Detection of canine skin and subcutaneous tumors by visible and near-infrared diffuse reflectance spectroscopy.

abstract：:Robot-assisted laparoscopic surgery is becoming an established technique for prostatectomy and is increasingly being explored for other types of cancer. Linking intraoperative imaging techniques, such as fluorescence guidance, with the three-dimensional insights provided by preoperative imaging remains a challenge. Na...

journal_title：Journal of biomedical optics

authors： van Oosterom MN,Engelen MA,van den Berg NS,KleinJan GH,van der Poel HG,Wendler T,van de Velde CJ,Navab N,van Leeuwen FW

更新日期：2016-08-01 00:00:00

abstract：:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced ...

journal_title：Journal of biomedical optics

authors： Yeh C,Hu S,Maslov K,Wang LV

更新日期：2012-07-01 00:00:00

abstract：:A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/t...

journal_title：Journal of biomedical optics

authors： Jacques SL,Pogue BW

更新日期：2008-07-01 00:00:00

abstract：:The atrial pacemaker complex is responsible for the initiation and early propagation of cardiac impulses. Optical coherence tomography (OCT), a nondestructive imaging modality with spatial resolutions of ∼1 to 15 μm, can be used to identify unique fiber orientation patterns in this region of the heart. Functionally ch...

journal_title：Journal of biomedical optics

authors： Ambrosi CM,Fedorov VV,Schuessler RB,Rollins AM,Efimov IR

更新日期：2012-07-01 00:00:00

abstract：:The fibrillar collagen network in tumor and normal tissues is different due to remodeling of the extracellular matrix during the malignant process. Collagen type I fibers have the crystalline and noncentrosymmetric properties required for generating the second-harmonic signal. The content and structure of collagen wer...

journal_title：Journal of biomedical optics

authors： Hompland T,Erikson A,Lindgren M,Lindmo T,de Lange Davies C

更新日期：2008-09-01 00:00:00

abstract：:Oxidative stress has become an exciting area of schizophrenia (SCZ) research, and provides ample opportunities and hope for a better understanding of its pathophysiology, which may lead to new treatment strategies. The first objective of the present study was to analyze the oxidative stress markers in breath samples o...

journal_title：Journal of biomedical optics

authors： Popa C,Petrus M,Bratu AM

更新日期：2015-05-01 00:00:00

abstract：SIGNIFICANCE:A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was proposed as a support for diagnosing neurodegenerative pathologies, including different forms of dementia and Alzheimer's disease (AD). In this field, timely and reliable discrimination and diagnosis are critical aspects ...

journal_title：Journal of biomedical optics

authors： Cennamo G,Montorio D,Morra VB,Criscuolo C,Lanzillo R,Salvatore E,Camerlingo C,Lisitskiy M,Delfino I,Portaccio M,Lepore M

更新日期：2020-08-01 00:00:00

abstract：:Differential phase optical coherence tomography (DPOCT) is introduced to measure optical path length changes in response to pulsed laser irradiation (585 nm). An analytical equation that includes thermoelastic surface displacement and thermorefractive index change is derived to predict optical path length change in re...

journal_title：Journal of biomedical optics

authors： Kim J,Oh J,Milner TE

更新日期：2006-07-01 00:00:00

abstract：:The damage mechanism for near-infrared radiation (IRR) induced cataract is unclear. Both a photochemical and a thermal mechanism were suggested. The current paper aims to elucidate a photochemical effect based on investigation of irradiance-exposure time reciprocity. Groups of 20 rats were unilaterally exposed to 96-W...

journal_title：Journal of biomedical optics

authors： Yu Z,Schulmeister K,Talebizadeh N,Kronschläger M,Söderberg P

更新日期：2015-01-01 00:00:00

abstract：:Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a n...

journal_title：Journal of biomedical optics

authors： Rollins AM,Yazdanfar S,Barton JK,Izatt JA

更新日期：2002-01-01 00:00:00

abstract：:We examine the morphological and chemical changes in the pulp chamber dentin after using endodontic agents by scanning electron microscopy (SEM), Fourier transform Raman spectroscopy (FT-Raman), and micro energy-dispersive x-ray fluorescence spectrometry (μEDXRF). Thirty teeth were sectioned exposing the pulp chamber ...

