Combined anatomical optical coherence tomography and intraluminal pressure reveal viscoelasticity of the in vivo airway.

abstract：:Peripheral nerve injury in vivo promotes a regenerative growth in vitro characterized by an improved neurite regrowth. Knowledge of the conditioning injury effects on both morphology and mechanical properties of live sensory neurons could be instrumental to understand the cellular and molecular mechanisms leading to t...

journal_title：Journal of biomedical optics

authors： Benzina O,Szabo V,Lucas O,Saab MB,Cloitre T,Scamps F,Gergely C,Martin M

更新日期：2013-10-01 00:00:00

abstract：:The advantages of using a telecentric imaging system in digital holographic microscopy (DHM) to study biological specimens are highlighted. To this end, the performances of nontelecentric DHM and telecentric DHM are evaluated from the quantitative phase imaging (QPI) point of view. The evaluated stability of the micro...

journal_title：Journal of biomedical optics

authors： Doblas A,Sánchez-Ortiga E,Martínez-Corral M,Saavedra G,Garcia-Sucerquia J

更新日期：2014-04-01 00:00:00

abstract：:We assess the properties of contact pressure applied by manually operated fiber-optic probes as a function of the operator, probe contact area, and sample stiffness. First, the mechanical properties of human skin sites with different skin structures, thicknesses, and underlying tissues were studied by in vivo indentat...

journal_title：Journal of biomedical optics

authors： Bregar M,Cugmas B,Naglic P,Hartmann D,Pernuš F,Likar B,Bürmen M

更新日期：2015-01-01 00:00:00

abstract：:Imaging technologies working in the spatial frequency domain are becoming increasingly popular for generating wide-field maps of optical properties, enabling rapid analysis of tissue parameters. While acquisition methods have become faster and are now performing in real-time, processing methods remain slow, precluding...

journal_title：Journal of biomedical optics

authors： Angelo J,Vargas CR,Lee BT,Bigio IJ,Gioux S

更新日期：2016-11-01 00:00:00

abstract：:Colorectal cancer is one of the most aggressive cancers usually occurring in people above the age of 50 years. In the United States, colorectal cancer is the third most diagnosed cancer. The American Cancer Society has estimated 96,830 new cases of colon cancer and 40,000 new cases of rectal cancer in 2014 in the Unit...

journal_title：Journal of biomedical optics

authors： Salman A,Sebbag G,Argov S,Mordechai S,Sahu RK

更新日期：2015-07-01 00:00:00

abstract：:Cellularity of the fibrous caps of coronary atheromas, manifested by the infiltration of macrophages (average size, 20 to 30 microm), is thought to weaken the structural integrity of the cap and predispose plaques to rupture. Therefore, an imaging technology capable of identifying macrophages within fibroatheroma caps...

journal_title：Journal of biomedical optics

authors： Tanaka A,Tearney GJ,Bouma BE

更新日期：2010-01-01 00:00:00

abstract：:We demonstrate the first application of Raman spectroscopy in diagnosing nonmalignant, premalignant, malignant, and metastatic stages of breast cancer in a three-dimensional (3-D) cell culture model that closely mimics an in vivo environment. Comprehensive study comparing classification in two-dimensional (2-D) and 3-...

journal_title：Journal of biomedical optics

authors： Damayanti NP,Fang Y,Parikh MR,Craig AP,Kirshner J,Irudayaraj J

更新日期：2013-11-01 00:00:00

abstract：SIGNIFICANCE:Spatial frequency domain imaging (SFDI) is an imaging modality that projects spatially modulated light patterns to determine optical property maps for absorption and reduced scattering of biological tissue via a pixel-by-pixel data acquisition and analysis procedure. Compressive sensing (CS) is a signal pr...

journal_title：Journal of biomedical optics

authors： Mellors BOL,Bentley A,Spear AM,Howle CR,Dehghani H

更新日期：2020-11-01 00:00:00

abstract：:Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in >25  %   of cases due to positive or closely involved margin...

journal_title：Journal of biomedical optics

authors： Schaefer JM,Barth CW,Davis SC,Gibbs SL

更新日期：2019-02-01 00:00:00

abstract：:Second-harmonic-generation (SHG) microscopy has emerged as a powerful tool to image unstained living tissues and probe their molecular and supramolecular organization. In this article, we review the physical basis of SHG, highlighting how coherent summation of second-harmonic response leads to the sensitivity of polar...

