Abstract:
:Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, current fiber-based and photodiode-based systems have difficulties achieving this goal due to challenges in sampling the reflectance with a high enough resolution. We introduce a compact, low-cost architecture for srDRS based on the use of a multipixel imaging sensor and light-emitting diodes to achieve lensless diffuse reflectance imaging in contact with the tissue with high spatial resolution. For proof-of-concept, a prototype device, involving a commercially available complementary metal-oxide semiconductor coupled with a fiber-optic plate, was fabricated. Diffuse reflectance profiles were acquired at 645 nm at source-to-detector separations ranging from 480 μm to 4 mm with a resolution of 16.7 μm. Absorption coefficients (μa) and reduced scattering coefficients (μs') of homogeneous tissue-mimicking phantoms were measured with 4.2 ± 3.5 % and 7.0 ± 4.6 % error, respectively. The results obtained confirm the potential of our approach for quantitative characterization of tissue optical properties in contact imaging modality. This study is a first step toward the development of low-cost, wearable devices for skin condition diagnosis in vivo.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Petitdidier N,Koenig A,Gerbelot R,Grateau H,Gioux S,Jallon Pdoi
10.1117/1.JBO.23.11.115003subject
Has Abstractpub_date
2018-11-01 00:00:00pages
1-9issue
11eissn
1083-3668issn
1560-2281pii
JBO-180306Rjournal_volume
23pub_type
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