Robot-assisted three-dimensional registration for cochlear implant surgery using a common-path swept-source optical coherence tomography probe.

abstract：:Recent technological advancements in the photonics industry have led to a resurgence of interest in optical glucose sensing and to realistic progress toward the development of an optical glucose sensor. Such a sensor has the potential to significantly improve the quality of life for the estimated 16 million diabetics ...

journal_title：Journal of biomedical optics

authors： McNichols RJ,Coté GL

更新日期：2000-01-01 00:00:00

abstract：:A computer simulation called RHME (Retinal Heating in Moving Eye) is developed to simulate the heating pattern that occurs in the retina during a long-duration exposure to a continuous wave laser beam. The simulation takes into account eye movements that occur during a deliberate fixation. Due to the rapid (millisecon...

journal_title：Journal of biomedical optics

authors： Lund BJ

更新日期：2004-09-01 00:00:00

abstract：:Hemoglobin (Hb), as one of main components of blood, has a unique quaternary structure. Its release of oxygen is controlled by oxygen partial pressure (PO2). We investigate the specific spectroscopic changes in Hb under different PO2 levels to optimize clinical methods of measuring tissue PO2. The transmissivity of Hb...

journal_title：Journal of biomedical optics

authors： Liu P,Zhu Z,Zeng C,Nie G

更新日期：2012-12-01 00:00:00

abstract：:Three major analytical tools in imaging science are summarized and demonstrated relative to optical imaging in vivo. Standard resolution testing is optimal when infinite contrast is used and hardware evaluation is the goal. However, deep tissue imaging of absorption or fluorescent contrast agents in vivo often present...

journal_title：Journal of biomedical optics

authors： Pogue BW,Davis SC,Song X,Brooksby BA,Dehghani H,Paulsen KD

更新日期：2006-05-01 00:00:00

abstract：:Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, the residual spectrum, the difference between the observed and modeled diffuse reflectance spectra, was attributed to single elastic light scattering from epithelial nucle...

journal_title：Journal of biomedical optics

authors： Lau C,Sćepanović O,Mirkovic J,McGee S,Yu CC,Fulghum S,Wallace M,Tunnell J,Bechtel K,Feld M

更新日期：2009-03-01 00:00:00

abstract：:The objective of the study is the quantitative analysis of the dose-time dependences of changes occurring in collagen of bladder and rectum after gamma-irradiation using optical methods [nonlinear microscopy in a second harmonic generation (SHG) detection regime and cross-polarization optical coherence tomography (CP ...

journal_title：Journal of biomedical optics

authors： Kochueva M,Dudenkova V,Kuznetsov S,Varlamova A,Sergeeva E,Kiseleva E,Maslennikova A

更新日期：2018-08-01 00:00:00

abstract：:We describe the use of a biochip based on complementary metal oxide semiconductor (CMOS) technology for detection of specific genetic sequences using molecular beacons (MB) immobilized on solid surfaces as probes. The applicability of this miniature detection system for screening for the BRCA1 gene is evaluated using ...

journal_title：Journal of biomedical optics

authors： Culha M,Stokes DL,Griffin GD,Vo-Dinh T

更新日期：2004-05-01 00:00:00

abstract：:Planar glass waveguides with a specific number of modes were fabricated by Ag(+)-Na(+) exchange in Schott SG11 glass. The effective refractive indices were determined using m-line spectroscopy in both s- and p-polarization. By using the reversed Wentzel-Kramers-Brillouin approximation, the index profiles were describe...

journal_title：Journal of biomedical optics

authors： Hassanzadeh A,Nitsche M,Armstrong S,Nabavi N,Harrison R,Dixon SJ,Langbein U,Mittler S

更新日期：2010-05-01 00:00:00

abstract：:Previous studies suggest that altered corneal temperature may be a feature of schizophrenia, but the association between major depressive disorder (MDD) and corneal temperature has yet to be assessed. The aim of this study is to investigate whether eye temperature is different among MDD patients than among healthy ind...

journal_title：Journal of biomedical optics

authors： Maller JJ,George SS,Viswanathan RP,Fitzgerald PB,Junor P

更新日期：2016-02-01 00:00:00

abstract：:Imaging technologies working in the spatial frequency domain are becoming increasingly popular for generating wide-field maps of optical properties, enabling rapid analysis of tissue parameters. While acquisition methods have become faster and are now performing in real-time, processing methods remain slow, precluding...

