Modeling of the temporal effects of heating during infrared neural stimulation.


:A model of infrared neural stimulation (INS) has been developed to allow the temporal characteristics of different stimulation parameters and geometries to be better understood. The model uses a finite element approach to solve the heat equation and allow detailed analysis of heat during INS with both microsecond and millisecond laser pulses. When compared with experimental data, the model provides insight into the mechanisms behind INS. In particular, the analysis suggests that there may be two broad regimes of INS: the process tends to be limited by the total pulse energy for pulse lengths below 100 μs, while the temperature gradient with respect to time becomes more important above 100 μs.


J Biomed Opt


Thompson AC,Wade SA,Cadusch PJ,Brown WG,Stoddart PR




Has Abstract


2013-03-01 00:00:00














  • Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway.

    abstract::It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combin...

    journal_title:Journal of biomedical optics

    pub_type: 信件


    authors: Balakrishnan S,Bu R,Iftimia N,Price H,Zdanski C,Oldenburg AL

    更新日期:2018-10-01 00:00:00

  • Quantitative tool for rapid disease mapping using optical coherence tomography images of azoxymethane-treated mouse colon.

    abstract::Optical coherence tomography (OCT) can provide new insight into disease progression and therapy by enabling nondestructive, serial imaging of in vivo cancer models. In previous studies, we have shown the utility of endoscopic OCT for identifying adenomas in the azoxymethane-treated mouse model of colorectal cancer and...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Winkler AM,Rice PF,Drezek RA,Barton JK

    更新日期:2010-07-01 00:00:00

  • Changes induced by peripheral nerve injury in the morphology and nanomechanics of sensory neurons.

    abstract::Peripheral nerve injury in vivo promotes a regenerative growth in vitro characterized by an improved neurite regrowth. Knowledge of the conditioning injury effects on both morphology and mechanical properties of live sensory neurons could be instrumental to understand the cellular and molecular mechanisms leading to t...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Benzina O,Szabo V,Lucas O,Saab MB,Cloitre T,Scamps F,Gergely C,Martin M

    更新日期:2013-10-01 00:00:00

  • In vitro detection and quantification of enamel and root caries using infrared photothermal radiometry and modulated luminescence.

    abstract::Artificially created demineralized and remineralized carious lesions on the root and enamel of human teeth were examined by photothermal radiometry (PTR) and modulated luminescence (LUM). Fourteen extracted human teeth were used and a lesion was created on a 1 mmx4 mm rectangular window, spanning root to enamel, using...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Jeon RJ,Hellen A,Matvienko A,Mandelis A,Abrams SH,Amaechi BT

    更新日期:2008-05-01 00:00:00

  • Raman spectroscopy of in vivo cutaneous melanin.

    abstract::We successfully acquire the in vivo Raman spectrum of melanin from human skin using a rapid near-infrared (NIR) Raman spectrometer. The Raman signals of in vivo cutaneous melanin are similar to those observed from natural and synthetic eumelanins. The melanin Raman spectrum is dominated by two intense and broad peaks ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Huang Z,Lui H,Chen XK,Alajlan A,McLean DI,Zeng H

    更新日期:2004-11-01 00:00:00

  • Band analysis of hydrated human skin stratum corneum attenuated total reflectance fourier transform infrared spectra in vivo.

    abstract::Water content is an important factor for skin condition. The determination of the hydration state of the skin is necessary to obtain basic knowledge about the penetration and loss of water in the skin stratum corneum. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is used to measure hy...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Lucassen GW,van Veen GN,Jansen JA

    更新日期:1998-07-01 00:00:00

  • Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography.

    abstract::Angle-resolved optical scattering properties of ovarian tissue, on different optical coherence tomography (OCT) imaging planes, were quantitatively measured by fitting the compounded OCT A-lines into a single scattering model. Higher cross correlation value of angle-resolved scattering coefficients between different O...

    journal_title:Journal of biomedical optics

    pub_type: 信件


    authors: Yang Y,Wang T,Brewer M,Zhu Q

    更新日期:2012-09-01 00:00:00

  • Classification of skin moles from optical spectropolarimetric images: a pilot study.

    abstract::A new skin-imaging method, which was developed recently, gives an informative image data about skin moles by collecting scattered polarized light reflected from their tissue area at different wavelengths and polarizations. This method is called as optical rotational spectropolarimetric imaging (ORSI), which scans the ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Graham L,Yitzhaky Y,Abdulhalim I

    更新日期:2013-11-01 00:00:00

  • Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study.

    abstract::According to the valence asymmetry hypothesis, the left/right asymmetry of prefrontal cortex (PFC) activity is correlated with specific emotional responses to mental stress and personality traits. Here, we evaluated the relation between emotional state and asymmetry in PFC activity at rest by using near-infrared spect...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Ishikawa W,Sato M,Fukuda Y,Matsumoto T,Takemura N,Sakatani K