journal_title：Journal of biomedical optics

authors： Vanzi F,Sacconi L,Cicchi R,Pavone FS

更新日期：2012-06-01 00:00:00

abstract：:A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable co...

journal_title：Journal of biomedical optics

authors： Blazkiewicz P,Blazkiewicz K,Verhaege A,Anissimov YG,Roberts MS,Zvyagin AV

更新日期：2006-01-01 00:00:00

abstract：:In this work experimental tissue phantoms and numerical models were developed to estimate photon migration through the fetal head in utero. The tissue phantoms incorporate a fetal head within an amniotic fluid sac surrounded by a maternal tissue layer. A continuous wave, dual-wavelength (lambda = 760 and 850 nm) spect...

journal_title：Journal of biomedical optics

authors： Vishnoi G,Hielscher AH,Ramanujam N,Chance B

更新日期：2000-04-01 00:00:00

abstract：:Oral cancer is one of the most common cancers worldwide. One-fifth of the world's oral cancer subjects are from India and other South Asian countries. The present Raman mapping study was carried out to understand biochemical variations in normal and malignant oral buccal mucosa. Data were acquired using WITec alpha 30...

journal_title：Journal of biomedical optics

authors： Behl I,Kukreja L,Deshmukh A,Singh SP,Mamgain H,Hole AR,Krishna CM

更新日期：2014-12-01 00:00:00

abstract：:Doppler optical coherence tomography (DOCT) provides a novel method to measure blood flow velocity in vessels with diameter at micrometer scale. In this study, a developed spectral domain DOCT system is applied to monitor cerebral blood flow velocity changes in a rat. An animal model with a cranial window is used, and...

journal_title：Journal of biomedical optics

authors： Wang C,Yang Y,Ding Z,Meng J,Wang K,Yang W,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:The earliest steps of breast cancer begin with aberrations in mammary ductal structure. Techniques that enable an investigator to image in situ and then analyze the same tissue using biochemical tools facilitates identification of genetic networks and signaling pathways active in the imaged structure. Cellular confoca...

journal_title：Journal of biomedical optics

authors： Parrish A,Halama E,Tilli MT,Freedman M,Furth PA

更新日期：2005-09-01 00:00:00

abstract：:A new, simple, high-speed, and hardware-only integration-based fluorescence-lifetime-sensing algorithm using a center-of-mass method (CMM) is proposed to implement lifetime calculations, and its signal-to-noise-ratio based on statistics theory is also deduced. Compared to the commonly used iterative least-squares meth...

journal_title：Journal of biomedical optics

authors： Li DU,Rae B,Andrews R,Arlt J,Henderson R

更新日期：2010-01-01 00:00:00

abstract：:The spatiotemporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of alpha-chloralose-urethane anesthetized rats (n=10) with optical imaging at 570 nm through a thinned skull. Activation of the cortex was carried out by elect...

journal_title：Journal of biomedical optics

authors： Li P,Luo Q,Luo W,Chen S,Cheng H,Zeng S

更新日期：2003-10-01 00:00:00

abstract：:Blood smear analysis has remained a crucial diagnostic tool for pathologists despite the advent of automatic analyzers such as flow cytometers and impedance counters. Though these current methods have proven to be indispensible tools for physicians and researchers alike, they provide limited information on the detaile...

journal_title：Journal of biomedical optics

authors： Mir M,Ding H,Wang Z,Reedy J,Tangella K,Popescu G

更新日期：2010-03-01 00:00:00

abstract：:This study investigates the correlation of tumor blood oxygenation and tumor pO(2) with respect to carbogen inhalation. After having refined and validated the algorithms for calculating hemoglobin concentrations, we used near-infrared spectroscopy (NIRS) to measure changes of oxygenated hemoglobin concentration (delta...

journal_title：Journal of biomedical optics

authors： Kim JG,Zhao D,Song Y,Constantinescu A,Mason RP,Liu H

更新日期：2003-01-01 00:00:00

abstract：:We describe the use of a biochip based on complementary metal oxide semiconductor (CMOS) technology for detection of specific genetic sequences using molecular beacons (MB) immobilized on solid surfaces as probes. The applicability of this miniature detection system for screening for the BRCA1 gene is evaluated using ...

