Prehistological evaluation of benign and malignant pigmented skin lesions with optical computed tomography.

abstract：:We report a photonic approach for selective inactivation of viruses with a near-infrared subpicosecond laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as the M13 bacteriophage and the tobacco mosaic virus to pathogenic viruses such as the human ...

journal_title：Journal of biomedical optics

authors： Tsen KT,Tsen SW,Fu Q,Lindsay SM,Kibler K,Jacobs B,Wu TC,Karanam B,Jagu S,Roden RB,Hung CF,Sankey OF,Ramakrishna B,Kiang JG

更新日期：2009-11-01 00:00:00

abstract：:Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, curre...

journal_title：Journal of biomedical optics

authors： Petitdidier N,Koenig A,Gerbelot R,Grateau H,Gioux S,Jallon P

更新日期：2018-11-01 00:00:00

abstract：:Fluorescence molecular tomography (FMT) is an important in vivo imaging modality to visualize physiological and pathological processes in small animals. However, FMT reconstruction is ill-posed and ill-conditioned due to strong optical scattering in deep tissues, which results in poor spatial resolution. It is well kn...

journal_title：Journal of biomedical optics

authors： Baikejiang R,Zhao Y,Fite BZ,Ferrara KW,Li C

更新日期：2017-05-01 00:00:00

abstract：:So far, the study of the optical clearing is almost always about healthy tissue. However, the ultimate goal is to detect diseases for clinical application. Optical clearing on diseased skins is explored. The effect is evaluated by applying a combined liquid paraffin and glycerol mixed solution on several kinds of dise...

journal_title：Journal of biomedical optics

authors： Shan H,Liang Y,Wang J,Li Y

更新日期：2012-11-01 00:00:00

abstract：:The aim is to study cerebral vascular functional connectivity during motor tasks and resting state using multichannel frequency-domain near-infrared spectrophotometry. Maps of 5.7 × 10.8 cm size displaying changes in cerebral oxyhemoglobin (O(2)Hb), deoxyhemoglobin (HHb), and total hemoglobin (tHb) concentrations were...

journal_title：Journal of biomedical optics

authors： Wolf U,Toronov V,Choi JH,Gupta R,Michalos A,Gratton E,Wolf M

更新日期：2011-08-01 00:00:00

abstract：:We present a multimodal optical microscope that incorporates six imaging modalities on one common platform. The imaging modalities include three staring modes, optical quadrature microscopy (OQM), differential interference contrast (DIC) microscopy, and epi-fluorescence microscopy, and three scanning modes, confocal r...

journal_title：Journal of biomedical optics

authors： Warger WC 2nd,Laevsky GS,Townsend DJ,Rajadhyaksha M,DiMarzio CA

更新日期：2007-07-01 00:00:00

abstract：:Spectral resolved tissue imaging has a broad range of biomedical applications such as the minimally invasive diagnosis of diseases and the study of wound healing and tissue engineering processes. Two-photon microscopy imaging of endogenous fluorescence has been shown to be a powerful method for the quantification of t...

journal_title：Journal of biomedical optics

authors： Laiho LH,Pelet S,Hancewicz TM,Kaplan PD,So PT

更新日期：2005-03-01 00:00:00

abstract：:We examine the morphological and chemical changes in the pulp chamber dentin after using endodontic agents by scanning electron microscopy (SEM), Fourier transform Raman spectroscopy (FT-Raman), and micro energy-dispersive x-ray fluorescence spectrometry (μEDXRF). Thirty teeth were sectioned exposing the pulp chamber ...

journal_title：Journal of biomedical optics

authors： Pascon FM,Kantovitz KR,Soares LE,Santo AM,Martin AA,Puppin-Rontani RM

更新日期：2012-07-01 00:00:00

abstract：:We investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in extent and location, depending on the occurrence of laser-induce...

journal_title：Journal of biomedical optics

authors： Roach WP,Cain CP,Narayan DG,Noojin GD,Boppart SA,Birngruber R,Fujimoto JG,Toth CA

更新日期：2004-11-01 00:00:00

abstract：:The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

journal_title：Journal of biomedical optics

authors： Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

更新日期：2012-07-01 00:00:00

abstract：:In this study we examine the implications of excitation saturation on fluorescence recovery after photobleaching (FRAP) experiments. In particular we present both experimental and theoretical evidence that fluorescein, one of the most frequently used fluorophores in FRAP, does not always comply with the basic assumpti...

