos S,Pitman MB,Patel A,Iftimia N

更新日期：2014-05-01 00:00:00

abstract：:Clinical imaging techniques for the anterior segment of the eye provide excellent anatomical information, but molecular imaging techniques are lacking. Molecular photoacoustic imaging is one option to address this need, but implementation requires use of contrast agents to distinguish molecular targets from background...

journal_title：Journal of biomedical optics

authors： Kubelick KP,Snider EJ,Ethier CR,Emelianov S

更新日期：2019-05-01 00:00:00

abstract：:Microcirculation lesion is a common symptom of chronic liver diseases in the form of vasculature deformation and circulation alteration. In acute to chronic liver diseases such as biliary atresia, microcirculation lesion can have an early onset. Detection of microcirculation lesion is meaningful for studying the progr...

journal_title：Journal of biomedical optics

authors： Yan J,Kang Y,Xu S,Ong LL,Zhuo S,Bunte RM,Chen N,Asada HH,So PT,Wanless IR,Yu H

更新日期：2014-01-01 00:00:00

abstract：:Fourier transform infrared (FTIR) microspectroscopy has been used to estimate the spatial proteoglycan (PG) and collagen contents in articular cartilage (AC). However, it is not clear whether the results of FTIR analyses are consistent between different species. Our aim was to clarify how three different FTIR PG param...

journal_title：Journal of biomedical optics

authors： Rieppo L,Närhi T,Helminen HJ,Jurvelin JS,Saarakkala S,Rieppo J

更新日期：2013-09-01 00:00:00

abstract：:Several studies demonstrated that the cyclic adenosine monophosphate (cAMP), an important second messenger, is involved in the mechanism of low-level laser irradiation (LLLI) treatment. However, most of these studies obtained the cAMP level in cell culture extracts or supernatant. In this study, the cAMP level in livi...

journal_title：Journal of biomedical optics

authors： Huang Y,Zheng L,Yang H,Chen J,Wang Y,Li H,Xie S,Zeng H

更新日期：2015-05-01 00:00:00

abstract：:Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) w...

journal_title：Journal of biomedical optics

authors： Jia Y,An L,Wang RK

更新日期：2009-09-01 00:00:00

abstract：:There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The results of these experim...

journal_title：Journal of biomedical optics

authors： Baranoski GV,Chen TF,Kimmel BW,Miranda E,Yim D

更新日期：2012-09-01 00:00:00

abstract：:Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is relatively transparent for activated light and can protect the PpIX against denaturation induced by the extreme bioenvironment. The mesop...

journal_title：Journal of biomedical optics

authors： Qian J,Gharibi A,He S

更新日期：2009-01-01 00:00:00

abstract：:Lumpectomy coupled with radiation therapy and/or chemotherapy is commonly used to treat breast cancer patients. We are developing an enhanced thermal IR imaging technique that has the potential to provide real-time imaging to guide tissue excision during a lumpectomy by delineating tumor margins. This enhanced thermal...

journal_title：Journal of biomedical optics

authors： Case JR,Young MA,Dréau D,Trammell SR

更新日期：2015-11-01 00:00:00

abstract：:We have been developing a Mach-Zehnder type of optical frequency domain reflectometry optical coherence tomography (OFDR-OCT) that uses discretely swept superstructure-grating distributed Bragg- reflector (SSG-DBR) lasers developed for telecommunication fields and has a 12-mm-depth range. We report images obtained wit...

journal_title：Journal of biomedical optics

authors： Kakuma H,Ohbayashi K,Arakawa Y

更新日期：2008-01-01 00:00:00

abstract：:Fluorescence lifetime imaging (FLi) could potentially improve exogenous near-infrared (NIR) fluorescence imaging, because it offers the capability of discriminating a signal of interest from background, provides real-time monitoring of a chemical environment, and permits the use of several different fluorescent dyes h...

journal_title：Journal of biomedical optics

authors： Gioux S,Lomnes SJ,Choi HS,Frangioni JV

更新日期：2010-03-01 00:00:00

abstract：:Motion artifacts are the most significant sources of noise in the context of pediatric brain imaging designs and data analyses, especially in applications of functional near-infrared spectroscopy (fNIRS), in which it can completely affect the quality of the data acquired. Different methods have been developed to corre...

