Spatial extent of cochlear infrared neural stimulation determined by tone-on-light masking.

abstract：:Angle-resolved signals of polarized light scattered by biological cells provide rich information on cell morphology. Quantitative study of these signals can lead to new methods to develop and improve high-throughput instrumentation for cell probing such as scattering-based flow cytometry. We employ a goniometer system...

journal_title：Journal of biomedical optics

authors： Ding H,Lu JQ,Brock RS,McConnell TJ,Ojeda JF,Jacobs KM,Hu XH

更新日期：2007-05-01 00:00:00

abstract：:Optical technique based on diffuse reflectance measurement combined with indocyanine green (ICG) bolus tracking is extensively tested as a method for clinical assessment of brain perfusion in adults at the bedside. Methodology of multiwavelength and time-resolved detection of fluorescence light excited in the ICG is p...

journal_title：Journal of biomedical optics

authors： Gerega A,Milej D,Weigl W,Botwicz M,Zolek N,Kacprzak M,Wierzejski W,Toczylowska B,Mayzner-Zawadzka E,Maniewski R,Liebert A

更新日期：2012-08-01 00:00:00

abstract：:The cyclic peptide, cyclopentapeptide cyclo(lys-Arg-Gly-Asp-phe) (c(KRGDf)), which is known to target alpha(v)beta3 integrin, is dual-labeled with a radiotracer, (111)indium, for gamma scintigraphy as well as with a near-infrared dye, IRDye800, for continuous-wave (cw) imaging of alpha(v)beta3 positive human M21 melan...

journal_title：Journal of biomedical optics

authors： Houston JP,Ke S,Wang W,Li C,Sevick-Muraca EM

更新日期：2005-09-01 00:00:00

abstract：:Heart disease is the primary cause of death in the western world. Many of these deaths are caused by the rupture of vulnerable plaque. Vulnerable plaques are characterized by a large lipid core covered by a thin fibrous cap. One method for detecting these plaques is reflection spectroscopy. Several studies have invest...

journal_title：Journal of biomedical optics

authors： Lilledahl MB,Haugen OA,Barkost M,Svaasand LO

更新日期：2006-03-01 00:00:00

abstract：:An adaptive pulse shaper controlled by multiphoton intrapulse interference phase scanning (MIIPS) was used, together with a prism-pair, to measure and cancel high-order phase distortions introduced by a high-numerical-aperture objective and other dispersive elements of a two-photon laser-scanning microscope. The deliv...

journal_title：Journal of biomedical optics

authors： Xi P,Andegeko Y,Pestov D,Lovozoy VV,Dantus M

更新日期：2009-01-01 00:00:00

abstract：:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced ...

journal_title：Journal of biomedical optics

authors： Yeh C,Hu S,Maslov K,Wang LV

更新日期：2012-07-01 00:00:00

abstract：:Second-harmonic generation (SHG) imaging can help reveal interactions between collagen fibers and cancer cells. Quantitative analysis of SHG images of collagen fibers is challenged by the heterogeneity of collagen structures and low signal-to-noise ratio often found while imaging collagen in tissue. The role of collag...

journal_title：Journal of biomedical optics

authors： Bredfeldt JS,Liu Y,Pehlke CA,Conklin MW,Szulczewski JM,Inman DR,Keely PJ,Nowak RD,Mackie TR,Eliceiri KW

更新日期：2014-01-01 00:00:00

abstract：:Microstructures of unstained human melanoma skin tissues have been examined by multimodal nonlinear optical microscopy. The polarized shape of the individual melanoma cell can be readily recognized-a phenotype that has been identified in laboratory cultures as characteristic of proliferating melanocytes but has not be...

journal_title：Journal of biomedical optics

authors： Zhang K,Zhang W,Yang CY,Yang H

更新日期：2009-03-01 00:00:00

abstract：:Current diagnostic capabilities and limitations of fluorescence endomicroscopy in the cervix are assessed by qualitative and quantitative image analysis. Four cervical tissue types are investigated: normal columnar epithelium, normal and precancerous squamous epithelium, and stromal tissue. This study focuses on the p...

journal_title：Journal of biomedical optics

authors： Schlosser C,Bodenschatz N,Lam S,Lee M,McAlpine JN,Miller DM,Van Niekerk DJ,Follen M,Guillaud M,MacAulay CE,Lane PM

