Ammonia and ethylene biomarkers in the respiration of the people with schizophrenia using photoacoustic spectroscopy.

abstract：:Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requi...

journal_title：Journal of biomedical optics

authors： Pinto M,Zorn KC,Tremblay JP,Desroches J,Dallaire F,Aubertin K,Marple E,Kent C,Leblond F,Trudel D,Lesage F

更新日期：2019-02-01 00:00:00

abstract：:Amblyopia is a form of visual impairment caused by ocular misalignment (strabismus) or defocus in an otherwise healthy eye. If detected early, the condition can be fully treated, yet over half of all children with amblyopia under age 5 escape detection. We developed a Pediatric Vision Screener (PVS) to detect amblyopi...

journal_title：Journal of biomedical optics

authors： Nassif DS,Piskun NV,Gramatikov BI,Guyton DL,Hunter DG

更新日期：2004-11-01 00:00:00

abstract：:Simplified measurement of macular pigment optical density (MPOD) is important because of the ocular health benefits that are attributed to these retinal carotenoids. Here, we describe a novel instrument designed for this purpose, based on heterochromatic flicker photometry (HFP), which removes a number of difficulties...

journal_title：Journal of biomedical optics

authors： Bone RA,Mukherjee A

更新日期：2013-10-01 00:00:00

abstract：:We have applied wide-field digital interferometry (WFDI) to examine the morphology and dynamics of live red blood cells (RBCs) from individuals who suffer from sickle cell anemia (SCA), a genetic disorder that affects the structure and mechanical properties of RBCs. WFDI is a noncontact, label-free optical microscopy ...

journal_title：Journal of biomedical optics

authors： Shaked NT,Satterwhite LL,Telen MJ,Truskey GA,Wax A

更新日期：2011-03-01 00:00:00

abstract：:As small animal optical imaging and tomography are gaining popularity for interrogating functional and molecular events in vivo, it becomes increasingly necessary to gain knowledge of the optical properties of the species investigated to better understand and describe photon propagation through their tissues. To achie...

journal_title：Journal of biomedical optics

authors： Niedre MJ,Turner GM,Ntziachristos V

更新日期：2006-11-01 00:00:00

abstract：:We have developed a novel nitroimidazole indocyanine dye conjugate for tumor-targeted hypoxia fluorescence tomography. The hypoxia probe has been evaluated in vitro using tumor cell lines and in vivo with tumor targeting in mice. The in vitro cell studies were performed to assess fluorescence labeling differences betw...

journal_title：Journal of biomedical optics

authors： Biswal NC,Pavlik C,Smith MB,Aguirre A,Xu Y,Zanganeh S,Kuhn LT,Claffey KP,Zhu Q

更新日期：2011-06-01 00:00:00

abstract：:Polarized Raman spectroscopy allows measurement of molecular orientation and composition and is widely used in the study of polymer systems. Here, we extend the technique to the extraction of quantitative orientation information from bone tissue, which is optically thick and highly turbid. We discuss multiple scatteri...

journal_title：Journal of biomedical optics

authors： Raghavan M,Sahar ND,Wilson RH,Mycek MA,Pleshko N,Kohn DH,Morris MD

更新日期：2010-05-01 00:00:00

abstract：:Spasticity is a motor disorder frequently present in individuals with cerebral palsy (CP). This study aimed to evaluate the effect of low-level laser therapy (LLLT) on the spasticity of the masseter and anterior temporal muscle fibers in children with CP over three weeks of intermittent laser exposures. The bite force...

journal_title：Journal of biomedical optics

authors： Santos MT,Diniz MB,Gouw-Soares SC,Lopes-Martins RA,Frigo L,Baeder FM

更新日期：2016-02-01 00:00:00

abstract：:This paper explains the term low-coherence interferometry, reviews the early development of optical low-coherence reflectometry, and shows some of the paths that led to the field of biomedical optics. This paper demonstrates that early technical developments in the telecommunications industry resulted in a myriad of t...

journal_title：Journal of biomedical optics

authors： Masters BR

更新日期：1999-04-01 00:00:00

abstract：:We used two-photon laser scanning microscopy (TPLSM) to demonstrate for the first time its potential in studying relational details at the cellular level of atherogenesis in intact, viable mouse carotid arteries. Isolated and mounted arteries of ApoE-/-mice, aged 15 or 21 weeks (7 and 13 weeks on western diet), were i...