journal_title：Journal of biomedical optics

authors： Pascon FM,Kantovitz KR,Soares LE,Santo AM,Martin AA,Puppin-Rontani RM

更新日期：2012-07-01 00:00:00

abstract：:Image resolution and signal level in fluorescence microscopy through inhomogeneous turbid media consisting of scatterers of multiple sizes under single- (1p), two- (2p), and three-photon (3p) excitation have been investigated based on a modified Monte Carlo model. The effects of the size distribution and the concentra...

journal_title：Journal of biomedical optics

authors： Deng X,Gan X,Gu M

更新日期：2003-07-01 00:00:00

abstract：:Ultraviolet radiation from solar exposure is a key extrinsic factor responsible for premature skin aging (i.e., photo-aging). Recent advances using in vivo multiphoton tomography (MPT) demonstrate the efficacy of this approach to assess intrinsic and extrinsic skin aging as an alternative to existing invasive techniqu...

journal_title：Journal of biomedical optics

authors： Sanchez WY,Obispo C,Ryan E,Grice JE,Roberts MS

更新日期：2013-06-01 00:00:00

abstract：:We recently developed an algorithm for multiplexed fluorescence tomographic imaging of at least four fluorophores concurrently in the red and near-infrared wavelength region by jointly using spectral and temporal data. We report the design of a fluorescence tomography instrument that acquires spectral and temporal dat...

journal_title：Journal of biomedical optics

authors： Mu Y,Pera V,Niedre M

更新日期：2016-10-01 00:00:00

abstract：:We present the light scattering properties of individual human red blood cells (RBCs). We show that both the RBC static and dynamic scattering signals are altered by adenosine 5'-triphosphate (ATP)-driven membrane metabolic remodeling. To measure the light scattering signal from individual RBCs, we use diffraction pha...

journal_title：Journal of biomedical optics

authors： Park Y,Best-Popescu CA,Dasari RR,Popescu G

更新日期：2011-01-01 00:00:00

abstract：:A Monte Carlo algorithm is applied to simulate the measurements of a sample with glass slides sandwiched between the double integrating sphere (DIS) setup. The effects caused by various parameters, such as the sample port of integrating sphere, thicknesses, and optical properties of the sample, on light losses and opt...

journal_title：Journal of biomedical optics

authors： Zhu D,Lu W,Zeng S,Luo Q

更新日期：2007-11-01 00:00:00

abstract：:Low-level light therapy has been shown to improve in vitro wound healing. However, well-defined parameters of different light sources for this therapy are lacking. The goal of this study was (1) to determine if the wavelengths tested are effective for in vitro wound healing and (2) to compare a laser and a light-emitt...

journal_title：Journal of biomedical optics

authors： Spitler R,Berns MW

更新日期：2014-03-01 00:00:00

abstract：:Noninvasive diagnostic tools, such as Trichoscan®, reflectance confocal microscopy (RCM), and optical coherence tomography (OCT), are efficient methods of hair shaft and growth evaluation. The aim of this study was to carry out a comparative assessment of these three medical procedures by measuring the hair shaft and ...

journal_title：Journal of biomedical optics

authors： Kuck M,Schanzer S,Ulrich M,Garcia Bartels N,Meinke MC,Fluhr J,Krah M,Blume-Peytavi U,Stockfleth E,Lademann J

更新日期：2012-10-01 00:00:00

abstract：:Utilizing a laser scanning confocal microscope system, the refractive indices of articular cartilage (AC) with mechanical or biochemical degenerations were characterized to investigate whether potential correlations exist between refractive index (RI) and cartilage degeneration. The cartilage samples collected from th...

journal_title：Journal of biomedical optics

authors： Wang K,Wu J,Day R,Kirk TB,Hu X

更新日期：2016-09-01 00:00:00

abstract：:Emission and excitation spectra of collagen were recorded in the ultraviolet and visible regions. The existence of several types of chromophores absorbing and emitting throughout these spectral regions was observed. It was shown that laser irradiation at 355 and 532 nm caused collagen fluorescence photobleaching by 30...

journal_title：Journal of biomedical optics

authors： Yova D,Hovhannisyan V,Theodossiou T

更新日期：2001-01-01 00:00:00

abstract：:We demonstrate the utility of functional near-infrared spectroscopy (fNIRS) as a tool for physicians to study cortical plasticity in children with cerebral palsy (CP). Motor cortex activation patterns were studied in five healthy children and five children with CP (8.4+/-2.3 years old in both groups) performing a fing...