journal_title：Journal of biomedical optics

authors： Angelo J,Vargas CR,Lee BT,Bigio IJ,Gioux S

更新日期：2016-11-01 00:00:00

abstract：:To improve surgical guidance toward prostate draining lymph nodes, we investigate the potential of intraoperative fluorescence imaging and combined pre- and intraoperative multimodality imaging approaches. Transgenic adenocarcinoma mouse prostate mice with spontaneous prostate tumors are injected intratumorally with: ...

journal_title：Journal of biomedical optics

authors： van Leeuwen AC,Buckle T,Bendle G,Vermeeren L,Valdés Olmos R,van de Poel HG,van Leeuwen FW

更新日期：2011-01-01 00:00:00

abstract：:Characterization and three-dimensional (3-D) localization of human cancerous prostate tissue embedded in normal prostate tissue were demonstrated using backscattering scanning polarization imaging and an inverse imaging reconstruction algorithm, optical tomography using independent component analysis (OPTICA). Two-dim...

journal_title：Journal of biomedical optics

authors： Pu Y,Wang W,Xu M,Eastham JA,Tang G,Alfano RR

更新日期：2012-08-01 00:00:00

abstract：:We present Monte Carlo modeling studies to provide a quantitative understanding of contrast observed in spatially resolved reflectance spectra of normal and highly dysplastic cervical tissue. Simulations have been carried out to analyze the sensitivity of spectral measurements to a range of changes in epithelial and s...

journal_title：Journal of biomedical optics

authors： Arifler D,MacAulay C,Follen M,Richards-Kortum R

更新日期：2006-11-01 00:00:00

abstract：:A compact handpiece combining high resolution fluorescence (HRF) imaging with optical coherence tomography (OCT) was developed to provide real-time assessment of oral lesions. This multimodal imaging device simultaneously captures coregistered en face images with subcellular detail alongside cross-sectional images of ...

journal_title：Journal of biomedical optics

authors： Higgins LM,Pierce MC

更新日期：2014-08-01 00:00:00

abstract：:It is challenging to image fluorescence objects with high spatial resolution in a highly scattering medium. Recently reported temperature-sensitive indocyanine green-loaded pluronic nanocapsules can potentially alleviate this problem. Here we demonstrate a frequency-domain temperature-modulated fluorescence tomography...

journal_title：Journal of biomedical optics

authors： Lin Y,Kwong TC,Bolisay L,Gulsen G

更新日期：2012-05-01 00:00:00

abstract：:Discrimination of benign and malignant melanocytic lesions is a major issue in clinical dermatology. Assessment of the thickness of melanoma is critical for prognosis and treatment selection. We aimed to evaluate a novel optical computed tomography (optical-CT) system as a tool for three-dimensional (3-D) imaging of m...

journal_title：Journal of biomedical optics

authors： Kokolakis A,Zacharakis G,Krasagakis K,Lasithiotakis K,Favicchio R,Spiliopoulos G,Giannikaki E,Ripoll J,Tosca A

更新日期：2012-06-01 00:00:00

abstract：:Optical spectroscopy has shown potential as a real-time, in vivo, diagnostic tool for identifying neoplasia during endoscopy. We present the development of a diagnostic algorithm to classify elastic-scattering spectroscopy (ESS) spectra as either neoplastic or non-neoplastic. The algorithm is based on pattern recognit...

journal_title：Journal of biomedical optics

authors： Rodriguez-Diaz E,Castanon DA,Singh SK,Bigio IJ

更新日期：2011-06-01 00:00:00

abstract：:Mid-IR semiconductor lasers of two wavelength bands, 5.4 and 9.6 microm, are applied to measure aqueous glucose concentration ranging from 0 to 500 mgdL with Intralipid emulsion (0 to 8%) added as a fat simulator. The absorption coefficient micro(a) is found linear with respect to glucose and Intralipid concentrations...

journal_title：Journal of biomedical optics

authors： Guo B,Wang Y,Wang Y,Le HQ

更新日期：2007-03-01 00:00:00

abstract：:We have developed a novel nitroimidazole indocyanine dye conjugate for tumor-targeted hypoxia fluorescence tomography. The hypoxia probe has been evaluated in vitro using tumor cell lines and in vivo with tumor targeting in mice. The in vitro cell studies were performed to assess fluorescence labeling differences betw...

journal_title：Journal of biomedical optics

authors： Biswal NC,Pavlik C,Smith MB,Aguirre A,Xu Y,Zanganeh S,Kuhn LT,Claffey KP,Zhu Q

