Near infrared fluorescent optical imaging for nodal staging.

abstract：:Computer simulation is used to facilitate the design of fiber-probe geometries that enable enhanced detection of optical signals arising from specific tissue depths. Obtaining understanding of the relationship between fiber-probe design and tissue interrogation is critical when developing strategies for optical detect...

journal_title：Journal of biomedical optics

authors： Wang AM,Bender JE,Pfefer J,Utzinger U,Drezek RA

更新日期：2005-07-01 00:00:00

abstract：:Photobiological research in the last 30 yr has shown the existence of ultraweak photon emission in biological tissue, which can be detected with sophisticated photomultiplier systems. Although the emission of this ultraweak radiation, often termed biophotons, is extremely low in mammalian cells, it can be efficiently ...

journal_title：Journal of biomedical optics

authors： Niggli HJ,Tudisco S,Privitera G,Applegate LA,Scordino A,Musumeci F

更新日期：2005-03-01 00:00:00

abstract：:Cochlear implantation offers the potential to restore sensitive hearing in patients with severe to profound deafness. However, surgical placement of the electrode array within the cochlea can produce trauma to sensorineural components, particularly if the initial turn of the cochlea is not successfully navigated as th...

journal_title：Journal of biomedical optics

authors： Gurbani SS,Wilkening P,Zhao M,Gonenc B,Cheon GW,Iordachita II,Chien W,Taylor RH,Niparko JK,Kang JU

更新日期：2014-05-01 00:00:00

abstract：:A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/t...

journal_title：Journal of biomedical optics

authors： Jacques SL,Pogue BW

更新日期：2008-07-01 00:00:00

abstract：:Complete and continuous imaging of microvascular networks is crucial for a wide variety of biomedical applications. Photoacoustic tomography can provide high resolution microvascular imaging using hemoglobin within red blood cells (RBCs) as an endogenic contrast agent. However, intermittent RBC flow in capillaries res...

journal_title：Journal of biomedical optics

authors： Yao J,Maslov K,Hu S,Wang LV

更新日期：2009-09-01 00:00:00

abstract：:Doxorubicin is a commonly used chemotherapeutic employed to treat multiple human cancers, including numerous sarcomas and carcinomas. Furthermore, doxorubicin possesses strong fluorescent properties that make it an ideal reagent for modeling drug delivery by examining its distribution in cells and tissues. However, wh...

journal_title：Journal of biomedical optics

authors： Carlson M,Watson AL,Anderson L,Largaespada DA,Provenzano PP

更新日期：2017-11-01 00:00:00

abstract：:We demonstrate that using time-resolved two-photon excitation endogenous fluorescence microscopy, the cadmium (Cd)-induced cellular toxic level can be assessed by the free-to protein-bound reduced nicotinamide adenine dinucleotide (free/bound NADH) ratio in a living cell. NADH fluorescence excited at 730 nm is capture...

journal_title：Journal of biomedical optics

authors： Li D,Yang MS,Lin T,Zheng W,Qu JY

更新日期：2009-09-01 00:00:00

abstract：:Optical imaging using voltage-sensitive dyes has become an important tool for studying vortex-like electrical waves in the heart. Such waves, known as spiral or scroll waves, can spontaneously form in pathological ventricular myocardium, causing ventricular fibrillation and sudden death. Until recently, observations o...

journal_title：Journal of biomedical optics

authors： Bernus O,Mukund KS,Pertsov AM

更新日期：2007-01-01 00:00:00

abstract：:Autofluorescence, the endogenous fluorescence present in cells and tissues, has historically been considered a nuisance in biomedical imaging. Many endogenous fluorophores, specifically, collagen, elastin, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide (FAD), are found throughout the human body. In...

journal_title：Journal of biomedical optics

authors： Deal J,Mayes S,Browning C,Hill S,Rider P,Boudreaux C,Rich TC,Leavesley SJ

更新日期：2018-12-01 00:00:00

abstract：:The study of red blood cell (RBC) aggregation is of great interest because of its implications for human health. Altered RBC aggregation can lead to microcirculatory problems as in vascular pathologies, such as hypertension and diabetes, due to a decrease in the erythrocyte surface electric charge and an increase in t...