journal_title：Journal of biomedical optics

authors： Khan B,Tian F,Behbehani K,Romero MI,Delgado MR,Clegg NJ,Smith L,Reid D,Liu H,Alexandrakis G

更新日期：2010-05-01 00:00:00

abstract：:Using commercially available organic fluorophores, the current applications of Förster (fluorescence) resonance energy transfer (FRET) are limited to about 80 Å. However, many essential activities in cells are spatially and/or temporally dependent on the assembly/disassembly of transient complexes consisting of large-...

journal_title：Journal of biomedical optics

authors： Maliwal BP,Raut S,Fudala R,D'Auria S,Marzullo VM,Luini A,Gryczynski I,Gryczynski Z

更新日期：2012-01-01 00:00:00

abstract：:We describe a wide-field optical tomography technique, which allows the measurement-guided optimization of illumination patterns for enhanced reconstruction performances. The iterative optimization of the excitation pattern aims at reducing the dynamic range in photons transmitted through biological tissue. It increas...

journal_title：Journal of biomedical optics

authors： Venugopal V,Intes X

更新日期：2013-03-01 00:00:00

abstract：:Imaging technologies working in the spatial frequency domain are becoming increasingly popular for generating wide-field maps of optical properties, enabling rapid analysis of tissue parameters. While acquisition methods have become faster and are now performing in real-time, processing methods remain slow, precluding...

journal_title：Journal of biomedical optics

authors： Angelo J,Vargas CR,Lee BT,Bigio IJ,Gioux S

更新日期：2016-11-01 00:00:00

abstract：:We present a novel fluorescence imaging system developed for real-time interventional imaging applications. The system implements a correction scheme that improves the accuracy of epi-illumination fluorescence images for light intensity variation in tissues. The implementation is based on the use of three cameras oper...

journal_title：Journal of biomedical optics

authors： Themelis G,Yoo JS,Soh KS,Schulz R,Ntziachristos V

更新日期：2009-11-01 00:00:00

abstract：:Within the framework of further development of unified Monte Carlo code for the needs of biomedical optics and biophotonics, we present an approach for modeling of coherent polarized light propagation in highly scattering turbid media, such as biological tissues. The temporal coherence of light, linear and circular po...

journal_title：Journal of biomedical optics

authors： Doronin A,Macdonald C,Meglinski I

更新日期：2014-02-01 00:00:00

abstract：:Polarization interferometry (PI) techniques, which are able to improve surface plasmon resonance (SPR) sensing performance and reduce restrictions on allowable parameters of SPR-supporting metal films, have been experimentally realized only in SPR sensors using monochromatic light as a source. Wavelength-interrogation...

journal_title：Journal of biomedical optics

authors： Liu Z,Liu L,Wang X,Shi H,Chong X,Ma S,Ji Y,Guo J,Ma H,He Y

更新日期：2012-03-01 00:00:00

abstract：:Selective photothermal interaction using dye enhancement has proven to be effective in minimizing surrounding tissue damage and delivering energy to target tissue. During laser irradiation, the process of photon absorption and thermal energy diffusion in the target tissue and its surrounding tissue are crucial. Such i...

journal_title：Journal of biomedical optics

authors： Crochet JJ,Gnyawali SC,Chen Y,Lemley EC,Wang LV,Chen WR

更新日期：2006-05-01 00:00:00

abstract：:The study of red blood cell (RBC) aggregation is of great interest because of its implications for human health. Altered RBC aggregation can lead to microcirculatory problems as in vascular pathologies, such as hypertension and diabetes, due to a decrease in the erythrocyte surface electric charge and an increase in t...

journal_title：Journal of biomedical optics

authors： Toderi MA,Castellini HV,Riquelme BD

更新日期：2017-01-01 00:00:00

abstract：SIGNIFICANCE:Detailed biochemical and morphological imaging of the plaque burdened coronary arteries holds the promise of improved understanding of atherosclerosis plaque development, ultimately leading to better diagnostics and therapies. AIM:Development of a dual-modality intravascular catheter supporting swept-sour...

journal_title：Journal of biomedical optics

authors： Chen X,Kim W,Serafino M,Tan Z,Jo J,Applegate B

更新日期：2020-09-01 00:00:00