journal_title：Journal of biomedical optics

authors： Braeckmans K,Stubbe BG,Remaut K,Demeester J,De Smedt SC

更新日期：2006-07-01 00:00:00

abstract：:A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows ...

journal_title：Journal of biomedical optics

authors： El-Ghussein F,Mastanduno MA,Jiang S,Pogue BW,Paulsen KD

更新日期：2014-01-01 00:00:00

abstract：:The efficacy of existing therapies and the discovery of innovative treatments for central nervous system (CNS) diseases have been limited by the lack of appropriate methods to investigate complex molecular processes at the synaptic level. To improve our capability to investigate complex mechanisms of synaptic signalin...

journal_title：Journal of biomedical optics

authors： Labrecque S,Sylvestre JP,Marcet S,Mangiarini F,Bourgoin B,Verhaegen M,Blais-Ouellette S,De Koninck P

更新日期：2016-04-30 00:00:00

abstract：:The refractive index of blood is a key biophysical parameter, which can reflect the physiological state. We measured the refractive index of whole blood and other components, such as serum, plasma, and hemoglobin, based on internal reflection by using a homemade apparatus in the spectral range of 400 to 750 nm. In add...

journal_title：Journal of biomedical optics

authors： Liu S,Deng Z,Li J,Wang J,Huang N,Cui R,Zhang Q,Mei J,Zhou W,Zhang C,Ye Q,Tian J

更新日期：2019-03-01 00:00:00

abstract：:An algorithm was developed to obtain depth-resolved local optical axis in birefringent samples by using conventional polarization-sensitive optical coherence tomography (PSOCT) that uses a single circularly polarized incident light. The round-trip sample Jones matrices were first constructed from the cumulative PSOCT ...

journal_title：Journal of biomedical optics

authors： Fan C,Yao G

更新日期：2012-11-01 00:00:00

abstract：:We report the design of a novel laser line-triangulation laryngoscope for the quantitative visualization of the three-dimensional movements of human vocal folds during phonation. This is the first successful in vivo recording of the three-dimensional movements of human vocal folds in absolute values. Triangulation ima...

journal_title：Journal of biomedical optics

authors： George NA,de Mul FF,Qiu Q,Rakhorst G,Schutte HK

更新日期：2008-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) is an alternative to radical surgical resection for T1a or nonresectable carcinomas of the gastroesophageal junction. Besides the concentration of the photosensitizer, the light distribution in tissue is responsible for tumor destruction. For this reason, knowledge about the behavior of ligh...

journal_title：Journal of biomedical optics

authors： Holmer C,Lehmann KS,Wanken J,Reissfelder C,Roggan A,Mueller G,Buhr HJ,Ritz JP

更新日期：2007-01-01 00:00:00

abstract：:By applying linear perturbation theory to the radiation transport equation, the inverse problem of optical diffusion tomography can be reduced to a set of linear equations, Wμ=R, where W is the weight function, μ are the cross-section perturbations to be imaged, and R is the detector readings perturbations. We have st...

journal_title：Journal of biomedical optics

authors： Chang J,Graber HL,Barbour RL

更新日期：1998-04-01 00:00:00

abstract：:Frequency-domain diffuse optical spectroscopy (FD-DOS) utilizes intensity-modulated light to characterize optical scattering and absorption in thick tissue. Previous FD-DOS systems have been limited by large device footprints, complex electronics, high costs, and limited acquisition speeds, all of which complicate acc...

journal_title：Journal of biomedical optics

authors： Torjesen A,Istfan R,Roblyer D

更新日期：2017-03-01 00:00:00

abstract：:We have employed near-infrared optical methods to measure noninvasively the dynamics of muscle blood flow and oxygen saturation (StO2) during cuff occlusion and plantar flexion exercise. Relative muscle oxygen consumption (rVO2) was also computed from these data. Diffuse correlation spectroscopy provides information a...

journal_title：Journal of biomedical optics

authors： Yu G,Durduran T,Lech G,Zhou C,Chance B,Mohler ER 3rd,Yodh AG

更新日期：2005-03-01 00:00:00

abstract：:The Nikon C1 confocal laser scanning microscope is a relatively inexpensive and user-friendly instrument. We describe a straightforward method to convert the C1 for multiphoton microscopy utilizing direct coupling of a femtosecond near-infrared laser into the scan head and fiber optic transmission of emission light to...