更新日期：2011-06-01 00:00:00

abstract：:Full-field optical coherence tomography (FF-OCT) capable of in vivo cellular-level imaging is demonstrated for nonscanning horizontal cross-sectional imaging. The system is based on a white light interference microscope illuminated by a thermal light source. A dual-channel two-dimensional (2-D) detection technique inc...

journal_title：Journal of biomedical optics

authors： Akiba M,Chan KP

更新日期：2007-11-01 00:00:00

abstract：:Nitric oxide (NO) has been recently demonstrated to enhance apoptosis of glial cells induced by photodynamic therapy (PDT), but to protect glial cells from PDT-induced necrosis in the crayfish stretch receptor, a simple neuroglial preparation that consists of a single mechanosensory neuron enveloped by satellite glial...

journal_title：Journal of biomedical optics

authors： Kovaleva VD,Uzdensky AB

更新日期：2016-10-01 00:00:00

abstract：:Biomedical applications of terahertz (THz) radiation are appealing because THz radiation is nonionizing and has the demonstrated ability to detect intrinsic contrasts between cancerous and normal tissue. A linear polarization-sensitive detection technique for tumor margin delineation has already been demonstrated; how...

journal_title：Journal of biomedical optics

authors： Martin JP,Joseph CS,Giles RH

更新日期：2016-07-01 00:00:00

abstract：:Laser-assisted cartilage reshaping is mediated by thermally induced stress relaxation, and may be used to alter cartilage morphology for reconstructive surgical procedures in the upper airway and face without carving, morselizing, or suturing. Internal stress σ(t), integrated backscattered light intensity I(t) from a ...

journal_title：Journal of biomedical optics

authors： Wong BJ,Milner TE,Kim HH,Stuart Nelson J,Sobol EN

更新日期：1998-10-01 00:00:00

abstract：:Fluorescence molecular tomography (FMT) is an important in vivo imaging modality to visualize physiological and pathological processes in small animals. However, FMT reconstruction is ill-posed and ill-conditioned due to strong optical scattering in deep tissues, which results in poor spatial resolution. It is well kn...

journal_title：Journal of biomedical optics

authors： Baikejiang R,Zhao Y,Fite BZ,Ferrara KW,Li C

更新日期：2017-05-01 00:00:00

abstract：:Doppler optical coherence tomography (DOCT) provides a novel method to measure blood flow velocity in vessels with diameter at micrometer scale. In this study, a developed spectral domain DOCT system is applied to monitor cerebral blood flow velocity changes in a rat. An animal model with a cranial window is used, and...

journal_title：Journal of biomedical optics

authors： Wang C,Yang Y,Ding Z,Meng J,Wang K,Yang W,Xu Y

更新日期：2011-04-01 00:00:00

abstract：:The feasibility of spatial frequency domain imaging (SFDI) for breast surgical margin assessment was evaluated in tissue-simulating phantoms and in fully intact lumpectomy specimens at the time of surgery. Phantom data was evaluated according to contrast-detail resolution, quantitative accuracy and model-data goodness...

journal_title：Journal of biomedical optics

authors： Laughney AM,Krishnaswamy V,Rice TB,Cuccia DJ,Barth RJ,Tromberg BJ,Paulsen KD,Pogue BW,Wells WA

更新日期：2013-03-01 00:00:00

abstract：:A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/t...

journal_title：Journal of biomedical optics

authors： Jacques SL,Pogue BW

更新日期：2008-07-01 00:00:00

abstract：:Optical microanglography (OMAG) is a recently developed imaging modality capable of volumetric imaging of dynamic blood perfusion, down to capillary level resolution, with an imaging depth up to 2.00 mm beneath the tissue surface. We report the use of OMAG to monitor the cerebral blood flow (CBF) over the cortex of mo...

journal_title：Journal of biomedical optics

authors： Jia Y,Alkayed N,Wang RK

更新日期：2009-07-01 00:00:00

abstract：:This study aimed to evaluate the concept of using high-resolution optical coherence tomography (OCT) imaging to rapidly assess surgical specimens and determine if cancer positive margins were left behind in the surgical bed. A mouse model of breast cancer was used in this study. Surgical specimens from 30 animals were...

journal_title：Journal of biomedical optics

authors： Savastru D,Chang EW,Miclos S,Pitman MB,Patel A,Iftimia N

更新日期：2014-05-01 00:00:00

abstract：:Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c...

journal_title：Journal of biomedical optics

authors： Sorensen LC,Leung TS,Greisen G

更新日期：2008-11-01 00:00:00