Abstract:
:Malaria parasites induce morphological, biochemical, and mechanical changes in red blood cells (RBCs). Mechanical variations are closely related to the deformability of individual RBCs. The deformation of various RBCs, including healthy and malaria-infected RBCs (iRBCs), can be directly observed through quantitative phase imaging (QPI). The effects of chloroquine treatment on the mechanical property variation of iRBCs were investigated using time-resolved holographic QPI of single live cells on a millisecond time scale. The deformabilities of healthy RBCs, iRBCs, and drug-treated iRBCs were compared, and the effect of chloroquine on iRBC restoration was experimentally examined. The present results are beneficial to elucidate the dynamic characteristics of iRBCs and the effect of the antimalarial drug on iRBCs.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Byeon H,Ha YR,Lee SJdoi
10.1117/1.JBO.20.11.115003subject
Has Abstractpub_date
2015-11-01 00:00:00pages
115003issue
11eissn
1083-3668issn
1560-2281pii
2469605journal_volume
20pub_type
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