Abstract:
:Blood pulse wave velocity (PWV) is an important physiological parameter that characterizes vascular stiffness. In this letter, we present electrocardiogram-synchronized, photoacoustic microscopy for noninvasive quantification of the PWV in the peripheral vessels of living mice. Interestingly, blood pulse wave-induced fluctuations in blood flow speed were clearly observed in arteries and arterioles, but not in veins or venules. Simultaneously recorded electrocardiograms served as references to measure the travel time of the pulse wave between two cross sections of a chosen vessel and vessel segmentation analysis enabled accurate quantification of the travel distance. PWVs were quantified in ten vessel segments from two mice. Statistical analysis shows a linear correlation between the PWV and the vessel diameter which agrees with known physiology.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Yeh C,Hu S,Maslov K,Wang LVdoi
10.1117/1.JBO.17.7.070504subject
Has Abstractpub_date
2012-07-01 00:00:00pages
070504issue
7eissn
1083-3668issn
1560-2281journal_volume
17pub_type
杂志文章abstract::Compact optical imagers that can detect both spectral and polarization signatures are required in many biomedical applications. An acousto-optic-tunable-filter (AOTF)-based imager is ideally suited to provide both agile spectral and polarization signatures. Such an imager can be readily used for real-time in vivo medi...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.2102507
更新日期:2005-09-01 00:00:00
abstract::In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunt...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.2992139
更新日期:2008-11-01 00:00:00
abstract::A reflectance volume holographic imaging (VHI) endoscope has been designed for simultaneous in vivo imaging of surface and subsurface tissue structures. Prior utilization of VHI systems has been limited to ex vivo tissue imaging. The VHI system presented in this work is designed for laparoscopic use. It consists of a ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.22.5.056010
更新日期:2017-05-01 00:00:00
abstract::Optical clearing is a well-known phenomenon. It is based on the matching of refractive indices of a bulk material and scattering particles. The same principle is also used in scattering-based optical measurements of different constituents, such as glucose. By registering changes in scattering, it is possible to evalua...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.2904957
更新日期:2008-03-01 00:00:00
abstract::Recent technological advancements in the photonics industry have led to a resurgence of interest in optical glucose sensing and to realistic progress toward the development of an optical glucose sensor. Such a sensor has the potential to significantly improve the quality of life for the estimated 16 million diabetics ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.429962
更新日期:2000-01-01 00:00:00
abstract::We describe the use of a Teflon-AF liquid core optical fiber (LCOF) geometry to enhance the collection of Raman scattering from the biochemical creatinine, dissolved in water and in urine. At short integration times, where shot noise is most troublesome, the enhanced signal leads to greater accuracy in estimating the ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1917842
更新日期:2005-05-01 00:00:00
abstract::Quantitative and qualitative evaluations of structure and composition are important in monitoring development of engineered vascular tissue both in vitro and in vivo. Destructive techniques are an obstacle for performing time-lapse analyses from a single sample or animal. This study demonstrates the ability of time-re...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.19.8.080503
更新日期:2014-08-01 00:00:00
abstract::Fluorescence lifetime imaging (FLi) could potentially improve exogenous near-infrared (NIR) fluorescence imaging, because it offers the capability of discriminating a signal of interest from background, provides real-time monitoring of a chemical environment, and permits the use of several different fluorescent dyes h...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3368997
更新日期:2010-03-01 00:00:00
abstract::Fluorescence spectroscopy has been widely investigated as a technique for identifying pathological tissue; however, unrelated subject-to-subject variations in spectra complicate data analysis and interpretation. We describe and evaluate a new biosensing technique, differential laser-induced perturbation spectroscopy (...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.17.6.067002
更新日期:2012-06-01 00:00:00
abstract::Sugar-rich diets and poor dental hygiene promote the formation of a biofilm (plaque) that strongly adheres to the dental enamel surface and fosters the evolution of aciduric bacteria. The acid contributes to demineralization of the exterior tooth enamel, which accelerates after the pH drops below a critical value (∼5....