journal_title：Journal of biomedical optics

authors： Culha M,Stokes DL,Griffin GD,Vo-Dinh T

更新日期：2004-05-01 00:00:00

abstract：:Current diagnostic capabilities and limitations of fluorescence endomicroscopy in the cervix are assessed by qualitative and quantitative image analysis. Four cervical tissue types are investigated: normal columnar epithelium, normal and precancerous squamous epithelium, and stromal tissue. This study focuses on the p...

journal_title：Journal of biomedical optics

authors： Schlosser C,Bodenschatz N,Lam S,Lee M,McAlpine JN,Miller DM,Van Niekerk DJ,Follen M,Guillaud M,MacAulay CE,Lane PM

更新日期：2016-12-01 00:00:00

abstract：:We describe the protocol for an inexpensive and nondestructive optical reflectance assay for the measurement of biofilm formation. Reflectance data are obtained using an Ocean Optics (Dunedin, Florida) USB 2000 spectrometer with a polychromatic light source. A fiber optic cable is used both for illumination and collec...

journal_title：Journal of biomedical optics

authors： Broschat SL,Loge FJ,Peppin JD,White D,Call DR,Kuhn E

更新日期：2005-07-01 00:00:00

abstract：:The area of in vivo sensing using optical fibers commonly uses materials such as silica and polymethyl methacrylate, both of which possess much higher modulus than human tissue. The mechanical mismatch between materials and living tissue has been seen to cause higher levels of glial encapsulation, scarring, and inflam...

journal_title：Journal of biomedical optics

authors： McMillan S,Rader C,Jorfi M,Pickrell G,Foster EJ

更新日期：2017-02-01 00:00:00

abstract：:Toward developing a new method for restoring tissue viscoelasticity in scarred vocal folds, we previously proposed a method to localize biomaterials within subepithelial voids ablated using ultrafast laser pulses. The clinical implementation of this method necessitates the quantification of the laser parameters for ab...

journal_title：Journal of biomedical optics

authors： Yildirim M,Ferhanoglu O,Kobler J,Zeitels SM,Ben-Yakar A

更新日期：2013-11-01 00:00:00

abstract：:Three-dimensional (3-D) tissue imaging offers substantial benefits to a wide range of biomedical investigations from cardiovascular biology, diabetes, Alzheimer's disease to cancer. Two-photon tissue cytometry is a novel technique based on high-speed multiphoton microscopy coupled with automated histological sectionin...

journal_title：Journal of biomedical optics

authors： Ragan T,Sylvan JD,Kim KH,Huang H,Bahlmann K,Lee RT,So PT

更新日期：2007-01-01 00:00:00

abstract：:We describe the implementation and use of an adaptive optics loop in the imaging path of a commercial wide field microscope. We show that it is possible to maintain the optical performances of the original microscope when imaging through aberrant biological samples. The sources used for illuminating the adaptive optic...

journal_title：Journal of biomedical optics

authors： Vermeulen P,Muro E,Pons T,Loriette V,Fragola A

更新日期：2011-07-01 00:00:00

abstract：:The reflection and transmission of coherent light from a biological system can yield information about its condition. In the case of blood exposed to the air, there is a change in the properties of the speckle patterns observed in the coagulation process. This can be studied by means of the rate of temporal variation,...

journal_title：Journal of biomedical optics

authors： Yokoi N,Aizu Y,Uozumi J

更新日期：2018-12-01 00:00:00

abstract：:A side-viewing, 2.3-mm diameter, surface magnifying chromoendoscopy-optical coherence tomography (SMC-OCT) endoscope has been designed for simultaneous, nondestructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of the mouse colon. A 30,000 element fib...

journal_title：Journal of biomedical optics

authors： Wall RA,Barton JK

更新日期：2012-08-01 00:00:00

abstract：:The erratum notes a correction to Fig. 5 for the published article. ...

journal_title：Journal of biomedical optics

authors： Mundo AI,Greening GJ,Fahr MJ,Hale LN,Bullard EA,Rajaram N,Muldoon TJ

更新日期：2020-04-01 00:00:00

abstract：:Blood, being a suspension of deformable red cells suspended in plasma, displays flow dynamics considerably more complicated than those of an ideal Newtonian fluid. Flow dynamics in blood capillaries of a few hundred micrometers in diameter are investigated using Doppler optical coherence tomography (DOCT) and Doppler ...

journal_title：Journal of biomedical optics

authors： Moger J,Matcher SJ,Winlove CP,Shore A

更新日期：2004-09-01 00:00:00