Subcellular imaging of epithelium with time-lapse optical coherence tomography.

abstract：:We compared light-induced fluorescence (LIF) to nominal injected drug dose for predicting the depth of necrosis response to photodynamic therapy (PDT) in a murine tumor model. Mice were implanted with radiation-induced fibrosarcoma (RIF) and were injected with 0, 5, or 10 mg/kg Photofrin. 630-nm light (30 J/cm(2), 75 ...

journal_title：Journal of biomedical optics

authors： Cheung R,Solonenko M,Busch TM,Del Piero F,Putt ME,Hahn SM,Yodh AG

更新日期：2003-04-01 00:00:00

abstract：:A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows ...

journal_title：Journal of biomedical optics

authors： El-Ghussein F,Mastanduno MA,Jiang S,Pogue BW,Paulsen KD

更新日期：2014-01-01 00:00:00

abstract：:For a long time, the antioxidative status in cattle has been discussed as an indicator for stress conditions resulting from disease or exertion. Until now, invasive approaches have been necessary to obtain blood samples or biopsy materials and gain insights into the antioxidative status of cattle. Due to these efforts...

journal_title：Journal of biomedical optics

authors： Klein J,Darvin ME,Müller KE,Lademann J

更新日期：2012-10-01 00:00:00

abstract：:Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenat...

journal_title：Journal of biomedical optics

authors： Gareau DS,Truffer F,Perry KA,Pham TH,Enestvedt CK,Dolan JP,Hunter JG,Jacques SL

更新日期：2010-11-01 00:00:00

abstract：:Autofluorescence of the cornea within specific wavelength region and dynamic light scattering measurements of ocular tissue have both been used for early-stage detection of the presence of diabetic retinopathy. In the present study, autofluorescence of the cornea and dynamic light scattering in the cornea and vitreous...

journal_title：Journal of biomedical optics

authors： Rovati L,Fankhauser F,Docchio F,Van Best J

更新日期：1998-07-01 00:00:00

abstract：:Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, the residual spectrum, the difference between the observed and modeled diffuse reflectance spectra, was attributed to single elastic light scattering from epithelial nucle...

journal_title：Journal of biomedical optics

authors： Lau C,Sćepanović O,Mirkovic J,McGee S,Yu CC,Fulghum S,Wallace M,Tunnell J,Bechtel K,Feld M

更新日期：2009-03-01 00:00:00

abstract：:In breast surgery, a lack of knowledge about what is below the tissue surface may lead to positive tumor margins and iatrogenic damage. Diffuse reflectance spectroscopy (DRS) is a spectroscopic technique that can distinguish between healthy and tumor tissue making it a suitable technology for intraoperative guidance. ...

journal_title：Journal of biomedical optics

authors： Adank MW,Fleischer JC,Dankelman J,Hendriks BHW

更新日期：2018-11-01 00:00:00

abstract：SIGNIFICANCE:Optical coherence tomography (OCT) has proven useful for detecting various oral maxillofacial abnormalities. To apply it to clinical applications including biopsy guidance and routine screening, a handheld imaging probe is indispensable. OCT probes reported for oral maxillofacial imaging were either based ...

journal_title：Journal of biomedical optics

authors： Li K,Yang Z,Liang W,Shang J,Liang Y,Wan S

更新日期：2020-04-01 00:00:00

abstract：:Second-harmonic generation (SHG) imaging can help reveal interactions between collagen fibers and cancer cells. Quantitative analysis of SHG images of collagen fibers is challenged by the heterogeneity of collagen structures and low signal-to-noise ratio often found while imaging collagen in tissue. The role of collag...

journal_title：Journal of biomedical optics

authors： Bredfeldt JS,Liu Y,Pehlke CA,Conklin MW,Szulczewski JM,Inman DR,Keely PJ,Nowak RD,Mackie TR,Eliceiri KW

更新日期：2014-01-01 00:00:00

abstract：:The erratum notes a correction to Fig. 5 for the published article. ...

journal_title：Journal of biomedical optics

authors： Mundo AI,Greening GJ,Fahr MJ,Hale LN,Bullard EA,Rajaram N,Muldoon TJ

更新日期：2020-04-01 00:00:00

abstract：:Inexpensive near-infrared microscopy (NIRM) was developed as a convenient technique to detect the medulla loss of scalp hair while reducing analytical time with easy sample preparation, leading to a field screening tool for breast cancer. NIRM has been evaluated as an alternative to synchrotron-based nanoscopy and to ...

