Monitoring of drug and stimulation induced cerebral blood flow velocity changes in rat sensory cortex using spectral domain Doppler optical coherence tomography.

abstract：SIGNIFICANCE:The potential of fluorescence lifetime imaging microscopy (FLIM) is recently being recognized, especially in biological studies. However, FLIM does not directly measure the lifetimes, rather it records the fluorescence decay traces. The lifetimes and/or abundances have to be estimated from these traces dur...

journal_title：Journal of biomedical optics

authors： Guo S,Silge A,Bae H,Tolstik T,Meyer T,Matziolis G,Schmitt M,Popp J,Bocklitz T

更新日期：2021-01-01 00:00:00

abstract：:Extension of optical monitoring of intact tissues from the visible and ultraviolet to the near-infrared (NIR) range (700-1300 nm) was first undertaken in 1977 for the purpose of monitoring the redox behavior of Cytochrome c oxidase (cyt c ox) in vivo. Soon it became evident that the much greater NIR translucency of sk...

journal_title：Journal of biomedical optics

authors： Jo Bsis-Vandervliet FF

更新日期：1999-10-01 00:00:00

abstract：:Measuring the elasticity distribution inside the human body is of great interest because elastic abnormalities can serve as indicators of several diseases. We present a method for mapping elasticity inside soft tissues by imaging surface acoustic waves (SAWs) with digital holographic interferometry. With this method, ...

journal_title：Journal of biomedical optics

authors： Li S,Mohan KD,Sanders WW,Oldenburg AL

更新日期：2011-11-01 00:00:00

abstract：:For clinical optoacoustic imaging, linear probes are preferably used because they allow versatile imaging of the human body with real-time display and free-hand probe guidance. The two-dimensional (2-D) optoacoustic image obtained with this type of probe is generally interpreted as a 2-D cross-section of the tissue ju...

journal_title：Journal of biomedical optics

authors： Preisser S,Bush NL,Gertsch-Grover AG,Peeters S,Bailey AE,Bamber JC,Frenz M,Jaeger M

更新日期：2013-02-01 00:00:00

abstract：:Active optics such as deformable mirrors can be used to control both focal depth and aberrations during scanning laser microscopy. If the focal depth can be changed dynamically during scanning, then imaging of oblique surfaces becomes possible. If aberrations can be corrected dynamically during scanning, an image can ...

journal_title：Journal of biomedical optics

authors： Archer-Zhang CC,Foster WB,Downey RD,Arrasmith CL,Dickensheets DL

更新日期：2016-12-01 00:00:00

abstract：:Surgical resection of pancreatic cancer represents the only chance of cure and long-term survival in this common disease. Unfortunately, determination of a cancer-free margin at surgery is based on one or two tiny frozen section biopsies, which is far from ideal. Not surprisingly, cancer is usually left behind and is ...

journal_title：Journal of biomedical optics

authors： Cromey B,McDaniel A,Matsunaga T,Vagner J,Kieu KQ,Banerjee B

更新日期：2018-04-01 00:00:00

abstract：:Real-time medical imaging systems such as reflectance confocal microscopes and optical coherence microscopes are being tested in multiple-patient and multiple-center clinical trials. The modulation transfer function (MTF) of these systems at any given time influences the image information content and can affect the in...

journal_title：Journal of biomedical optics

authors： Wang Z,Glazowski CE,Zavislan JM

更新日期：2007-09-01 00:00:00

abstract：:This paper presents comprehensive and depth-resolved retinal microvasculature images within human retina achieved by a newly developed ultrahigh sensitive optical microangiography (UHS-OMAG) system. Due to its high flow sensitivity, UHS-OMAG is much more sensitive to tissue motion due to the involuntary movement of th...

journal_title：Journal of biomedical optics

authors： An L,Shen TT,Wang RK

更新日期：2011-10-01 00:00:00

abstract：:Traditional white-light and fluorescent imaging techniques provide powerful methods to extract high-resolution information from two-dimensional (2-D) sections, but to retrieve information from a three-dimensional (3-D) volume they require relatively slow scanning methods that result in increased acquisition time. Usin...

journal_title：Journal of biomedical optics

authors： Duocastella M,Sun B,Arnold CB

更新日期：2012-05-01 00:00:00

abstract：:Biological systems with intrinsic luminescent properties serve as powerful and noninvasive bioreporters for real-time and label-free monitoring of cell physiology. This study employs the bioluminescent marine bacterium Vibrio fischeri to investigate the effects of separated microwave electric (E) and magnetic (H) fiel...

