Monte Carlo simulation of multiphoton fluorescence microscopic imaging through inhomogeneous tissuelike turbid media.

abstract：:The goal of this study was to determine the diagnostic capability of a multimodal spectral diagnosis (SD) for in vivo noninvasive disease diagnosis of melanoma and nonmelanoma skin cancers. We acquired reflectance, fluorescence, and Raman spectra from 137 lesions in 76 patients using custom-built optical fiber-based c...

journal_title：Journal of biomedical optics

authors： Lim L,Nichols B,Migden MR,Rajaram N,Reichenberg JS,Markey MK,Ross MI,Tunnell JW

更新日期：2014-01-01 00:00:00

abstract：:A Monte Carlo algorithm is applied to simulate the measurements of a sample with glass slides sandwiched between the double integrating sphere (DIS) setup. The effects caused by various parameters, such as the sample port of integrating sphere, thicknesses, and optical properties of the sample, on light losses and opt...

journal_title：Journal of biomedical optics

authors： Zhu D,Lu W,Zeng S,Luo Q

更新日期：2007-11-01 00:00:00

abstract：:Clinical imaging techniques for the anterior segment of the eye provide excellent anatomical information, but molecular imaging techniques are lacking. Molecular photoacoustic imaging is one option to address this need, but implementation requires use of contrast agents to distinguish molecular targets from background...

journal_title：Journal of biomedical optics

authors： Kubelick KP,Snider EJ,Ethier CR,Emelianov S

更新日期：2019-05-01 00:00:00

abstract：:The objective is to characterize the impact of different ablation parameters on the thermal load during corneal refractive surgery by means of excimer laser ablation on porcine eyes. One hundred eleven ablations were performed in 105 porcine eyes. Each ablation was recorded using infrared thermography and analyzed mai...

journal_title：Journal of biomedical optics

authors： Arba Mosquera S,Verma S

更新日期：2015-07-01 00:00:00

abstract：:Time-resolved measurement of early arriving photons through diffusive media has been shown to effectively reduce the high degree of light scatter in biological tissue. However, the experimentally achievable reduction in photon scatter and the impact of time-gated detection on instrument noise performance is not well u...

journal_title：Journal of biomedical optics

authors： Valim N,Brock J,Niedre M

更新日期：2010-11-01 00:00:00

abstract：:As molecular imaging moves towards lower detection limits, the elimination of endogenous background signals becomes imperative. We present a facile background-suppression technique that specifically segregates the signal from surface-enhanced Raman scattering (SERS)-active nanoparticles (NPs) from the tissue autofluor...

journal_title：Journal of biomedical optics

authors： Mallia RJ,McVeigh PZ,Veilleux I,Wilson BC

更新日期：2012-07-01 00:00:00

abstract：SIGNIFICANCE:Although the clinical potential for Raman spectroscopy (RS) has been anticipated for decades, it has only recently been used in neurosurgery. Still, few devices have succeeded in making their way into the operating room. With recent technological advancements, however, vibrational sensing is poised to be a...

journal_title：Journal of biomedical optics

authors： DePaoli D,Lemoine É,Ember K,Parent M,Prud'homme M,Cantin L,Petrecca K,Leblond F,Côté DC

更新日期：2020-05-01 00:00:00

abstract：:Anastomotic complication is a major morbidity associated with esophagectomy. Gastric ischemia after conduit creation contributes to anastomotic complications, but a reliable method to assess oxygenation in the gastric conduit is lacking. We hypothesize that fiber optic spectroscopy can reliably assess conduit oxygenat...

journal_title：Journal of biomedical optics

authors： Gareau DS,Truffer F,Perry KA,Pham TH,Enestvedt CK,Dolan JP,Hunter JG,Jacques SL

更新日期：2010-11-01 00:00:00

abstract：:The morphogenetic relationship between early patterning and polarity formation is of fundamental interest and remains a controversial issue in preimplantation embryonic development. We use a label-free three-dimensional (3-D) imaging technique of full-field optical coherence tomography (FF-OCT) successfully for the fi...

journal_title：Journal of biomedical optics

authors： Zheng JG,Huo T,Chen T,Wang C,Zhang N,Tian N,Zhao F,Lu D,Chen D,Ma W,Sun JL,Xue P

更新日期：2013-01-01 00:00:00

abstract：:Dental erosion starts with a chemical attack on dental tissue causing tooth demineralization, altering the tooth structure and making it more sensitive to mechanical erosion. Medical diagnosis of dental erosion is commonly achieved through a visual inspection by the dentist during dental checkups and is therefore high...

