Shining Future of Biomedical Optics

abstract：:Our aim is the development of a simple optical method for pulse wave profile, pulse wave delay time, and blood flow measurement. The method is based on recording the Doppler frequency shift related to a moving target--blood vessel walls or small particles. The Doppler signal is detected using the self-mixing that occu...

journal_title：Journal of biomedical optics

authors： Meigas K,Hinrikus H,Kattai R,Lass J

更新日期：2003-01-01 00:00:00

abstract：:Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c...

journal_title：Journal of biomedical optics

authors： Sorensen LC,Leung TS,Greisen G

更新日期：2008-11-01 00:00:00

abstract：:Higher-order optical errors of the human eye are often responsible for reduced visual acuity in spite of an optimal spherical or cylindrical refraction. These optical aberrations are of natural origin or can result from operations in the eye that involve optical structures. The ocular aberrometer presented is based on...

journal_title：Journal of biomedical optics

authors： Mierdel P,Kaemmerer M,Mrochen M,Krinke HE,Seiler T

更新日期：2001-04-01 00:00:00

abstract：:This paper explains the term low-coherence interferometry, reviews the early development of optical low-coherence reflectometry, and shows some of the paths that led to the field of biomedical optics. This paper demonstrates that early technical developments in the telecommunications industry resulted in a myriad of t...

journal_title：Journal of biomedical optics

authors： Masters BR

更新日期：1999-04-01 00:00:00

abstract：:A model that describes the concentration of photothermal (light-to-heat converters) compounds as a function of depth in a turbid medium is developed. The system consists of a pump laser (808 nm modulated at 400 Hz), which heats a photothermal compound, and a phase sensitive spectral domain optical coherence tomography...

journal_title：Journal of biomedical optics

authors： Guan G,Reif R,Huang Z,Wang RK

更新日期：2011-12-01 00:00:00

abstract：:Traditional phase-resolved Doppler optical coherence tomography (DOCT) has been reported to have potential for characterizing local fluid flow within a microporous scaffold. In this work, we apply Doppler optical microangiography (DOMAG), a new imaging technique developed by combining optical microangiography (OMAG) w...

journal_title：Journal of biomedical optics

authors： Jia Y,An L,Wang RK

更新日期：2009-09-01 00:00:00

abstract：:Radiotherapy is one of the main methods to treat cancer. However, due to the propagation pattern of high-energy photons in tissue and their inability to discriminate between healthy and malignant tissues, healthy tissues may also be damaged, causing undesired side effects. A possible method for internal electron thera...

journal_title：Journal of biomedical optics

authors： Tepper M,Barkai U,Gannot I

更新日期：2015-05-01 00:00:00

abstract：:Nitric oxide (NO) has been recently demonstrated to enhance apoptosis of glial cells induced by photodynamic therapy (PDT), but to protect glial cells from PDT-induced necrosis in the crayfish stretch receptor, a simple neuroglial preparation that consists of a single mechanosensory neuron enveloped by satellite glial...

journal_title：Journal of biomedical optics

authors： Kovaleva VD,Uzdensky AB

更新日期：2016-10-01 00:00:00

abstract：:Ophthalmic surgery may benefit from use of more precise fiber delivery systems during laser surgery. Some current ophthalmic surgical techniques rely on tedious mechanical dissection of tissue layers. In this study, chains of sapphire microspheres integrated into a hollow waveguide distal tip are used for erbium:YAG l...

journal_title：Journal of biomedical optics

authors： Hutchens TC,Darafsheh A,Fardad A,Antoszyk AN,Ying HS,Astratov VN,Fried NM

更新日期：2012-06-01 00:00:00

abstract：:Near-infrared spectroscopy is a novel imaging technique potentially sensitive to both brain hemodynamics (slow signal) and neuronal activity (fast optical signal, FOS). The big challenge of measuring FOS noninvasively lies in the presumably low signal-to-noise ratio. Thus, detectability of the FOS has been controversi...

