Abstract:
:We present the design and experimental results of a new MEMS-based endoscopic optical coherence tomography (OCT) probe. The uniqueness of this miniature OCT imaging probe is a two-axis MEMS mirror with through-silicon vias (TSVs) for interconnecting. The TSV interconnection enables ultracompact probe design, successfully reducing the probe size to only 2.6 mm in diameter. The MEMS mirror is actuated by an electrothermal actuator that is capable of scanning ± 16° at only 3.6 V DC. Two-dimensional and three-dimensional OCT images of microspheres embedded in PDMS and acute rat brain tissue have been obtained with this miniature probe in a time-domain OCT system.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Liu L,Wu L,Sun J,Lin E,Xie Hdoi
10.1117/1.3533323subject
Has Abstractpub_date
2011-02-01 00:00:00pages
026006issue
2eissn
1083-3668issn
1560-2281journal_volume
16pub_type
杂志文章abstract::Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mo...
journal_title:Journal of biomedical optics
pub_type: 信件
doi:10.1117/1.3207121
更新日期:2009-07-01 00:00:00
abstract::In this work experimental tissue phantoms and numerical models were developed to estimate photon migration through the fetal head in utero. The tissue phantoms incorporate a fetal head within an amniotic fluid sac surrounded by a maternal tissue layer. A continuous wave, dual-wavelength (lambda = 760 and 850 nm) spect...
journal_title:Journal of biomedical optics
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abstract::We describe a systematic approach to image, track, and quantify the movements of HIV viruses embedded in human cervical mucus. The underlying motivation for this study is that, in HIV-infected adults, women account for more than half of all new cases and most of these women acquire the infection through heterosexual c...
journal_title:Journal of biomedical optics
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abstract::We present the light scattering properties of individual human red blood cells (RBCs). We show that both the RBC static and dynamic scattering signals are altered by adenosine 5'-triphosphate (ATP)-driven membrane metabolic remodeling. To measure the light scattering signal from individual RBCs, we use diffraction pha...
journal_title:Journal of biomedical optics
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doi:10.1117/1.3524509
更新日期:2011-01-01 00:00:00
abstract::The present report addresses the application of surface plasmon resonance (SPR) phenomenon for urea sensing. The former promises a high sensitivity, label-free detection, and real-time information by monitoring the refractive index change at the metal–dielectric interface. In the present report, a highly sensitive ure...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
abstract::The objective of this work was to compare the accuracy of analyte concentration estimation when using transmission versus diffuse reflectance spectroscopy of a scattering medium. Monte Carlo ray tracing of light through the medium was used in conjunction with pure component absorption spectra and Beer-Lambert absorpti...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
abstract::Optical coherence tomography (OCT)-based elasticity imaging can map soft tissue elasticity based on speckle-tracking of elastic wave propagation using highly sensitive phase measurements of OCT signals. Using a fixed elastic wave source and moving detection, current imaging sequences have difficulty in reconstructing ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2016-11-01 00:00:00
abstract::We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal-oxide-semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.18.10.101303
更新日期:2013-10-01 00:00:00
abstract::Micrometer scale resolution full-field optical coherence tomography (FF-OCT) is developed for imaging human graft corneas. Three-dimensional (3-D) images with ultrahigh resolution (respectively, 1 and 1.5 μm in the axial and transverse directions), comparable to traditional histological sections, are obtained allowing...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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abstract::We present three-dimensional (3-D) in vivo photoacoustic (PA) images of the blood vasculature of a chicken chorioallantoic membrane (CAM) obtained by using a fiber-based noncontact PA tomography system. With a fiber-optic heterodyne interferometer, the system measures the surface displacement of a sample, induced by t...
journal_title:Journal of biomedical optics
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更新日期:2015-10-01 00:00:00
abstract::High-speed (video-rate) fluorescence lifetime imaging (FLIM) through a flexible endoscope is reported based on gated optical image intensifier technology. The optimization and potential application of FLIM to tissue autofluorescence for clinical applications are discussed. ...
journal_title:Journal of biomedical optics
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abstract::Reduction of optical scattering in turbid biological tissues using nonreactive chemical agents has potential applications for light-based diagnostics and therapeutics. Optical clearing effects by exogenous chemical agents, in particular sugars and sugar alcohols, have been found to be temporary with tissue rehydration...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
abstract::According to the valence asymmetry hypothesis, the left/right asymmetry of prefrontal cortex (PFC) activity is correlated with specific emotional responses to mental stress and personality traits. Here, we evaluated the relation between emotional state and asymmetry in PFC activity at rest by using near-infrared spect...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.19.2.027005
更新日期:2014-02-01 00:00:00
abstract::A quantification method to measure endocytosis was designed to assess cellular uptake and specificity of a targeting nanoparticle platform. A simple N -hydroxysuccinimide ester conjugation technique to functionalize 100-nm hollow silica nanoshell particles with fluorescent reporter fluorescein isothiocyanate and folat...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
abstract::Studies of bioluminescence in living animals, such as cell-based biosensor applications, require measurement of light at different wavelengths, but accurate light measurement is impeded by absorption by tissues at wavelengths<600 nm. We present a novel approach to this problem--the use of a plastic window in the skin/...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.2795567
更新日期:2007-09-01 00:00:00
abstract::Animal models are widely used to investigate the pathological mechanisms of spinal cord injury (SCI), most commonly in rats. It is well known that compromised blood flow caused by mechanical disruption of the vasculature can produce irreversible damage and cell death in hypoperfused tissue regions and spinal cord tiss...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.18.3.037005
更新日期:2013-03-01 00:00:00
abstract::Cardiac architecture is inherently three-dimensional, yet most characterizations rely on two-dimensional histological slices or dissociated cells, which remove the native geometry of the heart. We previously developed a method for labeling intact heart sections without dissociation and imaging large volumes while pres...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3200939
更新日期:2009-07-01 00:00:00
abstract::Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells (RBCs) as an endogenic contrast agent. However, intermittent RBC flow in capillaries res...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3251044
更新日期:2009-09-01 00:00:00
abstract::We address the automatic differentiation of human tissue using multispectral imaging with promising potential for automatic visualization during surgery. Currently, tissue types have to be continuously differentiated based on the surgeon's knowledge only. Further, automatic methods based on optical in vivo properties ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.23.9.091409
更新日期:2018-05-01 00:00:00
abstract::The acousto-optic deflector (AOD) is highly preferred in laser scanning microscopy for its fast scanning ability and random-addressing capability. However, its application in two-photon microscopy is frustrated by the dispersion of the AOD, which results in beam distortion and pulse lengthening. We report the analysis...
journal_title:Journal of biomedical optics
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更新日期:2012-07-01 00:00:00
abstract:UNLABELLED:Temperature changes caused by laser irradiation can promote damage to the surrounding dental tissues. In this study, we evaluated the temperature changes of recently extracted human mandibular incisors during intracanal irradiation with an 810-nm diode laser at different settings. Fifty mandibular incisors w...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3426310
更新日期:2010-05-01 00:00:00
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journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
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journal_title:Journal of biomedical optics
pub_type: 杂志文章
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