更新日期：2016-12-01 00:00:00

abstract：:The epithelium (EP) thickness and the standard deviation (SD) of A-mode scan intensity in the laminar propria (LP) layer are used as effective indicators for the diagnosis of oral submucous fibrosis (OSF) based on the noninvasive clinical scanning of a swept-source optical coherence tomography (OCT) system of approxim...

journal_title：Journal of biomedical optics

authors： Lee CK,Tsai MT,Lee HC,Chen HM,Chiang CP,Wang YM,Yang CC

更新日期：2009-09-01 00:00:00

abstract：:We report on wide-field imaging of pulsatile motion induced by blood flow using heterodyne holographic interferometry on the thumb of a healthy volunteer, in real time. Optical Doppler images were measured with green laser light by a frequency-shifted Mach-Zehnder interferometer in off-axis configuration. The recorded...

journal_title：Journal of biomedical optics

authors： Bencteux J,Pagnoux P,Kostas T,Bayat S,Atlan M

更新日期：2015-06-01 00:00:00

abstract：:Obstruction in the upper airway can often cause reductions in breathing or gas exchange efficiency and lead to rest disorders such as sleep apnea. Imaging diagnosis of the obstruction region has been accomplished using computed tomography (CT) and magnetic resonance imaging (MRI). However CT requires the use of ionizi...

journal_title：Journal of biomedical optics

authors： Jing J,Zhang J,Loy AC,Wong BJ,Chen Z

更新日期：2012-11-01 00:00:00

abstract：:Characterization and three-dimensional (3-D) localization of human cancerous prostate tissue embedded in normal prostate tissue were demonstrated using backscattering scanning polarization imaging and an inverse imaging reconstruction algorithm, optical tomography using independent component analysis (OPTICA). Two-dim...

journal_title：Journal of biomedical optics

authors： Pu Y,Wang W,Xu M,Eastham JA,Tang G,Alfano RR

更新日期：2012-08-01 00:00:00

abstract：:The properties of polarized light emerging from turbid media in the exact backscattering direction are studied by modulating the incident light polarization state and isolating the synchronous signal with lock-in amplifier detection. The results are reported for polystyrene microsphere suspensions in distilled water, ...

journal_title：Journal of biomedical optics

authors： Studinski RC,Vitkin IA

更新日期：2000-07-01 00:00:00

abstract：:The Nikon C1 confocal laser scanning microscope is a relatively inexpensive and user-friendly instrument. We describe a straightforward method to convert the C1 for multiphoton microscopy utilizing direct coupling of a femtosecond near-infrared laser into the scan head and fiber optic transmission of emission light to...

journal_title：Journal of biomedical optics

authors： Mancuso JJ,Larson AM,Wensel TG,Saggau P

更新日期：2009-05-01 00:00:00

abstract：:The ability to quantitatively determine tissue fluorescence is of interest for the purpose of better understanding the details of photodynamic therapy of skin cancer. In particular, we are interested in quantifying protoporphyrin IX (PpIX) in vivo. We present a method of correcting fluorescence for effects of native t...

journal_title：Journal of biomedical optics

authors： Saager RB,Cuccia DJ,Saggese S,Kelly KM,Durkin AJ

更新日期：2011-12-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:We demonstrate the first application of Raman spectroscopy in diagnosing nonmalignant, premalignant, malignant, and metastatic stages of breast cancer in a three-dimensional (3-D) cell culture model that closely mimics an in vivo environment. Comprehensive study comparing classification in two-dimensional (2-D) and 3-...

journal_title：Journal of biomedical optics

authors： Damayanti NP,Fang Y,Parikh MR,Craig AP,Kirshner J,Irudayaraj J

更新日期：2013-11-01 00:00:00

abstract：:We describe a wide-field optical tomography technique, which allows the measurement-guided optimization of illumination patterns for enhanced reconstruction performances. The iterative optimization of the excitation pattern aims at reducing the dynamic range in photons transmitted through biological tissue. It increas...

journal_title：Journal of biomedical optics

authors： Venugopal V,Intes X

更新日期：2013-03-01 00:00:00

abstract：:The metabolic rate of oxygen consumption, an important indicator of tissue metabolism, can be expressed as the change of net blood oxygen flux into and out of a tissue region per 100 g of tissue. In this work, we propose a photoacoustic and Doppler ultrasound method for imaging local blood oxygen flux of a single vess...