journal_title：Journal of biomedical optics

authors： Medvedev AV,Kainerstorfer JM,Borisov SV,Gandjbakhche AH,Vanmeter J

更新日期：2010-11-01 00:00:00

abstract：:The effect of sampling region size and tissue heterogeneity is examined using fluorescence histogram assessment in a rat prostate tumor model with benzoporphyrin derivative fluorophore. Spatial heterogeneity in the fluorescence signal occurs on both macroscopic and microscopic scales. The periphery of the tumor is mor...

journal_title：Journal of biomedical optics

authors： Pogue BW,Chen B,Zhou X,Hoopes PJ

更新日期：2005-07-01 00:00:00

abstract：:Three-dimensional (3-D) tissue imaging offers substantial benefits to a wide range of biomedical investigations from cardiovascular biology, diabetes, Alzheimer's disease to cancer. Two-photon tissue cytometry is a novel technique based on high-speed multiphoton microscopy coupled with automated histological sectionin...

journal_title：Journal of biomedical optics

authors： Ragan T,Sylvan JD,Kim KH,Huang H,Bahlmann K,Lee RT,So PT

更新日期：2007-01-01 00:00:00

abstract：:The spectroscopy of analyte-specific molecular vibrations in tissue thin sections has opened up a path toward histopathology without the need for tissue staining. However, biomedical vibrational imaging has not yet advanced from academic research to routine histopathology due to long acquisition times for the microsco...

journal_title：Journal of biomedical optics

authors： Kröger N,Egl A,Engel M,Gretz N,Haase K,Herpich I,Kränzlin B,Neudecker S,Pucci A,Schönhals A,Vogt J,Petrich W

更新日期：2014-01-01 00:00:00

abstract：SIGNIFICANCE:The retina is critical for vision, and several diseases may alter its biomechanical properties. However, assessing the biomechanical properties of the retina nondestructively is a challenge due to its fragile nature and location within the eye globe. Advancements in Brillouin spectroscopy have provided the...

journal_title：Journal of biomedical optics

authors： Ambekar YS,Singh M,Scarcelli G,Rueda EM,Hall BM,Poché RA,Larin KV

更新日期：2020-09-01 00:00:00

abstract：:The properties of polarized light emerging from turbid media in the exact backscattering direction are studied by modulating the incident light polarization state and isolating the synchronous signal with lock-in amplifier detection. The results are reported for polystyrene microsphere suspensions in distilled water, ...

journal_title：Journal of biomedical optics

authors： Studinski RC,Vitkin IA

更新日期：2000-07-01 00:00:00

abstract：:Penetration profiles of topically applied drugs and cosmetic products provide important information on their efficacy. The application of tape stripping in combination with UV/VIS spectroscopy is checked to determine the local position of topically applied substances inside the stratum corneum, the penetration profile...

journal_title：Journal of biomedical optics

authors： Weigmann HJ,Jacobi U,Antoniou C,Tsikrikas GN,Wendel V,Rapp C,Gers-Barlag H,Sterry W,Lademann J

更新日期：2005-01-01 00:00:00

abstract：:We investigate a technology to create a high temperature heat source on the tip surface of the glass fiber proposed for medical surgery applications. Using 4 to 6 W power level semiconductor lasers at a wavelength of 980 nm, a laser coupled fiber tip was preprocessed to contain a certain amount of titanium oxide powde...

journal_title：Journal of biomedical optics

authors： Fujimoto T,Imai Y,Tei K,Ito S,Kanazawa H,Yamaguchi S

更新日期：2014-01-01 00:00:00

abstract：:A classifier capable of ranking structural alterations of the cytoskeleton is developed. Images of cytoskeletal microtubules obtained from the epifluorescence microscopy of primary culture rat hepatocytes are analyzed. Morphological descriptors are extracted by contour and mass fractal analysis, direct methods, and sp...

journal_title：Journal of biomedical optics

authors： Crosta GF,Urani C,Fumarola L

更新日期：2006-03-01 00:00:00

abstract：:We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real time. Optical Doppler images were measured with green laser light by a frequency-shifted Mach-Zehnder interferometer in off-axis configuration. The recorded...

journal_title：Journal of biomedical optics

authors： Bencteux J,Pagnoux P,Kostas T,Bayat S,Atlan M

更新日期：2015-06-01 00:00:00

abstract：:Ultraviolet radiation from solar exposure is a key extrinsic factor responsible for premature skin aging (i.e., photo-aging). Recent advances using in vivo multiphoton tomography (MPT) demonstrate the efficacy of this approach to assess intrinsic and extrinsic skin aging as an alternative to existing invasive techniqu...

