Quantification of fiber orientation in the canine atrial pacemaker complex using optical coherence tomography.

abstract：:Fluorescence image-guided surgery (FIGS) is an emerging technique in oncology, neurology, and cardiology. To adapt intraoperative imaging for various surgical applications, increasingly flexible and compact FIGS instruments are necessary. We present a compact, portable FIGS system and demonstrate its use in cardiovasc...

journal_title：Journal of biomedical optics

authors： Wang X,Bhaumik S,Li Q,Staudinger VP,Yazdanfar S

更新日期：2010-03-01 00:00:00

abstract：:The morphogenetic relationship between early patterning and polarity formation is of fundamental interest and remains a controversial issue in preimplantation embryonic development. We use a label-free three-dimensional (3-D) imaging technique of full-field optical coherence tomography (FF-OCT) successfully for the fi...

journal_title：Journal of biomedical optics

authors： Zheng JG,Huo T,Chen T,Wang C,Zhang N,Tian N,Zhao F,Lu D,Chen D,Ma W,Sun JL,Xue P

更新日期：2013-01-01 00:00:00

abstract：:Serum Raman spectroscopy (RS) has previously shown potential in oral cancer diagnosis and recurrence prediction. To evaluate the potential of serum RS in oral cancer screening, premalignant and cancer-specific detection was explored in the present study using 328 subjects belonging to healthy controls, premalignant, d...

journal_title：Journal of biomedical optics

authors： Sahu AK,Dhoot S,Singh A,Sawant SS,Nandakumar N,Talathi-Desai S,Garud M,Pagare S,Srivastava S,Nair S,Chaturvedi P,Murali Krishna C

更新日期：2015-11-01 00:00:00

abstract：:Discrete form sensitivity functions are derived for a number of measurement types employed in autocorrelation-based ultrasound-modulated optical tomography. The Jacobian for a particular problem is constructed from the set of such sensitivity functions arising from a raster scan of a focused ultrasound field through a...

journal_title：Journal of biomedical optics

authors： Powell S,Leung TS

更新日期：2013-12-01 00:00:00

abstract：:Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and ...

journal_title：Journal of biomedical optics

authors： Kuck M,Schanzer S,Ulrich M,Garcia Bartels N,Meinke MC,Fluhr J,Krah M,Blume-Peytavi U,Stockfleth E,Lademann J

更新日期：2012-10-01 00:00:00

abstract：:Sinus blockages are a common reason for physician visits, affecting one out of seven people in the United States, and often require medical treatment. Diagnosis in the primary care setting is challenging because symptom criteria (via detailed clinical history) plus objective imaging [computed tomography (CT) or endosc...

journal_title：Journal of biomedical optics

authors： Cerussi AE,Mishra N,You J,Bhandarkar N,Wong B

更新日期：2015-03-01 00:00:00

abstract：:Quantitative microscopy has been extensively used in biomedical research and has provided significant insights into structure and dynamics at the cell and tissue level. The entire procedure of quantitative microscopy is comprised of specimen preparation, light absorption/reflection/emission from the specimen, microsco...

journal_title：Journal of biomedical optics

authors： Huang K,Murphy RF

更新日期：2004-09-01 00:00:00

abstract：:The composition of cartilage is predictive of its in vivo performance. Therefore, the ability to assess its primary macromolecular components, proteoglycan (PG) and collagen, is of great importance. In the current study, we hypothesized that PG content and distribution in tissue engineered cartilage could be determine...

journal_title：Journal of biomedical optics

authors： Kim M,Bi X,Horton WE,Spencer RG,Camacho NP

更新日期：2005-05-01 00:00:00

abstract：:Motion artifacts are the most significant sources of noise in the context of pediatric brain imaging designs and data analyses, especially in applications of functional near-infrared spectroscopy (fNIRS), in which it can completely affect the quality of the data acquired. Different methods have been developed to corre...

journal_title：Journal of biomedical optics

authors： Hu XS,Arredondo MM,Gomba M,Confer N,DaSilva AF,Johnson TD,Shalinsky M,Kovelman I

更新日期：2015-01-01 00:00:00

abstract：:A compact handpiece combining high resolution fluorescence (HRF) imaging with optical coherence tomography (OCT) was developed to provide real-time assessment of oral lesions. This multimodal imaging device simultaneously captures coregistered en face images with subcellular detail alongside cross-sectional images of ...

