Modeling optical behavior of birefringent biological tissues for evaluation of quantitative polarized light microscopy.

Abstract:

:Quantitative polarized light microscopy (qPLM) is a popular tool for the investigation of birefringent architectures in biological tissues. Collagen, the most abundant protein in mammals, is such a birefringent material. Interpretation of results of qPLM in terms of collagen network architecture and anisotropy is challenging, because different collagen networks may yield equal qPLM results. We created a model and used the linear optical behavior of collagen to construct a Jones or Mueller matrix for a histological cartilage section in an optical qPLM train. Histological sections of tendon were used to validate the basic assumption of the model. Results show that information on collagen densities is needed for the interpretation of qPLM results in terms of collagen anisotropy. A parameter that is independent of the optical system and that measures collagen fiber anisotropy is introduced, and its physical interpretation is discussed. With our results, we can quantify which part of different qPLM results is due to differences in collagen densities and which part is due to changes in the collagen network. Because collagen fiber orientation and anisotropy are important for tissue function, these results can improve the biological and medical relevance of qPLM results.

journal_name

J Biomed Opt

authors

van Turnhout MC,Kranenbarg S,van Leeuwen JL

doi

10.1117/1.3241986

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

054018

issue

5

eissn

1083-3668

issn

1560-2281

journal_volume

14

pub_type

杂志文章
  • Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography.

    abstract::A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3659211

    authors: Guan G,Reif R,Huang Z,Wang RK

    更新日期:2011-12-01 00:00:00

  • Noninvasive assessment of diabetic foot ulcers with diffuse photon density wave methodology: pilot human study.

    abstract::A pilot human study is conducted to evaluate the potential of using diffuse photon density wave (DPDW) methodology at near-infrared (NIR) wavelengths (685 to 830 nm) to monitor changes in tissue hemoglobin concentration in diabetic foot ulcers. Hemoglobin concentration is measured by DPDW in 12 human wounds for a peri...

    journal_title:Journal of biomedical optics

    pub_type: 临床试验,杂志文章

    doi:10.1117/1.3275467

    authors: Papazoglou ES,Neidrauer M,Zubkov L,Weingarten MS,Pourrezaei K

    更新日期:2009-11-01 00:00:00

  • Acousto-optic-tunable-filter-based spectropolarimetric imagers for medical diagnostic applications--instrument design point of view.

    abstract::Compact optical imagers that can detect both spectral and polarization signatures are required in many biomedical applications. An acousto-optic-tunable-filter (AOTF)-based imager is ideally suited to provide both agile spectral and polarization signatures. Such an imager can be readily used for real-time in vivo medi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2102507

    authors: Gupta N

    更新日期:2005-09-01 00:00:00

  • Stress Relaxation of Porcine Septal Cartilage During Nd:YAG (λ=1.32 μm) Laser Irradiation: Mechanical, Optical, and Thermal Responses.

    abstract::Laser-assisted cartilage reshaping is mediated by thermally induced stress relaxation, and may be used to alter cartilage morphology for reconstructive surgical procedures in the upper airway and face without carving, morselizing, or suturing. Internal stress σ(t), integrated backscattered light intensity I(t) from a ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.429896

    authors: Wong BJ,Milner TE,Kim HH,Stuart Nelson J,Sobol EN

    更新日期:1998-10-01 00:00:00

  • Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model.

    abstract::Renal ischemia that occurs intraoperatively during procedures requiring clamping of the renal artery (such as renal procurement for transplantation and partial nephrectomy for renal cancer) is known to have a significant impact on the viability of that kidney. To better understand the dynamics of intraoperative renal ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.3.035001

    authors: Crane NJ,Huffman SW,Alemozaffar M,Gage FA,Levin IW,Elster EA

    更新日期:2013-03-01 00:00:00

  • Appearance of breast cysts in planar geometry photoacoustic mammography using 1064-nm excitation.

    abstract::In the search for improved imaging modalities for detection and diagnosis of breast cancer, a high negative prediction value is also important. Photoacoustic (optoacoustic) imaging is a relatively new technique that has high potential for visualizing breast malignancies, but little is known about the photoacoustic app...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.12.126009

    authors: Heijblom M,Piras D,Maartens E,Huisman EJ,van den Engh FM,Klaase JM,Steenbergen W,Manohar S