journal_title：Journal of biomedical optics

authors： Hu XS,Arredondo MM,Gomba M,Confer N,DaSilva AF,Johnson TD,Shalinsky M,Kovelman I

更新日期：2015-01-01 00:00:00

abstract：:Oral cancer is one of the most common cancers worldwide. One-fifth of the world's oral cancer subjects are from India and other South Asian countries. The present Raman mapping study was carried out to understand biochemical variations in normal and malignant oral buccal mucosa. Data were acquired using WITec alpha 30...

journal_title：Journal of biomedical optics

authors： Behl I,Kukreja L,Deshmukh A,Singh SP,Mamgain H,Hole AR,Krishna CM

更新日期：2014-12-01 00:00:00

abstract：:Hemoglobin (Hb), as one of main components of blood, has a unique quaternary structure. Its release of oxygen is controlled by oxygen partial pressure (PO2). We investigate the specific spectroscopic changes in Hb under different PO2 levels to optimize clinical methods of measuring tissue PO2. The transmissivity of Hb...

journal_title：Journal of biomedical optics

authors： Liu P,Zhu Z,Zeng C,Nie G

更新日期：2012-12-01 00:00:00

abstract：:Photospallation is proposed as the primary mechanism behind our recent animal studies involving corneal ablation by nanosecond-pulse mid-IR laser beams. Following a brief summary of earlier work directed to refractive procedures in the mid-IR, a preliminary analysis is presented, based on simple one-dimensional models...

journal_title：Journal of biomedical optics

authors： Hoffman HJ,Telfair WB

更新日期：1999-10-01 00:00:00

abstract：:We fabricate scaffolds with a fine linear grating (periodicity of 1 to 8 microm and height of 1 microm) on a glass substrate for controlling cardiomyocyte orientation. The fabrication is done by the solidification of a liquid photopolymerizable material using two laser beam interference. As the photopolymerizable mate...

journal_title：Journal of biomedical optics

authors： Fujita A,Fujita K,Nakamura O,Matsuda T,Kawata S

更新日期：2006-03-01 00:00:00

abstract：:Animal models are widely used to investigate the pathological mechanisms of spinal cord injury (SCI), most commonly in rats. It is well known that compromised blood flow caused by mechanical disruption of the vasculature can produce irreversible damage and cell death in hypoperfused tissue regions and spinal cord tiss...

journal_title：Journal of biomedical optics

authors： Phillips JP,Cibert-Goton V,Langford RM,Shortland PJ

更新日期：2013-03-01 00:00:00

abstract：:Fluorescence cystoscopy (FC) efficiently enhances the detection and improves the therapeutic management of early bladder cancer. During an FC, about 150 ml of water is needed to inflate the bladder. The water is quickly diluted by urine which can be fluorescent. If this bladder washout fluid (BWF) becomes fluorescent,...

journal_title：Journal of biomedical optics

authors： Zellweger M,Martoccia C,Mengin M,Iselin C,van den Bergh H,Wagnières G

更新日期：2015-06-01 00:00:00

abstract：:Low-level light therapy has been shown to improve in vitro wound healing. However, well-defined parameters of different light sources for this therapy are lacking. The goal of this study was (1) to determine if the wavelengths tested are effective for in vitro wound healing and (2) to compare a laser and a light-emitt...

journal_title：Journal of biomedical optics

authors： Spitler R,Berns MW

更新日期：2014-03-01 00:00:00

abstract：:To improve surgical guidance toward prostate draining lymph nodes, we investigate the potential of intraoperative fluorescence imaging and combined pre- and intraoperative multimodality imaging approaches. Transgenic adenocarcinoma mouse prostate mice with spontaneous prostate tumors are injected intratumorally with: ...

journal_title：Journal of biomedical optics

authors： van Leeuwen AC,Buckle T,Bendle G,Vermeeren L,Valdés Olmos R,van de Poel HG,van Leeuwen FW

