Intravascular near-infrared fluorescence catheter with ultrasound guidance and blood attenuation correction.

abstract：:Focusing light inside highly scattering media is a challenging task in biomedical optical imaging, manipulation, and therapy. A recent invention has overcome this challenge by time reversing ultrasonically encoded diffuse light to an ultrasound-modulated volume inside a turbid medium. In this technique, a photorefract...

journal_title：Journal of biomedical optics

authors： Yang Q,Xu X,Lai P,Xu D,Wang LV

更新日期：2013-11-01 00:00:00

abstract：:A new skin-imaging method, which was developed recently, gives an informative image data about skin moles by collecting scattered polarized light reflected from their tissue area at different wavelengths and polarizations. This method is called as optical rotational spectropolarimetric imaging (ORSI), which scans the ...

journal_title：Journal of biomedical optics

authors： Graham L,Yitzhaky Y,Abdulhalim I

更新日期：2013-11-01 00:00:00

abstract：:Laser-assisted cartilage reshaping is mediated by thermally induced stress relaxation, and may be used to alter cartilage morphology for reconstructive surgical procedures in the upper airway and face without carving, morselizing, or suturing. Internal stress σ(t), integrated backscattered light intensity I(t) from a ...

journal_title：Journal of biomedical optics

authors： Wong BJ,Milner TE,Kim HH,Stuart Nelson J,Sobol EN

更新日期：1998-10-01 00:00:00

abstract：:A reflectance volume holographic imaging (VHI) endoscope has been designed for simultaneous in vivo imaging of surface and subsurface tissue structures. Prior utilization of VHI systems has been limited to ex vivo tissue imaging. The VHI system presented in this work is designed for laparoscopic use. It consists of a ...

journal_title：Journal of biomedical optics

authors： Howlett ID,Han W,Gordon M,Rice P,Barton JK,Kostuk RK

更新日期：2017-05-01 00:00:00

abstract：:Given the several difficulties associated with histology, including difficulty in continuous monitoring, this study aimed to investigate the feasibility of optical imaging modalities—cross-polarization color (CPC) imaging, erythema index (EI) imaging, and laser speckle contrast (LSC) imaging—for continuous evaluation ...

journal_title：Journal of biomedical optics

authors： Son T,Yoon HJ,Lee S,Jang WS,Jung B,Kim WU

更新日期：2014-01-01 00:00:00

abstract：:Pilot results on the application of the finite-difference time-domain (FDTD) approach for studying the implementation of the optical immersion technique for the visualization of single and multiple gold nanoparticles in biological cells are presented. We focus on two different scenarios considering single biological c...

journal_title：Journal of biomedical optics

authors： Tanev S,Tuchin VV,Paddon P

更新日期：2006-11-01 00:00:00

abstract：:In order to diagnose cancer, a sample must be removed, prepared, and examined under a microscope, which is expensive, invasive, and time consuming. Fiber optic fluorescence endomicroscopy, where an image guide is used to obtain high-resolution images of tissue in vivo, has shown promise as an alternative to convention...

journal_title：Journal of biomedical optics

authors： Kyrish M,Dobbs J,Jain S,Wang X,Yu D,Richards-Kortum R,Tkaczyk TS

更新日期：2013-09-01 00:00:00

abstract：:Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, the residual spectrum, the difference between the observed and modeled diffuse reflectance spectra, was attributed to single elastic light scattering from epithelial nucle...

journal_title：Journal of biomedical optics

authors： Lau C,Sćepanović O,Mirkovic J,McGee S,Yu CC,Fulghum S,Wallace M,Tunnell J,Bechtel K,Feld M

更新日期：2009-03-01 00:00:00

abstract：:A stable optical system is required to acquire a high-quality image. A motionless lensless setup is designated to obtain high-resolution and large field of view images. The sample is sequentially illuminated with multiple random phase patterns, and the recorded images are subtracted from the system calibration images ...

journal_title：Journal of biomedical optics

authors： Hussain A,Li Y,Liu D,Kuang C,Liu X

更新日期：2017-11-01 00:00:00

abstract：:Pulse oximeters are widely used for noninvasive monitoring of oxygen saturation in arterial blood hemoglobin. We present a transmittance pulse oximetry system based on near-infrared (NIR) laser diodes (750 and 850 nm) for monitoring oxygen saturation of arterial blood hemoglobin. The pulse oximetry system is made up o...

