Computer model to investigate the effect of eye movements on retinal heating during long-duration fixation on a laser source.

abstract：:Spasticity is a motor disorder frequently present in individuals with cerebral palsy (CP). This study aimed to evaluate the effect of low-level laser therapy (LLLT) on the spasticity of the masseter and anterior temporal muscle fibers in children with CP over three weeks of intermittent laser exposures. The bite force...

journal_title：Journal of biomedical optics

authors： Santos MT,Diniz MB,Gouw-Soares SC,Lopes-Martins RA,Frigo L,Baeder FM

更新日期：2016-02-01 00:00:00

abstract：:Optically sectioned detection of fluorescence immunoassays using a confocal microscope enables the creation of both homo- and heterogeneous planar format assays. We report a set assays requiring optically sectioned detection using a model system and analysis procedures for separating signals of a surface layer from an...

journal_title：Journal of biomedical optics

authors： Ghafari H,Zhou Y,Ali S,Hanley QS

更新日期：2009-11-01 00:00:00

abstract：:Autofluorescence, the endogenous fluorescence present in cells and tissues, has historically been considered a nuisance in biomedical imaging. Many endogenous fluorophores, specifically, collagen, elastin, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide (FAD), are found throughout the human body. In...

journal_title：Journal of biomedical optics

authors： Deal J,Mayes S,Browning C,Hill S,Rider P,Boudreaux C,Rich TC,Leavesley SJ

更新日期：2018-12-01 00:00:00

abstract：:Biomedical applications of terahertz (THz) radiation are appealing because THz radiation is nonionizing and has the demonstrated ability to detect intrinsic contrasts between cancerous and normal tissue. A linear polarization-sensitive detection technique for tumor margin delineation has already been demonstrated; how...

journal_title：Journal of biomedical optics

authors： Martin JP,Joseph CS,Giles RH

更新日期：2016-07-01 00:00:00

abstract：:Computer simulation is used to facilitate the design of fiber-probe geometries that enable enhanced detection of optical signals arising from specific tissue depths. Obtaining understanding of the relationship between fiber-probe design and tissue interrogation is critical when developing strategies for optical detect...

journal_title：Journal of biomedical optics

authors： Wang AM,Bender JE,Pfefer J,Utzinger U,Drezek RA

更新日期：2005-07-01 00:00:00

abstract：:Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements....

journal_title：Journal of biomedical optics

authors： Churmakov DY,Meglinski IV,Greenhalgh DA

更新日期：2004-03-01 00:00:00

abstract：:This study introduces a single-channel optical video stereomicroscope based on a transparent rotating deflector (TRD) for high-resolution and high-magnification stereomicroscopy. The existing stereomicroscopes have some limitations, such as limited resolution and magnification, fixed optical channel, and the necessity...

journal_title：Journal of biomedical optics

authors： Radfar E,Park J,Jung B

更新日期：2016-12-01 00:00:00

abstract：:We present three-dimensional (3-D) high-resolution spectral-domain optical coherence microscopy (SD-OCM) by using a supercontinuum (SC) fiber laser source with 300-nm spectral bandwidth (full-width at half-maximum) in the 1700-nm spectral band. By using low-coherence interferometry with SC light and a confocal detecti...

journal_title：Journal of biomedical optics

authors： Yamanaka M,Hayakawa N,Nishizawa N

更新日期：2019-07-01 00:00:00

abstract：:Discrete form sensitivity functions are derived for a number of measurement types employed in autocorrelation-based ultrasound-modulated optical tomography. The Jacobian for a particular problem is constructed from the set of such sensitivity functions arising from a raster scan of a focused ultrasound field through a...

journal_title：Journal of biomedical optics

authors： Powell S,Leung TS

更新日期：2013-12-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a potential clinical tool for enamel lesion monitoring. Swept-source OCT findings were compared with cross-sectional nanohardness findings of enamel. Subsurface bovine enamel lesions in three groups were subjected to (1) deionized water (control), (2) phosphoryl oligosaccharide of...

journal_title：Journal of biomedical optics

authors： Mandurah MM,Sadr A,Shimada Y,Kitasako Y,Nakashima S,Bakhsh TA,Tagami J,Sumi Y

