Noninvasive monitoring of hemodynamic stress using quantitative near-infrared frequency-domain photon migration spectroscopy.

abstract：:By using a novel temporal characterization technique, we determined that a threshold average laser power of 160 mW is required to drill through a 0.75-mm-thick cortical bone for a Nd:YVO(4) mode-locked laser oscillator with a peak intensity of 1.3 GWcm(2). The ablation mechanism is identified as average-power induced ...

journal_title：Journal of biomedical optics

authors： Lee YM,Tu RY,Chiang AC,Huang YC

更新日期：2007-11-01 00:00:00

abstract：:Pulse oximeters are widely used for noninvasive monitoring of oxygen saturation in arterial blood hemoglobin. We present a transmittance pulse oximetry system based on near-infrared (NIR) laser diodes (750 and 850 nm) for monitoring oxygen saturation of arterial blood hemoglobin. The pulse oximetry system is made up o...

journal_title：Journal of biomedical optics

authors： Lopez Silva SM,Dotor Castilla ML,Silveira Martin JP

更新日期：2003-07-01 00:00:00

abstract：:We present a hybrid method that combines a multilayered scaling method and a perturbation method to speed up the Monte Carlo simulation of diffuse reflectance from a multilayered tissue model with finite-size tumor-like heterogeneities. The proposed method consists of two steps. In the first step, a set of photon traj...

journal_title：Journal of biomedical optics

authors： Zhu C,Liu Q

更新日期：2012-01-01 00:00:00

abstract：:Bacterial contamination of blood products is one of the most frequent infectious complications of transfusion. Since glucose levels in blood supplies decrease as bacteria proliferate, it should be possible to detect the presence of bacterial contamination by measuring the glucose concentrations in the blood components...

journal_title：Journal of biomedical optics

authors： Suzuki Y,Maruo K,Zhang AW,Shimogaki K,Ogawa H,Hirayama F

更新日期：2012-01-01 00:00:00

abstract：:Fluorescence lifetime imaging microscopy (FLIM) using multiphoton excitation techniques is now finding an important place in quantitative imaging of protein-protein interactions and intracellular physiology. Recent developments in multiphoton FLIM methods are reviewed and a novel multiphoton FLIM system using a streak...

journal_title：Journal of biomedical optics

authors： Krishnan RV,Masuda A,Centonze VE,Herman B

更新日期：2003-07-01 00:00:00

abstract：SIGNIFICANCE:The arterial carbon dioxide (CO2) partial pressure PaCO2 is a clinically relevant variable. However, its measurement requires arterial blood sampling or bulky and expensive transcutaneous PtcCO2 meters. While the spectrophotometric determination of hemoglobin species-such as oxy-hemoglobin (O2Hb) and deoxy...

journal_title：Journal of biomedical optics

authors： Dervieux E,Bodinier Q,Uhring W,Théron M

更新日期：2020-10-01 00:00:00

abstract：:We introduce a needle probe based on photoacoustics (PA) to extend the scope of optical needle methods in guiding biopsies. Pulsed light is coupled to an optical fiber in a needle to be inserted in tissue, and PA signals are detected using an ultrasound imager used for needle guidance. This PA needle samples large vol...

journal_title：Journal of biomedical optics

authors： Piras D,Grijsen C,Schütte P,Steenbergen W,Manohar S

更新日期：2013-07-01 00:00:00

abstract：:Optical coherence tomography (OCT) is an emerging technology for high-resolution, noncontact imaging of transparent and scattering media. Polarization-sensitive optical coherence tomography (PS-OCT) is a functional extension of OCT that can image birefringent properties of a biological sample. PS-OCT was used to measu...

journal_title：Journal of biomedical optics

authors： Götzinger E,Pircher M,Sticker M,Fercher AF,Hitzenberger CK

更新日期：2004-01-01 00:00:00

abstract：:In this study we examine the implications of excitation saturation on fluorescence recovery after photobleaching (FRAP) experiments. In particular we present both experimental and theoretical evidence that fluorescein, one of the most frequently used fluorophores in FRAP, does not always comply with the basic assumpti...

journal_title：Journal of biomedical optics

authors： Braeckmans K,Stubbe BG,Remaut K,Demeester J,De Smedt SC

更新日期：2006-07-01 00:00:00

abstract：:We describe the implementation and use of an adaptive optics loop in the imaging path of a commercial wide field microscope. We show that it is possible to maintain the optical performances of the original microscope when imaging through aberrant biological samples. The sources used for illuminating the adaptive optic...

