Abstract:
:We report noninvasive, in vivo optical imaging deep within a mouse brain by swept-source optical coherence tomography (SS-OCT), enabled by a 1.3-μm vertical cavity surface emitting laser (VCSEL). VCSEL SS-OCT offers a constant signal sensitivity of 105 dB throughout an entire depth of 4.25 mm in air, ensuring an extended usable imaging depth range of more than 2 mm in turbid biological tissue. Using this approach, we show deep brain imaging in mice with an open-skull cranial window preparation, revealing intact mouse brain anatomy from the superficial cerebral cortex to the deep hippocampus. VCSEL SS-OCT would be applicable to small animal studies for the investigation of deep tissue compartments in living brains where diseases such as dementia and tumor can take their toll.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Choi WJ,Wang RKdoi
10.1117/1.JBO.20.10.106004subject
Has Abstractpub_date
2015-10-01 00:00:00pages
106004issue
10eissn
1083-3668issn
1560-2281pii
2458790journal_volume
20pub_type
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