journal_title：Journal of biomedical optics

authors： Megens RT,oude Egbrink MG,Merkx M,Slaaf DW,van Zandvoort MA

更新日期：2008-07-01 00:00:00

abstract：:In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submic...

journal_title：Journal of biomedical optics

authors： Drexler W,Liu M,Kumar A,Kamali T,Unterhuber A,Leitgeb RA

更新日期：2014-01-01 00:00:00

abstract：:The tissue metabolic rate of oxygen consumption (tMRO2) is a clinically relevant marker for a number of pathologies including cancer and arterial occlusive disease. We present and validate a noncontact method for quantitatively mapping tMRO2 over a wide, scalable field of view at 16  frames  /  s. We achieve this by d...

journal_title：Journal of biomedical optics

authors： Ghijsen M,Lentsch GR,Gioux S,Brenner M,Durkin AJ,Choi B,Tromberg BJ

更新日期：2018-03-01 00:00:00

abstract：:Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and ...

journal_title：Journal of biomedical optics

authors： Kuck M,Schanzer S,Ulrich M,Garcia Bartels N,Meinke MC,Fluhr J,Krah M,Blume-Peytavi U,Stockfleth E,Lademann J

更新日期：2012-10-01 00:00:00

abstract：:A microelectromechanical system (MEMS) mirror based endoscopic swept-source optical coherence tomography (SS-OCT) system that can perform three-dimensional (3-D) imaging at high speed is reported. The key component enabling 3-D endoscopic imaging is a two-axis MEMS scanning mirror which has a 0.8×0.8  mm2 mirror plate...

journal_title：Journal of biomedical optics

authors： Wang D,Fu L,Wang X,Gong Z,Samuelson S,Duan C,Jia H,Ma JS,Xie H

更新日期：2013-08-01 00:00:00

abstract：:Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast t...

journal_title：Journal of biomedical optics

authors： Michaelsen KE,Krishnaswamy V,Shi L,Vedantham S,Karellas A,Pogue BW,Paulsen KD,Poplack SP

更新日期：2016-09-01 00:00:00

abstract：:Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenat...

journal_title：Journal of biomedical optics

authors： Gareau DS,Truffer F,Perry KA,Pham TH,Enestvedt CK,Dolan JP,Hunter JG,Jacques SL

更新日期：2010-11-01 00:00:00

abstract：:Noninvasive cardiovascular imaging could lead to the early detection and timely treatment of complex atherosclerotic lesions responsible for major cardiovascular events. Recent investigations have suggested that optical coherence tomography (OCT) is an ideal diagnostic tool due to the high resolution this technology a...

journal_title：Journal of biomedical optics

authors： Ghosn MG,Carbajal EF,Befrui NA,Tellez A,Granada JF,Larin KV

更新日期：2008-01-01 00:00:00

abstract：:We describe a systematic approach to image, track, and quantify the movements of HIV viruses embedded in human cervical mucus. The underlying motivation for this study is that, in HIV-infected adults, women account for more than half of all new cases and most of these women acquire the infection through heterosexual c...

journal_title：Journal of biomedical optics

authors： Boukari F,Makrogiannis S,Nossal R,Boukari H

更新日期：2016-09-01 00:00:00

abstract：:Immersion optical clearing makes it possible to use transmission polarized-light microscopy for characterization of thick (200 to 2000  μm) layers of biological tissues. We discuss polarization properties of thick samples in the context of the problem of characterization of collagen fiber alignment in connective tissu...

journal_title：Journal of biomedical optics

authors： Yakovlev DD,Shvachkina ME,Sherman MM,Spivak AV,Pravdin AB,Yakovlev DA

更新日期：2016-07-01 00:00:00

abstract：:The specificity of molecular and functional photoacoustic (PA) images depends on the accuracy of the photoacoustic absorption spectroscopy. The PA signal is proportional to the product of the optical absorption coefficient and local light fluence; quantitative PA measurements of the optical absorption coefficient ther...

journal_title：Journal of biomedical optics

authors： Bauer AQ,Nothdurft RE,Erpelding TN,Wang LV,Culver JP

更新日期：2011-09-01 00:00:00

abstract：:The scattering of polarized light from a two layer scattering medium is investigated using Monte Carlo simulations. First order and normalized second order moments are used to analyze the spatial properties of the emerging light in different polarization states. Linearly and circularly polarized illumination is used t...