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:Temperature changes caused by laser irradiation can promote damage to the surrounding dental tissues. In this study, we evaluated the temperature changes of recently extracted human mandibular incisors during intracanal irradiation with an 810-nm diode laser at different settings. Fifty mandibular incisors w...

journal_title：Journal of biomedical optics

authors： da Fonseca Alvarez A,Moura-Netto C,Daliberto Frugoli A,Fernando C,Aranha AC,Davidowicz H

更新日期：2012-01-01 00:00:00

abstract：:Optically sectioned detection of fluorescence immunoassays using a confocal microscope enables the creation of both homo- and heterogeneous planar format assays. We report a set assays requiring optically sectioned detection using a model system and analysis procedures for separating signals of a surface layer from an...

journal_title：Journal of biomedical optics

authors： Ghafari H,Zhou Y,Ali S,Hanley QS

更新日期：2009-11-01 00:00:00

abstract：:In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunt...

journal_title：Journal of biomedical optics

authors： McGee S,Mirkovic J,Mardirossian V,Elackattu A,Yu CC,Kabani S,Gallagher G,Pistey R,Galindo L,Badizadegan K,Wang Z,Dasari R,Feld MS,Grillone G

更新日期：2008-11-01 00:00:00

abstract：:Using single-molecule microscopy, we present a method to quantify the number of single autofluorescent proteins when they cannot be optically resolved. This method relies on the measurement of the total intensity emitted by each aggregate until it photobleaches. This strategy overcomes the inherent problem of blinking...

journal_title：Journal of biomedical optics

authors： Cognet L,Tardin C,Négrier ML,Breillat C,Coussen F,Choquet D,Lounis B

更新日期：2008-05-01 00:00:00

abstract：:The objective is to characterize the impact of different ablation parameters on the thermal load during corneal refractive surgery by means of excimer laser ablation on porcine eyes. One hundred eleven ablations were performed in 105 porcine eyes. Each ablation was recorded using infrared thermography and analyzed mai...

journal_title：Journal of biomedical optics

authors： Arba Mosquera S,Verma S

更新日期：2015-07-01 00:00:00

abstract：:Pelvic organ prolapse (POP) occurs when changes to the pelvic organ support structures cause descent or herniation of the pelvic organs into the vagina. Clinical evaluation of POP is a series of manual measurements known as the pelvic organ prolapse quantification (POP-Q) score. However, it fails to identify the mecha...

journal_title：Journal of biomedical optics

authors： Parkinson LA,Gargett CE,Young N,Rosamilia A,Vashi AV,Werkmeister JA,Papageorgiou AW,Arkwright JW

更新日期：2016-12-01 00:00:00

abstract：:In the present study, we evaluated the applicability of ex vivo photoacoustic imaging (PAI) on small animal organs. We used photoacoustic tomography (PAT) to visualize infarcted areas within murine hearts and compared these data to other imaging techniques [magnetic resonance imaging (MRI), micro-computed tomography] ...

journal_title：Journal of biomedical optics

authors： Holotta M,Grossauer H,Kremser C,Torbica P,Völkl J,Degenhart G,Esterhammer R,Nuster R,Paltauf G,Jaschke W

更新日期：2011-03-01 00:00:00

abstract：:Cancer-related enzyme activity can be detected noninvasively using activatable fluorescent molecular probes. In contrast to "always-on" fluorescent molecular probes, activatable probes are relatively nonfluorescent at the time of administration due to intramolecular fluorescence resonance energy transfer (FRET). Enzym...

journal_title：Journal of biomedical optics

authors： Solomon M,Guo K,Sudlow GP,Berezin MY,Edwards WB,Achilefu S,Akers WJ

更新日期：2011-06-01 00:00:00

abstract：:For a long time, the antioxidative status in cattle has been discussed as an indicator for stress conditions resulting from disease or exertion. Until now, invasive approaches have been necessary to obtain blood samples or biopsy materials and gain insights into the antioxidative status of cattle. Due to these efforts...

journal_title：Journal of biomedical optics

authors： Klein J,Darvin ME,Müller KE,Lademann J

更新日期：2012-10-01 00:00:00