    更新日期:2013-12-01 00:00:00

  • Reproducibility of parameters of postocclusive reactive hyperemia measured by diffuse optical tomography.

    abstract::The application of near-infrared spectroscopy (NIRS) to assess microvascular function has shown promising results. An important limitation when using a single source-detector pair, however, is the lack of depth sensitivity. Diffuse optical tomography (DOT) overcomes this limitation using an array of sources and detect...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.6.066012

    authors: Vidal-Rosas EE,Billings SA,Chico T,Coca D

    更新日期:2016-06-01 00:00:00

  • Stress analysis in oral obturator prostheses, part II: photoelastic imaging.

    abstract::In part I of the study, two attachment systems [O-ring; bar-clip (BC)] were used, and the system with three individualized O-rings provided the lowest stress on the implants and the support tissues. Therefore, the aim of this study was to assess the stress distribution, through the photoelastic method, on implant-reta...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.6.066012

    authors: Pesqueira AA,Goiato MC,da Silva EV,Haddad MF,Moreno A,Zahoui A,dos Santos DM

    更新日期:2014-06-01 00:00:00

  • Simultaneous imaging of multiple focal planes for three-dimensional microscopy using ultra-high-speed adaptive optics.

    abstract::Traditional white-light and fluorescent imaging techniques provide powerful methods to extract high-resolution information from two-dimensional (2-D) sections, but to retrieve information from a three-dimensional (3-D) volume they require relatively slow scanning methods that result in increased acquisition time. Usin...

    journal_title:Journal of biomedical optics

    pub_type: 信件

    doi:10.1117/1.JBO.17.5.050505

    authors: Duocastella M,Sun B,Arnold CB

    更新日期:2012-05-01 00:00:00

  • Dual/differential coherent anti-Stokes Raman scattering module for multiphoton microscopes with a femtosecond Ti:sapphire oscillator.

    abstract::In the last decade, coherent anti-Stokes Raman scattering (CARS) microscopy has emerged as a powerful multiphoton imaging technique offering label-free chemical sensitivity and high three-dimensional resolution. However, its widespread application in the life sciences has been hampered by the use of costly pulsed lase...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.6.066004

    authors: Li B,Borri P,Langbein W

    更新日期:2013-06-01 00:00:00

  • Phase-function corrected diffusion model for diffuse reflectance of a pencil beam obliquely incident on a semi-infinite turbid medium.

    abstract::Oblique incidence reflectometry (OIR) is an established technique for the estimation of tissue optical properties. However, a sensing footprint of a few transport mean-free paths is often needed when diffusion-regime-based algorithms are used. Smaller-footprint probes require improved light-propagation models and inve...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.6.067005

    authors: Zemp RJ

    更新日期:2013-06-01 00:00:00

  • Adaptive optics for fluorescence wide-field microscopy using spectrally independent guide star and markers.

    abstract::We describe the implementation and use of an adaptive optics loop in the imaging path of a commercial wide field microscope. We show that it is possible to maintain the optical performances of the original microscope when imaging through aberrant biological samples. The sources used for illuminating the adaptive optic...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3603847

    authors: Vermeulen P,Muro E,Pons T,Loriette V,Fragola A

    更新日期:2011-07-01 00:00:00

  • Diagnosis of breast cancer using fluorescence and diffuse reflectance spectroscopy: a Monte-Carlo-model-based approach.

    abstract::We explore the use of Monte-Carlo-model-based approaches for the analysis of fluorescence and diffuse reflectance spectra measured ex vivo from breast tissues. These models are used to extract the absorption, scattering, and fluorescence properties of malignant and nonmalignant tissues and to diagnose breast cancer ba...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2931078

    authors: Zhu C,Palmer GM,Breslin TM,Harter J,Ramanujam N

    更新日期:2008-05-01 00:00:00

  • Potential of optical microangiography to monitor cerebral blood perfusion and vascular plasticity following traumatic brain injury in mice in vivo.

    abstract::Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mo...

    journal_title:Journal of biomedical optics

    pub_type: 信件

    doi:10.1117/1.3207121

    authors: Jia Y,Alkayed N,Wang RK

    更新日期:2009-07-01 00:00:00

  • Photochemical decontamination of red cell concentrates with the silicon phthalocyanine pc 4 and red light.