journal_title：Journal of biomedical optics

authors： Vermeulen P,Muro E,Pons T,Loriette V,Fragola A

更新日期：2011-07-01 00:00:00

abstract：:We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8 microm in free space and system sensitivity of 108 dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze t...

journal_title：Journal of biomedical optics

authors： Tsai MT,Lee HC,Lu CW,Wang YM,Lee CK,Yang CC,Chiang CP

更新日期：2008-07-01 00:00:00

abstract：:We report that the pathologic components present within the atheromatous plaques of ApoE knock-out mice can reflect significant amounts of mid-infrared (mid-IR) light. Furthermore, the reflected light spectra contained the unique signatures of a variety of biologic features including those found in unstable or "vulner...

journal_title：Journal of biomedical optics

authors： Holman HY,Bjornstad KA,Martin MC,McKinney WR,Blakely EA,Blankenberg FG

更新日期：2008-05-01 00:00:00

abstract：:Diffuse reflectance spectroscopy, which has been demonstrated as a noninvasive diagnostic technique, relies on quantitative models for extracting optical property values from turbid media, such as biological tissues. We review and compare reflectance models that have been published, and we test similar models over a m...

journal_title：Journal of biomedical optics

authors： Calabro KW,Bigio IJ

更新日期：2014-01-01 00:00:00

abstract：:A fully integrated trimodality fluorescence, diffuse optical, and x-ray computed tomography (FT/DOT/XCT) system for small animal imaging is reported in this work. The main purpose of this system is to obtain quantitatively accurate fluorescence concentration images using a multimodality approach. XCT offers anatomical...

journal_title：Journal of biomedical optics

authors： Lin Y,Barber WC,Iwanczyk JS,Roeck WW,Nalcioglu O,Gulsen G

更新日期：2010-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder that leads to a decline in cognitive and intellectual abilities and an irreversible mental deterioration. Based on multidisciplinary AD research, the most universally accepted hypotheses on AD pathogenesis are the intracerebral aggregate formation of beta-amyloi...

journal_title：Journal of biomedical optics

authors： Kim CB,Choi YY,Song WK,Song KB

更新日期：2014-05-01 00:00:00

abstract：:High resolution is important for sensitive detection of subtle distortions of retinal morphology at an early stage of eye diseases. We demonstrate virtually structured detection (VSD) as a feasible method to achieve in vivo super-resolution ophthalmoscopy. A line-scanning strategy was employed to achieve a super-resol...

journal_title：Journal of biomedical optics

authors： Liu C,Zhi Y,Wang B,Thapa D,Chen Y,Alam M,Lu Y,Yao X

更新日期：2016-12-01 00:00:00

abstract：:We have used an adaptive optics confocal scanning laser ophthalmoscope to assess oxygen saturation in small retinal vessels. Images of the vessels with a diameter smaller than 50 μm are recorded at oxygen sensitive and isosbestic wavelengths (680 and 796 nm, respectively). The vessel optical densities (ODs) are determ...

journal_title：Journal of biomedical optics

authors： Li H,Lu J,Shi G,Zhang Y

更新日期：2011-11-01 00:00:00

abstract：:Sinus blockages are a common reason for physician visits, affecting one out of seven people in the United States, and often require medical treatment. Diagnosis in the primary care setting is challenging because symptom criteria (via detailed clinical history) plus objective imaging [computed tomography (CT) or endosc...

journal_title：Journal of biomedical optics

authors： Cerussi AE,Mishra N,You J,Bhandarkar N,Wong B

更新日期：2015-03-01 00:00:00

abstract：:Nonmelanoma skin cancer is the most common form of human cancer, often resulting in high morbidity. Low visual contrast of these tumors makes their delineation a challenging problem. Employing a linearly polarized monochromatic light source and a wide-field CCD camera, we have developed a technique for fluorescence po...

journal_title：Journal of biomedical optics

authors： Yaroslavsky AN,Salomatina EV,Neel V,Anderson R,Flotte T

更新日期：2007-01-01 00:00:00

abstract：:Intraductal carcinoma is a precancerous lesion of the breast and the immediate precursor of invasive ductal carcinoma. Multiphoton microscopy (MPM) was used to monitor the progression from intraductal carcinoma to invasive ductal carcinoma, which can improve early detection of precursor lesions and halt progression to...

journal_title：Journal of biomedical optics

authors： Wu Y,Fu F,Lian Y,Nie Y,Zhuo S,Wang C,Chen J

更新日期：2015-09-01 00:00:00

abstract：:We have applied wide-field digital interferometry (WFDI) to examine the morphology and dynamics of live red blood cells (RBCs) from individuals who suffer from sickle cell anemia (SCA), a genetic disorder that affects the structure and mechanical properties of RBCs. WFDI is a noncontact, label-free optical microscopy ...