journal_title：Journal of biomedical optics

authors： Williams CF,Geroni GM,Lloyd D,Choi H,Clark N,Pirog A,Lees J,Porch A

更新日期：2019-02-01 00:00:00

abstract：:We present a system combining optical coherence tomography (OCT) and multispectral imaging (MSI) for coregistered structural imaging and surface color imaging. We first describe and numerically validate an optimization model to guide the selection of the MSI wavelengths and their relative intensities. We then demonstr...

journal_title：Journal of biomedical optics

authors： Attendu X,Bourget MH,de Sivry-Houle MP,Boudoux C

更新日期：2019-11-01 00:00:00

abstract：:A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable co...

journal_title：Journal of biomedical optics

authors： Blazkiewicz P,Blazkiewicz K,Verhaege A,Anissimov YG,Roberts MS,Zvyagin AV

更新日期：2006-01-01 00:00:00

abstract：:A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal t...

journal_title：Journal of biomedical optics

authors： Hammer DX,Ferguson RD,Patel AH,Vazquez V,Husain D

更新日期：2012-02-01 00:00:00

abstract：:Real-time monitoring of functional tissue parameters, such as local blood oxygenation, based on optical imaging could provide groundbreaking advances in the diagnosis and interventional therapy of various diseases. Although photoacoustic (PA) imaging is a modality with great potential to measure optical absorption dee...

journal_title：Journal of biomedical optics

authors： Kirchner T,Gröhl J,Maier-Hein L

更新日期：2018-05-01 00:00:00

abstract：:Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the corne...

journal_title：Journal of biomedical optics

authors： Shin S,Bae JK,Ahn Y,Kim H,Choi G,Yoo YS,Joo CK,Moon S,Jung W

更新日期：2017-12-01 00:00:00

abstract：:Current techniques to assess lymph node metastases in cancer patients include lymphoscintigraphy after administration of a nonspecific radiocolloid in order to locate and resect lymph nodes for pathological examination of harbored cancer cells. Clinical trials involving intradermal or subcutaneous injection of antibod...

journal_title：Journal of biomedical optics

authors： Sampath L,Wang W,Sevick-Muraca EM

更新日期：2008-07-01 00:00:00

abstract：:SpineLab is a software tool developed for reconstructing neuronal feature skeletons from three-dimensional single- or multi-photon image stacks. These images often suffer from limited resolution and a low signal-to-noise ratio, making the extraction of morphometric information difficult. To overcome this limitation, w...

journal_title：Journal of biomedical optics

authors： Jungblut D,Vlachos A,Schuldt G,Zahn N,Deller T,Wittum G

更新日期：2012-07-01 00:00:00

abstract：:Penetration profiles of topically applied drugs and cosmetic products provide important information on their efficacy. The application of tape stripping in combination with UV/VIS spectroscopy is checked to determine the local position of topically applied substances inside the stratum corneum, the penetration profile...

journal_title：Journal of biomedical optics

authors： Weigmann HJ,Jacobi U,Antoniou C,Tsikrikas GN,Wendel V,Rapp C,Gers-Barlag H,Sterry W,Lademann J

更新日期：2005-01-01 00:00:00

abstract：:We have been developing a Mach-Zehnder type of optical frequency domain reflectometry optical coherence tomography (OFDR-OCT) that uses discretely swept superstructure-grating distributed Bragg- reflector (SSG-DBR) lasers developed for telecommunication fields and has a 12-mm-depth range. We report images obtained wit...

journal_title：Journal of biomedical optics

authors： Kakuma H,Ohbayashi K,Arakawa Y

更新日期：2008-01-01 00:00:00

abstract：:We demonstrate the utility of functional near-infrared spectroscopy (fNIRS) as a tool for physicians to study cortical plasticity in children with cerebral palsy (CP). Motor cortex activation patterns were studied in five healthy children and five children with CP (8.4+/-2.3 years old in both groups) performing a fing...

journal_title：Journal of biomedical optics

authors： Khan B,Tian F,Behbehani K,Romero MI,Delgado MR,Clegg NJ,Smith L,Reid D,Liu H,Alexandrakis G