journal_title：Journal of biomedical optics

authors： Toderi MA,Castellini HV,Riquelme BD

更新日期：2017-01-01 00:00:00

abstract：:The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

journal_title：Journal of biomedical optics

authors： Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

更新日期：2012-07-01 00:00:00

abstract：:The epithelium (EP) thickness and the standard deviation (SD) of A-mode scan intensity in the laminar propria (LP) layer are used as effective indicators for the diagnosis of oral submucous fibrosis (OSF) based on the noninvasive clinical scanning of a swept-source optical coherence tomography (OCT) system of approxim...

journal_title：Journal of biomedical optics

authors： Lee CK,Tsai MT,Lee HC,Chen HM,Chiang CP,Wang YM,Yang CC

更新日期：2009-09-01 00:00:00

abstract：:We present a study using a method able to assess tissue oxygenation, taking into account the absorption and the level of scattering in myocardial tissue using a calibrated fiber optic probe. With this method, interindividual comparisons of oxygenation can be made despite varying tissue optical properties during corona...

journal_title：Journal of biomedical optics

authors： Häggblad E,Lindbergh T,Karlsson MG,Casimir-Ahn H,Salerud EG,Strömberg T

更新日期：2008-09-01 00:00:00

abstract：SIGNIFICANCE:Optical coherence tomography (OCT) has proven useful for detecting various oral maxillofacial abnormalities. To apply it to clinical applications including biopsy guidance and routine screening, a handheld imaging probe is indispensable. OCT probes reported for oral maxillofacial imaging were either based ...

journal_title：Journal of biomedical optics

authors： Li K,Yang Z,Liang W,Shang J,Liang Y,Wan S

更新日期：2020-04-01 00:00:00

abstract：:Utilizing a laser scanning confocal microscope system, the refractive indices of articular cartilage (AC) with mechanical or biochemical degenerations were characterized to investigate whether potential correlations exist between refractive index (RI) and cartilage degeneration. The cartilage samples collected from th...

journal_title：Journal of biomedical optics

authors： Wang K,Wu J,Day R,Kirk TB,Hu X

更新日期：2016-09-01 00:00:00

abstract：:An adaptive pulse shaper controlled by multiphoton intrapulse interference phase scanning (MIIPS) was used, together with a prism-pair, to measure and cancel high-order phase distortions introduced by a high-numerical-aperture objective and other dispersive elements of a two-photon laser-scanning microscope. The deliv...

journal_title：Journal of biomedical optics

authors： Xi P,Andegeko Y,Pestov D,Lovozoy VV,Dantus M

更新日期：2009-01-01 00:00:00

abstract：:Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolve...

journal_title：Journal of biomedical optics

authors： Yi J,Radosevich AJ,Stypula-Cyrus Y,Mutyal NN,Azarin SM,Horcher E,Goldberg MJ,Bianchi LK,Bajaj S,Roy HK,Backman V

更新日期：2014-03-01 00:00:00

abstract：:Optical coherence tomography (OCT) is a potential clinical tool for enamel lesion monitoring. Swept-source OCT findings were compared with cross-sectional nanohardness findings of enamel. Subsurface bovine enamel lesions in three groups were subjected to (1) deionized water (control), (2) phosphoryl oligosaccharide of...

journal_title：Journal of biomedical optics

authors： Mandurah MM,Sadr A,Shimada Y,Kitasako Y,Nakashima S,Bakhsh TA,Tagami J,Sumi Y

更新日期：2013-04-01 00:00:00

abstract：:Optical measurements of metabolism are ideally acquired in vivo; however, intravital measurements are often impractical. Accurate ex vivo assessments would greatly broaden the applicability of optical measurements of metabolism. We investigate the use of live tissue culture experiments to serve as a surrogate for in v...

journal_title：Journal of biomedical optics

authors： Walsh AJ,Poole KM,Duvall CL,Skala MC

更新日期：2012-11-01 00:00:00

abstract：:Discrete form sensitivity functions are derived for a number of measurement types employed in autocorrelation-based ultrasound-modulated optical tomography. The Jacobian for a particular problem is constructed from the set of such sensitivity functions arising from a raster scan of a focused ultrasound field through a...