journal_title：Journal of biomedical optics

authors： Lopez Silva SM,Dotor Castilla ML,Silveira Martin JP

更新日期：2003-07-01 00:00:00

abstract：:SpineLab is a software tool developed for reconstructing neuronal feature skeletons from three-dimensional single- or multi-photon image stacks. These images often suffer from limited resolution and a low signal-to-noise ratio, making the extraction of morphometric information difficult. To overcome this limitation, w...

journal_title：Journal of biomedical optics

authors： Jungblut D,Vlachos A,Schuldt G,Zahn N,Deller T,Wittum G

更新日期：2012-07-01 00:00:00

abstract：:In this study we examine the implications of excitation saturation on fluorescence recovery after photobleaching (FRAP) experiments. In particular we present both experimental and theoretical evidence that fluorescein, one of the most frequently used fluorophores in FRAP, does not always comply with the basic assumpti...

journal_title：Journal of biomedical optics

authors： Braeckmans K,Stubbe BG,Remaut K,Demeester J,De Smedt SC

更新日期：2006-07-01 00:00:00

abstract：:Parametric and nonparametric data processing schemes for analyzing translating laser speckle data used to investigate the mechanical behavior of biological tissues are examined. Cross-correlation, minimum mean square estimator, maximum likelihood, and maximum entropy approaches are discussed and compared on speckle da...

journal_title：Journal of biomedical optics

authors： Duncan DD,Kirkpatrick SJ

更新日期：2001-10-01 00:00:00

abstract：:We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocess...

journal_title：Journal of biomedical optics

authors： Gong P,Chin L,Es'haghian S,Liew YM,Wood FM,Sampson DD,McLaughlin RA

更新日期：2014-12-01 00:00:00

abstract：:The metabolic rate of oxygen consumption, an important indicator of tissue metabolism, can be expressed as the change of net blood oxygen flux into and out of a tissue region per 100 g of tissue. In this work, we propose a photoacoustic and Doppler ultrasound method for imaging local blood oxygen flux of a single vess...

journal_title：Journal of biomedical optics

authors： Jiang Y,Forbrich A,Harrison T,Zemp RJ

更新日期：2012-03-01 00:00:00

abstract：:Second-harmonic generation (SHG) imaging can help reveal interactions between collagen fibers and cancer cells. Quantitative analysis of SHG images of collagen fibers is challenged by the heterogeneity of collagen structures and low signal-to-noise ratio often found while imaging collagen in tissue. The role of collag...

journal_title：Journal of biomedical optics

authors： Bredfeldt JS,Liu Y,Pehlke CA,Conklin MW,Szulczewski JM,Inman DR,Keely PJ,Nowak RD,Mackie TR,Eliceiri KW

更新日期：2014-01-01 00:00:00

abstract：:We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional in vivo imaging of human breast tumor based on large optical data sets. Images of oxy-, deoxy-, and total hemoglobin concentration as well as blood oxygen saturation and tissue scattering were reconstructed. Tumor ma...

journal_title：Journal of biomedical optics

authors： Choe R,Konecky SD,Corlu A,Lee K,Durduran T,Busch DR,Pathak S,Czerniecki BJ,Tchou J,Fraker DL,Demichele A,Chance B,Arridge SR,Schweiger M,Culver JP,Schnall MD,Putt ME,Rosen MA,Yodh AG

更新日期：2009-03-01 00:00:00

abstract：:A synchrotron light source dedicated to medical applications has been designed at National Institute of Radiological Sciences. The storage ring, with circumference of 80 m, is designed for acceleration of 2.3 GeV and a stored current of 420 mA. It is equipped with two multipole wigglers to produce sufficient photon fl...

journal_title：Journal of biomedical optics

authors： Torikoshi M,Tsunoo T,Endo M,Noda K,Kumada M,Yamada S,Soga F,Hyodo K

更新日期：2001-07-01 00:00:00

abstract：:Intrauterine photoacoustic and ultrasound imaging are probe-based imaging modalities with translational potential for use in detecting endometrial diseases. This deep-tissue imaging probe design allows for the retrofitting of commercially available endometrial sampling curettes. The imaging probe presented here has a ...

journal_title：Journal of biomedical optics

authors： Miranda C,Barkley J,Smith B

更新日期：2018-04-01 00:00:00

abstract：:The area of in vivo sensing using optical fibers commonly uses materials such as silica and polymethyl methacrylate, both of which possess much higher modulus than human tissue. The mechanical mismatch between materials and living tissue has been seen to cause higher levels of glial encapsulation, scarring, and inflam...