journal_title：Journal of biomedical optics

authors： Choi Y,Jeong YJ,Jeon JG,Park SH,Choi HR,Kim JK

更新日期：2019-09-01 00:00:00

abstract：:Kinetics of optical tweezers (OT)-induced spontaneous aggregation and disaggregation of red blood cells (RBCs) were studied at the level of cell doublets to assess RBC interaction mechanics. Measurements were performed under in vitro conditions in plasma and fibrinogen and fibrinogen + albumin solutions. The RBC spont...

journal_title：Journal of biomedical optics

authors： Lee K,Kinnunen M,Khokhlova MD,Lyubin EV,Priezzhev AV,Meglinski I,Fedyanin AA

更新日期：2016-03-01 00:00:00

abstract：SIGNIFICANCE:The blood-brain barrier (BBB) is a major obstacle to detecting and treating brain tumors. Overcoming this challenge will facilitate the early and accurate detection of brain lesions and guide surgical resection of tumors. AIM:We generated an orthotopic brain tumor model that simulates the pathophysiology ...

journal_title：Journal of biomedical optics

authors： Habimana-Griffin L,Ye D,Carpenter J,Prior J,Sudlow G,Marsala L,Mixdorf M,Rubin J,Chen H,Achilefu S

更新日期：2020-02-01 00:00:00

abstract：:Metal nanoparticles can be functionalized with biomolecules to selectively localize in precancerous tissues and can act as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo (MC) simulations to analyze photon propagation through nanoparticle-labeled tissues and...

journal_title：Journal of biomedical optics

authors： Cihan C,Arifler D

更新日期：2011-08-01 00:00:00

abstract：:A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable co...

journal_title：Journal of biomedical optics

authors： Blazkiewicz P,Blazkiewicz K,Verhaege A,Anissimov YG,Roberts MS,Zvyagin AV

更新日期：2006-01-01 00:00:00

abstract：:Intracellular oxygen concentration is of primary importance in determining numerous physiological and pathological processes in biological systems. In this paper, we describe the application of the oxygen sensing indicator, ruthenium dibipyridine 4-(1"-pyrenyl)-2,2'-bipyridine chloride [Ru(bpy-pyr)(bpy)(2)], for molec...

journal_title：Journal of biomedical optics

authors： Ji J,Rosenzweig N,Jones I,Rosenzweig Z

更新日期：2002-07-01 00:00:00

abstract：:We examine the morphological and chemical changes in the pulp chamber dentin after using endodontic agents by scanning electron microscopy (SEM), Fourier transform Raman spectroscopy (FT-Raman), and micro energy-dispersive x-ray fluorescence spectrometry (μEDXRF). Thirty teeth were sectioned exposing the pulp chamber ...

journal_title：Journal of biomedical optics

authors： Pascon FM,Kantovitz KR,Soares LE,Santo AM,Martin AA,Puppin-Rontani RM

更新日期：2012-07-01 00:00:00

abstract：:High resolution is important for sensitive detection of subtle distortions of retinal morphology at an early stage of eye diseases. We demonstrate virtually structured detection (VSD) as a feasible method to achieve in vivo super-resolution ophthalmoscopy. A line-scanning strategy was employed to achieve a super-resol...

journal_title：Journal of biomedical optics

authors： Liu C,Zhi Y,Wang B,Thapa D,Chen Y,Alam M,Lu Y,Yao X

更新日期：2016-12-01 00:00:00

abstract：:We experimentally implement label-free phase microscopy using wide-field digital interferometry (WFDI) techniques to retrieve quantitative volumetric data of articular chondrocyte dynamics. Using the scanless interferometric system, we visualize chondrocyte swelling and bursting induced by hypo-osmotic pressure. Recon...

journal_title：Journal of biomedical optics

authors： Shaked NT,Finan JD,Guilak F,Wax A

更新日期：2010-01-01 00:00:00

abstract：:We have employed near-infrared optical methods to measure noninvasively the dynamics of muscle blood flow and oxygen saturation (StO2) during cuff occlusion and plantar flexion exercise. Relative muscle oxygen consumption (rVO2) was also computed from these data. Diffuse correlation spectroscopy provides information a...