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.24.1.017001
更新日期:2019-01-01 00:00:00
abstract::Photobiological research in the last 30 yr has shown the existence of ultraweak photon emission in biological tissue, which can be detected with sophisticated photomultiplier systems. Although the emission of this ultraweak radiation, often termed biophotons, is extremely low in mammalian cells, it can be efficiently ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1899185
更新日期:2005-03-01 00:00:00
abstract:SIGNIFICANCE:In breast-preserving tumor surgery, the inspection of the excised tissue boundaries for tumor residue is too slow to provide feedback during the surgery. The discovery of positive margins requires a new surgery which is difficult and associated with low success. If the re-excision could be done immediately...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.25.9.096001
更新日期:2020-09-01 00:00:00
abstract::The objective of this work was to compare the accuracy of analyte concentration estimation when using transmission versus diffuse reflectance spectroscopy of a scattering medium. Monte Carlo ray tracing of light through the medium was used in conjunction with pure component absorption spectra and Beer-Lambert absorpti...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.23.1.018001
更新日期:2018-01-01 00:00:00
abstract::Hemorrhagic hypovolemia and inotropic agent administration were used to manipulate cardiac output (CO) and oxygen delivery in rabbits to investigate the correlation between noninvasive frequency domain photon migration (FDPM) spectroscopy and invasive hemodynamic monitoring parameters. Frequency-domain photon migratio...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1427046
更新日期:2002-01-01 00:00:00
abstract::The attenuation of near-infrared (NIR) light intensity as it propagates in a turbid medium like biological tissue is described by modified the Beer–Lambert law (MBLL). The MBLL is generally used to quantify the changes in tissue chromophore concentrations for NIR spectroscopic data analysis. Even though MBLL is effect...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.21.7.076012
更新日期:2016-07-01 00:00:00
abstract::Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requi...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.24.2.025001
更新日期:2019-02-01 00:00:00
abstract::In the present study, we evaluated the applicability of ex vivo photoacoustic imaging (PAI) on small animal organs. We used photoacoustic tomography (PAT) to visualize infarcted areas within murine hearts and compared these data to other imaging techniques [magnetic resonance imaging (MRI), micro-computed tomography] ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3556720
更新日期:2011-03-01 00:00:00
abstract::The ability to noninvasively image embryonic vascular anatomy in mouse models is an important requirement for characterizing the development of the normal cardiovascular system and malformations in the heart and vascular supply. Photoacoustic imaging, which can provide high resolution non invasive images of the vascul...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.17.6.061220
更新日期:2012-06-01 00:00:00
abstract::Measuring the elasticity distribution inside the human body is of great interest because elastic abnormalities can serve as indicators of several diseases. We present a method for mapping elasticity inside soft tissues by imaging surface acoustic waves (SAWs) with digital holographic interferometry. With this method, ...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3646211
更新日期:2011-11-01 00:00:00
abstract::The spectroscopy of analyte-specific molecular vibrations in tissue thin sections has opened up a path toward histopathology without the need for tissue staining. However, biomedical vibrational imaging has not yet advanced from academic research to routine histopathology due to long acquisition times for the microsco...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.19.11.111607
更新日期:2014-01-01 00:00:00
abstract::The infrared and Raman spectroscopy of bone and teeth tissues are reviewed. Characteristic spectra are obtained for both the mineral and protein components of these tissues. Vibrational spectroscopy is used to study the mineralization process, to define the chemical structure changes accompanying bone diseases, and to...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.429994
更新日期:2000-07-01 00:00:00
abstract::Fluorescence imaging for detection of non-muscle-invasive bladder cancer is based on the selective production and accumulation of fluorescing porphyrins-mainly, protoporphyrin IX-in cancerous tissues after the instillation of Hexvix®. Although the sensitivity of this procedure is very good, its specificity is somewhat...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3484257
更新日期:2010-09-01 00:00:00
abstract::Discrete form sensitivity functions are derived for a number of measurement types employed in autocorrelation-based ultrasound-modulated optical tomography. The Jacobian for a particular problem is constructed from the set of such sensitivity functions arising from a raster scan of a focused ultrasound field through a...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.18.12.126020
更新日期:2013-12-01 00:00:00
abstract::Second-harmonic-generation (SHG) microscopy has emerged as a powerful tool to image unstained living tissues and probe their molecular and supramolecular organization. In this article, we review the physical basis of SHG, highlighting how coherent summation of second-harmonic response leads to the sensitivity of polar...
journal_title:Journal of biomedical optics
pub_type: 杂志文章,评审
doi:10.1117/1.JBO.17.6.060901
更新日期:2012-06-01 00:00:00
abstract::Several studies demonstrated that the cyclic adenosine monophosphate (cAMP), an important second messenger, is involved in the mechanism of low-level laser irradiation (LLLI) treatment. However, most of these studies obtained the cAMP level in cell culture extracts or supernatant. In this study, the cAMP level in livi...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.JBO.20.5.051029
更新日期:2015-05-01 00:00:00
abstract::Diffusion of two model drugs-benzyl nicotinate and ibuprofen-and the plasma macromolecule albumin across atherosclerotic rabbit aorta was studied ex vivo by attenuated total reflection-Fourier transform infrared (ATR-FTIR) imaging. Solutions of these molecules were applied to the endothelial surface of histological se...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3174395
更新日期:2009-07-01 00:00:00
abstract::Photodynamic therapy (PDT) is an alternative cancer treatment modality that offers localized treatment using a photosensitizer and light. However, tumor angiogenesis is a major concern following PDT-induced hypoxia as it promotes recurrence. Bevacizumab is a monoclonal antibody that targets vascular endothelial growth...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3281671
更新日期:2010-01-01 00:00:00
abstract::Doppler optical coherence tomography (DOCT) provides a novel method to measure blood flow velocity in vessels with diameter at micrometer scale. In this study, a developed spectral domain DOCT system is applied to monitor cerebral blood flow velocity changes in a rat. An animal model with a cranial window is used, and...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3560286
更新日期:2011-04-01 00:00:00
abstract::Recaldent is a product of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). The remineralizing potential of CPP-ACP per se, or when combined with 0.22% Fl gel on artificially demineralized enamel using laser florescence, is investigated. Mesial surfaces of 15 sound human molars are tested using a He-Cd lase...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.3210780
更新日期:2009-07-01 00:00:00
abstract::The spatiotemporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of alpha-chloralose-urethane anesthetized rats (n=10) with optical imaging at 570 nm through a thinned skull. Activation of the cortex was carried out by elect...
journal_title:Journal of biomedical optics
pub_type: 杂志文章
doi:10.1117/1.1609199
更新日期:2003-10-01 00:00:00