journal_title：Journal of biomedical optics

authors： Jiang Y,Forbrich A,Harrison T,Zemp RJ

更新日期：2012-03-01 00:00:00

abstract：:Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mo...

journal_title：Journal of biomedical optics

authors： Jia Y,Alkayed N,Wang RK

更新日期：2009-07-01 00:00:00

abstract：:Suture ligation of blood vessels during surgery can be time-consuming and skill-intensive. Energy-based, electrosurgical, and ultrasonic devices have recently replaced the use of sutures and mechanical clips (which leave foreign objects in the body) for many surgical procedures, providing rapid hemostasis during surge...

journal_title：Journal of biomedical optics

authors： Cilip CM,Rosenbury SB,Giglio N,Hutchens TC,Schweinsberger GR,Kerr D,Latimer C,Nau WH,Fried NM

更新日期：2013-05-01 00:00:00

abstract：:Using single-molecule microscopy, we present a method to quantify the number of single autofluorescent proteins when they cannot be optically resolved. This method relies on the measurement of the total intensity emitted by each aggregate until it photobleaches. This strategy overcomes the inherent problem of blinking...

journal_title：Journal of biomedical optics

authors： Cognet L,Tardin C,Négrier ML,Breillat C,Coussen F,Choquet D,Lounis B

更新日期：2008-05-01 00:00:00

abstract：:The damage mechanism for near-infrared radiation (IRR) induced cataract is unclear. Both a photochemical and a thermal mechanism were suggested. The current paper aims to elucidate a photochemical effect based on investigation of irradiance-exposure time reciprocity. Groups of 20 rats were unilaterally exposed to 96-W...

journal_title：Journal of biomedical optics

authors： Yu Z,Schulmeister K,Talebizadeh N,Kronschläger M,Söderberg P

更新日期：2015-01-01 00:00:00

abstract：:We have applied wide-field digital interferometry (WFDI) to examine the morphology and dynamics of live red blood cells (RBCs) from individuals who suffer from sickle cell anemia (SCA), a genetic disorder that affects the structure and mechanical properties of RBCs. WFDI is a noncontact, label-free optical microscopy ...

journal_title：Journal of biomedical optics

authors： Shaked NT,Satterwhite LL,Telen MJ,Truskey GA,Wax A

更新日期：2011-03-01 00:00:00

abstract：:Near-infrared spectroscopy is a novel imaging technique potentially sensitive to both brain hemodynamics (slow signal) and neuronal activity (fast optical signal, FOS). The big challenge of measuring FOS noninvasively lies in the presumably low signal-to-noise ratio. Thus, detectability of the FOS has been controversi...

journal_title：Journal of biomedical optics

authors： Medvedev AV,Kainerstorfer JM,Borisov SV,Gandjbakhche AH,Vanmeter J

更新日期：2010-11-01 00:00:00

abstract：:Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the corne...

journal_title：Journal of biomedical optics

authors： Shin S,Bae JK,Ahn Y,Kim H,Choi G,Yoo YS,Joo CK,Moon S,Jung W

更新日期：2017-12-01 00:00:00

abstract：:Environmental metastability of zirconia (ZrO2) ceramic in the human body [represented by a tetragonal-to-monoclinic (t→m) phase transformation] takes place on the surface of the artificial joint and proceeds with time toward its interior. Its quantitative characterization is mandatory for the safety of joint implants ...

journal_title：Journal of biomedical optics

authors： Zhu W,Sugano N,Pezzotti G

更新日期：2013-12-01 00:00:00

abstract：:Optical resolution photoacoustic microscopy (ORPAM) is important for various biomedical applications, such as the study of cellular structures, microcirculation systems, and tumor angiogenesis. However, the lateral resolution of a conventional ORPAM is limited by optical diffraction. In this work, we report a simulati...

journal_title：Journal of biomedical optics

authors： Upputuri PK,Wen ZB,Wu Z,Pramanik M

更新日期：2014-01-01 00:00:00

abstract：:Monitoring a degranulation process in a live mast cell is a quite important issue in immunology and pharmacology. Because the size of a granule is normally much smaller than the resolution limit of an optical microscope system, there is no direct real-time live cell imaging technique for observing degranulation proces...

journal_title：Journal of biomedical optics

authors： Yang W,Lee S,Lee J,Bae Y,Kim D

更新日期：2010-07-01 00:00:00