Abstract:
:A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable continuous in vivo drug sensing, removing the necessity for complex microdialysis systems. We use a biological phantom to examine the reliable detection of a fluorescence signal from small dye molecules in the presence of large fluorophores and scatterers. We find that spectral artefacts arising from scatterers and large fluorophores are substantially suppressed, simplifying the spectral analysis. In addition, the measured sampling rate of 157 s is superior to existing in vivo tissue assaying techniques such as microdialysis, which can take tens of minutes.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Blazkiewicz P,Blazkiewicz K,Verhaege A,Anissimov YG,Roberts MS,Zvyagin AVdoi
10.1117/1.2166086subject
Has Abstractpub_date
2006-01-01 00:00:00pages
014033issue
1eissn
1083-3668issn
1560-2281journal_volume
11pub_type
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