journal_title：Journal of biomedical optics

authors： Sanchez WY,Obispo C,Ryan E,Grice JE,Roberts MS

更新日期：2013-06-01 00:00:00

abstract：:Using single-molecule microscopy, we present a method to quantify the number of single autofluorescent proteins when they cannot be optically resolved. This method relies on the measurement of the total intensity emitted by each aggregate until it photobleaches. This strategy overcomes the inherent problem of blinking...

journal_title：Journal of biomedical optics

authors： Cognet L,Tardin C,Négrier ML,Breillat C,Coussen F,Choquet D,Lounis B

更新日期：2008-05-01 00:00:00

abstract：:A main field in biomedical optics research is diffuse optical tomography, where intensity variations of the transmitted light traversing through tissue are detected. Mathematical models and reconstruction algorithms based on finite element methods and Monte Carlo simulations describe the light transport inside the tis...

journal_title：Journal of biomedical optics

authors： Baum K,Hartmann R,Bischoff T,Oelerich JO,Finkensieper S,Heverhagen JT

更新日期：2012-12-01 00:00:00

abstract：:Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix®. Although the sensitivity of this procedure is very good, its specificity is somewhat...

journal_title：Journal of biomedical optics

authors： Lovisa B,Jichlinski P,Weber BC,Aymon D,van den Bergh H,Wagnières G

更新日期：2010-09-01 00:00:00

abstract：:So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of dise...

journal_title：Journal of biomedical optics

authors： Shan H,Liang Y,Wang J,Li Y

更新日期：2012-11-01 00:00:00

abstract：:Artificial neural stimulation is widely used in clinic, rehabilitation, and research. One of the limitations of electrical stimulation is the current spread in tissue. Recently, pulsed mid-infrared laser stimulation of nerves has been investigated as an alternative stimulation method. The likely benefits of infrared n...

journal_title：Journal of biomedical optics

authors： Matic AI,Walsh JT Jr,Richter CP

更新日期：2011-11-01 00:00:00

abstract：:This paper presents comprehensive and depth-resolved retinal microvasculature images within human retina achieved by a newly developed ultrahigh sensitive optical microangiography (UHS-OMAG) system. Due to its high flow sensitivity, UHS-OMAG is much more sensitive to tissue motion due to the involuntary movement of th...

journal_title：Journal of biomedical optics

authors： An L,Shen TT,Wang RK

更新日期：2011-10-01 00:00:00

abstract：:Cancer is the main cause of canine morbidity and mortality. The existing evaluation of tumors requires an experienced veterinarian and usually includes invasive procedures (e.g., fine-needle aspiration) that can be unpleasant for the dog and the owner. We investigate visible and near-infrared diffuse reflectance spect...

journal_title：Journal of biomedical optics

authors： Cugmas B,Plavec T,Bregar M,Naglič P,Pernuš F,Likar B,Bürmen M

更新日期：2015-03-01 00:00:00

abstract：:We present an imaging-based method for noncontact spirometry. The method tracks the subtle respiratory-induced shoulder movement of a subject, builds a calibration curve, and determines the flow-volume spirometry curve and vital respiratory parameters, including forced expiratory volume in the first second, forced vit...

journal_title：Journal of biomedical optics

authors： Liu C,Yang Y,Tsow F,Shao D,Tao N

更新日期：2017-05-01 00:00:00

abstract：:We present methods for visualizing the dynamic response of biological samples to laser-induced heating. Our approach utilizes optical frequency-domain imaging to detect, spatially localize, and monitor unique dynamic signatures that arise within zones of active tissue denaturation. Since this information is precisely ...

journal_title：Journal of biomedical optics

authors： Vakoc BJ,Tearney GJ,Bouma BE

更新日期：2007-03-01 00:00:00

abstract：:Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements....

journal_title：Journal of biomedical optics

authors： Churmakov DY,Meglinski IV,Greenhalgh DA

更新日期：2004-03-01 00:00:00