Real-time full-field photoacoustic imaging using an ultrasonic camera.

abstract：SIGNIFICANCE:A noninvasive method based on surface-enhanced Raman spectroscopy (SERS) of tears was proposed as a support for diagnosing neurodegenerative pathologies, including different forms of dementia and Alzheimer's disease (AD). In this field, timely and reliable discrimination and diagnosis are critical aspects ...

journal_title：Journal of biomedical optics

authors： Cennamo G,Montorio D,Morra VB,Criscuolo C,Lanzillo R,Salvatore E,Camerlingo C,Lisitskiy M,Delfino I,Portaccio M,Lepore M

更新日期：2020-08-01 00:00:00

abstract：:Near-infrared spectroscopy is a novel imaging technique potentially sensitive to both brain hemodynamics (slow signal) and neuronal activity (fast optical signal, FOS). The big challenge of measuring FOS noninvasively lies in the presumably low signal-to-noise ratio. Thus, detectability of the FOS has been controversi...

journal_title：Journal of biomedical optics

authors： Medvedev AV,Kainerstorfer JM,Borisov SV,Gandjbakhche AH,Vanmeter J

更新日期：2010-11-01 00:00:00

abstract：:A synchrotron light source dedicated to medical applications has been designed at National Institute of Radiological Sciences. The storage ring, with circumference of 80 m, is designed for acceleration of 2.3 GeV and a stored current of 420 mA. It is equipped with two multipole wigglers to produce sufficient photon fl...

journal_title：Journal of biomedical optics

authors： Torikoshi M,Tsunoo T,Endo M,Noda K,Kumada M,Yamada S,Soga F,Hyodo K

更新日期：2001-07-01 00:00:00

abstract：:So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of dise...

journal_title：Journal of biomedical optics

authors： Shan H,Liang Y,Wang J,Li Y

更新日期：2012-11-01 00:00:00

abstract：:The present work describes the fabrication and characterization of an optical fiber pH sensor using a sol–gel technique. The sensing head configuration is incorporated using a short section of no-core fiber, coated with tetraethyl orthosilicate and spliced at the end of a single mode fiber with a bulge. Different type...

journal_title：Journal of biomedical optics

authors： Bhardwaj V,Pathak AK,Singh VK

更新日期：2017-05-01 00:00:00

abstract：:The tissue metabolic rate of oxygen consumption (tMRO2) is a clinically relevant marker for a number of pathologies including cancer and arterial occlusive disease. We present and validate a noncontact method for quantitatively mapping tMRO2 over a wide, scalable field of view at 16  frames  /  s. We achieve this by d...

journal_title：Journal of biomedical optics

authors： Ghijsen M,Lentsch GR,Gioux S,Brenner M,Durkin AJ,Choi B,Tromberg BJ

更新日期：2018-03-01 00:00:00

abstract：:Diffusion of therapeutic macromolecules through the extracellular matrix of tumor tissue is a crucial step in drug delivery. We use fluorescence correlation spectroscopy (FCS) to measure diffusion of IgG (150 kDa) and dextrans (155 kDa and 2 MDa) in solution, 5% gelatin hydrogel, and multicellular spheroids. Gel and s...

journal_title：Journal of biomedical optics

authors： Reitan NK,Juthajan A,Lindmo T,de Lange Davies C

更新日期：2008-09-01 00:00:00

abstract：:Immersion optical clearing makes it possible to use transmission polarized-light microscopy for characterization of thick (200 to 2000  μm) layers of biological tissues. We discuss polarization properties of thick samples in the context of the problem of characterization of collagen fiber alignment in connective tissu...

journal_title：Journal of biomedical optics

authors： Yakovlev DD,Shvachkina ME,Sherman MM,Spivak AV,Pravdin AB,Yakovlev DA

更新日期：2016-07-01 00:00:00

abstract：:It is hypothesized that the local, viscoelastic (time-dependent) properties of the airway are important to accurately model and ultimately predict dynamic airway collapse in airway obstruction. Toward this end, we present a portable, endoscopic, swept-source anatomical optical coherence tomography (aOCT) system combin...

journal_title：Journal of biomedical optics

authors： Balakrishnan S,Bu R,Iftimia N,Price H,Zdanski C,Oldenburg AL

更新日期：2018-10-01 00:00:00

abstract：:We develop a label-free optical technique to image and discriminate undifferentiated human embryonic stem cells (hESCs) from their differentiating progenies in vitro. Using intrinsic cellular fluorophores, we perform fluorescence lifetime microscopy (FLIM) and phasor analysis to obtain hESC metabolic signatures. We id...