journal_title：Journal of biomedical optics

authors： Shaked NT,Satterwhite LL,Telen MJ,Truskey GA,Wax A

更新日期：2011-03-01 00:00:00

abstract：:SpineLab is a software tool developed for reconstructing neuronal feature skeletons from three-dimensional single- or multi-photon image stacks. These images often suffer from limited resolution and a low signal-to-noise ratio, making the extraction of morphometric information difficult. To overcome this limitation, w...

journal_title：Journal of biomedical optics

authors： Jungblut D,Vlachos A,Schuldt G,Zahn N,Deller T,Wittum G

更新日期：2012-07-01 00:00:00

abstract：:Amblyopia ("lazy eye") is a major public health problem, caused by misalignment of the eyes (strabismus) or defocus. If detected early in childhood, there is an excellent response to therapy, yet most children are detected too late to be treated effectively. Commercially available vision screening devices that test fo...

journal_title：Journal of biomedical optics

authors： Irsch K,Gramatikov BI,Wu YK,Guyton DL

更新日期：2014-06-01 00:00:00

abstract：:Current techniques to assess lymph node metastases in cancer patients include lymphoscintigraphy after administration of a nonspecific radiocolloid in order to locate and resect lymph nodes for pathological examination of harbored cancer cells. Clinical trials involving intradermal or subcutaneous injection of antibod...

journal_title：Journal of biomedical optics

authors： Sampath L,Wang W,Sevick-Muraca EM

更新日期：2008-07-01 00:00:00

abstract：:Cellular therapies hold promise to replace the implantation of whole organs in the treatment of disease. For most cell types, in vivo viability depends on oxygen delivery to avoid the toxic effects of hypoxia. A promising approach is the in situ vascularization of implantable devices which can mediate hypoxia and impr...

journal_title：Journal of biomedical optics

authors： Weidling J,Sameni S,Lakey JR,Botvinick E

更新日期：2014-08-01 00:00:00

abstract：:Spasticity is a motor disorder frequently present in individuals with cerebral palsy (CP). This study aimed to evaluate the effect of low-level laser therapy (LLLT) on the spasticity of the masseter and anterior temporal muscle fibers in children with CP over three weeks of intermittent laser exposures. The bite force...

journal_title：Journal of biomedical optics

authors： Santos MT,Diniz MB,Gouw-Soares SC,Lopes-Martins RA,Frigo L,Baeder FM

更新日期：2016-02-01 00:00:00

abstract：:We investigate a technology to create a high temperature heat source on the tip surface of the glass fiber proposed for medical surgery applications. Using 4 to 6 W power level semiconductor lasers at a wavelength of 980 nm, a laser coupled fiber tip was preprocessed to contain a certain amount of titanium oxide powde...

journal_title：Journal of biomedical optics

authors： Fujimoto T,Imai Y,Tei K,Ito S,Kanazawa H,Yamaguchi S

更新日期：2014-01-01 00:00:00

abstract：:We have developed a near-infrared (NIR) fluorescence goggle system based on the complementary metal-oxide-semiconductor active pixel sensor imaging and see-through display technologies. The fluorescence goggle system is a compact wearable intraoperative fluorescence imaging and display system that can guide surgery in...

journal_title：Journal of biomedical optics

authors： Liu Y,Njuguna R,Matthews T,Akers WJ,Sudlow GP,Mondal S,Tang R,Gruev V,Achilefu S

更新日期：2013-10-01 00:00:00

abstract：:Toward developing a new method for restoring tissue viscoelasticity in scarred vocal folds, we previously proposed a method to localize biomaterials within subepithelial voids ablated using ultrafast laser pulses. The clinical implementation of this method necessitates the quantification of the laser parameters for ab...

journal_title：Journal of biomedical optics

authors： Yildirim M,Ferhanoglu O,Kobler J,Zeitels SM,Ben-Yakar A

更新日期：2013-11-01 00:00:00

abstract：:The acousto-optic deflector (AOD) is highly preferred in laser scanning microscopy for its fast scanning ability and random-addressing capability. However, its application in two-photon microscopy is frustrated by the dispersion of the AOD, which results in beam distortion and pulse lengthening. We report the analysis...

journal_title：Journal of biomedical optics

authors： Zeng S,Lv X,Bi K,Zhan C,Li D,Chen WR,Xiong W,Jacques SL,Luo Q

更新日期：2007-03-01 00:00:00