journal_title：Journal of biomedical optics

authors： Abou Nader C,Pellen F,Loutfi H,Mansour R,Le Jeune B,Le Brun G,Abboud M

更新日期：2016-07-01 00:00:00

abstract：:Laser welding has the potential to become an effective method for wound closure and healing without sutures. Closure of skin incisions by laser welding with a combination of two near-infrared lasers (980 and 1064 nm), was performed for the first time in this study. One centimeter long, full-thickness incisions were ma...

journal_title：Journal of biomedical optics

authors： Hu L,Lu Z,Wang B,Cao J,Ma X,Tian Z,Gao Z,Qin L,Wu X,Liu Y,Wang L

更新日期：2011-03-01 00:00:00

abstract：:Spectrally resolved two-photon excited autofluorescence imaging is used to distinguish different cell types and functional areas during dynamic processes in the living gut. Excitation and emission spectra of mucosal tissue and tissue components are correlated to spectra of endogenous chromophores. We show that selecti...

journal_title：Journal of biomedical optics

authors： Orzekowsky-Schroeder R,Klinger A,Martensen B,Blessenohl M,Gebert A,Vogel A,Hüttmann G

更新日期：2011-11-01 00:00:00

abstract：:We report an accurate optical differentiation technique between healthy and malaria-infected erythrocytes by quasi-simultaneous measurements of transmittance, reflectance, and scattering properties of unstained blood smears using a multispectral and multimode light-emitting diode microscope. We propose a technique for...

journal_title：Journal of biomedical optics

authors： Merdasa A,Brydegaard M,Svanberg S,Zoueu JT

更新日期：2013-03-01 00:00:00

abstract：SIGNIFICANCE:Optical coherence tomography (OCT) has proven useful for detecting various oral maxillofacial abnormalities. To apply it to clinical applications including biopsy guidance and routine screening, a handheld imaging probe is indispensable. OCT probes reported for oral maxillofacial imaging were either based ...

journal_title：Journal of biomedical optics

authors： Li K,Yang Z,Liang W,Shang J,Liang Y,Wan S

更新日期：2020-04-01 00:00:00

abstract：:A tutorial introduction to diffuse light transport is presented. The basic analytic equations of time-resolved, steady-state and modulated light transport are introduced. The perturbation method for handling slight heterogeneities in optical properties is outlined. The treatment of boundary conditions such as an air/t...

journal_title：Journal of biomedical optics

authors： Jacques SL,Pogue BW

更新日期：2008-07-01 00:00:00

abstract：:We experimentally study potential mechanisms by which the enhancement factor in low-coherence enhanced backscattering (LEBS) can probe subtle variations in radial intensity distribution in weakly scattering media. We use enhanced backscattering of light by implementing either (1) low spatial coherence illumination or ...

journal_title：Journal of biomedical optics

authors： Liu J,Xu Z,Song Q,Konger RL,Kim YL

更新日期：2010-05-01 00:00:00

abstract：:In breast surgery, a lack of knowledge about what is below the tissue surface may lead to positive tumor margins and iatrogenic damage. Diffuse reflectance spectroscopy (DRS) is a spectroscopic technique that can distinguish between healthy and tumor tissue making it a suitable technology for intraoperative guidance. ...

journal_title：Journal of biomedical optics

authors： Adank MW,Fleischer JC,Dankelman J,Hendriks BHW

更新日期：2018-11-01 00:00:00

abstract：:A classifier capable of ranking structural alterations of the cytoskeleton is developed. Images of cytoskeletal microtubules obtained from the epifluorescence microscopy of primary culture rat hepatocytes are analyzed. Morphological descriptors are extracted by contour and mass fractal analysis, direct methods, and sp...

journal_title：Journal of biomedical optics

authors： Crosta GF,Urani C,Fumarola L

更新日期：2006-03-01 00:00:00

abstract：:A new, simple, high-speed, and hardware-only integration-based fluorescence-lifetime-sensing algorithm using a center-of-mass method (CMM) is proposed to implement lifetime calculations, and its signal-to-noise-ratio based on statistics theory is also deduced. Compared to the commonly used iterative least-squares meth...

journal_title：Journal of biomedical optics

authors： Li DU,Rae B,Andrews R,Arlt J,Henderson R

更新日期：2010-01-01 00:00:00

abstract：:Previous studies have shown the ability of many lymphatic vessels to contract phasically to pump lymph. Every lymphangion can act like a heart with pacemaker sites that initiate the phasic contractions. The contractile wave propagates along the vessel to synchronize the contraction. However, determining the location o...