    更新日期:2014-02-01 00:00:00

  • Tool for simulating the focusing of arbitrary vector beams in free-space and stratified media.

    abstract::Vectorial models of focused beams are important to a variety of fields including microscopy, lithography, optical physics, and biomedical imaging. This has led to many models being developed, which calculate how beams of various profiles are focused both in free space and in the presence of stratified media. The major...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Munro PRT

    更新日期:2018-09-01 00:00:00

  • Optical properties of adenocarcinoma and squamous cell carcinoma of the gastroesophageal junction.

    abstract::Photodynamic therapy (PDT) is an alternative to radical surgical resection for T1a or nonresectable carcinomas of the gastroesophageal junction. Besides the concentration of the photosensitizer, the light distribution in tissue is responsible for tumor destruction. For this reason, knowledge about the behavior of ligh...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Holmer C,Lehmann KS,Wanken J,Reissfelder C,Roggan A,Mueller G,Buhr HJ,Ritz JP

    更新日期:2007-01-01 00:00:00

  • Table top surface plasmon resonance measurement system for efficient urea biosensing using ZnO thin film matrix.

    abstract::The present report addresses the application of surface plasmon resonance (SPR) phenomenon for urea sensing. The former promises a high sensitivity, label-free detection, and real-time information by monitoring the refractive index change at the metal–dielectric interface. In the present report, a highly sensitive ure...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Paliwal A,Tomar M,Gupta V

    更新日期:2016-08-01 00:00:00

  • Quantitative detection of chemical compounds in human hair with coherent anti-Stokes Raman scattering microscopy.

    abstract::Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are produced in the cortex ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Zimmerley M,Lin CY,Oertel DC,Marsh JM,Ward JL,Potma EO

    更新日期:2009-07-01 00:00:00

  • Analyzing reflectance spectra of human skin in legal medicine.

    abstract::Our current research in the framework of an interdisciplinary project focuses on modelling the dynamics of the hemoglobin reoxygenation process in post-mortem human skin by reflectance spectrometry. The observations of reoxygenation of hemoglobin in livores after postmortem exposure to a cold environment relate the re...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Belenki L,Sterzik V,Schulz K,Bohnert M

    更新日期:2013-01-01 00:00:00

  • Intraoperative hyperspectral determination of human tissue properties.

    abstract::We address the automatic differentiation of human tissue using multispectral imaging with promising potential for automatic visualization during surgery. Currently, tissue types have to be continuously differentiated based on the surgeon's knowledge only. Further, automatic methods based on optical in vivo properties ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Wisotzky EL,Uecker FC,Arens P,Dommerich S,Hilsmann A,Eisert P

    更新日期:2018-05-01 00:00:00

  • Linear reconstruction of absorption perturbations in coherent ultrasound-modulated optical tomography.

    abstract::Discrete form sensitivity functions are derived for a number of measurement types employed in autocorrelation-based ultrasound-modulated optical tomography. The Jacobian for a particular problem is constructed from the set of such sensitivity functions arising from a raster scan of a focused ultrasound field through a...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Powell S,Leung TS

    更新日期:2013-12-01 00:00:00

  • Human graft cornea and laser incisions imaging with micrometer scale resolution full-field optical coherence tomography.

    abstract::Micrometer scale resolution full-field optical coherence tomography (FF-OCT) is developed for imaging human graft corneas. Three-dimensional (3-D) images with ultrahigh resolution (respectively, 1 and 1.5 μm in the axial and transverse directions), comparable to traditional histological sections, are obtained allowing...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Latour G,Georges G,Lamoine LS,Deumié C,Conrath J,Hoffart L

    更新日期:2010-09-01 00:00:00

  • Interplay of tumor vascular oxygenation and tumor pO2 observed using near-infrared spectroscopy, an oxygen needle electrode, and 19F MR pO2 mapping.

    abstract::This study investigates the correlation of tumor blood oxygenation and tumor pO(2) with respect to carbogen inhalation. After having refined and validated the algorithms for calculating hemoglobin concentrations, we used near-infrared spectroscopy (NIRS) to measure changes of oxygenated hemoglobin concentration (delta...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Kim JG,Zhao D,Song Y,Constantinescu A,Mason RP,Liu H

    更新日期:2003-01-01 00:00:00

  • In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature.

    abstract::Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the latter collecting label-free backscattering data with comparable lateral but much higher axia...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Zhang P,Zam A,Jian Y,Wang X,Li Y,Lam KS,Burns ME,Sarunic MV,Pugh EN Jr,Zawadzki RJ

    更新日期:2015-01-01 00:00:00

  • Dynamic performance of microelectromechanical systems deformable mirrors for use in an active/adaptive two-photon microscope.

    abstract::Active optics such as deformable mirrors can be used to control both focal depth and aberrations during scanning laser microscopy. If the focal depth can be changed dynamically during scanning, then imaging of oblique surfaces becomes possible. If aberrations can be corrected dynamically during scanning, an image can ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Archer-Zhang CC,Foster WB,Downey RD,Arrasmith CL,Dickensheets DL