journal_title：Journal of biomedical optics

authors： Higgins LM,Pierce MC

更新日期：2014-08-01 00:00:00

abstract：SIGNIFICANCE:Although the clinical potential for Raman spectroscopy (RS) has been anticipated for decades, it has only recently been used in neurosurgery. Still, few devices have succeeded in making their way into the operating room. With recent technological advancements, however, vibrational sensing is poised to be a...

journal_title：Journal of biomedical optics

authors： DePaoli D,Lemoine É,Ember K,Parent M,Prud'homme M,Cantin L,Petrecca K,Leblond F,Côté DC

更新日期：2020-05-01 00:00:00

abstract：:Differential phase optical coherence tomography (DPOCT) is introduced to measure optical path length changes in response to pulsed laser irradiation (585 nm). An analytical equation that includes thermoelastic surface displacement and thermorefractive index change is derived to predict optical path length change in re...

journal_title：Journal of biomedical optics

authors： Kim J,Oh J,Milner TE

更新日期：2006-07-01 00:00:00

abstract：:Oblique incidence reflectometry (OIR) is an established technique for the estimation of tissue optical properties. However, a sensing footprint of a few transport mean-free paths is often needed when diffusion-regime-based algorithms are used. Smaller-footprint probes require improved light-propagation models and inve...

journal_title：Journal of biomedical optics

authors： Zemp RJ

更新日期：2013-06-01 00:00:00

abstract：:Optical quantification of large lesions imaged with diffuse optical tomography in reflection geometry is depth dependence due to the exponential decay of photon density waves. We introduce a depth-correction method that incorporates the target depth information provided by coregistered ultrasound. It is based on balan...

journal_title：Journal of biomedical optics

authors： Tavakoli B,Zhu Q

更新日期：2011-05-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:The transmembrane protein prestin is crucial to outer hair cell (OHC) electromotility and contributes to the sensitivity and frequency selectivity of mammalian hearing. The molecular mechanisms of electromotility remain unclear, but prestin is purported to function as both a voltage sensor and a molecular motor. Under...

journal_title：Journal of biomedical optics

authors： Organ LE,Raphael RM

更新日期：2007-03-01 00:00:00

abstract：:We fabricate scaffolds with a fine linear grating (periodicity of 1 to 8 microm and height of 1 microm) on a glass substrate for controlling cardiomyocyte orientation. The fabrication is done by the solidification of a liquid photopolymerizable material using two laser beam interference. As the photopolymerizable mate...

journal_title：Journal of biomedical optics

authors： Fujita A,Fujita K,Nakamura O,Matsuda T,Kawata S

更新日期：2006-03-01 00:00:00

abstract：SIGNIFICANCE:Adaptive optics optical coherence tomography (AO-OCT) technology enables non-invasive, high-resolution three-dimensional (3D) imaging of the retina and promises earlier detection of ocular disease. However, AO-OCT data are corrupted by eye-movement artifacts that must be removed in post-processing, a proce...

journal_title：Journal of biomedical optics

authors： Kurokawa K,Crowell JA,Do N,Lee JJ,Miller DT

更新日期：2021-01-01 00:00:00

abstract：:The objective of this work was to compare the accuracy of analyte concentration estimation when using transmission versus diffuse reflectance spectroscopy of a scattering medium. Monte Carlo ray tracing of light through the medium was used in conjunction with pure component absorption spectra and Beer-Lambert absorpti...

journal_title：Journal of biomedical optics

authors： Gardner CM

更新日期：2018-01-01 00:00:00

abstract：:We have built an all-solid-state camera that is directly modulated at the pixel level for frequency-domain fluorescence lifetime imaging microscopy (FLIM) measurements. This novel camera eliminates the need for an image intensifier through the use of an application-specific charge coupled device design in a frequency-...

journal_title：Journal of biomedical optics

authors： Zhao Q,Schelen B,Schouten R,van den Oever R,Leenen R,van Kuijk H,Peters I,Polderdijk F,Bosiers J,Raspe M,Jalink K,Geert Sander de Jong J,van Geest B,Stoop K,Young IT