journal_title：Journal of biomedical optics

authors： Akl TJ,Nepiyushchikh ZV,Gashev AA,Zawieja DC,Cot GL

更新日期：2011-02-01 00:00:00

abstract：:The formation of kidney stones is a common and highly studied disease, which causes intense pain and presents a high recidivism. In order to find the causes of this problem, the characterization of the main compounds is of great importance. In this sense, the analysis of the composition and structure of the stone can ...

journal_title：Journal of biomedical optics

authors： Blanco F,López-Mesas M,Serranti S,Bonifazi G,Havel J,Valiente M

更新日期：2012-07-01 00:00:00

abstract：:We have presented an innovative laser-assisted reduction surgery (LARS) based on plasma-induced ablation and photodisruption effects. In addition, we developed a laser operation system. Fetuses of mice from the Institute for Cancer Research that were immersed in physiological saline were irradiated by convergent-pulse...

journal_title：Journal of biomedical optics

authors： Wang Y,Xiong Q,Ye Z,Ge J

更新日期：2013-11-01 00:00:00

abstract：:Angle-resolved signals of polarized light scattered by biological cells provide rich information on cell morphology. Quantitative study of these signals can lead to new methods to develop and improve high-throughput instrumentation for cell probing such as scattering-based flow cytometry. We employ a goniometer system...

journal_title：Journal of biomedical optics

authors： Ding H,Lu JQ,Brock RS,McConnell TJ,Ojeda JF,Jacobs KM,Hu XH

更新日期：2007-05-01 00:00:00

abstract：:Pedicle screw (PS) fixation has been widely used for spine diseases. Scientists and clinicians employ several approaches to navigate PS during operation. We have demonstrated the feasibility of monitoring the reduced scattering coefficient (μ's) on the trajectory of PS using near-infrared spectroscopy (NIRS). To perfo...

journal_title：Journal of biomedical optics

authors： Liu Y,Wang Y,Qian Z,Zhao J,Cao X,Li W

更新日期：2014-01-01 00:00:00

abstract：:We describe a wide-field optical tomography technique, which allows the measurement-guided optimization of illumination patterns for enhanced reconstruction performances. The iterative optimization of the excitation pattern aims at reducing the dynamic range in photons transmitted through biological tissue. It increas...

journal_title：Journal of biomedical optics

authors： Venugopal V,Intes X

更新日期：2013-03-01 00:00:00

abstract：:A reflectance volume holographic imaging (VHI) endoscope has been designed for simultaneous in vivo imaging of surface and subsurface tissue structures. Prior utilization of VHI systems has been limited to ex vivo tissue imaging. The VHI system presented in this work is designed for laparoscopic use. It consists of a ...

journal_title：Journal of biomedical optics

authors： Howlett ID,Han W,Gordon M,Rice P,Barton JK,Kostuk RK

更新日期：2017-05-01 00:00:00

abstract：:We used two-photon laser scanning microscopy (TPLSM) to demonstrate for the first time its potential in studying relational details at the cellular level of atherogenesis in intact, viable mouse carotid arteries. Isolated and mounted arteries of ApoE-/-mice, aged 15 or 21 weeks (7 and 13 weeks on western diet), were i...

journal_title：Journal of biomedical optics

authors： Megens RT,oude Egbrink MG,Merkx M,Slaaf DW,van Zandvoort MA

更新日期：2008-07-01 00:00:00

abstract：:Model-based light scattering spectroscopy (LSS) seemed a promising technique for in-vivo diagnosis of dysplasia in multiple organs. In the studies, the residual spectrum, the difference between the observed and modeled diffuse reflectance spectra, was attributed to single elastic light scattering from epithelial nucle...

journal_title：Journal of biomedical optics

authors： Lau C,Sćepanović O,Mirkovic J,McGee S,Yu CC,Fulghum S,Wallace M,Tunnell J,Bechtel K,Feld M

更新日期：2009-03-01 00:00:00

abstract：:Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requi...

journal_title：Journal of biomedical optics

authors： Pinto M,Zorn KC,Tremblay JP,Desroches J,Dallaire F,Aubertin K,Marple E,Kent C,Leblond F,Trudel D,Lesage F

更新日期：2019-02-01 00:00:00

abstract：:Fourier domain (FD) techniques have increasingly gained attention in optical coherence tomography (OCT). This is primarily due to their demonstrated sensitivity of two to three orders of magnitude over conventional time-domain techniques. FDOCT images are subject to two primary sources of artifacts. First, a complex c...

journal_title：Journal of biomedical optics

authors： Davis AM,Choma MA,Izatt JA

更新日期：2005-11-01 00:00:00