journal_title：Journal of biomedical optics

authors： Powell S,Leung TS

更新日期：2013-12-01 00:00:00

abstract：:Photoacoustic imaging has become an emerging tool for theranostic applications. Not only does it help in

journal_title：Journal of biomedical optics

authors： Sivasubramanian K,Mathiyazhakan M,Wiraja C,Upputuri PK,Xu C,Pramanik M

更新日期：2017-04-01 00:00:00

abstract：:Multiphoton microscopy has evolved into a powerful bioimaging tool in three dimensions. However, the ability to image biological specimens in-depth can be hindered by sample spherical aberration and scattering. These two phenomena can result in the degradation of image resolution and the loss of detected multiphoton s...

journal_title：Journal of biomedical optics

authors： Lo W,Sun Y,Lin SJ,Jee SH,Dong CY

更新日期：2005-05-01 00:00:00

abstract：:Monitoring a degranulation process in a live mast cell is a quite important issue in immunology and pharmacology. Because the size of a granule is normally much smaller than the resolution limit of an optical microscope system, there is no direct real-time live cell imaging technique for observing degranulation proces...

journal_title：Journal of biomedical optics

authors： Yang W,Lee S,Lee J,Bae Y,Kim D

更新日期：2010-07-01 00:00:00

abstract：:We present a simple wide-field imaging technique, called HiLo microscopy, that is capable of producing optically sectioned images in real time, comparable in quality to confocal laser scanning microscopy. The technique is based on the fusion of two raw images, one acquired with speckle illumination and another with st...

journal_title：Journal of biomedical optics

authors： Lim D,Ford TN,Chu KK,Mertz J

更新日期：2011-01-01 00:00:00

abstract：:Pelvic organ prolapse (POP) occurs when changes to the pelvic organ support structures cause descent or herniation of the pelvic organs into the vagina. Clinical evaluation of POP is a series of manual measurements known as the pelvic organ prolapse quantification (POP-Q) score. However, it fails to identify the mecha...

journal_title：Journal of biomedical optics

authors： Parkinson LA,Gargett CE,Young N,Rosamilia A,Vashi AV,Werkmeister JA,Papageorgiou AW,Arkwright JW

更新日期：2016-12-01 00:00:00

abstract：:We used two-photon laser scanning microscopy (TPLSM) to demonstrate for the first time its potential in studying relational details at the cellular level of atherogenesis in intact, viable mouse carotid arteries. Isolated and mounted arteries of ApoE-/-mice, aged 15 or 21 weeks (7 and 13 weeks on western diet), were i...

journal_title：Journal of biomedical optics

authors： Megens RT,oude Egbrink MG,Merkx M,Slaaf DW,van Zandvoort MA

更新日期：2008-07-01 00:00:00

abstract：:Selective retina treatment (SRT) is a novel short pulsed laser therapy of several retinal diseases associated with a decreased metabolism at the retinal pigment epithelium (RPE). The range of laser pulse energies is small, in which the desired selective RPE disintegration is achieved without adverse effects to the neu...

journal_title：Journal of biomedical optics

authors： Neumann J,Brinkmann R

更新日期：2006-07-01 00:00:00

abstract：:The ability to noninvasively image embryonic vascular anatomy in mouse models is an important requirement for characterizing the development of the normal cardiovascular system and malformations in the heart and vascular supply. Photoacoustic imaging, which can provide high resolution non invasive images of the vascul...

journal_title：Journal of biomedical optics

authors： Laufer J,Norris F,Cleary J,Zhang E,Treeby B,Cox B,Johnson P,Scambler P,Lythgoe M,Beard P

更新日期：2012-06-01 00:00:00

abstract：:Fluorescence diagnostic techniques are notable amongst many other optical methods because they offer high sensitivity and noninvasive measurement of tissue properties. However, a combination of multiple scattering and physical heterogeneity of biological tissues hampers interpretation of the fluorescence measurements....

journal_title：Journal of biomedical optics

authors： Churmakov DY,Meglinski IV,Greenhalgh DA

更新日期：2004-03-01 00:00:00

abstract：:We present systematic characterization of a photoacoustic imaging system optimized for rapid, high-resolution tomographic imaging of small animals. The system is based on a 128-element ultrasonic transducer array with a 5-MHz center frequency and 80% bandwidth shaped to a quarter circle of 25 mm radius. A 16-channel d...

journal_title：Journal of biomedical optics

authors： Gamelin J,Aguirre A,Maurudis A,Huang F,Castillo D,Wang LV,Zhu Q

更新日期：2008-03-01 00:00:00