journal_title：Journal of biomedical optics

authors： Stockford IM,Morgan SP,Chang PC,Walker JG

更新日期：2002-07-01 00:00:00

abstract：:Oral cancer is one of the most common cancers worldwide. One-fifth of the world's oral cancer subjects are from India and other South Asian countries. The present Raman mapping study was carried out to understand biochemical variations in normal and malignant oral buccal mucosa. Data were acquired using WITec alpha 30...

journal_title：Journal of biomedical optics

authors： Behl I,Kukreja L,Deshmukh A,Singh SP,Mamgain H,Hole AR,Krishna CM

更新日期：2014-12-01 00:00:00

abstract：:The essential feature of the confocal laser scanning microscope (cLSM) is the generation of optical sections by the removal of out-of-focus light. About ten years ago, structured illumination microscopy (SIM) was introduced as an alternative method for obtaining optical sections from biological specimens. Here we comp...

journal_title：Journal of biomedical optics

authors： Weigel A,Schild D,Zeug A

更新日期：2009-01-01 00:00:00

abstract：:Blood, being a suspension of deformable red cells suspended in plasma, displays flow dynamics considerably more complicated than those of an ideal Newtonian fluid. Flow dynamics in blood capillaries of a few hundred micrometers in diameter are investigated using Doppler optical coherence tomography (DOCT) and Doppler ...

journal_title：Journal of biomedical optics

authors： Moger J,Matcher SJ,Winlove CP,Shore A

更新日期：2004-09-01 00:00:00

abstract：:This work reviews our research during the past several years on time-resolved (TR) near-infrared diffuse optical tomography (DOT). Following an introduction of the measuring modes, two proposed schemes of image reconstruction in TR-DOT are described: one utilizes the full TR data, and the other, referred to as the mod...

journal_title：Journal of biomedical optics

authors： Zhao H,Gao F,Tanikawa Y,Yamada Y

更新日期：2007-11-01 00:00:00

abstract：:Optical technique based on diffuse reflectance measurement combined with indocyanine green (ICG) bolus tracking is extensively tested as a method for clinical assessment of brain perfusion in adults at the bedside. Methodology of multiwavelength and time-resolved detection of fluorescence light excited in the ICG is p...

journal_title：Journal of biomedical optics

authors： Gerega A,Milej D,Weigl W,Botwicz M,Zolek N,Kacprzak M,Wierzejski W,Toczylowska B,Mayzner-Zawadzka E,Maniewski R,Liebert A

更新日期：2012-08-01 00:00:00

abstract：:A stable optical system is required to acquire a high-quality image. A motionless lensless setup is designated to obtain high-resolution and large field of view images. The sample is sequentially illuminated with multiple random phase patterns, and the recorded images are subtracted from the system calibration images ...

journal_title：Journal of biomedical optics

authors： Hussain A,Li Y,Liu D,Kuang C,Liu X

更新日期：2017-11-01 00:00:00

abstract：:As molecular imaging moves towards lower detection limits, the elimination of endogenous background signals becomes imperative. We present a facile background-suppression technique that specifically segregates the signal from surface-enhanced Raman scattering (SERS)-active nanoparticles (NPs) from the tissue autofluor...

journal_title：Journal of biomedical optics

authors： Mallia RJ,McVeigh PZ,Veilleux I,Wilson BC

更新日期：2012-07-01 00:00:00

abstract：:We present a system combining optical coherence tomography (OCT) and multispectral imaging (MSI) for coregistered structural imaging and surface color imaging. We first describe and numerically validate an optimization model to guide the selection of the MSI wavelengths and their relative intensities. We then demonstr...

journal_title：Journal of biomedical optics

authors： Attendu X,Bourget MH,de Sivry-Houle MP,Boudoux C

更新日期：2019-11-01 00:00:00

abstract：:We demonstrate a quasinoncontact photoacoustic imaging method using a homodyne interferometer with a long coherence length laser. The generated photoacoustic signal is detected by a system that is locked at its maximum sensitivity through the use of balanced detection and zero-crossing triggering. The balanced detecto...

journal_title：Journal of biomedical optics

authors： Lu J,Gao Y,Ma Z,Zhou H,Wang RK,Wang Y

更新日期：2017-03-01 00:00:00