更新日期：2012-12-01 00:00:00

abstract：:Cancer is the main cause of canine morbidity and mortality. The existing evaluation of tumors requires an experienced veterinarian and usually includes invasive procedures (e.g., fine-needle aspiration) that can be unpleasant for the dog and the owner. We investigate visible and near-infrared diffuse reflectance spect...

journal_title：Journal of biomedical optics

authors： Cugmas B,Plavec T,Bregar M,Naglič P,Pernuš F,Likar B,Bürmen M

更新日期：2015-03-01 00:00:00

abstract：:We experimentally compare the performance and image contrast of spontaneous Raman and coherent Stokes Raman scattering microscopy. We demonstrate the differences between these techniques on a series of geometry-controlled samples that range in complexity from a point (array of tips) to one-dimensional (line grating) a...

journal_title：Journal of biomedical optics

authors： Kim H,Michaels CA,Bryant GW,Stranick SJ

更新日期：2011-02-01 00:00:00

abstract：:Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the latter collecting label-free backscattering data with comparable lateral but much higher axia...

journal_title：Journal of biomedical optics

authors： Zhang P,Zam A,Jian Y,Wang X,Li Y,Lam KS,Burns ME,Sarunic MV,Pugh EN Jr,Zawadzki RJ

更新日期：2015-01-01 00:00:00

abstract：:Obstruction in the upper airway can often cause reductions in breathing or gas exchange efficiency and lead to rest disorders such as sleep apnea. Imaging diagnosis of the obstruction region has been accomplished using computed tomography (CT) and magnetic resonance imaging (MRI). However CT requires the use of ionizi...

journal_title：Journal of biomedical optics

authors： Jing J,Zhang J,Loy AC,Wong BJ,Chen Z

更新日期：2012-11-01 00:00:00

abstract：:Diffuse reflectance spectroscopy, which has been demonstrated as a noninvasive diagnostic technique, relies on quantitative models for extracting optical property values from turbid media, such as biological tissues. We review and compare reflectance models that have been published, and we test similar models over a m...

journal_title：Journal of biomedical optics

authors： Calabro KW,Bigio IJ

更新日期：2014-01-01 00:00:00

abstract：:Quantitative polarized light microscopy (qPLM) is a popular tool for the investigation of birefringent architectures in biological tissues. Collagen, the most abundant protein in mammals, is such a birefringent material. Interpretation of results of qPLM in terms of collagen network architecture and anisotropy is chal...

journal_title：Journal of biomedical optics

authors： van Turnhout MC,Kranenbarg S,van Leeuwen JL

更新日期：2009-09-01 00:00:00

abstract：:Several studies demonstrated that the cyclic adenosine monophosphate (cAMP), an important second messenger, is involved in the mechanism of low-level laser irradiation (LLLI) treatment. However, most of these studies obtained the cAMP level in cell culture extracts or supernatant. In this study, the cAMP level in livi...

journal_title：Journal of biomedical optics

authors： Huang Y,Zheng L,Yang H,Chen J,Wang Y,Li H,Xie S,Zeng H

更新日期：2015-05-01 00:00:00

abstract：:We introduce a needle probe based on photoacoustics (PA) to extend the scope of optical needle methods in guiding biopsies. Pulsed light is coupled to an optical fiber in a needle to be inserted in tissue, and PA signals are detected using an ultrasound imager used for needle guidance. This PA needle samples large vol...

journal_title：Journal of biomedical optics

authors： Piras D,Grijsen C,Schütte P,Steenbergen W,Manohar S

更新日期：2013-07-01 00:00:00

abstract：:A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal t...

journal_title：Journal of biomedical optics

authors： Hammer DX,Ferguson RD,Patel AH,Vazquez V,Husain D

更新日期：2012-02-01 00:00:00

abstract：:Photobiological research in the last 30 yr has shown the existence of ultraweak photon emission in biological tissue, which can be detected with sophisticated photomultiplier systems. Although the emission of this ultraweak radiation, often termed biophotons, is extremely low in mammalian cells, it can be efficiently ...

journal_title：Journal of biomedical optics

authors： Niggli HJ,Tudisco S,Privitera G,Applegate LA,Scordino A,Musumeci F

更新日期：2005-03-01 00:00:00