    abstract::Virus inactivation in red blood cell concentrates (RBCC) is being studied in order to increase the safety of the blood supply. For this purpose we have been studying the silicon phthalocyanine (Pc 4), a photosensitizer activated with red light. Two approaches were used to achieve enhanced selectivity of Pc 4 for virus...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.429931

    authors: Ben-Hur E,Zuk MM,Oetjen J,Chan WS,Lenny L,Horowitz B

    更新日期:1999-07-01 00:00:00

  • Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study.

    abstract::We present for the first time in vivo full three-dimensional (3-D) photoacoustic tomography (PAT) of the distal interphalangeal joint in a human subject. Both absorbed energy density and absorption coefficient images of the joint are quantitatively obtained using our finite-element-based photoacoustic image reconstruc...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3257246

    authors: Sun Y,Sobel E,Jiang H

    更新日期:2009-11-01 00:00:00

  • In vivo simultaneous multispectral fluorescence imaging with spectral multiplexed volume holographic imaging system.

    abstract::A simultaneous multispectral fluorescence imaging system incorporating multiplexed volume holographic grating (VHG) is developed to acquire multispectral images of an object in one shot. With the multiplexed VHG, the imaging system can provide the distribution and spectral characteristics of multiple fluorophores in t...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.6.060502

    authors: Lv Y,Zhang J,Zhang D,Cai W,Chen N,Luo J

    更新日期:2016-06-01 00:00:00

  • Analysis of sampling volume and tissue heterogeneity on the in vivo detection of fluorescence.

    abstract::The effect of sampling region size and tissue heterogeneity is examined using fluorescence histogram assessment in a rat prostate tumor model with benzoporphyrin derivative fluorophore. Spatial heterogeneity in the fluorescence signal occurs on both macroscopic and microscopic scales. The periphery of the tumor is mor...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2002978

    authors: Pogue BW,Chen B,Zhou X,Hoopes PJ

    更新日期:2005-07-01 00:00:00

  • Sensitivity map of laser tweezers Raman spectroscopy for single-cell analysis of colorectal cancer.

    abstract::Raman spectroscopy on single, living epithelial cells captured in a laser trap is shown to have diagnostic power over colorectal cancer. This new single-cell technology comprises three major components: primary culture processing of human tissue samples to produce single-cell suspensions, Raman detection on singly tra...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2748060

    authors: Zheng F,Qin Y,Chen K

    更新日期:2007-05-01 00:00:00

  • Caries detection and quantification around stained pits and fissures in occlusal tooth surfaces with fluorescence.

    abstract::Occlusal discoloration due to staining frequently occurs on the pits and fissures of teeth. Noncariogenic discoloration (non-CD) refers to the attachment of staining chromogens to sound surfaces, whereas cariogenic discoloration (CD) represents the discoloration of porous structures due to bacterial metabolites and mi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.23.9.091402

    authors: Lee HS,Kim SK,Park SW,de Josselin de Jong E,Kwon HK,Jeong SH,Kim BI

    更新日期:2018-03-01 00:00:00

  • Influence of phase function on modeled optical response of nanoparticle-labeled epithelial tissues.

    abstract::Metal nanoparticles can be functionalized with biomolecules to selectively localize in precancerous tissues and can act as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo (MC) simulations to analyze photon propagation through nanoparticle-labeled tissues and...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.3608999

    authors: Cihan C,Arifler D

    更新日期:2011-08-01 00:00:00

  • Antibody-based magnetic nanoparticle immunoassay for quantification of Alzheimer's disease pathogenic factor.

    abstract::Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive and intellectual abilities and an irreversible mental deterioration. Based on multidisciplinary AD research, the most universally accepted hypotheses on AD pathogenesis are the intracerebral aggregate formation of beta-amyloi...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.5.051205

    authors: Kim CB,Choi YY,Song WK,Song KB

    更新日期:2014-05-01 00:00:00

  • Preliminary evaluation of optical glucose sensing in red cell concentrations using near-infrared diffuse-reflectance spectroscopy.

    abstract::Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.17.1.017004

    authors: Suzuki Y,Maruo K,Zhang AW,Shimogaki K,Ogawa H,Hirayama F

    更新日期:2012-01-01 00:00:00

  • Spatially resolved reflectance spectroscopy for diagnosis of cervical precancer: Monte Carlo modeling and comparison to clinical measurements.