更新日期：2013-04-01 00:00:00

abstract：:Most ovarian cancers are diagnosed at advanced stages due to the lack of efficacious screening techniques. Photoacoustic tomography (PAT) has a potential to image tumor angiogenesis and detect early neovascular changes of the ovary. We have developed a coregistered PAT and ultrasound (US) prototype system for real-tim...

journal_title：Journal of biomedical optics

authors： Salehi HS,Li H,Merkulov A,Kumavor PD,Vavadi H,Sanders M,Kueck A,Brewer MA,Zhu Q

更新日期：2016-04-30 00:00:00

abstract：:Functional near-infrared spectroscopy (fNIRS), acquired simultaneously with electroencephalography (EEG), allows the investigation of hemodynamic brain responses to epileptic activity. Because the presumed epileptogenic focus is patient-specific, an appropriate source/detector (SD) montage has to be reconfigured for e...

journal_title：Journal of biomedical optics

authors： Machado A,Marcotte O,Lina JM,Kobayashi E,Grova C

更新日期：2014-02-01 00:00:00

abstract：:The study of red blood cell (RBC) aggregation is of great interest because of its implications for human health. Altered RBC aggregation can lead to microcirculatory problems as in vascular pathologies, such as hypertension and diabetes, due to a decrease in the erythrocyte surface electric charge and an increase in t...

journal_title：Journal of biomedical optics

authors： Toderi MA,Castellini HV,Riquelme BD

更新日期：2017-01-01 00:00:00

abstract：:The fibrillar collagen network in tumor and normal tissues is different due to remodeling of the extracellular matrix during the malignant process. Collagen type I fibers have the crystalline and noncentrosymmetric properties required for generating the second-harmonic signal. The content and structure of collagen wer...

journal_title：Journal of biomedical optics

authors： Hompland T,Erikson A,Lindgren M,Lindmo T,de Lange Davies C

更新日期：2008-09-01 00:00:00

abstract：:Raman spectroscopy on single, living epithelial cells captured in a laser trap is shown to have diagnostic power over colorectal cancer. This new single-cell technology comprises three major components: primary culture processing of human tissue samples to produce single-cell suspensions, Raman detection on singly tra...

journal_title：Journal of biomedical optics

authors： Zheng F,Qin Y,Chen K

更新日期：2007-05-01 00:00:00

abstract：:Intracellular oxygen concentration is of primary importance in determining numerous physiological and pathological processes in biological systems. In this paper, we describe the application of the oxygen sensing indicator, ruthenium dibipyridine 4-(1"-pyrenyl)-2,2'-bipyridine chloride [Ru(bpy-pyr)(bpy)(2)], for molec...

journal_title：Journal of biomedical optics

authors： Ji J,Rosenzweig N,Jones I,Rosenzweig Z

更新日期：2002-07-01 00:00:00

abstract：:We describe a wide-field optical tomography technique, which allows the measurement-guided optimization of illumination patterns for enhanced reconstruction performances. The iterative optimization of the excitation pattern aims at reducing the dynamic range in photons transmitted through biological tissue. It increas...

journal_title：Journal of biomedical optics

authors： Venugopal V,Intes X

更新日期：2013-03-01 00:00:00

abstract：:Optical fiber technology has significantly bolstered the growth of photonics applications in basic life sciences research and in biomedical diagnosis, therapy, monitoring, and surgery. The unique operational characteristics of diverse fibers have been exploited to realize advanced biomedical functions in areas such as...

journal_title：Journal of biomedical optics

authors： Keiser G,Xiong F,Cui Y,Shum PP

更新日期：2014-08-01 00:00:00

abstract：:In the present applications of optical coherence tomography (OCT), parameters besides pure morphology are evaluated in skin tissue under in vivo conditions. Spatially mapped refractive indices and scattering coefficients may support tissue characterization for research and diagnostic purposes in cosmetics/pharmacy and...

journal_title：Journal of biomedical optics

authors： Knüttel A,Boehlau-Godau M

更新日期：2000-01-01 00:00:00

abstract：:A method is proposed for determining the glucose concentration on the human fingertip by extracting two optical parameters, namely the optical rotation angle and the depolarization index, using a Mueller optical coherence tomography technique and a genetic algorithm. The feasibility of the proposed method is demonstra...

journal_title：Journal of biomedical optics

authors： Chen TL,Lo YL,Liao CC,Phan QH

更新日期：2018-04-01 00:00:00

abstract：:Penetration profiles of topically applied drugs and cosmetic products provide important information on their efficacy. The application of tape stripping in combination with UV/VIS spectroscopy is checked to determine the local position of topically applied substances inside the stratum corneum, the penetration profile...