journal_title：Journal of biomedical optics

authors： Yu G,Durduran T,Lech G,Zhou C,Chance B,Mohler ER 3rd,Yodh AG

更新日期：2005-03-01 00:00:00

abstract：:Autofluorescence-based imaging techniques have become very important in the ophthalmological field. Being noninvasive and very sensitive, they are broadly used in clinical routines. Conventional autofluorescence intensity imaging is largely influenced by the strong fluorescence of lipofuscin, a fluorophore that can be...

journal_title：Journal of biomedical optics

authors： Sauer L,Andersen KM,Dysli C,Zinkernagel MS,Bernstein PS,Hammer M

更新日期：2018-09-01 00:00:00

abstract：:Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mo...

journal_title：Journal of biomedical optics

authors： Jia Y,Alkayed N,Wang RK

更新日期：2009-07-01 00:00:00

abstract：:It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combin...

journal_title：Journal of biomedical optics

authors： Balakrishnan S,Bu R,Iftimia N,Price H,Zdanski C,Oldenburg AL

更新日期：2018-10-01 00:00:00

abstract：:We measure the tumor vascular response to varying irradiance rates during photodynamic therapy (PDT) in a Dunning rat prostate model with interstitial Doppler optical coherence tomography (IS-DOCT). Rats are given a photosensitizer drug, Photofrin, and the tumors are exposed to light (635 nm) with irradiance rates ran...

journal_title：Journal of biomedical optics

authors： Standish BA,Jin X,Smolen J,Mariampillai A,Munce NR,Wilson BC,Vitkin IA,Yang VX

更新日期：2007-05-01 00:00:00

abstract：:We investigate optoelectronic properties of integrated structures comprising semiconductor light-emitting materials for optical probes of microscopic biological systems. Compound semiconductors are nearly ideal light emitters for probing cells and other microorganisms because of their spectral match to the transparenc...

journal_title：Journal of biomedical optics

authors： Gourley PL,Copeland RG,Cox JD,Hendricks JK,McDonald AE,Peterson SL,Sasaki DY

更新日期：2002-10-01 00:00:00

abstract：:We present a novel confocal microscope that has dual-axis architecture and biaxial postobjective scanning for the collection of fluorescence images from biological specimens. This design uses two low-numerical-aperture lenses to achieve high axial resolution and long working distance, and the scanning mirror located d...

journal_title：Journal of biomedical optics

authors： Wang TD,Contag CH,Mandella MJ,Chan NY,Kino GS

更新日期：2004-07-01 00:00:00

abstract：:To improve surgical guidance toward prostate draining lymph nodes, we investigate the potential of intraoperative fluorescence imaging and combined pre- and intraoperative multimodality imaging approaches. Transgenic adenocarcinoma mouse prostate mice with spontaneous prostate tumors are injected intratumorally with: ...

journal_title：Journal of biomedical optics

authors： van Leeuwen AC,Buckle T,Bendle G,Vermeeren L,Valdés Olmos R,van de Poel HG,van Leeuwen FW

更新日期：2011-01-01 00:00:00

abstract：:Predicting the distribution of light inside any turbid media, such as biological tissue, requires detailed information about the optical properties of the medium, including the absorption and scattering coefficients and the anisotropy factor. Particularly, in biophotonic applications where photons directly interact wi...

journal_title：Journal of biomedical optics

authors： Azimipour M,Baumgartner R,Liu Y,Jacques SL,Eliceiri K,Pashaie R

更新日期：2014-01-01 00:00:00

abstract：:In this study we examine the implications of excitation saturation on fluorescence recovery after photobleaching (FRAP) experiments. In particular we present both experimental and theoretical evidence that fluorescein, one of the most frequently used fluorophores in FRAP, does not always comply with the basic assumpti...

journal_title：Journal of biomedical optics

authors： Braeckmans K,Stubbe BG,Remaut K,Demeester J,De Smedt SC

更新日期：2006-07-01 00:00:00

abstract：:Quantification of nicotinamide adenine dinucleotide (NADH) changes during functional brain activation and pathological conditions provides critical insight into brain metabolism. Of the different imaging modalities, two-photon laser scanning microscopy (TPLSM) is becoming an important tool for cellular-resolution meas...

journal_title：Journal of biomedical optics

authors： Baraghis E,Devor A,Fang Q,Srinivasan VJ,Wu W,Lesage F,Ayata C,Kasischke KA,Boas DA,Sakadzić S

更新日期：2011-10-01 00:00:00