    abstract::We present Monte Carlo modeling studies to provide a quantitative understanding of contrast observed in spatially resolved reflectance spectra of normal and highly dysplastic cervical tissue. Simulations have been carried out to analyze the sensitivity of spectral measurements to a range of changes in epithelial and s...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.2398932

    authors: Arifler D,MacAulay C,Follen M,Richards-Kortum R

    更新日期:2006-11-01 00:00:00

  • Optical imaging for brain tissue characterization using relative fluorescence lifetime imaging.

    abstract::An autofluorescence lifetime wide-field imaging system that can generate contrast in underlying tissue structures of normal and malignant brain tissue samples with video rate acquisition and processing time is presented. Images of the investigated tissues were acquired with high resolution (∼35 μm) using an algorithm ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.18.6.060504

    authors: Papour A,Taylor Z,Sherman A,Sanchez D,Lucey G,Liau L,Stafsudd O,Yong W,Grundfest W

    更新日期:2013-06-01 00:00:00

  • Characterization of a multicore fiber image guide for nonlinear endoscopic imaging using two-photon fluorescence and second-harmonic generation.

    abstract::Multiphoton microscopy (MPM) has the capacity to record second-harmonic generation (SHG) and endogenous two-photon excitation fluorescence (2PEF) signals emitted from biological tissues. The development of fiber-based miniaturized endomicroscopes delivering pulses in the femtosecond range will allow the transfer of MP...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.24.10.106004

    authors: Garofalakis A,Kruglik SG,Mansuryan T,Gillibert A,Thiberville L,Louradour F,Vever-Bizet C,Bourg-Heckly G

    更新日期:2019-10-01 00:00:00

  • Measuring red blood cell flow dynamics in a glass capillary using Doppler optical coherence tomography and Doppler amplitude optical coherence tomography.

    abstract::Blood, being a suspension of deformable red cells suspended in plasma, displays flow dynamics considerably more complicated than those of an ideal Newtonian fluid. Flow dynamics in blood capillaries of a few hundred micrometers in diameter are investigated using Doppler optical coherence tomography (DOCT) and Doppler ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.1781163

    authors: Moger J,Matcher SJ,Winlove CP,Shore A

    更新日期:2004-09-01 00:00:00

  • Ultrasensitive opto-microfluidic immunosensor integrating gold nanoparticle-enhanced chemiluminescence and highly stable organic photodetector.

    abstract::The expensive fabrication of current opto-microfluidic sensors is a barrier to the successful adoption of these devices in point-of-care testing. This work reports a simple inexpensive opto-microfluidic device incorporating a poly(dimethylsiloxane)-glass hybrid microfluidic chip modified with gold nanoparticles and a ...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.19.3.030504

    authors: Pires NM,Dong T

    更新日期:2014-03-01 00:00:00

  • Multiplexed neural recording along a single optical fiber via optical reflectometry.

    abstract::We introduce the design and theoretical analysis of a fiber-optic architecture for neural recording without contrast agents, which transduces neural electrical signals into a multiplexed optical readout. Our sensor design is inspired by electro-optic modulators, which modulate the refractive index of a waveguide by ap...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.21.5.057003

    authors: Rodriques SG,Marblestone AH,Scholvin J,Dapello J,Sarkar D,Mankin M,Gao R,Wood L,Boyden ES

    更新日期:2016-05-01 00:00:00

  • In vivo wide-field multispectral scanning laser ophthalmoscopy-optical coherence tomography mouse retinal imager: longitudinal imaging of ganglion cells, microglia, and Müller glia, and mapping of the mouse retinal and choroidal vasculature.

    abstract::Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) provide complementary views of the retina, with the former collecting fluorescence data with good lateral but relatively low-axial resolution, and the latter collecting label-free backscattering data with comparable lateral but much higher axia...

    journal_title:Journal of biomedical optics

    pub_type: 杂志文章

    doi:10.1117/1.JBO.20.12.126005

    authors: Zhang P,Zam A,Jian Y,Wang X,Li Y,Lam KS,Burns ME,Sarunic MV,Pugh EN Jr,Zawadzki RJ

    更新日期:2015-01-01 00:00:00