journal_title：Journal of biomedical optics

authors： Weigmann HJ,Jacobi U,Antoniou C,Tsikrikas GN,Wendel V,Rapp C,Gers-Barlag H,Sterry W,Lademann J

更新日期：2005-01-01 00:00:00

abstract：:A real-time photoacoustic imaging system is designed and built. This system is based on a commercially available ultrasound imaging system. It can achieve a frame rate of 8 frames/sec. Vasculature in the hand of a human volunteer is imaged, and the resulting photoacoustic image is combined with the ultrasound image. T...

journal_title：Journal of biomedical optics

authors： Kolkman RG,Brands PJ,Steenbergen W,van Leeuwen TG

更新日期：2008-09-01 00:00:00

abstract：:Optical coherence tomography (OCT) provides more parameters than pure morphology does. In a recent paper [A. Knuettel and M. Boehlau-Godau, J. Biomed. Opt. 5(1) 83-92 (2000)] we have shown that the refractive index (RI) can be evaluated in a localized manner in skin tissue under in vivo conditions. Based on a theory, ...

journal_title：Journal of biomedical optics

authors： Knüttel A,Bonev S,Knaak W

更新日期：2004-03-01 00:00:00

abstract：:Blood, being a suspension of deformable red cells suspended in plasma, displays flow dynamics considerably more complicated than those of an ideal Newtonian fluid. Flow dynamics in blood capillaries of a few hundred micrometers in diameter are investigated using Doppler optical coherence tomography (DOCT) and Doppler ...

journal_title：Journal of biomedical optics

authors： Moger J,Matcher SJ,Winlove CP,Shore A

更新日期：2004-09-01 00:00:00

abstract：:A new imaging approach, structured light scatteroscopy (SLS), is demonstrated, which offers rapid wide-field imaging of microscopic morphological variations in bulk tissue surfaces. Elastic scattering of light offers exquisite sensitivity to ultrastructural changes at multiple size scales ranging from nanometers to mi...

journal_title：Journal of biomedical optics

authors： Krishnaswamy V,Elliott JT,McClatchy DM 3rd,Barth RJ Jr,Wells WA,Pogue BW,Paulsen KD

更新日期：2014-01-01 00:00:00

abstract：:Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) w...

journal_title：Journal of biomedical optics

authors： Jia Y,An L,Wang RK

更新日期：2009-09-01 00:00:00

abstract：:Lihong V. Wang summarizes his tenure as Editor-in-Chief of the Journal of Biomedical Optics and introduces his successor, Brian Pogue, who will assume the role in January 2018. ...

journal_title：Journal of biomedical optics

authors： Wang V

更新日期：2017-10-04 00:00:00

abstract：:Optical spectroscopy has shown potential as a real-time, in vivo, diagnostic tool for identifying neoplasia during endoscopy. We present the development of a diagnostic algorithm to classify elastic-scattering spectroscopy (ESS) spectra as either neoplastic or non-neoplastic. The algorithm is based on pattern recognit...

journal_title：Journal of biomedical optics

authors： Rodriguez-Diaz E,Castanon DA,Singh SK,Bigio IJ

更新日期：2011-06-01 00:00:00

abstract：:In part I of the study, two attachment systems [O-ring; bar-clip (BC)] were used, and the system with three individualized O-rings provided the lowest stress on the implants and the support tissues. Therefore, the aim of this study was to assess the stress distribution, through the photoelastic method, on implant-reta...

journal_title：Journal of biomedical optics

authors： Pesqueira AA,Goiato MC,da Silva EV,Haddad MF,Moreno A,Zahoui A,dos Santos DM

更新日期：2014-06-01 00:00:00

abstract：:Treatment of deep venous thrombosis (DVT)--a primary cause of potentially fatal pulmonary embolism (PE)--depends on the age of the thrombus. The existing clinical imaging methods are capable of visualizing a thrombus but cannot determine the age of the blood clot. Therefore, there is a need for an imaging technique to...

journal_title：Journal of biomedical optics

authors： Karpiouk AB,Aglyamov SR,Mallidi S,Shah J,Scott WG,Rubin JM,Emelianov SY

更新日期：2008-09-01 00:00:00