journal_title：Journal of biomedical optics

authors： Mancuso JJ,Larson AM,Wensel TG,Saggau P

更新日期：2009-05-01 00:00:00

abstract：SIGNIFICANCE:Photothermal optical coherence tomography (PT-OCT) has the promise to offer structural images coregistered with chemical composition information, which can offer a significant impact in early detection of diseases such as atherosclerosis. AIM:We take the first step in understanding the relation between PT...

journal_title：Journal of biomedical optics

authors： Salimi M,Villiger M,Tabatabaei N

更新日期：2020-12-01 00:00:00

abstract：:Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in >25  %   of cases due to positive or closely involved margin...

journal_title：Journal of biomedical optics

authors： Schaefer JM,Barth CW,Davis SC,Gibbs SL

更新日期：2019-02-01 00:00:00

abstract：:Image resolution and signal level in fluorescence microscopy through inhomogeneous turbid media consisting of scatterers of multiple sizes under single- (1p), two- (2p), and three-photon (3p) excitation have been investigated based on a modified Monte Carlo model. The effects of the size distribution and the concentra...

journal_title：Journal of biomedical optics

authors： Deng X,Gan X,Gu M

更新日期：2003-07-01 00:00:00

abstract：:When irradiated with nanosecond laser pulses, gold nanoparticles allow for manipulation or destruction of cells and proteins with high spatial and temporal precision. Gold nanorods are especially attractive, because they have an up-to-20-fold stronger absorption than a sphere of equal volume, which is shifted to the o...

journal_title：Journal of biomedical optics

authors： Rudnitzki F,Bever M,Rahmanzadeh R,Brieger K,Endl E,Groll J,Hüttmann G

更新日期：2012-05-01 00:00:00

abstract：:Recent technological advancements in the photonics industry have led to a resurgence of interest in optical glucose sensing and to realistic progress toward the development of an optical glucose sensor. Such a sensor has the potential to significantly improve the quality of life for the estimated 16 million diabetics ...

journal_title：Journal of biomedical optics

authors： McNichols RJ,Coté GL

更新日期：2000-01-01 00:00:00

abstract：:We investigated the effect of thiazone, a widely used penetration enhancer, on in vitro porcine skin and muscle tissue by single-integrating sphere technique during optical clearing (OC) treatment. The results showed that thiazone induced an increase on the total transmittance of skin which led to a reduction in that ...

journal_title：Journal of biomedical optics

authors： Jin X,Deng Z,Wang J,Ye Q,Mei J,Zhou W,Zhang C,Tian J

更新日期：2016-10-01 00:00:00

abstract：:Optically derived tissue properties across a range of breast densities and the effects of breast compression on estimates of hemoglobin, oxygen metabolism, and water and lipid concentrations were obtained from a coregistered imaging system that integrates near-infrared spectral tomography (NIRST) with digital breast t...

journal_title：Journal of biomedical optics

authors： Michaelsen KE,Krishnaswamy V,Shi L,Vedantham S,Karellas A,Pogue BW,Paulsen KD,Poplack SP

更新日期：2016-09-01 00:00:00

abstract：:The essential feature of the confocal laser scanning microscope (cLSM) is the generation of optical sections by the removal of out-of-focus light. About ten years ago, structured illumination microscopy (SIM) was introduced as an alternative method for obtaining optical sections from biological specimens. Here we comp...

journal_title：Journal of biomedical optics

authors： Weigel A,Schild D,Zeug A

更新日期：2009-01-01 00:00:00

abstract：:We compared light-induced fluorescence (LIF) to nominal injected drug dose for predicting the depth of necrosis response to photodynamic therapy (PDT) in a murine tumor model. Mice were implanted with radiation-induced fibrosarcoma (RIF) and were injected with 0, 5, or 10 mg/kg Photofrin. 630-nm light (30 J/cm(2), 75 ...

journal_title：Journal of biomedical optics

authors： Cheung R,Solonenko M,Busch TM,Del Piero F,Putt ME,Hahn SM,Yodh AG

更新日期：2003-04-01 00:00:00