journal_title：Journal of biomedical optics

authors： Stringari C,Sierra R,Donovan PJ,Gratton E

更新日期：2012-04-01 00:00:00

abstract：:Pedicle screw (PS) fixation has been widely used for spine diseases. Scientists and clinicians employ several approaches to navigate PS during operation. We have demonstrated the feasibility of monitoring the reduced scattering coefficient (μ's) on the trajectory of PS using near-infrared spectroscopy (NIRS). To perfo...

journal_title：Journal of biomedical optics

authors： Liu Y,Wang Y,Qian Z,Zhao J,Cao X,Li W

更新日期：2014-01-01 00:00:00

abstract：:The essential feature of the confocal laser scanning microscope (cLSM) is the generation of optical sections by the removal of out-of-focus light. About ten years ago, structured illumination microscopy (SIM) was introduced as an alternative method for obtaining optical sections from biological specimens. Here we comp...

journal_title：Journal of biomedical optics

authors： Weigel A,Schild D,Zeug A

更新日期：2009-01-01 00:00:00

abstract：SIGNIFICANCE:Adaptive optics optical coherence tomography (AO-OCT) technology enables non-invasive, high-resolution three-dimensional (3D) imaging of the retina and promises earlier detection of ocular disease. However, AO-OCT data are corrupted by eye-movement artifacts that must be removed in post-processing, a proce...

journal_title：Journal of biomedical optics

authors： Kurokawa K,Crowell JA,Do N,Lee JJ,Miller DT

更新日期：2021-01-01 00:00:00

abstract：:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced ...

journal_title：Journal of biomedical optics

authors： Yeh C,Hu S,Maslov K,Wang LV

更新日期：2012-07-01 00:00:00

abstract：:We report noninvasive, in vivo optical imaging deep within a mouse brain by swept-source optical coherence tomography (SS-OCT), enabled by a 1.3-μm vertical cavity surface emitting laser (VCSEL). VCSEL SS-OCT offers a constant signal sensitivity of 105 dB throughout an entire depth of 4.25 mm in air, ensuring an exten...

journal_title：Journal of biomedical optics

authors： Choi WJ,Wang RK

更新日期：2015-10-01 00:00:00

abstract：:The metabolic rate of oxygen consumption, an important indicator of tissue metabolism, can be expressed as the change of net blood oxygen flux into and out of a tissue region per 100 g of tissue. In this work, we propose a photoacoustic and Doppler ultrasound method for imaging local blood oxygen flux of a single vess...

journal_title：Journal of biomedical optics

authors： Jiang Y,Forbrich A,Harrison T,Zemp RJ

更新日期：2012-03-01 00:00:00

abstract：:Surgical nerve damage due to difficulty with identification remains a major risk for postsurgical complications and decreased quality of life. Fluorescence-guided surgery offers a means to specifically highlight tissues of interest such as nerves and a number of fluorescence-guided surgical systems are in clinical tri...

journal_title：Journal of biomedical optics

authors： Korber J,Barth C,Gibbs S

更新日期：2018-07-01 00:00:00

abstract：:The epithelium (EP) thickness and the standard deviation (SD) of A-mode scan intensity in the laminar propria (LP) layer are used as effective indicators for the diagnosis of oral submucous fibrosis (OSF) based on the noninvasive clinical scanning of a swept-source optical coherence tomography (OCT) system of approxim...

journal_title：Journal of biomedical optics

authors： Lee CK,Tsai MT,Lee HC,Chen HM,Chiang CP,Wang YM,Yang CC

更新日期：2009-09-01 00:00:00

abstract：:Photospallation is proposed as the primary mechanism behind our recent animal studies involving corneal ablation by nanosecond-pulse mid-IR laser beams. Following a brief summary of earlier work directed to refractive procedures in the mid-IR, a preliminary analysis is presented, based on simple one-dimensional models...

journal_title：Journal of biomedical optics

authors： Hoffman HJ,Telfair WB

更新日期：1999-10-01 00:00:00

abstract：:Most reconstruction algorithms used in photoacoustic tomography do not account for the effects of acoustic attenuation on the recorded signals. For experimental measurements made in biological tissue, the frequency dependent acoustic attenuation causes high frequency components of the propagating photoacoustic waves t...