journal_title：Journal of biomedical optics

authors： McMillan S,Rader C,Jorfi M,Pickrell G,Foster EJ

更新日期：2017-02-01 00:00:00

abstract：:Near-infrared diffuse optical tomography (DOT), one of the most sophisticated optical imaging techniques for observations through biological tissue, allows 3-D quantitative imaging of optical properties, which include functional and anatomical information. With DOT, it is expected to be possible to overcome the limita...

journal_title：Journal of biomedical optics

authors： Hoshi Y,Yamada Y

更新日期：2016-09-01 00:00:00

abstract：:Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative p...

journal_title：Journal of biomedical optics

authors： Byeon H,Ha YR,Lee SJ

更新日期：2015-11-01 00:00:00

abstract：:Cortical spreading depression (CSD) is a pronounced depolarization of neurons and glia that spreads slowly across the cortex followed by a period of depressed electrophysiological activity. The vascular changes associated with CSD are a large transient increase in blood flow followed by a prolonged decrease lasting gr...

journal_title：Journal of biomedical optics

authors： Guiou M,Sheth S,Nemoto M,Walker M,Pouratian N,Ba A,Toga AW

更新日期：2005-01-01 00:00:00

abstract：:For clinical optoacoustic imaging, linear probes are preferably used because they allow versatile imaging of the human body with real-time display and free-hand probe guidance. The two-dimensional (2-D) optoacoustic image obtained with this type of probe is generally interpreted as a 2-D cross-section of the tissue ju...

journal_title：Journal of biomedical optics

authors： Preisser S,Bush NL,Gertsch-Grover AG,Peeters S,Bailey AE,Bamber JC,Frenz M,Jaeger M

更新日期：2013-02-01 00:00:00

abstract：:The specificity of the hemodynamic response function (HRF) is determined spatially by the vascular architecture and temporally by the evolution of hemodynamic changes. Here, we used functional photoacoustic microscopy (fPAM) to investigate single cerebral blood vessels of rats after left forepaw stimulation. In this s...

journal_title：Journal of biomedical optics

authors： Liao LD,Lin CT,Shih YY,Lai HY,Zhao WT,Duong TQ,Chang JY,Chen YY,Li ML

更新日期：2012-06-01 00:00:00

abstract：:Optical imaging using voltage-sensitive dyes has become an important tool for studying vortex-like electrical waves in the heart. Such waves, known as spiral or scroll waves, can spontaneously form in pathological ventricular myocardium, causing ventricular fibrillation and sudden death. Until recently, observations o...

journal_title：Journal of biomedical optics

authors： Bernus O,Mukund KS,Pertsov AM

更新日期：2007-01-01 00:00:00

abstract：:We have combined a confocal laser scanning head modified for TPE (two-photon excitation) microscopy with some spectroscopic modules to study single molecules and molecular aggregates. The behavior of the TPE microscope unit has been characterized by means of point spread function measurements and of the demonstration ...

journal_title：Journal of biomedical optics

authors： Diaspro A,Chirico G,Federici F,Cannone F,Beretta S,Robello M

更新日期：2001-07-01 00:00:00

abstract：:Smart toilets could be used to monitor different components of urine in daily life for early detection of lifestyle-related diseases and prompt provision of treatment. For analysis of biological samples such as urine by midinfrared spectroscopy, thin-film samples like liquid cells are needed because of the strong abso...

journal_title：Journal of biomedical optics

authors： Yamamoto N,Kawashima N,Kitazaki T,Mori K,Kang H,Nishiyama A,Wada K,Ishimaru I

更新日期：2018-05-01 00:00:00

abstract：:In order to monitor dynamic physiological events in near-real time, a variety of photoacoustic computed tomography (PACT) systems have been developed that can rapidly acquire data. Previously reported studies of dynamic PACT have employed conventional static methods to reconstruct a temporally ordered sequence of imag...

journal_title：Journal of biomedical optics

authors： Wang K,Xia J,Li C,Wang LV,Anastasio MA

更新日期：2014-05-01 00:00:00

abstract：:The acousto-optic deflector (AOD) is highly preferred in laser scanning microscopy for its fast scanning ability and random-addressing capability. However, its application in two-photon microscopy is frustrated by the dispersion of the AOD, which results in beam distortion and pulse lengthening. We report the analysis...

journal_title：Journal of biomedical optics

authors： Zeng S,Lv X,Bi K,Zhan C,Li D,Chen WR,Xiong W,Jacques SL,Luo Q

更新日期：2007-03-01 00:00:00