更新日期：2010-05-01 00:00:00

abstract：:Ultrasmall scale implants have recently attracted focus as valuable tools for monitoring both acute and chronic diseases. Semiconductor optical technologies are the key to miniaturizing these devices to the long-sought sub-mm scale, which will enable long-term use of these devices for medical applications. This can al...

journal_title：Journal of biomedical optics

authors： Mujeeb-U-Rahman M,Adalian D,Chang CF,Scherer A

更新日期：2015-09-01 00:00:00

abstract：:Biomedical applications of terahertz (THz) radiation are appealing because THz radiation is nonionizing and has the demonstrated ability to detect intrinsic contrasts between cancerous and normal tissue. A linear polarization-sensitive detection technique for tumor margin delineation has already been demonstrated; how...

journal_title：Journal of biomedical optics

authors： Martin JP,Joseph CS,Giles RH

更新日期：2016-07-01 00:00:00

abstract：:High resolution is important for sensitive detection of subtle distortions of retinal morphology at an early stage of eye diseases. We demonstrate virtually structured detection (VSD) as a feasible method to achieve in vivo super-resolution ophthalmoscopy. A line-scanning strategy was employed to achieve a super-resol...

journal_title：Journal of biomedical optics

authors： Liu C,Zhi Y,Wang B,Thapa D,Chen Y,Alam M,Lu Y,Yao X

更新日期：2016-12-01 00:00:00

abstract：:By applying linear perturbation theory to the radiation transport equation, the inverse problem of optical diffusion tomography can be reduced to a set of linear equations, Wμ=R, where W is the weight function, μ are the cross-section perturbations to be imaged, and R is the detector readings perturbations. We have st...

journal_title：Journal of biomedical optics

authors： Chang J,Graber HL,Barbour RL

更新日期：1998-04-01 00:00:00

abstract：:Ultraviolet radiation from solar exposure is a key extrinsic factor responsible for premature skin aging (i.e., photo-aging). Recent advances using in vivo multiphoton tomography (MPT) demonstrate the efficacy of this approach to assess intrinsic and extrinsic skin aging as an alternative to existing invasive techniqu...

journal_title：Journal of biomedical optics

authors： Sanchez WY,Obispo C,Ryan E,Grice JE,Roberts MS

更新日期：2013-06-01 00:00:00

abstract：:The effect of glucose on fluorescence of synthesized ZnCdS nanoparticles in the presence of glucose oxidase or in a mixture of glucose oxidase and peroxidase has been investigated. Behavior of fluorescence characteristics of ZnCdS nanoparticles with nonstabilized surface and coated with polymer shell is compared. It h...

journal_title：Journal of biomedical optics

authors： Kochubey VI,Volkova EK,Konyukhova JG

更新日期：2014-01-01 00:00:00

abstract：:We present a novel Fourier-domain angle-resolved low-coherence interferometry (a /LCI) fiber probe designed for in vivo clinical application in gastrointestinal endoscopy. The a/LCI technique measures the depth-resolved angular scattering distribution to determine the size distribution and optical density of cell nucl...

journal_title：Journal of biomedical optics

authors： Zhu Y,Terry NG,Woosley JT,Shaheen NJ,Wax A

更新日期：2011-01-01 00:00:00

abstract：:In the present applications of optical coherence tomography (OCT), parameters besides pure morphology are evaluated in skin tissue under in vivo conditions. Spatially mapped refractive indices and scattering coefficients may support tissue characterization for research and diagnostic purposes in cosmetics/pharmacy and...

journal_title：Journal of biomedical optics

authors： Knüttel A,Boehlau-Godau M

更新日期：2000-01-01 00:00:00

abstract：:The essential feature of the confocal laser scanning microscope (cLSM) is the generation of optical sections by the removal of out-of-focus light. About ten years ago, structured illumination microscopy (SIM) was introduced as an alternative method for obtaining optical sections from biological specimens. Here we comp...

journal_title：Journal of biomedical optics

authors： Weigel A,Schild D,Zeug A

更新日期：2009-01-01 00:00:00

abstract：:Intraoperative applications of near-infrared (NIR) fluorescent contrast agents can be aided by instrumentation capable of merging the view of surgical field with that of NIR fluorescence. We demonstrate augmented microscopy, an intraoperative imaging technique in which bright-field (real) and electronically processed ...

journal_title：Journal of biomedical optics

authors： Watson JR,Gainer CF,Martirosyan N,Skoch J,Lemole GM Jr,Anton R,Romanowski M

更新日期：2015-10-01 00:00:00