journal_title：Journal of biomedical optics

authors： Treeby BE

更新日期：2013-03-01 00:00:00

abstract：:The earliest steps of breast cancer begin with aberrations in mammary ductal structure. Techniques that enable an investigator to image in situ and then analyze the same tissue using biochemical tools facilitates identification of genetic networks and signaling pathways active in the imaged structure. Cellular confoca...

journal_title：Journal of biomedical optics

authors： Parrish A,Halama E,Tilli MT,Freedman M,Furth PA

更新日期：2005-09-01 00:00:00

abstract：:Polarized Raman spectroscopy allows measurement of molecular orientation and composition and is widely used in the study of polymer systems. Here, we extend the technique to the extraction of quantitative orientation information from bone tissue, which is optically thick and highly turbid. We discuss multiple scatteri...

journal_title：Journal of biomedical optics

authors： Raghavan M,Sahar ND,Wilson RH,Mycek MA,Pleshko N,Kohn DH,Morris MD

更新日期：2010-05-01 00:00:00

abstract：:Studies of bioluminescence in living animals, such as cell-based biosensor applications, require measurement of light at different wavelengths, but accurate light measurement is impeded by absorption by tissues at wavelengths<600 nm. We present a novel approach to this problem--the use of a plastic window in the skin/...

journal_title：Journal of biomedical optics

authors： Huang Q,Acha V,Yow R,Schneider E,Sardar DK,Hornsby PJ

更新日期：2007-09-01 00:00:00

abstract：:The reflection and transmission of coherent light from a biological system can yield information about its condition. In the case of blood exposed to the air, there is a change in the properties of the speckle patterns observed in the coagulation process. This can be studied by means of the rate of temporal variation,...

journal_title：Journal of biomedical optics

authors： Yokoi N,Aizu Y,Uozumi J

更新日期：2018-12-01 00:00:00

abstract：:We employ Fourier-transform Raman spectroscopy to study normal and tumoral human breast tissues, including several subtypes of cancers. We analyzed 194 Raman spectra from breast tissues that were separated into 9 groups according to their corresponding histopathological diagnosis. The assignment of the relevant Raman ...

journal_title：Journal of biomedical optics

authors： Bitar RA,Martinho Hda S,Tierra-Criollo CJ,Zambelli Ramalho LN,Netto MM,Martin AA

更新日期：2006-09-01 00:00:00

abstract：:A side-viewing, 2.3-mm diameter, surface magnifying chromoendoscopy-optical coherence tomography (SMC-OCT) endoscope has been designed for simultaneous, nondestructive surface fluorescence visualization and cross-sectional imaging. We apply this endoscope to in vivo examination of the mouse colon. A 30,000 element fib...

journal_title：Journal of biomedical optics

authors： Wall RA,Barton JK

更新日期：2012-08-01 00:00:00

abstract：:Muscle blood flow (MBF) and muscle oxygen saturation (SmO(2)) were measured at eight locations (four proximal, four distal) over a 4 x 8 cm(2) area of the vastus lateralis at rest and immediately after isometric, maximal quadriceps contraction using multichannel, frequency-domain, near-infrared spectroscopy. A venous ...

journal_title：Journal of biomedical optics

authors： Quaresima V,Ferrari M,Franceschini MA,Hoimes ML,Fantini S

更新日期：2004-03-01 00:00:00

abstract：:Invasive brain cancer cells cannot be visualized during surgery and so they are often not removed. These residual cancer cells give rise to recurrences.

journal_title：Journal of biomedical optics

authors： Jermyn M,Desroches J,Mercier J,Tremblay MA,St-Arnaud K,Guiot MC,Petrecca K,Leblond F

更新日期：2016-09-01 00:00:00

abstract：:Prolonged excitation of fluorescent probes leads eventually to loss of their capacity to emit light. A decrease in the number of detected photons reduces subsequently the resolving power of a fluorescence microscope. Adverse effects of fluorescence intensity loss on the quality of microscopic images of biological spec...

journal_title：Journal of biomedical optics

authors： Bernas T,Robinson JP,Asem EK,Rajwa B

更新日期：2005-11-01 00:00:00

abstract：:Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, curre...

journal_title：Journal of biomedical optics

authors： Petitdidier N,Koenig A,Gerbelot R,Grateau H,Gioux S,Jallon P

更新日期：2018-11-01 00:00:00