    更新日期:2016-12-01 00:00:00

  • Low-cost, ultracompact handheld optical coherence tomography probe for in vivo oral maxillofacial tissue imaging.

    abstract:SIGNIFICANCE:Optical coherence tomography (OCT) has proven useful for detecting various oral maxillofacial abnormalities. To apply it to clinical applications including biopsy guidance and routine screening, a handheld imaging probe is indispensable. OCT probes reported for oral maxillofacial imaging were either based ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Li K,Yang Z,Liang W,Shang J,Liang Y,Wan S

    更新日期:2020-04-01 00:00:00

  • Effect of light losses of sample between two integrating spheres on optical properties estimation.

    abstract::A Monte Carlo algorithm is applied to simulate the measurements of a sample with glass slides sandwiched between the double integrating sphere (DIS) setup. The effects caused by various parameters, such as the sample port of integrating sphere, thicknesses, and optical properties of the sample, on light losses and opt...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Zhu D,Lu W,Zeng S,Luo Q

    更新日期:2007-11-01 00:00:00

  • Fast spatiotemporal image reconstruction based on low-rank matrix estimation for dynamic photoacoustic computed tomography.

    abstract::In order to monitor dynamic physiological events in near-real time, a variety of photoacoustic computed tomography (PACT) systems have been developed that can rapidly acquire data. Previously reported studies of dynamic PACT have employed conventional static methods to reconstruct a temporally ordered sequence of imag...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Wang K,Xia J,Li C,Wang LV,Anastasio MA

    更新日期:2014-05-01 00:00:00

  • Applications of compressive sensing in spatial frequency domain imaging.

    abstract:SIGNIFICANCE:Spatial frequency domain imaging (SFDI) is an imaging modality that projects spatially modulated light patterns to determine optical property maps for absorption and reduced scattering of biological tissue via a pixel-by-pixel data acquisition and analysis procedure. Compressive sensing (CS) is a signal pr...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Mellors BOL,Bentley A,Spear AM,Howle CR,Dehghani H

    更新日期:2020-11-01 00:00:00

  • Molecular interactions of exogenous chemical agents with collagen--implications for tissue optical clearing.

    abstract::Reduction of optical scattering in turbid biological tissues using nonreactive chemical agents has potential applications for light-based diagnostics and therapeutics. Optical clearing effects by exogenous chemical agents, in particular sugars and sugar alcohols, have been found to be temporary with tissue rehydration...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章,评审


    authors: Yeh AT,Hirshburg J

    更新日期:2006-01-01 00:00:00

  • Context encoding enables machine learning-based quantitative photoacoustics.

    abstract::Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. Although photoacoustic (PA) imaging is a modality with great potential to measure optical absorption dee...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Kirchner T,Gröhl J,Maier-Hein L

    更新日期:2018-05-01 00:00:00

  • Antibody-based magnetic nanoparticle immunoassay for quantification of Alzheimer's disease pathogenic factor.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive and intellectual abilities and an irreversible mental deterioration. Based on multidisciplinary AD research, the most universally accepted hypotheses on AD pathogenesis are the intracerebral aggregate formation of beta-amyloi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Kim CB,Choi YY,Song WK,Song KB

    更新日期:2014-05-01 00:00:00

  • Ambulatory diffuse optical tomography and multimodality physiological monitoring system for muscle and exercise applications.

    abstract::Ambulatory diffuse optical tomography (aDOT) is based on near-infrared spectroscopy (NIRS) and enables three-dimensional imaging of regional hemodynamics and oxygen consumption during a person’s normal activities. Although NIRS has been previously used for muscle assessment, it has been notably limited in terms of the...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Hu G,Zhang Q,Ivkovic V,Strangman GE

    更新日期:2016-09-01 00:00:00

  • Continuous monitoring of arthritis in animal models using optical imaging modalities.

    abstract::Given the several difficulties associated with histology, including difficulty in continuous monitoring, this study aimed to investigate the feasibility of optical imaging modalities—cross-polarization color (CPC) imaging, erythema index (EI) imaging, and laser speckle contrast (LSC) imaging—for continuous evaluation ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Son T,Yoon HJ,Lee S,Jang WS,Jung B,Kim WU

    更新日期:2014-01-01 00:00:00

  • In vivo spectral imaging of different cell types in the small intestine by two-photon excited autofluorescence.

    abstract::Spectrally resolved two-photon excited autofluorescence imaging is used to distinguish different cell types and functional areas during dynamic processes in the living gut. Excitation and emission spectra of mucosal tissue and tissue components are correlated to spectra of endogenous chromophores. We show that selecti...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章


    authors: Orzekowsky-Schroeder R,Klinger A,Martensen B,Blessenohl M,Gebert A,Vogel A,Hüttmann G

    更新日期:2011-11-01 00:00:00